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Obesity-Related Malignant Neoplasm

MedGen UID:
1717302
•Concept ID:
C5238327
•
Neoplastic Process

Definition

A malignant neoplasm that occurs in the context of obesity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVObesity-Related Malignant Neoplasm

Professional guidelines

PubMed

Probiotics and Polycystic Ovary Syndrome: A Perspective for Management in Adolescents with Obesity.
Calcaterra V, Rossi V, Massini G, Casini F, Zuccotti G, Fabiano V
Nutrients 2023 Jul 14;15(14) doi: 10.3390/nu15143144. PMID: 37513562Free PMC Article
Why primary obesity is a disease?
De Lorenzo A, Gratteri S, Gualtieri P, Cammarano A, Bertucci P, Di Renzo L
J Transl Med 2019 May 22;17(1):169. doi: 10.1186/s12967-019-1919-y. PMID: 31118060Free PMC Article
Management of Obesity.
Alamuddin N, Bakizada Z, Wadden TA
J Clin Oncol 2016 Dec 10;34(35):4295-4305. Epub 2016 Nov 7 doi: 10.1200/JCO.2016.66.8806. PMID: 27903153

Recent clinical studies

Etiology

Metabolic dysfunction and obesity-related cancer: Beyond obesity and metabolic syndrome.
Karra P, Winn M, Pauleck S, Bulsiewicz-Jacobsen A, Peterson L, Coletta A, Doherty J, Ulrich CM, Summers SA, Gunter M, Hardikar S, Playdon MC
Obesity (Silver Spring) 2022 Jul;30(7):1323-1334. doi: 10.1002/oby.23444. PMID: 35785479Free PMC Article
Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study.
Debras C, Chazelas E, Srour B, Druesne-Pecollo N, Esseddik Y, Szabo de Edelenyi F, Agaësse C, De Sa A, Lutchia R, Gigandet S, Huybrechts I, Julia C, Kesse-Guyot E, Allès B, Andreeva VA, Galan P, Hercberg S, Deschasaux-Tanguy M, Touvier M
PLoS Med 2022 Mar;19(3):e1003950. Epub 2022 Mar 24 doi: 10.1371/journal.pmed.1003950. PMID: 35324894Free PMC Article
Obesity and prostate cancer: A narrative review.
Wilson RL, Taaffe DR, Newton RU, Hart NH, Lyons-Wall P, Galvão DA
Crit Rev Oncol Hematol 2022 Jan;169:103543. Epub 2021 Nov 20 doi: 10.1016/j.critrevonc.2021.103543. PMID: 34808374
Metabolic pathways in obesity-related breast cancer.
Brown KA
Nat Rev Endocrinol 2021 Jun;17(6):350-363. Epub 2021 Apr 29 doi: 10.1038/s41574-021-00487-0. PMID: 33927368Free PMC Article
Obesity and cancer risk: Emerging biological mechanisms and perspectives.
Avgerinos KI, Spyrou N, Mantzoros CS, Dalamaga M
Metabolism 2019 Mar;92:121-135. Epub 2018 Nov 13 doi: 10.1016/j.metabol.2018.11.001. PMID: 30445141

Diagnosis

Obesity and multiple myeloma: Emerging mechanisms and perspectives.
Tentolouris A, Ntanasis-Stathopoulos I, Terpos E
Semin Cancer Biol 2023 Jul;92:45-60. Epub 2023 Apr 6 doi: 10.1016/j.semcancer.2023.04.003. PMID: 37030643
Metabolic dysfunction and obesity-related cancer: Beyond obesity and metabolic syndrome.
Karra P, Winn M, Pauleck S, Bulsiewicz-Jacobsen A, Peterson L, Coletta A, Doherty J, Ulrich CM, Summers SA, Gunter M, Hardikar S, Playdon MC
Obesity (Silver Spring) 2022 Jul;30(7):1323-1334. doi: 10.1002/oby.23444. PMID: 35785479Free PMC Article
Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study.
Debras C, Chazelas E, Srour B, Druesne-Pecollo N, Esseddik Y, Szabo de Edelenyi F, Agaësse C, De Sa A, Lutchia R, Gigandet S, Huybrechts I, Julia C, Kesse-Guyot E, Allès B, Andreeva VA, Galan P, Hercberg S, Deschasaux-Tanguy M, Touvier M
PLoS Med 2022 Mar;19(3):e1003950. Epub 2022 Mar 24 doi: 10.1371/journal.pmed.1003950. PMID: 35324894Free PMC Article
Why primary obesity is a disease?
De Lorenzo A, Gratteri S, Gualtieri P, Cammarano A, Bertucci P, Di Renzo L
J Transl Med 2019 May 22;17(1):169. doi: 10.1186/s12967-019-1919-y. PMID: 31118060Free PMC Article
Obesity and cancer risk: Emerging biological mechanisms and perspectives.
Avgerinos KI, Spyrou N, Mantzoros CS, Dalamaga M
Metabolism 2019 Mar;92:121-135. Epub 2018 Nov 13 doi: 10.1016/j.metabol.2018.11.001. PMID: 30445141

Therapy

Mediterranean diet and olive oil, microbiota, and obesity-related cancers. From mechanisms to prevention.
Almanza-Aguilera E, Cano A, Gil-Lespinard M, Burguera N, Zamora-Ros R, Agudo A, Farràs M
Semin Cancer Biol 2023 Oct;95:103-119. Epub 2023 Aug 4 doi: 10.1016/j.semcancer.2023.08.001. PMID: 37543179
Systematic Review and Meta-Analysis of the Impact of Bariatric Surgery on Future Cancer Risk.
Wilson RB, Lathigara D, Kaushal D
Int J Mol Sci 2023 Mar 24;24(7) doi: 10.3390/ijms24076192. PMID: 37047163Free PMC Article
Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study.
Debras C, Chazelas E, Srour B, Druesne-Pecollo N, Esseddik Y, Szabo de Edelenyi F, Agaësse C, De Sa A, Lutchia R, Gigandet S, Huybrechts I, Julia C, Kesse-Guyot E, Allès B, Andreeva VA, Galan P, Hercberg S, Deschasaux-Tanguy M, Touvier M
PLoS Med 2022 Mar;19(3):e1003950. Epub 2022 Mar 24 doi: 10.1371/journal.pmed.1003950. PMID: 35324894Free PMC Article
Genomic correlation, shared loci, and causal relationship between obesity and polycystic ovary syndrome: a large-scale genome-wide cross-trait analysis.
Liu Q, Zhu Z, Kraft P, Deng Q, Stener-Victorin E, Jiang X
BMC Med 2022 Feb 11;20(1):66. doi: 10.1186/s12916-022-02238-y. PMID: 35144605Free PMC Article
Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics.
Puchalska P, Crawford PA
Cell Metab 2017 Feb 7;25(2):262-284. doi: 10.1016/j.cmet.2016.12.022. PMID: 28178565Free PMC Article

Prognosis

Systematic Review and Meta-Analysis of the Impact of Bariatric Surgery on Future Cancer Risk.
Wilson RB, Lathigara D, Kaushal D
Int J Mol Sci 2023 Mar 24;24(7) doi: 10.3390/ijms24076192. PMID: 37047163Free PMC Article
"Time" for obesity-related cancer: The role of the circadian rhythm in cancer pathogenesis and treatment.
Miro C, Docimo A, Barrea L, Verde L, Cernea S, Sojat AS, Marina LV, Docimo G, Colao A, Dentice M, Muscogiuri G
Semin Cancer Biol 2023 Jun;91:99-109. Epub 2023 Mar 7 doi: 10.1016/j.semcancer.2023.03.003. PMID: 36893964
Obesity and prostate cancer: A narrative review.
Wilson RL, Taaffe DR, Newton RU, Hart NH, Lyons-Wall P, Galvão DA
Crit Rev Oncol Hematol 2022 Jan;169:103543. Epub 2021 Nov 20 doi: 10.1016/j.critrevonc.2021.103543. PMID: 34808374
Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk scores.
Bianco C, Jamialahmadi O, Pelusi S, Baselli G, Dongiovanni P, Zanoni I, Santoro L, Maier S, Liguori A, Meroni M, Borroni V, D'Ambrosio R, Spagnuolo R, Alisi A, Federico A, Bugianesi E, Petta S, Miele L, Vespasiani-Gentilucci U, Anstee QM, Stickel F, Hampe J, Fischer J, Berg T, Fracanzani AL, Soardo G, Reeves H, Prati D, Romeo S, Valenti L
J Hepatol 2021 Apr;74(4):775-782. Epub 2020 Nov 25 doi: 10.1016/j.jhep.2020.11.024. PMID: 33248170Free PMC Article
Childhood obesity as a predictor of morbidity in adulthood: a systematic review and meta-analysis.
Llewellyn A, Simmonds M, Owen CG, Woolacott N
Obes Rev 2016 Jan;17(1):56-67. Epub 2015 Oct 6 doi: 10.1111/obr.12316. PMID: 26440472

Clinical prediction guides

Metabolic dysfunction and obesity-related cancer: Beyond obesity and metabolic syndrome.
Karra P, Winn M, Pauleck S, Bulsiewicz-Jacobsen A, Peterson L, Coletta A, Doherty J, Ulrich CM, Summers SA, Gunter M, Hardikar S, Playdon MC
Obesity (Silver Spring) 2022 Jul;30(7):1323-1334. doi: 10.1002/oby.23444. PMID: 35785479Free PMC Article
Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study.
Debras C, Chazelas E, Srour B, Druesne-Pecollo N, Esseddik Y, Szabo de Edelenyi F, Agaësse C, De Sa A, Lutchia R, Gigandet S, Huybrechts I, Julia C, Kesse-Guyot E, Allès B, Andreeva VA, Galan P, Hercberg S, Deschasaux-Tanguy M, Touvier M
PLoS Med 2022 Mar;19(3):e1003950. Epub 2022 Mar 24 doi: 10.1371/journal.pmed.1003950. PMID: 35324894Free PMC Article
Genomic correlation, shared loci, and causal relationship between obesity and polycystic ovary syndrome: a large-scale genome-wide cross-trait analysis.
Liu Q, Zhu Z, Kraft P, Deng Q, Stener-Victorin E, Jiang X
BMC Med 2022 Feb 11;20(1):66. doi: 10.1186/s12916-022-02238-y. PMID: 35144605Free PMC Article
Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics.
Puchalska P, Crawford PA
Cell Metab 2017 Feb 7;25(2):262-284. doi: 10.1016/j.cmet.2016.12.022. PMID: 28178565Free PMC Article
Childhood obesity as a predictor of morbidity in adulthood: a systematic review and meta-analysis.
Llewellyn A, Simmonds M, Owen CG, Woolacott N
Obes Rev 2016 Jan;17(1):56-67. Epub 2015 Oct 6 doi: 10.1111/obr.12316. PMID: 26440472

Recent systematic reviews

Systematic Review and Meta-Analysis of the Impact of Bariatric Surgery on Future Cancer Risk.
Wilson RB, Lathigara D, Kaushal D
Int J Mol Sci 2023 Mar 24;24(7) doi: 10.3390/ijms24076192. PMID: 37047163Free PMC Article
Associations between potential causal factors and colorectal cancer risk: A systematic review and meta-analysis of Mendelian randomization studies.
Deng Y, Wang L, Huang J, Ding H, Wong MCS
J Dig Dis 2022 Aug;23(8-9):435-445. Epub 2022 Nov 20 doi: 10.1111/1751-2980.13130. PMID: 36169182
Signals from the Adipose Microenvironment and the Obesity-Cancer Link-A Systematic Review.
Himbert C, Delphan M, Scherer D, Bowers LW, Hursting S, Ulrich CM
Cancer Prev Res (Phila) 2017 Sep;10(9):494-506. doi: 10.1158/1940-6207.CAPR-16-0322. PMID: 28864539Free PMC Article
Childhood obesity as a predictor of morbidity in adulthood: a systematic review and meta-analysis.
Llewellyn A, Simmonds M, Owen CG, Woolacott N
Obes Rev 2016 Jan;17(1):56-67. Epub 2015 Oct 6 doi: 10.1111/obr.12316. PMID: 26440472
Obesity related adipokines and colorectal cancer: a review and meta-analysis.
Joshi RK, Lee SA
Asian Pac J Cancer Prev 2014;15(1):397-405. doi: 10.7314/apjcp.2014.15.1.397. PMID: 24528064

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