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Abnormal proportion of gamma-delta T cells

MedGen UID:
1718809
•Concept ID:
C5398018
•
Finding
Synonyms: Abnormal proportion of gamma-delta T-lymphocytes; Abnormal proportion of gammadelta T cells; Abnormal proprotion of gamma-delta T lymphocytes
 
HPO: HP:0500269

Definition

Abnormal proportion of gamma-delta T cells relative to the total number of T cells. [from HPO]

Recent clinical studies

Etiology

Immunological Features of Paranasal Sinus Mucosa in Patients with Graves' Orbitopathy.
Lu Y, Wu Y, Huang Y, Fang S, Li Y, Sun J, Zhou H
Front Endocrinol (Lausanne) 2020;11:621321. Epub 2021 Feb 10 doi: 10.3389/fendo.2020.621321. PMID: 33643223Free PMC Article
Joint BAPEN and British Society of Gastroenterology Symposium on 'Coeliac disease: basics and controversies'. Coeliac disease in the twenty-first century.
Dickey W
Proc Nutr Soc 2009 Aug;68(3):234-41. Epub 2009 Jun 3 doi: 10.1017/S0029665109001414. PMID: 19490742
Refractory celiac disease.
Ryan BM, Kelleher D
Gastroenterology 2000 Jul;119(1):243-51. doi: 10.1053/gast.2000.8530. PMID: 10889175
Increased frequency of abnormal gamma delta T cells in blood of patients with inflammatory bowel diseases.
Söderström K, Bucht A, Halapi E, Grönberg A, Magnusson I, Kiessling R
J Immunol 1996 Mar 15;156(6):2331-9. PMID: 8690925
gamma delta+ T cells are increased in patients with Parkinson's disease.
Fiszer U, Mix E, Fredrikson S, Kostulas V, Olsson T, Link H
J Neurol Sci 1994 Jan;121(1):39-45. doi: 10.1016/0022-510x(94)90154-6. PMID: 8133310

Diagnosis

Bartonella henselae masquerading as possible gamma-delta T-cell lymphoma in a paediatric patient with 22q11.2 deletion syndrome.
Davis K, Battaglia L, Kumar B, Ojaimi S
BMJ Case Rep 2021 Nov 30;14(11) doi: 10.1136/bcr-2021-245592. PMID: 34848411Free PMC Article
Joint BAPEN and British Society of Gastroenterology Symposium on 'Coeliac disease: basics and controversies'. Coeliac disease in the twenty-first century.
Dickey W
Proc Nutr Soc 2009 Aug;68(3):234-41. Epub 2009 Jun 3 doi: 10.1017/S0029665109001414. PMID: 19490742
TIA1 and mast cell tryptase in food allergy of children: increase of intraepithelial lymphocytes expressing TIA1 associates with allergy.
Augustin M, Karttunen TJ, Kokkonen J
J Pediatr Gastroenterol Nutr 2001 Jan;32(1):11-8. doi: 10.1097/00005176-200101000-00008. PMID: 11176318
Refractory celiac disease.
Ryan BM, Kelleher D
Gastroenterology 2000 Jul;119(1):243-51. doi: 10.1053/gast.2000.8530. PMID: 10889175
Intraepithelial gamma delta T-cell-receptor lymphocytes and genetic susceptibility to coeliac disease.
Holm K, Mäki M, Savilahti E, Lipsanen V, Laippala P, Koskimies S
Lancet 1992 Jun 20;339(8808):1500-3. doi: 10.1016/0140-6736(92)91262-7. PMID: 1351185

Therapy

Analysis of circulating T gamma/delta lymphocytes and CD16/56 cell populations in children and adolescents with Graves' disease.
Bossowski A, Urban M, Stasiak-Barmuta A
Pediatr Res 2003 Sep;54(3):425-9. Epub 2003 May 21 doi: 10.1203/01.PDR.0000076663.94850.44. PMID: 12761360
Abnormal expansion of peripheral gamma delta T cells in patients with neurologic disorders.
Yamamoto T, Hara T, Nanba E, Ohashi S, Suzuki N, Yoshino K, Takeshita K
Brain Behav Immun 1997 Sep;11(3):157-66. doi: 10.1006/brbi.1997.0495. PMID: 9417802
Gamma delta T lymphocyte regeneration after T lymphocyte-depleted bone marrow transplantation from mismatched family members or matched unrelated donors.
Cela ME, Holladay MS, Rooney CM, Richardson S, Alexander B, Krance RA, Brenner MK, Heslop HE
Bone Marrow Transplant 1996 Feb;17(2):243-7. PMID: 8640174
gamma delta+ T cells are increased in patients with Parkinson's disease.
Fiszer U, Mix E, Fredrikson S, Kostulas V, Olsson T, Link H
J Neurol Sci 1994 Jan;121(1):39-45. doi: 10.1016/0022-510x(94)90154-6. PMID: 8133310

Prognosis

Flow cytometric analysis of intestinal intraepithelial lymphocytes in the diagnosis of refractory celiac sprue.
Sanchez-Muñoz LB, Santón A, Cano A, Lopez A, Almeida J, Orfao A, Escribano L, Roy G
Eur J Gastroenterol Hepatol 2008 May;20(5):478-87. doi: 10.1097/MEG.0b013e3282f16a4b. PMID: 18403953
Refractory celiac disease.
Ryan BM, Kelleher D
Gastroenterology 2000 Jul;119(1):243-51. doi: 10.1053/gast.2000.8530. PMID: 10889175

Clinical prediction guides

Immunological Features of Paranasal Sinus Mucosa in Patients with Graves' Orbitopathy.
Lu Y, Wu Y, Huang Y, Fang S, Li Y, Sun J, Zhou H
Front Endocrinol (Lausanne) 2020;11:621321. Epub 2021 Feb 10 doi: 10.3389/fendo.2020.621321. PMID: 33643223Free PMC Article
Abnormal expansion of peripheral gamma delta T cells in patients with neurologic disorders.
Yamamoto T, Hara T, Nanba E, Ohashi S, Suzuki N, Yoshino K, Takeshita K
Brain Behav Immun 1997 Sep;11(3):157-66. doi: 10.1006/brbi.1997.0495. PMID: 9417802
Increased frequency of abnormal gamma delta T cells in blood of patients with inflammatory bowel diseases.
Söderström K, Bucht A, Halapi E, Grönberg A, Magnusson I, Kiessling R
J Immunol 1996 Mar 15;156(6):2331-9. PMID: 8690925
Gamma delta T lymphocyte regeneration after T lymphocyte-depleted bone marrow transplantation from mismatched family members or matched unrelated donors.
Cela ME, Holladay MS, Rooney CM, Richardson S, Alexander B, Krance RA, Brenner MK, Heslop HE
Bone Marrow Transplant 1996 Feb;17(2):243-7. PMID: 8640174
Gamma delta T cells and the immune response in visceral leishmaniasis.
Raziuddin S, Telmasani AW, el-Hag el-Awad M, al-Amari O, al-Janadi M
Eur J Immunol 1992 May;22(5):1143-8. doi: 10.1002/eji.1830220506. PMID: 1374336

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