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Pontine ischemic lacunes

MedGen UID:
1718709
•Concept ID:
C5397597
•
Pathologic Function
Synonym: Pontine ischaemic lacunes
 
HPO: HP:0032570

Definition

Lacunes are infarcts less than 15 mm in diameter in the cortical white matter or in the corona radiata, internal capsule, centrum semiovale, thalamus, basal ganglia, or pons. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPontine ischemic lacunes

Recent clinical studies

Etiology

Homocysteine is related to enlarged perivascular spaces in the brainstem in patients with isolated pontine infarction.
Fu Y, Yun W, Zhang Z, Ma Y, Xiao L, Zhang M, Zhu W
BMC Neurol 2022 Aug 11;22(1):296. doi: 10.1186/s12883-022-02744-9. PMID: 35953791Free PMC Article
Morphological classification of penetrating artery pontine infarcts and association with risk factors and prognosis: The SPS3 trial.
Wilson LK, Pearce LA, Arauz A, Anderson DC, Tapia J, Bazan C, Benavente OR, Field TS; SPS3 Investigators
Int J Stroke 2016 Jun;11(4):412-9. Epub 2016 Mar 8 doi: 10.1177/1747493016637366. PMID: 26956031
A comparison of location of acute symptomatic vs. 'silent' small vessel lesions.
Valdés Hernández Mdel C, Maconick LC, Muñoz Maniega S, Wang X, Wiseman S, Armitage PA, Doubal FN, Makin S, Sudlow CL, Dennis MS, Deary IJ, Bastin M, Wardlaw JM
Int J Stroke 2015 Oct;10(7):1044-50. Epub 2015 Jun 29 doi: 10.1111/ijs.12558. PMID: 26120782Free PMC Article
Basilar artery atherosclerotic plaques in paramedian and lacunar pontine infarctions: a high-resolution MRI study.
Klein IF, Lavallée PC, Mazighi M, Schouman-Claeys E, Labreuche J, Amarenco P
Stroke 2010 Jul;41(7):1405-9. Epub 2010 Jun 10 doi: 10.1161/STROKEAHA.110.583534. PMID: 20538696
An autopsy study of the incidence of lacunes in relation to age, hypertension, and arteriosclerosis.
Dozono K, Ishii N, Nishihara Y, Horie A
Stroke 1991 Aug;22(8):993-6. doi: 10.1161/01.str.22.8.993. PMID: 1866767

Diagnosis

Culprit Plaques of Large Parent Arteries, Rather than Cerebral Small Vessel Disease, Contribute to Early Neurological Deterioration in Stroke Patients with Intracranial Branch Atheromatous Disease.
Men X, Hu M, Guo Z, Li Y, Zheng L, Wu R, Huang X, Zhang B, Lu Z
Cerebrovasc Dis 2024;53(1):88-97. Epub 2023 Mar 30 doi: 10.1159/000530371. PMID: 36996763
Sleep-related breathing disorders in acute lacunar stroke.
Bonnin-Vilaplana M, Arboix A, Parra O, García-Eroles L, Montserrat JM, Massons J
J Neurol 2009 Dec;256(12):2036-42. doi: 10.1007/s00415-009-5236-x. PMID: 19629569
Transcranial Doppler pulsatility indices as a measure of diffuse small-vessel disease.
Kidwell CS, el-Saden S, Livshits Z, Martin NA, Glenn TC, Saver JL
J Neuroimaging 2001 Jul;11(3):229-35. doi: 10.1111/j.1552-6569.2001.tb00039.x. PMID: 11462287
Leg weakness due to stroke. Site of lesions, weakness patterns and causes.
Schneider R, Gautier JC
Brain 1994 Apr;117 ( Pt 2):347-54. doi: 10.1093/brain/117.2.347. PMID: 8186960
Capsular hypesthetic ataxic hemiparesis.
Helgason CM, Wilbur AC
Stroke 1990 Jan;21(1):24-33. doi: 10.1161/01.str.21.1.24. PMID: 2300988

Therapy

Morphological classification of penetrating artery pontine infarcts and association with risk factors and prognosis: The SPS3 trial.
Wilson LK, Pearce LA, Arauz A, Anderson DC, Tapia J, Bazan C, Benavente OR, Field TS; SPS3 Investigators
Int J Stroke 2016 Jun;11(4):412-9. Epub 2016 Mar 8 doi: 10.1177/1747493016637366. PMID: 26956031
Cavitation of deep lacunar infarcts in patients with first-ever lacunar stroke: a 2-year follow-up study with MR.
Loos CM, Staals J, Wardlaw JM, van Oostenbrugge RJ
Stroke 2012 Aug;43(8):2245-7. Epub 2012 Jun 12 doi: 10.1161/STROKEAHA.112.660076. PMID: 22693127

Prognosis

Culprit Plaques of Large Parent Arteries, Rather than Cerebral Small Vessel Disease, Contribute to Early Neurological Deterioration in Stroke Patients with Intracranial Branch Atheromatous Disease.
Men X, Hu M, Guo Z, Li Y, Zheng L, Wu R, Huang X, Zhang B, Lu Z
Cerebrovasc Dis 2024;53(1):88-97. Epub 2023 Mar 30 doi: 10.1159/000530371. PMID: 36996763
Morphological classification of penetrating artery pontine infarcts and association with risk factors and prognosis: The SPS3 trial.
Wilson LK, Pearce LA, Arauz A, Anderson DC, Tapia J, Bazan C, Benavente OR, Field TS; SPS3 Investigators
Int J Stroke 2016 Jun;11(4):412-9. Epub 2016 Mar 8 doi: 10.1177/1747493016637366. PMID: 26956031
Cavitation of deep lacunar infarcts in patients with first-ever lacunar stroke: a 2-year follow-up study with MR.
Loos CM, Staals J, Wardlaw JM, van Oostenbrugge RJ
Stroke 2012 Aug;43(8):2245-7. Epub 2012 Jun 12 doi: 10.1161/STROKEAHA.112.660076. PMID: 22693127
Differences between hypertensive and non-hypertensive ischemic stroke.
Arboix A, Roig H, Rossich R, Martínez EM, García-Eroles L
Eur J Neurol 2004 Oct;11(10):687-92. doi: 10.1111/j.1468-1331.2004.00910.x. PMID: 15469453
Transcranial Doppler pulsatility indices as a measure of diffuse small-vessel disease.
Kidwell CS, el-Saden S, Livshits Z, Martin NA, Glenn TC, Saver JL
J Neuroimaging 2001 Jul;11(3):229-35. doi: 10.1111/j.1552-6569.2001.tb00039.x. PMID: 11462287

Clinical prediction guides

Culprit Plaques of Large Parent Arteries, Rather than Cerebral Small Vessel Disease, Contribute to Early Neurological Deterioration in Stroke Patients with Intracranial Branch Atheromatous Disease.
Men X, Hu M, Guo Z, Li Y, Zheng L, Wu R, Huang X, Zhang B, Lu Z
Cerebrovasc Dis 2024;53(1):88-97. Epub 2023 Mar 30 doi: 10.1159/000530371. PMID: 36996763
Morphological classification of penetrating artery pontine infarcts and association with risk factors and prognosis: The SPS3 trial.
Wilson LK, Pearce LA, Arauz A, Anderson DC, Tapia J, Bazan C, Benavente OR, Field TS; SPS3 Investigators
Int J Stroke 2016 Jun;11(4):412-9. Epub 2016 Mar 8 doi: 10.1177/1747493016637366. PMID: 26956031
Differences between hypertensive and non-hypertensive ischemic stroke.
Arboix A, Roig H, Rossich R, Martínez EM, García-Eroles L
Eur J Neurol 2004 Oct;11(10):687-92. doi: 10.1111/j.1468-1331.2004.00910.x. PMID: 15469453
Transcranial Doppler pulsatility indices as a measure of diffuse small-vessel disease.
Kidwell CS, el-Saden S, Livshits Z, Martin NA, Glenn TC, Saver JL
J Neuroimaging 2001 Jul;11(3):229-35. doi: 10.1111/j.1552-6569.2001.tb00039.x. PMID: 11462287
Clinical study of 227 patients with lacunar infarcts.
Arboix A, Martí-Vilalta JL, García JH
Stroke 1990 Jun;21(6):842-7. doi: 10.1161/01.str.21.6.842. PMID: 2349585

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