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Central nervous system (CNS) tumors

MedGen UID:
1718191
•Concept ID:
C5394602
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral nervous system (CNS) tumors

Professional guidelines

PubMed

EANO guideline on rational molecular testing of gliomas, glioneuronal, and neuronal tumors in adults for targeted therapy selection.
Capper D, Reifenberger G, French PJ, Schweizer L, Weller M, Touat M, Niclou SP, Euskirchen P, Haberler C, Hegi ME, Brandner S, Le Rhun E, Rudà R, Sanson M, Tabatabai G, Sahm F, Wen PY, Wesseling P, Preusser M, van den Bent MJ
Neuro Oncol 2023 May 4;25(5):813-826. doi: 10.1093/neuonc/noad008. PMID: 36632791Free PMC Article
Guidelines in the management of CNS tumors.
Redjal N, Venteicher AS, Dang D, Sloan A, Kessler RA, Baron RR, Hadjipanayis CG, Chen CC, Ziu M, Olson JJ, Nahed BV
J Neurooncol 2021 Feb;151(3):345-359. Epub 2021 Feb 21 doi: 10.1007/s11060-020-03530-8. PMID: 33611702
Epigenetics in Clinical Management of Children and Adolescents with Brain Tumors.
La Madrid AM, Kieran MW
Curr Cancer Drug Targets 2018;18(1):57-64. doi: 10.2174/1568009617666170203164456. PMID: 28176655

Recent clinical studies

Etiology

Proton radiotherapy for glioma and glioblastoma.
Goff KM, Zheng C, Alonso-Basanta M
Chin Clin Oncol 2022 Dec;11(6):46. doi: 10.21037/cco-22-92. PMID: 36632979
Diagnostic, therapeutic, and prognostic implications of the 2021 World Health Organization classification of tumors of the central nervous system.
Gritsch S, Batchelor TT, Gonzalez Castro LN
Cancer 2022 Jan 1;128(1):47-58. Epub 2021 Oct 11 doi: 10.1002/cncr.33918. PMID: 34633681
Epidemiology of Brain and Other CNS Tumors.
Ostrom QT, Francis SS, Barnholtz-Sloan JS
Curr Neurol Neurosci Rep 2021 Nov 24;21(12):68. doi: 10.1007/s11910-021-01152-9. PMID: 34817716Free PMC Article
Brain and other central nervous system tumor statistics, 2021.
Miller KD, Ostrom QT, Kruchko C, Patil N, Tihan T, Cioffi G, Fuchs HE, Waite KA, Jemal A, Siegel RL, Barnholtz-Sloan JS
CA Cancer J Clin 2021 Sep;71(5):381-406. Epub 2021 Aug 24 doi: 10.3322/caac.21693. PMID: 34427324
Molecular pathology of tumors of the central nervous system.
Kristensen BW, Priesterbach-Ackley LP, Petersen JK, Wesseling P
Ann Oncol 2019 Aug 1;30(8):1265-1278. doi: 10.1093/annonc/mdz164. PMID: 31124566Free PMC Article

Diagnosis

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2015-2019.
Ostrom QT, Price M, Neff C, Cioffi G, Waite KA, Kruchko C, Barnholtz-Sloan JS
Neuro Oncol 2022 Oct 5;24(Suppl 5):v1-v95. doi: 10.1093/neuonc/noac202. PMID: 36196752Free PMC Article
Diagnostic, therapeutic, and prognostic implications of the 2021 World Health Organization classification of tumors of the central nervous system.
Gritsch S, Batchelor TT, Gonzalez Castro LN
Cancer 2022 Jan 1;128(1):47-58. Epub 2021 Oct 11 doi: 10.1002/cncr.33918. PMID: 34633681
CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2014-2018.
Ostrom QT, Cioffi G, Waite K, Kruchko C, Barnholtz-Sloan JS
Neuro Oncol 2021 Oct 5;23(12 Suppl 2):iii1-iii105. doi: 10.1093/neuonc/noab200. PMID: 34608945Free PMC Article
Brain and other central nervous system tumor statistics, 2021.
Miller KD, Ostrom QT, Kruchko C, Patil N, Tihan T, Cioffi G, Fuchs HE, Waite KA, Jemal A, Siegel RL, Barnholtz-Sloan JS
CA Cancer J Clin 2021 Sep;71(5):381-406. Epub 2021 Aug 24 doi: 10.3322/caac.21693. PMID: 34427324
Pediatric Brain Tumors.
Udaka YT, Packer RJ
Neurol Clin 2018 Aug;36(3):533-556. doi: 10.1016/j.ncl.2018.04.009. PMID: 30072070

Therapy

Intraventricular B7-H3 CAR T Cells for Diffuse Intrinsic Pontine Glioma: Preliminary First-in-Human Bioactivity and Safety.
Vitanza NA, Wilson AL, Huang W, Seidel K, Brown C, Gustafson JA, Yokoyama JK, Johnson AJ, Baxter BA, Koning RW, Reid AN, Meechan M, Biery MC, Myers C, Rawlings-Rhea SD, Albert CM, Browd SR, Hauptman JS, Lee A, Ojemann JG, Berens ME, Dun MD, Foster JB, Crotty EE, Leary SES, Cole BL, Perez FA, Wright JN, Orentas RJ, Chour T, Newell EW, Whiteaker JR, Zhao L, Paulovich AG, Pinto N, Gust J, Gardner RA, Jensen MC, Park JR
Cancer Discov 2023 Jan 9;13(1):114-131. doi: 10.1158/2159-8290.CD-22-0750. PMID: 36259971Free PMC Article
Major Features of the 2021 WHO Classification of CNS Tumors.
Smith HL, Wadhwani N, Horbinski C
Neurotherapeutics 2022 Oct;19(6):1691-1704. Epub 2022 May 16 doi: 10.1007/s13311-022-01249-0. PMID: 35578106Free PMC Article
Efficacy and safety of larotrectinib in TRK fusion-positive primary central nervous system tumors.
Doz F, van Tilburg CM, Geoerger B, Højgaard M, Øra I, Boni V, Capra M, Chisholm J, Chung HC, DuBois SG, Gallego-Melcon S, Gerber NU, Goto H, Grilley-Olson JE, Hansford JR, Hong DS, Italiano A, Kang HJ, Nysom K, Thorwarth A, Stefanowicz J, Tahara M, Ziegler DS, Gavrilovic IT, Norenberg R, Dima L, De La Cuesta E, Laetsch TW, Drilon A, Perreault S
Neuro Oncol 2022 Jun 1;24(6):997-1007. doi: 10.1093/neuonc/noab274. PMID: 34850167Free PMC Article
Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis.
Vitanza NA, Johnson AJ, Wilson AL, Brown C, Yokoyama JK, Künkele A, Chang CA, Rawlings-Rhea S, Huang W, Seidel K, Albert CM, Pinto N, Gust J, Finn LS, Ojemann JG, Wright J, Orentas RJ, Baldwin M, Gardner RA, Jensen MC, Park JR
Nat Med 2021 Sep;27(9):1544-1552. Epub 2021 Jul 12 doi: 10.1038/s41591-021-01404-8. PMID: 34253928
Molecular pathology of tumors of the central nervous system.
Kristensen BW, Priesterbach-Ackley LP, Petersen JK, Wesseling P
Ann Oncol 2019 Aug 1;30(8):1265-1278. doi: 10.1093/annonc/mdz164. PMID: 31124566Free PMC Article

Prognosis

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2015-2019.
Ostrom QT, Price M, Neff C, Cioffi G, Waite KA, Kruchko C, Barnholtz-Sloan JS
Neuro Oncol 2022 Oct 5;24(Suppl 5):v1-v95. doi: 10.1093/neuonc/noac202. PMID: 36196752Free PMC Article
Diagnostic, therapeutic, and prognostic implications of the 2021 World Health Organization classification of tumors of the central nervous system.
Gritsch S, Batchelor TT, Gonzalez Castro LN
Cancer 2022 Jan 1;128(1):47-58. Epub 2021 Oct 11 doi: 10.1002/cncr.33918. PMID: 34633681
Epidemiology of Brain and Other CNS Tumors.
Ostrom QT, Francis SS, Barnholtz-Sloan JS
Curr Neurol Neurosci Rep 2021 Nov 24;21(12):68. doi: 10.1007/s11910-021-01152-9. PMID: 34817716Free PMC Article
CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2014-2018.
Ostrom QT, Cioffi G, Waite K, Kruchko C, Barnholtz-Sloan JS
Neuro Oncol 2021 Oct 5;23(12 Suppl 2):iii1-iii105. doi: 10.1093/neuonc/noab200. PMID: 34608945Free PMC Article
Molecular pathology of tumors of the central nervous system.
Kristensen BW, Priesterbach-Ackley LP, Petersen JK, Wesseling P
Ann Oncol 2019 Aug 1;30(8):1265-1278. doi: 10.1093/annonc/mdz164. PMID: 31124566Free PMC Article

Clinical prediction guides

EANO guideline on rational molecular testing of gliomas, glioneuronal, and neuronal tumors in adults for targeted therapy selection.
Capper D, Reifenberger G, French PJ, Schweizer L, Weller M, Touat M, Niclou SP, Euskirchen P, Haberler C, Hegi ME, Brandner S, Le Rhun E, Rudà R, Sanson M, Tabatabai G, Sahm F, Wen PY, Wesseling P, Preusser M, van den Bent MJ
Neuro Oncol 2023 May 4;25(5):813-826. doi: 10.1093/neuonc/noad008. PMID: 36632791Free PMC Article
A phase I trial of metformin in combination with vincristine, irinotecan, and temozolomide in children with relapsed or refractory solid and central nervous system tumors: A report from the national pediatric cancer foundation.
Metts JL, Trucco M, Weiser DA, Thompson P, Sandler E, Smith T, Crimella J, Sansil S, Thapa R, Fridley BL, Llosa N, Badgett T, Gorlick R, Reed D, Gill J
Cancer Med 2023 Feb;12(4):4270-4281. Epub 2022 Sep 23 doi: 10.1002/cam4.5297. PMID: 36151773Free PMC Article
Detection of tumor-specific DNA methylation markers in the blood of patients with pituitary neuroendocrine tumors.
Herrgott GA, Asmaro KP, Wells M, Sabedot TS, Malta TM, Mosella MS, Nelson K, Scarpace L, Barnholtz-Sloan JS, Sloan AE, Selman WR, deCarvalho AC, Poisson LM, Mukherjee A, Robin AM, Lee IY, Snyder J, Walbert T, Rosenblum M, Mikkelsen T, Bhan A, Craig J, Kalkanis S, Rock J, Noushmehr H, Castro AV
Neuro Oncol 2022 Jul 1;24(7):1126-1139. doi: 10.1093/neuonc/noac050. PMID: 35212383Free PMC Article
Central nervous system tumors in 2-year rat carcinogenicity studies: perspectives on human risk assessment.
Sacaan A, Thibault S, Khan KN
J Toxicol Sci 2019;44(10):643-655. doi: 10.2131/jts.44.643. PMID: 31588056
Low-grade gliomas.
Ruiz J, Lesser GJ
Curr Treat Options Oncol 2009 Aug;10(3-4):231-42. Epub 2009 Apr 19 doi: 10.1007/s11864-009-0096-2. PMID: 19381819

Recent systematic reviews

Pesticide exposure and risk of Central Nervous System tumors in children: a systematic review with meta-analysis.
Mota ALC, Barbosa IM, Rodrigues AB, Chaves EMC, Almeida PC
Cien Saude Colet 2023 Sep;28(9):2583-2594. Epub 2023 Feb 2 doi: 10.1590/1413-81232023289.00262023. PMID: 37672448
Radiomics and machine learning for predicting the consistency of benign tumors of the central nervous system: A systematic review.
Koechli C, Zwahlen DR, Schucht P, Windisch P
Eur J Radiol 2023 Jul;164:110866. Epub 2023 May 7 doi: 10.1016/j.ejrad.2023.110866. PMID: 37207398
Neuroimaging features of FOXR2-activated CNS neuroblastoma: A case series and systematic review.
Shimazaki K, Kurokawa R, Franson A, Kurokawa M, Baba A, Bou-Maroun L, Kim J, Moritani T
J Neuroimaging 2023 May-Jun;33(3):359-367. Epub 2023 Feb 20 doi: 10.1111/jon.13095. PMID: 36806312
The global prevalence of primary central nervous system tumors: a systematic review and meta-analysis.
Salari N, Ghasemi H, Fatahian R, Mansouri K, Dokaneheifard S, Shiri MH, Hemmati M, Mohammadi M
Eur J Med Res 2023 Jan 20;28(1):39. doi: 10.1186/s40001-023-01011-y. PMID: 36670466Free PMC Article
Racial and ethnic disparities among children with primary central nervous system tumors in the US.
Nieblas-Bedolla E, Christophers B, Williams JR, Power-Hays A, Jimenez N, Rodriguez A
J Neurooncol 2021 May;152(3):451-466. Epub 2021 Mar 28 doi: 10.1007/s11060-021-03738-2. PMID: 33774801

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