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Reserve Cell Hyperplasia

MedGen UID:
1717117
•Concept ID:
C5237226
•
Pathologic Function

Definition

Hyperplasia of the immature cells located between the surface columnar epithelium and the basal layer. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReserve Cell Hyperplasia

Professional guidelines

PubMed

Quantitation of Ki-67 expression in the differential diagnosis of reserve cell hyperplasia vs. small cell lung carcinoma.
Grefte JM, Salet-van de Pol MR, Gemmink JH, Bulten J, Hanselaar AG, de Wilde PC
Acta Cytol 2004 Sep-Oct;48(5):608-12. doi: 10.1159/000326430. PMID: 15471251
Clinical viewpoint on the management of reserve cell hyperplasia, basal cell hyperplasia and dysplasia.
PALMER R, WENNER-MANGEN H
Acta Cytol 1961 Jul-Aug;5:263-5. PMID: 13732300

Recent clinical studies

Etiology

Elimination of reserve cells for prevention of HPV-associated cervical cancer.
Reich O, Regauer S
Virus Res 2023 May;329:199068. Epub 2023 Mar 16 doi: 10.1016/j.virusres.2023.199068. PMID: 36854360Free PMC Article
Efficacy of Bronchial Washing and Brushing Cytology in the Diagnosis of Non-Neoplastic Lung Diseases.
Giti R, Hosseinzadeh M
Acta Med Iran 2017 Oct;55(10):636-641. PMID: 29228529
Quantitation of Ki-67 expression in the differential diagnosis of reserve cell hyperplasia vs. small cell lung carcinoma.
Grefte JM, Salet-van de Pol MR, Gemmink JH, Bulten J, Hanselaar AG, de Wilde PC
Acta Cytol 2004 Sep-Oct;48(5):608-12. doi: 10.1159/000326430. PMID: 15471251
Decreased synthesis and expression of TGF-beta1, beta2, and beta3 in epithelium of HPV 16-positive cervical precancer: a study by microdissection, quantitative RT-PCR, and immunocytochemistry.
El-Sherif AM, Seth R, Tighe PJ, Jenkins D
J Pathol 2000 Dec;192(4):494-501. doi: 10.1002/1096-9896(200012)192:4<494::AID-PATH760>3.0.CO;2-W. PMID: 11113867
The prevalence of cervicitis, reserve cell hyperplasia, squamous metaplasia, and cervical dysplasia in Jewish women.
Czernobilsky B, Zeituni M, Lancet M, Mazor B, Baram A, Deligdish L
Obstet Gynecol 1977 May;49(5):587-91. PMID: 850575

Diagnosis

Cytopathological Findings in Bronchoalveolar Lavage from Patients with COVID-19.
Galeano Reyes SA, Dhimes Tejeda P, Steen B, Arcos Orozco HK, Ramos Pontón P
Acta Cytol 2022;66(6):532-541. Epub 2022 Jun 22 doi: 10.1159/000525339. PMID: 35732159Free PMC Article
Efficacy of Bronchial Washing and Brushing Cytology in the Diagnosis of Non-Neoplastic Lung Diseases.
Giti R, Hosseinzadeh M
Acta Med Iran 2017 Oct;55(10):636-641. PMID: 29228529
Cytology of nonneoplastic occupational and environmental diseases of the lung and pleura.
Laucirica R, Ostrowski ML
Arch Pathol Lab Med 2007 Nov;131(11):1700-8. doi: 10.5858/2007-131-1700-CONOAE. PMID: 17979490
Quantitation of Ki-67 expression in the differential diagnosis of reserve cell hyperplasia vs. small cell lung carcinoma.
Grefte JM, Salet-van de Pol MR, Gemmink JH, Bulten J, Hanselaar AG, de Wilde PC
Acta Cytol 2004 Sep-Oct;48(5):608-12. doi: 10.1159/000326430. PMID: 15471251
Recognition of atypical reserve cell hyperplasia in cervical smears and its diagnostic significance.
Boon ME, van Dunné FM, Vardaxis NJ
Mod Pathol 1995 Sep;8(7):786-94. PMID: 8539239

Therapy

The utility of p16(Ink4a) in discriminating between cervical intraepithelial neoplasia 1 and nonneoplastic equivocal lesions of the cervix.
Redman R, Rufforny I, Liu C, Wilkinson EJ, Massoll NA
Arch Pathol Lab Med 2008 May;132(5):795-9. doi: 10.5858/2008-132-795-TUOPID. PMID: 18466028
Cytology of nonneoplastic occupational and environmental diseases of the lung and pleura.
Laucirica R, Ostrowski ML
Arch Pathol Lab Med 2007 Nov;131(11):1700-8. doi: 10.5858/2007-131-1700-CONOAE. PMID: 17979490
Microglandular hyperplasia of the uterine cervix.
Chumas JC, Nelson B, Mann WJ, Chalas E, Kaplan CG
Obstet Gynecol 1985 Sep;66(3):406-9. PMID: 4022499
A clinicopathologic study of vagina and cervix in DES-exposed progeny.
Zerner J, Fu YS, Taxiarchis LN, Reagan JW, Richart RM
Diagn Gynecol Obstet 1980 Winter;2(4):245-56. PMID: 7215109
Aberrant glandular polypi of the uterine cervix associated with contraceptive pills: pathology and pathogenesis.
Govan AD, Black WP, Sharp JL
J Clin Pathol 1969 Jan;22(1):84-9. doi: 10.1136/jcp.22.1.84. PMID: 5784695Free PMC Article

Prognosis

Quantitation of Ki-67 expression in the differential diagnosis of reserve cell hyperplasia vs. small cell lung carcinoma.
Grefte JM, Salet-van de Pol MR, Gemmink JH, Bulten J, Hanselaar AG, de Wilde PC
Acta Cytol 2004 Sep-Oct;48(5):608-12. doi: 10.1159/000326430. PMID: 15471251
Clinicopathological study of the pattern and significance of cervical involvement in cases of endometrial adenocarcinoma.
Jordan LB, Al-Nafussi A
Int J Gynecol Cancer 2002 Jan-Feb;12(1):42-8. doi: 10.1046/j.1525-1438.2002.01076.x. PMID: 11860535
Minimal deviation endocervical adenocarcinoma: clinical and histologic features, immunohistochemical staining for carcinoembryonic antigen, and differentiation from confusing benign lesions.
Michael H, Grawe L, Kraus FT
Int J Gynecol Pathol 1984;3(3):261-76. PMID: 6500801
Progression and regression of cervical lesions. Review of smears from women followed without initial biopsy or treatment.
Spriggs AI, Boddington MM
J Clin Pathol 1980 Jun;33(6):517-22. doi: 10.1136/jcp.33.6.517. PMID: 7400354Free PMC Article

Clinical prediction guides

Cytopathological Findings in Bronchoalveolar Lavage from Patients with COVID-19.
Galeano Reyes SA, Dhimes Tejeda P, Steen B, Arcos Orozco HK, Ramos Pontón P
Acta Cytol 2022;66(6):532-541. Epub 2022 Jun 22 doi: 10.1159/000525339. PMID: 35732159Free PMC Article
Recognition of atypical reserve cell hyperplasia in cervical smears and its diagnostic significance.
Boon ME, van Dunné FM, Vardaxis NJ
Mod Pathol 1995 Sep;8(7):786-94. PMID: 8539239
Basal cell pseudopodia and the degree of maturation of squamous metaplasia of the uterine cervix: a morphometric quantification.
Twiggs LB, Clark BA, Okagaki T
Am J Obstet Gynecol 1983 May 1;146(1):69-74. doi: 10.1016/0002-9378(83)90929-8. PMID: 6846426
Squamous metaplasia with reserve cell hyperplasia in the esophagogastric junction zone.
Takubo K
Acta Pathol Jpn 1981 May;31(3):349-59. doi: 10.1111/j.1440-1827.1981.tb01379.x. PMID: 7270146
The prevalence of cervicitis, reserve cell hyperplasia, squamous metaplasia, and cervical dysplasia in Jewish women.
Czernobilsky B, Zeituni M, Lancet M, Mazor B, Baram A, Deligdish L
Obstet Gynecol 1977 May;49(5):587-91. PMID: 850575

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