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Obesity-Related Malignant Neoplasm

MedGen UID:
1717302
•Concept ID:
C5238327
•
Neoplastic Process

Definition

A malignant neoplasm that occurs in the context of obesity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVObesity-Related Malignant Neoplasm

Professional guidelines

PubMed

The Beneficial Effects of Essential Oils in Anti-Obesity Treatment.
De Blasio A, D'Anneo A, Lauricella M, Emanuele S, Giuliano M, Pratelli G, Calvaruso G, Carlisi D
Int J Mol Sci 2021 Oct 31;22(21) doi: 10.3390/ijms222111832. PMID: 34769261Free PMC Article
Why primary obesity is a disease?
De Lorenzo A, Gratteri S, Gualtieri P, Cammarano A, Bertucci P, Di Renzo L
J Transl Med 2019 May 22;17(1):169. doi: 10.1186/s12967-019-1919-y. PMID: 31118060Free PMC Article
Management of Obesity.
Alamuddin N, Bakizada Z, Wadden TA
J Clin Oncol 2016 Dec 10;34(35):4295-4305. Epub 2016 Nov 7 doi: 10.1200/JCO.2016.66.8806. PMID: 27903153

Recent clinical studies

Etiology

Metabolic dysfunction and obesity-related cancer: Beyond obesity and metabolic syndrome.
Karra P, Winn M, Pauleck S, Bulsiewicz-Jacobsen A, Peterson L, Coletta A, Doherty J, Ulrich CM, Summers SA, Gunter M, Hardikar S, Playdon MC
Obesity (Silver Spring) 2022 Jul;30(7):1323-1334. doi: 10.1002/oby.23444. PMID: 35785479Free PMC Article
Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study.
Debras C, Chazelas E, Srour B, Druesne-Pecollo N, Esseddik Y, Szabo de Edelenyi F, Agaësse C, De Sa A, Lutchia R, Gigandet S, Huybrechts I, Julia C, Kesse-Guyot E, Allès B, Andreeva VA, Galan P, Hercberg S, Deschasaux-Tanguy M, Touvier M
PLoS Med 2022 Mar;19(3):e1003950. Epub 2022 Mar 24 doi: 10.1371/journal.pmed.1003950. PMID: 35324894Free PMC Article
Obesity and prostate cancer: A narrative review.
Wilson RL, Taaffe DR, Newton RU, Hart NH, Lyons-Wall P, Galvão DA
Crit Rev Oncol Hematol 2022 Jan;169:103543. Epub 2021 Nov 20 doi: 10.1016/j.critrevonc.2021.103543. PMID: 34808374
Metabolic pathways in obesity-related breast cancer.
Brown KA
Nat Rev Endocrinol 2021 Jun;17(6):350-363. Epub 2021 Apr 29 doi: 10.1038/s41574-021-00487-0. PMID: 33927368Free PMC Article
Obesity and cancer risk: Emerging biological mechanisms and perspectives.
Avgerinos KI, Spyrou N, Mantzoros CS, Dalamaga M
Metabolism 2019 Mar;92:121-135. Epub 2018 Nov 13 doi: 10.1016/j.metabol.2018.11.001. PMID: 30445141

Diagnosis

Metabolic dysfunction and obesity-related cancer: Beyond obesity and metabolic syndrome.
Karra P, Winn M, Pauleck S, Bulsiewicz-Jacobsen A, Peterson L, Coletta A, Doherty J, Ulrich CM, Summers SA, Gunter M, Hardikar S, Playdon MC
Obesity (Silver Spring) 2022 Jul;30(7):1323-1334. doi: 10.1002/oby.23444. PMID: 35785479Free PMC Article
Hormonal Crosstalk Between Thyroid and Breast Cancer.
Halada S, Casado-Medrano V, Baran JA, Lee J, Chinmay P, Bauer AJ, Franco AT
Endocrinology 2022 Jul 1;163(7) doi: 10.1210/endocr/bqac075. PMID: 35587175Free PMC Article
Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study.
Debras C, Chazelas E, Srour B, Druesne-Pecollo N, Esseddik Y, Szabo de Edelenyi F, Agaësse C, De Sa A, Lutchia R, Gigandet S, Huybrechts I, Julia C, Kesse-Guyot E, Allès B, Andreeva VA, Galan P, Hercberg S, Deschasaux-Tanguy M, Touvier M
PLoS Med 2022 Mar;19(3):e1003950. Epub 2022 Mar 24 doi: 10.1371/journal.pmed.1003950. PMID: 35324894Free PMC Article
Why primary obesity is a disease?
De Lorenzo A, Gratteri S, Gualtieri P, Cammarano A, Bertucci P, Di Renzo L
J Transl Med 2019 May 22;17(1):169. doi: 10.1186/s12967-019-1919-y. PMID: 31118060Free PMC Article
Obesity and cancer risk: Emerging biological mechanisms and perspectives.
Avgerinos KI, Spyrou N, Mantzoros CS, Dalamaga M
Metabolism 2019 Mar;92:121-135. Epub 2018 Nov 13 doi: 10.1016/j.metabol.2018.11.001. PMID: 30445141

Therapy

Hormonal Crosstalk Between Thyroid and Breast Cancer.
Halada S, Casado-Medrano V, Baran JA, Lee J, Chinmay P, Bauer AJ, Franco AT
Endocrinology 2022 Jul 1;163(7) doi: 10.1210/endocr/bqac075. PMID: 35587175Free PMC Article
Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study.
Debras C, Chazelas E, Srour B, Druesne-Pecollo N, Esseddik Y, Szabo de Edelenyi F, Agaësse C, De Sa A, Lutchia R, Gigandet S, Huybrechts I, Julia C, Kesse-Guyot E, Allès B, Andreeva VA, Galan P, Hercberg S, Deschasaux-Tanguy M, Touvier M
PLoS Med 2022 Mar;19(3):e1003950. Epub 2022 Mar 24 doi: 10.1371/journal.pmed.1003950. PMID: 35324894Free PMC Article
Genomic correlation, shared loci, and causal relationship between obesity and polycystic ovary syndrome: a large-scale genome-wide cross-trait analysis.
Liu Q, Zhu Z, Kraft P, Deng Q, Stener-Victorin E, Jiang X
BMC Med 2022 Feb 11;20(1):66. doi: 10.1186/s12916-022-02238-y. PMID: 35144605Free PMC Article
Circulating adipokine concentrations and risk of five obesity-related cancers: A Mendelian randomization study.
Dimou NL, Papadimitriou N, Mariosa D, Johansson M, Brennan P, Peters U, Chanock SJ, Purdue M, Bishop DT, Gago-Dominquez M, Giles GG, Moreno V, Platz EA, Tangen CM, Wolk A, Zheng W, Wu X, Campbell PT, Giovannucci E, Lin Y; CCFR, Endometrial Cancer Association Consortium, Gunter MJ, Murphy N
Int J Cancer 2021 Apr 1;148(7):1625-1636. Epub 2020 Oct 26 doi: 10.1002/ijc.33338. PMID: 33038280Free PMC Article
Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics.
Puchalska P, Crawford PA
Cell Metab 2017 Feb 7;25(2):262-284. doi: 10.1016/j.cmet.2016.12.022. PMID: 28178565Free PMC Article

Prognosis

Obesity and endocrine-related cancer: The important role of IGF-1.
Zhong W, Wang X, Wang Y, Sun G, Zhang J, Li Z
Front Endocrinol (Lausanne) 2023;14:1093257. Epub 2023 Jan 23 doi: 10.3389/fendo.2023.1093257. PMID: 36755926Free PMC Article
Obesity and prostate cancer: A narrative review.
Wilson RL, Taaffe DR, Newton RU, Hart NH, Lyons-Wall P, Galvão DA
Crit Rev Oncol Hematol 2022 Jan;169:103543. Epub 2021 Nov 20 doi: 10.1016/j.critrevonc.2021.103543. PMID: 34808374
Obesity-associated Breast Cancer: Analysis of risk factors.
Engin A
Adv Exp Med Biol 2017;960:571-606. doi: 10.1007/978-3-319-48382-5_25. PMID: 28585217
Childhood obesity as a predictor of morbidity in adulthood: a systematic review and meta-analysis.
Llewellyn A, Simmonds M, Owen CG, Woolacott N
Obes Rev 2016 Jan;17(1):56-67. Epub 2015 Oct 6 doi: 10.1111/obr.12316. PMID: 26440472
Age-related consequences of childhood obesity.
Kelsey MM, Zaepfel A, Bjornstad P, Nadeau KJ
Gerontology 2014;60(3):222-8. Epub 2014 Jan 9 doi: 10.1159/000356023. PMID: 24434909

Clinical prediction guides

Metabolic dysfunction and obesity-related cancer: Beyond obesity and metabolic syndrome.
Karra P, Winn M, Pauleck S, Bulsiewicz-Jacobsen A, Peterson L, Coletta A, Doherty J, Ulrich CM, Summers SA, Gunter M, Hardikar S, Playdon MC
Obesity (Silver Spring) 2022 Jul;30(7):1323-1334. doi: 10.1002/oby.23444. PMID: 35785479Free PMC Article
Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study.
Debras C, Chazelas E, Srour B, Druesne-Pecollo N, Esseddik Y, Szabo de Edelenyi F, Agaësse C, De Sa A, Lutchia R, Gigandet S, Huybrechts I, Julia C, Kesse-Guyot E, Allès B, Andreeva VA, Galan P, Hercberg S, Deschasaux-Tanguy M, Touvier M
PLoS Med 2022 Mar;19(3):e1003950. Epub 2022 Mar 24 doi: 10.1371/journal.pmed.1003950. PMID: 35324894Free PMC Article
Obesity-associated Breast Cancer: Analysis of risk factors.
Engin A
Adv Exp Med Biol 2017;960:571-606. doi: 10.1007/978-3-319-48382-5_25. PMID: 28585217
Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics.
Puchalska P, Crawford PA
Cell Metab 2017 Feb 7;25(2):262-284. doi: 10.1016/j.cmet.2016.12.022. PMID: 28178565Free PMC Article
Childhood obesity as a predictor of morbidity in adulthood: a systematic review and meta-analysis.
Llewellyn A, Simmonds M, Owen CG, Woolacott N
Obes Rev 2016 Jan;17(1):56-67. Epub 2015 Oct 6 doi: 10.1111/obr.12316. PMID: 26440472

Recent systematic reviews

Systematic Review and Meta-Analysis of the Impact of Bariatric Surgery on Future Cancer Risk.
Wilson RB, Lathigara D, Kaushal D
Int J Mol Sci 2023 Mar 24;24(7) doi: 10.3390/ijms24076192. PMID: 37047163Free PMC Article
Does Bariatric Surgery Reduce the Risk of Colorectal Cancer in Individuals with Morbid Obesity? A Systematic Review and Meta-Analysis.
Chierici A, Amoretti P, Drai C, De Fatico S, Barriere J, Schiavo L, Iannelli A
Nutrients 2023 Jan 16;15(2) doi: 10.3390/nu15020467. PMID: 36678338Free PMC Article
Associations between potential causal factors and colorectal cancer risk: A systematic review and meta-analysis of Mendelian randomization studies.
Deng Y, Wang L, Huang J, Ding H, Wong MCS
J Dig Dis 2022 Aug;23(8-9):435-445. Epub 2022 Nov 20 doi: 10.1111/1751-2980.13130. PMID: 36169182
Obesity and esophageal cancer: GERD, Barrett´s esophagus, and molecular carcinogenic pathways.
Schlottmann F, Dreifuss NH, Patti MG
Expert Rev Gastroenterol Hepatol 2020 Jun;14(6):425-433. Epub 2020 May 22 doi: 10.1080/17474124.2020.1764348. PMID: 32441160
Childhood obesity as a predictor of morbidity in adulthood: a systematic review and meta-analysis.
Llewellyn A, Simmonds M, Owen CG, Woolacott N
Obes Rev 2016 Jan;17(1):56-67. Epub 2015 Oct 6 doi: 10.1111/obr.12316. PMID: 26440472

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