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Skin Verrucous Carcinoma

MedGen UID:
1718207
•Concept ID:
C5237206
•
Neoplastic Process

Definition

A verrucous carcinoma that arises from the skin. It usually affects the palms, soles, and distal digits. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin Verrucous Carcinoma

Professional guidelines

PubMed

Vulvar Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology.
Abu-Rustum NR, Yashar CM, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Gaillard S, Giuntoli R II, Glaser S, Holmes J, Howitt BE, Kendra K, Lea J, Lee N, Mantia-Smaldone G, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Rodabaugh K, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian N, Espinosa S
J Natl Compr Canc Netw 2024 Mar;22(2):117-135. doi: 10.6004/jnccn.2024.0013. PMID: 38503056
Surgical treatment of verrucous carcinoma: a review.
Fawaz B, Vieira C, Decker A, Lawrence N
J Dermatolog Treat 2022 Jun;33(4):1811-1815. Epub 2022 Jun 13 doi: 10.1080/09546634.2021.1914312. PMID: 33849379
Acral melanoma foot lesions. Part 2: clinical presentation, diagnosis, and management.
Desai A, Ugorji R, Khachemoune A
Clin Exp Dermatol 2018 Mar;43(2):117-123. Epub 2017 Dec 13 doi: 10.1111/ced.13323. PMID: 29235153

Recent clinical studies

Etiology

Vulvar Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology.
Abu-Rustum NR, Yashar CM, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Gaillard S, Giuntoli R II, Glaser S, Holmes J, Howitt BE, Kendra K, Lea J, Lee N, Mantia-Smaldone G, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Rodabaugh K, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian N, Espinosa S
J Natl Compr Canc Netw 2024 Mar;22(2):117-135. doi: 10.6004/jnccn.2024.0013. PMID: 38503056
Recent advances in cutaneous HPV infection.
Shimizu A, Yamaguchi R, Kuriyama Y
J Dermatol 2023 Mar;50(3):290-298. Epub 2023 Jan 5 doi: 10.1111/1346-8138.16697. PMID: 36601717
WHO 2022 classification of penile and scrotal cancers: updates and evolution.
Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
Head and neck verrucous carcinoma: A population-based analysis of incidence, treatment, and prognosis.
Wang N, Huang M, Lv H
Medicine (Baltimore) 2020 Jan;99(2):e18660. doi: 10.1097/MD.0000000000018660. PMID: 31914052Free PMC Article
Cutaneous Squamous Cell Carcinoma: A Review of High-Risk and Metastatic Disease.
Burton KA, Ashack KA, Khachemoune A
Am J Clin Dermatol 2016 Oct;17(5):491-508. doi: 10.1007/s40257-016-0207-3. PMID: 27358187

Diagnosis

Vulvar Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology.
Abu-Rustum NR, Yashar CM, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Gaillard S, Giuntoli R II, Glaser S, Holmes J, Howitt BE, Kendra K, Lea J, Lee N, Mantia-Smaldone G, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Rodabaugh K, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian N, Espinosa S
J Natl Compr Canc Netw 2024 Mar;22(2):117-135. doi: 10.6004/jnccn.2024.0013. PMID: 38503056
Pyoderma Gangranosum-Like Blastomycosis.
Mak J, Al Habeeb A, Al Kalabi M, Alavi A
J Cutan Med Surg 2018 Sep/Oct;22(5):519-521. Epub 2018 Feb 28 doi: 10.1177/1203475418760460. PMID: 29486592
Cutaneous Squamous Cell Carcinoma: A Review of High-Risk and Metastatic Disease.
Burton KA, Ashack KA, Khachemoune A
Am J Clin Dermatol 2016 Oct;17(5):491-508. doi: 10.1007/s40257-016-0207-3. PMID: 27358187
Nail tumors.
Richert B, Lecerf P, Caucanas M, André J
Clin Dermatol 2013 Sep-Oct;31(5):602-17. doi: 10.1016/j.clindermatol.2013.06.014. PMID: 24079590
Verrucous cyst.
Reis MD, Tellechea O, Baptista AP
Eur J Dermatol 1998 Apr-May;8(3):186-8. PMID: 9649670

Therapy

Surgical treatment of verrucous carcinoma: a review.
Fawaz B, Vieira C, Decker A, Lawrence N
J Dermatolog Treat 2022 Jun;33(4):1811-1815. Epub 2022 Jun 13 doi: 10.1080/09546634.2021.1914312. PMID: 33849379
Atypical presentations of cutaneous leishmaniasis: A systematic review.
Meireles CB, Maia LC, Soares GC, Teodoro IPP, Gadelha MDSV, da Silva CGL, de Lima MAP
Acta Trop 2017 Aug;172:240-254. Epub 2017 May 17 doi: 10.1016/j.actatropica.2017.05.022. PMID: 28526427
Buschke-Lowenstein tumor.
Rodríguez-Gutiérrez R, Rodarte-Shade M, González-Saldivar G, González-González JG
Am J Med Sci 2015 Jan;349(1):e1. doi: 10.1097/MAJ.0000000000000413. PMID: 25535884
Squamous cell carcinoma of the skin.
Rudolph R, Zelac DE
Plast Reconstr Surg 2004 Nov;114(6):82e-94e. doi: 10.1097/01.prs.0000138243.45735.8a. PMID: 15509920
Histopathology of cutaneous squamous cell carcinoma and its variants.
Kane CL, Keehn CA, Smithberger E, Glass LF
Semin Cutan Med Surg 2004 Mar;23(1):54-61. doi: 10.1016/s1085-5629(03)00088-9. PMID: 15095916

Prognosis

WHO 2022 classification of penile and scrotal cancers: updates and evolution.
Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
Head and neck verrucous carcinoma: A population-based analysis of incidence, treatment, and prognosis.
Wang N, Huang M, Lv H
Medicine (Baltimore) 2020 Jan;99(2):e18660. doi: 10.1097/MD.0000000000018660. PMID: 31914052Free PMC Article
Cutaneous Squamous Cell Carcinoma: A Review of High-Risk and Metastatic Disease.
Burton KA, Ashack KA, Khachemoune A
Am J Clin Dermatol 2016 Oct;17(5):491-508. doi: 10.1007/s40257-016-0207-3. PMID: 27358187
Nail tumors.
Richert B, Lecerf P, Caucanas M, André J
Clin Dermatol 2013 Sep-Oct;31(5):602-17. doi: 10.1016/j.clindermatol.2013.06.014. PMID: 24079590
Verrucous carcinoma of the skin and mucosa.
Schwartz RA
J Am Acad Dermatol 1995 Jan;32(1):1-21; quiz 22-4. doi: 10.1016/0190-9622(95)90177-9. PMID: 7822496

Clinical prediction guides

Pseudoepitheliomatous keratotic and micaceous balanitis: a series of eight cases.
Spencer A, Watchorn RE, Kravvas G, Ben-Salha I, Haider A, Francis N, Freeman A, Alnajjar HM, Muneer A, Bunker CB
J Eur Acad Dermatol Venereol 2022 Oct;36(10):1851-1856. Epub 2022 Jun 29 doi: 10.1111/jdv.18328. PMID: 35695159
Cutaneous Squamous Cell Carcinoma: A Review of High-Risk and Metastatic Disease.
Burton KA, Ashack KA, Khachemoune A
Am J Clin Dermatol 2016 Oct;17(5):491-508. doi: 10.1007/s40257-016-0207-3. PMID: 27358187
Squamous cell carcinoma of the skin.
Rudolph R, Zelac DE
Plast Reconstr Surg 2004 Nov;114(6):82e-94e. doi: 10.1097/01.prs.0000138243.45735.8a. PMID: 15509920
Pachyonychia congenita: a clinical study of 12 cases and review of the literature.
Su WP, Chun SI, Hammond DE, Gordon H
Pediatr Dermatol 1990 Mar;7(1):33-8. doi: 10.1111/j.1525-1470.1990.tb01070.x. PMID: 2140447
Carcinoma cuniculatum (verrucous carcinoma of the skin): a clinicopathologic study of 46 cases with ultrastructural observations.
Kao GF, Graham JH, Helwig EB
Cancer 1982 Jun 1;49(11):2395-403. doi: 10.1002/1097-0142(19820601)49:11<2395::aid-cncr2820491129>3.0.co;2-3. PMID: 7042070

Recent systematic reviews

Neovagina creation methods in Müllerian anomalies and risk of malignancy: insights from a systematic review.
Fedele F, Bulfoni A, Parazzini F, Busnelli A
Arch Gynecol Obstet 2024 Mar;309(3):801-812. Epub 2023 Jul 19 doi: 10.1007/s00404-023-07086-6. PMID: 37466686
Epithelioma Cuniculatum (Plantar Verrucous Carcinoma): A Systematic Review of Treatment Options.
Shwe Daniel S, Cox SV, Kraus CN, Elsensohn AN
Cutis 2023 Feb;111(2):E19-E24. doi: 10.12788/cutis.0720. PMID: 37075193
Surgical treatment of verrucous carcinoma: a review.
Fawaz B, Vieira C, Decker A, Lawrence N
J Dermatolog Treat 2022 Jun;33(4):1811-1815. Epub 2022 Jun 13 doi: 10.1080/09546634.2021.1914312. PMID: 33849379
Esophageal carcinoma cuniculatum: systematic review of the literature and report of two cases.
Lai Q, de Giacomo T, Consolo A, Castrovillari M, Melandro F, Cerbelli B, Pernazza A, Berloco PB, d'Amati G, Francioni F
Pathol Res Pract 2019 Oct;215(10):152602. Epub 2019 Aug 17 doi: 10.1016/j.prp.2019.152602. PMID: 31472995
Atypical presentations of cutaneous leishmaniasis: A systematic review.
Meireles CB, Maia LC, Soares GC, Teodoro IPP, Gadelha MDSV, da Silva CGL, de Lima MAP
Acta Trop 2017 Aug;172:240-254. Epub 2017 May 17 doi: 10.1016/j.actatropica.2017.05.022. PMID: 28526427

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