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Generalized Cutaneous Reticulohistiocytosis

MedGen UID:
1718790
•Concept ID:
C5239293
•
Disease or Syndrome

Definition

A reactive cutaneous proliferation of macrophages. It is characterized by the presence of giant cells with ground-glass cytoplasm. It presents with multiple cutaneous or mucosal papules or nodules. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGeneralized Cutaneous Reticulohistiocytosis

Professional guidelines

PubMed

Clinical and pathological evaluation of cladribine treatment response in a case series of patients with xanthoma disseminatum.
Zhou EY, Yu F, Wang Y, Bi Y, Tuan H, Huang Y, Wang B, Li J, Yin H, Li L, Zhao Y
Eur J Dermatol 2023 Jun 1;33(3):270-279. doi: 10.1684/ejd.2023.4502. PMID: 37594335
Cutaneous Manifestations not Considered Diagnostic Criteria for Neurofibromatosis Type 1. A Case-Control Study.
García-Martínez FJ, Duat-Rodríguez A, Andrés Esteban E, Torrelo A, Noguera Morel L, Hernández-Martín A
Actas Dermosifiliogr 2022 Nov-Dec;113(10):T923-T929. Epub 2022 Sep 24 doi: 10.1016/j.ad.2022.09.011. PMID: 36162491
Cutaneous Manifestations not Considered Diagnostic Criteria for Neurofibromatosis Type 1. A Case-Control Study.
García-Martínez FJ, Duat-Rodríguez A, Andrés Esteban E, Torrelo A, Noguera Morel L, Hernández-Martín A
Actas Dermosifiliogr 2022 Nov-Dec;113(10):923-929. Epub 2022 May 27 doi: 10.1016/j.ad.2022.05.014. PMID: 35636506

Recent clinical studies

Etiology

Cutaneous histiocytoses in children.
Fraitag S, Emile JF
Histopathology 2022 Jan;80(1):196-215. doi: 10.1111/his.14569. PMID: 34958507
Cutaneous paraneoplastic syndromes.
Wick MR, Patterson JW
Semin Diagn Pathol 2019 Jul;36(4):211-228. Epub 2019 Jan 31 doi: 10.1053/j.semdp.2019.01.001. PMID: 30736994
Risk of intraocular and other extracutaneous involvement in patients with cutaneous juvenile xanthogranuloma.
Samuelov L, Kinori M, Chamlin SL, Wagner A, Kenner-Bell BM, Paller AS, Kruse LL, Mancini AJ
Pediatr Dermatol 2018 May;35(3):329-335. Epub 2018 Feb 28 doi: 10.1111/pde.13437. PMID: 29488239
Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages.
Emile JF, Abla O, Fraitag S, Horne A, Haroche J, Donadieu J, Requena-Caballero L, Jordan MB, Abdel-Wahab O, Allen CE, Charlotte F, Diamond EL, Egeler RM, Fischer A, Herrera JG, Henter JI, Janku F, Merad M, Picarsic J, Rodriguez-Galindo C, Rollins BJ, Tazi A, Vassallo R, Weiss LM; Histiocyte Society
Blood 2016 Jun 2;127(22):2672-81. Epub 2016 Mar 10 doi: 10.1182/blood-2016-01-690636. PMID: 26966089Free PMC Article
Primary histiocytic dermatoses.
Ringel E, Moschella S
Arch Dermatol 1985 Dec;121(12):1531-41. PMID: 2998286

Diagnosis

Erdheim-Chester disease: a comprehensive review from the ophthalmologic perspective.
Kanakis M, Petrou P, Lourida G, Georgalas I
Surv Ophthalmol 2022 Mar-Apr;67(2):388-410. Epub 2021 May 31 doi: 10.1016/j.survophthal.2021.05.013. PMID: 34081930
Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages.
Emile JF, Abla O, Fraitag S, Horne A, Haroche J, Donadieu J, Requena-Caballero L, Jordan MB, Abdel-Wahab O, Allen CE, Charlotte F, Diamond EL, Egeler RM, Fischer A, Herrera JG, Henter JI, Janku F, Merad M, Picarsic J, Rodriguez-Galindo C, Rollins BJ, Tazi A, Vassallo R, Weiss LM; Histiocyte Society
Blood 2016 Jun 2;127(22):2672-81. Epub 2016 Mar 10 doi: 10.1182/blood-2016-01-690636. PMID: 26966089Free PMC Article
Langerhans cell histiocytosis.
Park L, Schiltz C, Korman N
J Cutan Med Surg 2012 Jan-Feb;16(1):45-9. doi: 10.1177/120347541201600109. PMID: 22417995
Mucocutaneous Splendore-Hoeppli phenomenon.
Hussein MR
J Cutan Pathol 2008 Nov;35(11):979-88. doi: 10.1111/j.1600-0560.2008.01045.x. PMID: 18976399
Primary histiocytic dermatoses.
Ringel E, Moschella S
Arch Dermatol 1985 Dec;121(12):1531-41. PMID: 2998286

Therapy

Clinical and pathological evaluation of cladribine treatment response in a case series of patients with xanthoma disseminatum.
Zhou EY, Yu F, Wang Y, Bi Y, Tuan H, Huang Y, Wang B, Li J, Yin H, Li L, Zhao Y
Eur J Dermatol 2023 Jun 1;33(3):270-279. doi: 10.1684/ejd.2023.4502. PMID: 37594335
Erdheim-Chester disease: a comprehensive review from the ophthalmologic perspective.
Kanakis M, Petrou P, Lourida G, Georgalas I
Surv Ophthalmol 2022 Mar-Apr;67(2):388-410. Epub 2021 May 31 doi: 10.1016/j.survophthal.2021.05.013. PMID: 34081930
Cutaneous Rosai - Dorfman disease in a patient with late syphilis and cervical cancer - case report and a review of literature.
Bielach-Bazyluk A, Serwin AB, Pilaszewicz-Puza A, Flisiak I
BMC Dermatol 2020 Dec 7;20(1):19. doi: 10.1186/s12895-020-00115-w. PMID: 33287799Free PMC Article
The Non-Langerhans Cell Histiocytoses (Rare Histiocytoses) - Clinical Aspects and Therapeutic Approaches.
Classen CF, Minkov M, Lehrnbecher T
Klin Padiatr 2016 Nov;228(6-07):294-306. Epub 2016 Nov 15 doi: 10.1055/s-0042-109713. PMID: 27846659
Cutaneous manifestations of hemophagocytic lymphohistiocytosis.
Morrell DS, Pepping MA, Scott JP, Esterly NB, Drolet BA
Arch Dermatol 2002 Sep;138(9):1208-12. doi: 10.1001/archderm.138.9.1208. PMID: 12224982

Prognosis

Cutaneous Manifestations not Considered Diagnostic Criteria for Neurofibromatosis Type 1. A Case-Control Study.
García-Martínez FJ, Duat-Rodríguez A, Andrés Esteban E, Torrelo A, Noguera Morel L, Hernández-Martín A
Actas Dermosifiliogr 2022 Nov-Dec;113(10):T923-T929. Epub 2022 Sep 24 doi: 10.1016/j.ad.2022.09.011. PMID: 36162491
Clinical and Pathological Characteristics and Outcomes Among Patients With Subcutaneous Panniculitis-like T-Cell Lymphoma and Related Adipotropic Lymphoproliferative Disorders.
Guitart J, Mangold AR, Martinez-Escala ME, Walker CJ, Comfere NI, Pulitzer M, Rieger KE, Torres-Cabala CA, Pincus LB, Kumar ES, Wang EBK, Park KE, Espinosa ML, Duvic M, Kim YH, Horwitz S
JAMA Dermatol 2022 Oct 1;158(10):1167-1174. doi: 10.1001/jamadermatol.2022.3347. PMID: 36001337Free PMC Article
Cutaneous Manifestations not Considered Diagnostic Criteria for Neurofibromatosis Type 1. A Case-Control Study.
García-Martínez FJ, Duat-Rodríguez A, Andrés Esteban E, Torrelo A, Noguera Morel L, Hernández-Martín A
Actas Dermosifiliogr 2022 Nov-Dec;113(10):923-929. Epub 2022 May 27 doi: 10.1016/j.ad.2022.05.014. PMID: 35636506
The Non-Langerhans Cell Histiocytoses (Rare Histiocytoses) - Clinical Aspects and Therapeutic Approaches.
Classen CF, Minkov M, Lehrnbecher T
Klin Padiatr 2016 Nov;228(6-07):294-306. Epub 2016 Nov 15 doi: 10.1055/s-0042-109713. PMID: 27846659
Primary histiocytic dermatoses.
Ringel E, Moschella S
Arch Dermatol 1985 Dec;121(12):1531-41. PMID: 2998286

Clinical prediction guides

Clinical and pathological evaluation of cladribine treatment response in a case series of patients with xanthoma disseminatum.
Zhou EY, Yu F, Wang Y, Bi Y, Tuan H, Huang Y, Wang B, Li J, Yin H, Li L, Zhao Y
Eur J Dermatol 2023 Jun 1;33(3):270-279. doi: 10.1684/ejd.2023.4502. PMID: 37594335
Cutaneous Manifestations not Considered Diagnostic Criteria for Neurofibromatosis Type 1. A Case-Control Study.
García-Martínez FJ, Duat-Rodríguez A, Andrés Esteban E, Torrelo A, Noguera Morel L, Hernández-Martín A
Actas Dermosifiliogr 2022 Nov-Dec;113(10):T923-T929. Epub 2022 Sep 24 doi: 10.1016/j.ad.2022.09.011. PMID: 36162491
Clinical and Pathological Characteristics and Outcomes Among Patients With Subcutaneous Panniculitis-like T-Cell Lymphoma and Related Adipotropic Lymphoproliferative Disorders.
Guitart J, Mangold AR, Martinez-Escala ME, Walker CJ, Comfere NI, Pulitzer M, Rieger KE, Torres-Cabala CA, Pincus LB, Kumar ES, Wang EBK, Park KE, Espinosa ML, Duvic M, Kim YH, Horwitz S
JAMA Dermatol 2022 Oct 1;158(10):1167-1174. doi: 10.1001/jamadermatol.2022.3347. PMID: 36001337Free PMC Article
Cutaneous Manifestations not Considered Diagnostic Criteria for Neurofibromatosis Type 1. A Case-Control Study.
García-Martínez FJ, Duat-Rodríguez A, Andrés Esteban E, Torrelo A, Noguera Morel L, Hernández-Martín A
Actas Dermosifiliogr 2022 Nov-Dec;113(10):923-929. Epub 2022 May 27 doi: 10.1016/j.ad.2022.05.014. PMID: 35636506
Frequency, clinical features and prognosis of cutaneous manifestations in adult patients with reactive haemophagocytic syndrome.
Fardet L, Galicier L, Vignon-Pennamen MD, Regnier S, Noguera ME, de Labarthe A, Raffoux E, Martinez V, Buyse S, Viguier M, Osio A, Lebbé C, Morel P, Dupuy A, Rybojad M
Br J Dermatol 2010 Mar;162(3):547-53. Epub 2009 Oct 10 doi: 10.1111/j.1365-2133.2009.09549.x. PMID: 19818067

Recent systematic reviews

Cutaneous-group histiocytoses associated with myeloid malignancies: A systematic review of 102 cases.
Bonometti A, Gliozzo J, Moltrasio C, Bagnoli F, Berti E
Australas J Dermatol 2021 May;62(2):e162-e169. Epub 2020 Oct 30 doi: 10.1111/ajd.13491. PMID: 33125722
A Multicenter Cross-Sectional Study and Systematic Review of Necrobiotic Xanthogranuloma With Proposed Diagnostic Criteria.
Nelson CA, Zhong CS, Hashemi DA, Ashchyan HJ, Brown-Joel Z, Noe MH, Imadojemu S, Micheletti RG, Vleugels RA, Wanat KA, Rosenbach M, Mostaghimi A
JAMA Dermatol 2020 Mar 1;156(3):270-279. doi: 10.1001/jamadermatol.2019.4221. PMID: 31940000Free PMC Article

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