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Reactive Xanthogranuloma

MedGen UID:
1718640
Concept ID:
C5239388
Disease or Syndrome

Definition

A reactive lesion characterized by the presence of a bland histiocytic cellular infiltrate admixed with giant cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReactive Xanthogranuloma

Professional guidelines

PubMed

Jaffe R, DeVaughn D, Langhoff E
Pediatr Dev Pathol 1998 May-Jun;1(3):216-21. doi: 10.1007/s100249900029. PMID: 10463281

Recent clinical studies

Etiology

Ungureanu IA, Cohen-Aubart F, Héritier S, Fraitag S, Charlotte F, Lequain H, Hélias-Rodzewicz Z, Haroche J, Donadieu J, Emile JF
Virchows Arch 2023 Jul;483(1):81-86. Epub 2023 Feb 9 doi: 10.1007/s00428-023-03508-7. PMID: 36754897
Pan Z, Xu ML
Surg Pathol Clin 2019 Sep;12(3):805-829. Epub 2019 Jun 8 doi: 10.1016/j.path.2019.03.013. PMID: 31352989
Luder CM, Nordmann TM, Ramelyte E, Mühleisen B, Kerl K, Guenova E, Dummer R
J Eur Acad Dermatol Venereol 2018 Jun;32(6):926-934. Epub 2018 Jan 31 doi: 10.1111/jdv.14794. PMID: 29341328
Romano RC, Fritchie KJ
Clin Lab Med 2017 Sep;37(3):603-631. Epub 2017 Jun 15 doi: 10.1016/j.cll.2017.05.007. PMID: 28802503
Newman B, Hu W, Nigro K, Gilliam AC
J Am Acad Dermatol 2007 Feb;56(2):302-16. Epub 2006 Oct 9 doi: 10.1016/j.jaad.2006.06.010. PMID: 17097374

Diagnosis

Ungureanu IA, Cohen-Aubart F, Héritier S, Fraitag S, Charlotte F, Lequain H, Hélias-Rodzewicz Z, Haroche J, Donadieu J, Emile JF
Virchows Arch 2023 Jul;483(1):81-86. Epub 2023 Feb 9 doi: 10.1007/s00428-023-03508-7. PMID: 36754897
Pan Z, Xu ML
Surg Pathol Clin 2019 Sep;12(3):805-829. Epub 2019 Jun 8 doi: 10.1016/j.path.2019.03.013. PMID: 31352989
Romano RC, Fritchie KJ
Clin Lab Med 2017 Sep;37(3):603-631. Epub 2017 Jun 15 doi: 10.1016/j.cll.2017.05.007. PMID: 28802503
Wanat KA, Kim B, Rosenbach M
Clin Dermatol 2016 Mar-Apr;34(2):214-41. Epub 2015 Nov 22 doi: 10.1016/j.clindermatol.2015.11.013. PMID: 26903187
Newman B, Hu W, Nigro K, Gilliam AC
J Am Acad Dermatol 2007 Feb;56(2):302-16. Epub 2006 Oct 9 doi: 10.1016/j.jaad.2006.06.010. PMID: 17097374

Therapy

Höck M, Zelger B, Schweigmann G, Brunner B, Zelger B, Kropshofer G, Kiechl-Kohlendorfer U
BMC Pediatr 2019 Apr 24;19(1):128. doi: 10.1186/s12887-019-1490-y. PMID: 31018833Free PMC Article
Allen CE, Parsons DW
Hematology Am Soc Hematol Educ Program 2015;2015:559-64. doi: 10.1182/asheducation-2015.1.559. PMID: 26637772
Hawryluk EB, Izikson L, English JC 3rd
Am J Clin Dermatol 2010;11(3):171-81. doi: 10.2165/11530080-000000000-00000. PMID: 20184390
Ho VH, Chevez-Barrios P, Jorgensen JL, Silkiss RZ, Esmaeli B
Tissue Antigens 2007 Aug;70(2):105-9. doi: 10.1111/j.1399-0039.2007.00863.x. PMID: 17610415
Miettinen M, Fetsch JF
Am J Surg Pathol 2006 Apr;30(4):521-8. doi: 10.1097/00000478-200604000-00014. PMID: 16625100

Prognosis

Genc Y, Akay BN, Okcu Heper A, Rosendahl C, Erdem C
Int J Dermatol 2020 Jan;59(1):66-75. Epub 2019 Jul 1 doi: 10.1111/ijd.14559. PMID: 31264200
Pan Z, Xu ML
Surg Pathol Clin 2019 Sep;12(3):805-829. Epub 2019 Jun 8 doi: 10.1016/j.path.2019.03.013. PMID: 31352989
Hilal T, DiCaudo DJ, Connolly SM, Reeder CB
Ann Hematol 2018 Aug;97(8):1471-1479. Epub 2018 Mar 22 doi: 10.1007/s00277-018-3301-1. PMID: 29568990
Newman B, Hu W, Nigro K, Gilliam AC
J Am Acad Dermatol 2007 Feb;56(2):302-16. Epub 2006 Oct 9 doi: 10.1016/j.jaad.2006.06.010. PMID: 17097374
Malone M
Histopathology 1991 Aug;19(2):105-19. doi: 10.1111/j.1365-2559.1991.tb00001.x. PMID: 1757066

Clinical prediction guides

Miljic D, Pekic S, Doknic M, Stojanovic M, Ilic S, Djurovic MN, Jemuovic Z, Milojevic T, Milicevic M, Jovanovic M, Medic Stojanoska M, Carić B, Radic N, Medenica S, Manojlovic Gacic E, Petakov M
Endocr J 2024 Mar 28;71(3):285-293. Epub 2024 Jan 27 doi: 10.1507/endocrj.EJ23-0398. PMID: 38281757
Genc Y, Akay BN, Okcu Heper A, Rosendahl C, Erdem C
Int J Dermatol 2020 Jan;59(1):66-75. Epub 2019 Jul 1 doi: 10.1111/ijd.14559. PMID: 31264200
Pouryazdanparast P, Yu L, Cutlan JE, Olsen SH, Fullen DR, Ma L
J Cutan Pathol 2009 Aug;36(8):859-64. Epub 2009 Nov 24 doi: 10.1111/j.1600-0560.2008.01179.x. PMID: 19040468
Le BH, Towfighi J, Kapadia SB, Lopes MB
Endocr Pathol 2007 Spring;18(1):23-30. doi: 10.1007/s12022-007-0011-y. PMID: 17652797
Tomaszewski MM, Lupton GP
J Cutan Pathol 1998 Mar;25(3):129-35. doi: 10.1111/j.1600-0560.1998.tb01704.x. PMID: 9550310

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