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Locally Advanced Anal Carcinoma

MedGen UID:
1717389
•Concept ID:
C5239284
•
Neoplastic Process

Definition

Anal carcinoma that has spread to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Anal Carcinoma

Professional guidelines

PubMed

Treatment algorithm and prognostic factors for patients with stage I-III carcinoma of the anal canal: a 20-year multicenter study.
Bruyere D, Monnien F, Colpart P, Roncarati P, Vuitton L, Hendrick E, Lepinoy A, Luquain A, Pilard C, Lerho T, Molimard C, Maingon P, Arnould L, Bone-Lepinoy MC, Dusserre L, Martin L, Reynders C, Ancion M, Peiffert D, Leroux A, Hubert P, Delhorme JB, Ghnassia JP, Woronoff AS, Delvenne P, Prétet JL, Bosset JF, Peulen O, Mougin C, Valmary-Degano S, Herfs M
Mod Pathol 2021 Jan;34(1):116-130. Epub 2020 Jul 29 doi: 10.1038/s41379-020-0637-6. PMID: 32728225
Volumetric intensity-modulated arc therapy vs. 3-dimensional conformal radiotherapy for primary chemoradiotherapy of anal carcinoma: Effects on treatment-related side effects and survival.
Weber HE, Dröge LH, Hennies S, Herrmann MK, Gaedcke J, Wolff HA
Strahlenther Onkol 2015 Nov;191(11):827-34. Epub 2015 Jun 8 doi: 10.1007/s00066-015-0859-6. PMID: 26050046
Chemoradiotherapy with capecitabine for locally advanced anal carcinoma: an alternative treatment option.
Meulendijks D, Dewit L, Tomasoa NB, van Tinteren H, Beijnen JH, Schellens JH, Cats A
Br J Cancer 2014 Oct 28;111(9):1726-33. Epub 2014 Aug 28 doi: 10.1038/bjc.2014.467. PMID: 25167226Free PMC Article

Recent clinical studies

Etiology

Immunotherapy in Anal Cancer.
Dhawan N, Afzal MZ, Amin M
Curr Oncol 2023 Apr 27;30(5):4538-4550. doi: 10.3390/curroncol30050343. PMID: 37232801Free PMC Article
Anal Cancer: The Past, Present and Future.
Gondal TA, Chaudhary N, Bajwa H, Rauf A, Le D, Ahmed S
Curr Oncol 2023 Mar 11;30(3):3232-3250. doi: 10.3390/curroncol30030246. PMID: 36975459Free PMC Article
Neoadjuvant Chemotherapy With CAPOX Versus Chemoradiation for Locally Advanced Rectal Cancer With Uninvolved Mesorectal Fascia (CONVERT): Initial Results of a Phase III Trial.
Mei WJ, Wang XZ, Li YF, Sun YM, Yang CK, Lin JZ, Wu ZG, Zhang R, Wang W, Li Y, Zhuang YZ, Lei J, Wan XB, Ren YK, Cheng Y, Li WL, Wang ZQ, Xu DB, Mo XW, Ju HX, Ye SW, Zhao JL, Zhang H, Gao YH, Zeng ZF, Xiao WW, Zhang XP, Zhang X, Xie E, Feng YF, Tang JH, Wu XJ, Chen G, Li LR, Lu ZH, Wan DS, Bei JX, Pan ZZ, Ding PR
Ann Surg 2023 Apr 1;277(4):557-564. Epub 2022 Dec 20 doi: 10.1097/SLA.0000000000005780. PMID: 36538627Free PMC Article
Neoadjuvant chemoradiotherapy combined with immunotherapy for locally advanced rectal cancer: A new era for anal preservation.
Wang Y, Shen L, Wan J, Zhang H, Wu R, Wang J, Wang Y, Xu Y, Cai S, Zhang Z, Xia F
Front Immunol 2022;13:1067036. Epub 2022 Dec 8 doi: 10.3389/fimmu.2022.1067036. PMID: 36569918Free PMC Article
Hidradenitis suppurativa.
Revuz J
J Eur Acad Dermatol Venereol 2009 Sep;23(9):985-98. doi: 10.1111/j.1468-3083.2009.03356.x. PMID: 19682181

Diagnosis

Prognostic and Predictive Markers for Patients With Anal Cancer.
Holliday EB, Peddireddy A, Morris VK
J Natl Compr Canc Netw 2023 Jun;21(6):678-684. doi: 10.6004/jnccn.2023.7031. PMID: 37308122
Anal Cancer: The Past, Present and Future.
Gondal TA, Chaudhary N, Bajwa H, Rauf A, Le D, Ahmed S
Curr Oncol 2023 Mar 11;30(3):3232-3250. doi: 10.3390/curroncol30030246. PMID: 36975459Free PMC Article
Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
A Review of Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer.
Li Y, Wang J, Ma X, Tan L, Yan Y, Xue C, Hui B, Liu R, Ma H, Ren J
Int J Biol Sci 2016;12(8):1022-31. Epub 2016 Jul 17 doi: 10.7150/ijbs.15438. PMID: 27489505Free PMC Article
Hidradenitis suppurativa.
Revuz J
J Eur Acad Dermatol Venereol 2009 Sep;23(9):985-98. doi: 10.1111/j.1468-3083.2009.03356.x. PMID: 19682181

Therapy

Practice-changing clinical trials in radiation oncology for gastrointestinal malignancies in 2021-2023.
Boustani J, Huguet F, Vendrely V
Cancer Radiother 2023 Dec;27(8):768-777. Epub 2023 Oct 26 doi: 10.1016/j.canrad.2023.08.001. PMID: 38415359
Anal Cancer: The Past, Present and Future.
Gondal TA, Chaudhary N, Bajwa H, Rauf A, Le D, Ahmed S
Curr Oncol 2023 Mar 11;30(3):3232-3250. doi: 10.3390/curroncol30030246. PMID: 36975459Free PMC Article
Neoadjuvant Chemotherapy With CAPOX Versus Chemoradiation for Locally Advanced Rectal Cancer With Uninvolved Mesorectal Fascia (CONVERT): Initial Results of a Phase III Trial.
Mei WJ, Wang XZ, Li YF, Sun YM, Yang CK, Lin JZ, Wu ZG, Zhang R, Wang W, Li Y, Zhuang YZ, Lei J, Wan XB, Ren YK, Cheng Y, Li WL, Wang ZQ, Xu DB, Mo XW, Ju HX, Ye SW, Zhao JL, Zhang H, Gao YH, Zeng ZF, Xiao WW, Zhang XP, Zhang X, Xie E, Feng YF, Tang JH, Wu XJ, Chen G, Li LR, Lu ZH, Wan DS, Bei JX, Pan ZZ, Ding PR
Ann Surg 2023 Apr 1;277(4):557-564. Epub 2022 Dec 20 doi: 10.1097/SLA.0000000000005780. PMID: 36538627Free PMC Article
A Review of Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer.
Li Y, Wang J, Ma X, Tan L, Yan Y, Xue C, Hui B, Liu R, Ma H, Ren J
Int J Biol Sci 2016;12(8):1022-31. Epub 2016 Jul 17 doi: 10.7150/ijbs.15438. PMID: 27489505Free PMC Article
Hidradenitis suppurativa.
Revuz J
J Eur Acad Dermatol Venereol 2009 Sep;23(9):985-98. doi: 10.1111/j.1468-3083.2009.03356.x. PMID: 19682181

Prognosis

Anorectal melanoma.
Fastner S, Hieken TJ, McWilliams RR, Hyngstrom J
J Surg Oncol 2023 Sep;128(4):635-644. Epub 2023 Jul 3 doi: 10.1002/jso.27381. PMID: 37395165
Prognostic and Predictive Markers for Patients With Anal Cancer.
Holliday EB, Peddireddy A, Morris VK
J Natl Compr Canc Netw 2023 Jun;21(6):678-684. doi: 10.6004/jnccn.2023.7031. PMID: 37308122
Neoadjuvant chemoradiotherapy combined with immunotherapy for locally advanced rectal cancer: A new era for anal preservation.
Wang Y, Shen L, Wan J, Zhang H, Wu R, Wang J, Wang Y, Xu Y, Cai S, Zhang Z, Xia F
Front Immunol 2022;13:1067036. Epub 2022 Dec 8 doi: 10.3389/fimmu.2022.1067036. PMID: 36569918Free PMC Article
Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
A Review of Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer.
Li Y, Wang J, Ma X, Tan L, Yan Y, Xue C, Hui B, Liu R, Ma H, Ren J
Int J Biol Sci 2016;12(8):1022-31. Epub 2016 Jul 17 doi: 10.7150/ijbs.15438. PMID: 27489505Free PMC Article

Clinical prediction guides

Biomarkers of pembrolizumab efficacy in advanced anal squamous cell carcinoma: analysis of a phase II clinical trial and a cohort of long-term responders.
Huffman BM, Singh H, Ali LR, Horick N, Wang SJ, Hoffman MT, Metayer KA, Murray S, Bird A, Abrams TA, Biller LH, Chan JA, Meyerhardt JA, McCleary NJ, Goessling W, Patel AK, Wisch JS, Yurgelun MB, Mouw K, Reardon B, Van Allen EM, Zerillo JA, Clark JW, Parikh A, Mayer RJ, Schlechter B, Ng K, Kumar S, Del Vecchio Fitz C, Kuperwasser C, Hanna GJ, Coveler AL, Rubinson DA, Welsh EL, Pfaff K, Rodig S, Dougan SK, Cleary JM
J Immunother Cancer 2024 Jan 25;12(1) doi: 10.1136/jitc-2023-008436. PMID: 38272561Free PMC Article
Prognostic and Predictive Markers for Patients With Anal Cancer.
Holliday EB, Peddireddy A, Morris VK
J Natl Compr Canc Netw 2023 Jun;21(6):678-684. doi: 10.6004/jnccn.2023.7031. PMID: 37308122
Neoadjuvant Chemotherapy With CAPOX Versus Chemoradiation for Locally Advanced Rectal Cancer With Uninvolved Mesorectal Fascia (CONVERT): Initial Results of a Phase III Trial.
Mei WJ, Wang XZ, Li YF, Sun YM, Yang CK, Lin JZ, Wu ZG, Zhang R, Wang W, Li Y, Zhuang YZ, Lei J, Wan XB, Ren YK, Cheng Y, Li WL, Wang ZQ, Xu DB, Mo XW, Ju HX, Ye SW, Zhao JL, Zhang H, Gao YH, Zeng ZF, Xiao WW, Zhang XP, Zhang X, Xie E, Feng YF, Tang JH, Wu XJ, Chen G, Li LR, Lu ZH, Wan DS, Bei JX, Pan ZZ, Ding PR
Ann Surg 2023 Apr 1;277(4):557-564. Epub 2022 Dec 20 doi: 10.1097/SLA.0000000000005780. PMID: 36538627Free PMC Article
Extramammary Paget disease.
St Claire K, Hoover A, Ashack K, Khachemoune A
Dermatol Online J 2019 Apr 15;25(4) PMID: 31046904
A Review of Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer.
Li Y, Wang J, Ma X, Tan L, Yan Y, Xue C, Hui B, Liu R, Ma H, Ren J
Int J Biol Sci 2016;12(8):1022-31. Epub 2016 Jul 17 doi: 10.7150/ijbs.15438. PMID: 27489505Free PMC Article

Recent systematic reviews

Effect of omentum preservation on long-term prognosis of locally advanced gastric cancer: a systematic review and meta-analysis.
Zhou X, Sheng W, Huang T, Ren W
World J Surg Oncol 2024 Sep 6;22(1):236. doi: 10.1186/s12957-024-03521-3. PMID: 39243034Free PMC Article
Immune-checkpoint inhibitors in anal squamous cell carcinoma: a systematic review and meta-analysis.
Pala L, De Pas T, Stucchi E, Catania C, Cocorocchio E, Zampino MG, Rossi G, Zattarin E, Di Muzio A, Laszlo D, Stucchi S, Conforti F
Semin Oncol 2023 Dec;50(6):140-143. Epub 2023 Nov 24 doi: 10.1053/j.seminoncol.2023.11.002. PMID: 38065801
Non-mucinous adenocarcinomas and squamous cell carcinomas of the anal region masquerading as abscess or fistula: a retrospective analysis and systematic review of literature.
Tekbaş A, Mothes H, Settmacher U, Schuele S
J Cancer Res Clin Oncol 2022 Jun;148(6):1509-1522. Epub 2021 Aug 2 doi: 10.1007/s00432-021-03747-8. PMID: 34338860Free PMC Article
Evaluating the efficacy of treatment options for anal intraepithelial neoplasia: a systematic review.
Brogden DRL, Walsh U, Pellino G, Kontovounisios C, Tekkis P, Mills SC
Int J Colorectal Dis 2021 Feb;36(2):213-226. Epub 2020 Sep 26 doi: 10.1007/s00384-020-03740-6. PMID: 32979069Free PMC Article
PET imaging in anal canal cancer: a systematic review and meta-analysis.
Mahmud A, Poon R, Jonker D
Br J Radiol 2017 Dec;90(1080):20170370. Epub 2017 Oct 3 doi: 10.1259/bjr.20170370. PMID: 28972796Free PMC Article

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