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High Risk Chronic Myelogenous Leukemia, BCR-ABL1 Positive

MedGen UID:
1719179
Concept ID:
C5239042
Neoplastic Process

Definition

A BCR-ABL1 positive chronic myelogenous leukemia with clinicopathologic, cytogenetic, and molecular findings that define a chronic myelogenous leukemia as high risk. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh Risk Chronic Myelogenous Leukemia, BCR-ABL1 Positive

Professional guidelines

PubMed

Iezza M, Cortesi S, Ottaviani E, Mancini M, Venturi C, Monaldi C, De Santis S, Testoni N, Soverini S, Rosti G, Cavo M, Castagnetti F
Cells 2023 Jun 23;12(13) doi: 10.3390/cells12131703. PMID: 37443737Free PMC Article
Senapati J, Sasaki K, Issa GC, Lipton JH, Radich JP, Jabbour E, Kantarjian HM
Blood Cancer J 2023 Apr 24;13(1):58. doi: 10.1038/s41408-023-00823-9. PMID: 37088793Free PMC Article
Sembill S, Ampatzidou M, Chaudhury S, Dworzak M, Kalwak K, Karow A, Kiani A, Krumbholz M, Luesink M, Naumann-Bartsch N, De Moerloose B, Osborn M, Schultz KR, Sedlacek P, Giona F, Zwaan CM, Shimada H, Versluijs B, Millot F, Hijiya N, Suttorp M, Metzler M
Leukemia 2023 Mar;37(3):505-517. Epub 2023 Jan 27 doi: 10.1038/s41375-023-01822-2. PMID: 36707619Free PMC Article

Recent clinical studies

Etiology

Iezza M, Cortesi S, Ottaviani E, Mancini M, Venturi C, Monaldi C, De Santis S, Testoni N, Soverini S, Rosti G, Cavo M, Castagnetti F
Cells 2023 Jun 23;12(13) doi: 10.3390/cells12131703. PMID: 37443737Free PMC Article
Senapati J, Sasaki K, Issa GC, Lipton JH, Radich JP, Jabbour E, Kantarjian HM
Blood Cancer J 2023 Apr 24;13(1):58. doi: 10.1038/s41408-023-00823-9. PMID: 37088793Free PMC Article
Sembill S, Ampatzidou M, Chaudhury S, Dworzak M, Kalwak K, Karow A, Kiani A, Krumbholz M, Luesink M, Naumann-Bartsch N, De Moerloose B, Osborn M, Schultz KR, Sedlacek P, Giona F, Zwaan CM, Shimada H, Versluijs B, Millot F, Hijiya N, Suttorp M, Metzler M
Leukemia 2023 Mar;37(3):505-517. Epub 2023 Jan 27 doi: 10.1038/s41375-023-01822-2. PMID: 36707619Free PMC Article
Vener C, Banzi R, Ambrogi F, Ferrero A, Saglio G, Pravettoni G, Sant M
Blood Adv 2020 Jun 23;4(12):2723-2735. doi: 10.1182/bloodadvances.2019001329. PMID: 32559295Free PMC Article
Hochhaus A, Saglio G, Hughes TP, Larson RA, Kim DW, Issaragrisil S, le Coutre PD, Etienne G, Dorlhiac-Llacer PE, Clark RE, Flinn IW, Nakamae H, Donohue B, Deng W, Dalal D, Menssen HD, Kantarjian HM
Leukemia 2016 May;30(5):1044-54. Epub 2016 Feb 3 doi: 10.1038/leu.2016.5. PMID: 26837842Free PMC Article

Diagnosis

Sembill S, Ampatzidou M, Chaudhury S, Dworzak M, Kalwak K, Karow A, Kiani A, Krumbholz M, Luesink M, Naumann-Bartsch N, De Moerloose B, Osborn M, Schultz KR, Sedlacek P, Giona F, Zwaan CM, Shimada H, Versluijs B, Millot F, Hijiya N, Suttorp M, Metzler M
Leukemia 2023 Mar;37(3):505-517. Epub 2023 Jan 27 doi: 10.1038/s41375-023-01822-2. PMID: 36707619Free PMC Article
Brümmendorf TH, Cortes JE, Milojkovic D, Gambacorti-Passerini C, Clark RE, le Coutre P, Garcia-Gutierrez V, Chuah C, Kota V, Lipton JH, Rousselot P, Mauro MJ, Hochhaus A, Hurtado Monroy R, Leip E, Purcell S, Yver A, Viqueira A, Deininger MW; BFORE study investigators
Leukemia 2022 Jul;36(7):1825-1833. Epub 2022 May 28 doi: 10.1038/s41375-022-01589-y. PMID: 35643868Free PMC Article
Vener C, Banzi R, Ambrogi F, Ferrero A, Saglio G, Pravettoni G, Sant M
Blood Adv 2020 Jun 23;4(12):2723-2735. doi: 10.1182/bloodadvances.2019001329. PMID: 32559295Free PMC Article
Raetz EA, Teachey DT
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):580-588. doi: 10.1182/asheducation-2016.1.580. PMID: 27913532Free PMC Article
Hochhaus A, Saglio G, Hughes TP, Larson RA, Kim DW, Issaragrisil S, le Coutre PD, Etienne G, Dorlhiac-Llacer PE, Clark RE, Flinn IW, Nakamae H, Donohue B, Deng W, Dalal D, Menssen HD, Kantarjian HM
Leukemia 2016 May;30(5):1044-54. Epub 2016 Feb 3 doi: 10.1038/leu.2016.5. PMID: 26837842Free PMC Article

Therapy

Senapati J, Sasaki K, Issa GC, Lipton JH, Radich JP, Jabbour E, Kantarjian HM
Blood Cancer J 2023 Apr 24;13(1):58. doi: 10.1038/s41408-023-00823-9. PMID: 37088793Free PMC Article
Brümmendorf TH, Cortes JE, Milojkovic D, Gambacorti-Passerini C, Clark RE, le Coutre P, Garcia-Gutierrez V, Chuah C, Kota V, Lipton JH, Rousselot P, Mauro MJ, Hochhaus A, Hurtado Monroy R, Leip E, Purcell S, Yver A, Viqueira A, Deininger MW; BFORE study investigators
Leukemia 2022 Jul;36(7):1825-1833. Epub 2022 May 28 doi: 10.1038/s41375-022-01589-y. PMID: 35643868Free PMC Article
Réa D, Mauro MJ, Boquimpani C, Minami Y, Lomaia E, Voloshin S, Turkina A, Kim DW, Apperley JF, Abdo A, Fogliatto LM, Kim DDH, le Coutre P, Saussele S, Annunziata M, Hughes TP, Chaudhri N, Sasaki K, Chee L, García-Gutiérrez V, Cortes JE, Aimone P, Allepuz A, Quenet S, Bédoucha V, Hochhaus A
Blood 2021 Nov 25;138(21):2031-2041. doi: 10.1182/blood.2020009984. PMID: 34407542Free PMC Article
Vener C, Banzi R, Ambrogi F, Ferrero A, Saglio G, Pravettoni G, Sant M
Blood Adv 2020 Jun 23;4(12):2723-2735. doi: 10.1182/bloodadvances.2019001329. PMID: 32559295Free PMC Article
Hochhaus A, Saglio G, Hughes TP, Larson RA, Kim DW, Issaragrisil S, le Coutre PD, Etienne G, Dorlhiac-Llacer PE, Clark RE, Flinn IW, Nakamae H, Donohue B, Deng W, Dalal D, Menssen HD, Kantarjian HM
Leukemia 2016 May;30(5):1044-54. Epub 2016 Feb 3 doi: 10.1038/leu.2016.5. PMID: 26837842Free PMC Article

Prognosis

Iezza M, Cortesi S, Ottaviani E, Mancini M, Venturi C, Monaldi C, De Santis S, Testoni N, Soverini S, Rosti G, Cavo M, Castagnetti F
Cells 2023 Jun 23;12(13) doi: 10.3390/cells12131703. PMID: 37443737Free PMC Article
Sembill S, Ampatzidou M, Chaudhury S, Dworzak M, Kalwak K, Karow A, Kiani A, Krumbholz M, Luesink M, Naumann-Bartsch N, De Moerloose B, Osborn M, Schultz KR, Sedlacek P, Giona F, Zwaan CM, Shimada H, Versluijs B, Millot F, Hijiya N, Suttorp M, Metzler M
Leukemia 2023 Mar;37(3):505-517. Epub 2023 Jan 27 doi: 10.1038/s41375-023-01822-2. PMID: 36707619Free PMC Article
Shahin OA, Chifotides HT, Bose P, Masarova L, Verstovsek S
Acta Haematol 2021;144(5):484-499. Epub 2021 Apr 21 doi: 10.1159/000512929. PMID: 33882481Free PMC Article
Raetz EA, Teachey DT
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):580-588. doi: 10.1182/asheducation-2016.1.580. PMID: 27913532Free PMC Article
Hochhaus A, Saglio G, Hughes TP, Larson RA, Kim DW, Issaragrisil S, le Coutre PD, Etienne G, Dorlhiac-Llacer PE, Clark RE, Flinn IW, Nakamae H, Donohue B, Deng W, Dalal D, Menssen HD, Kantarjian HM
Leukemia 2016 May;30(5):1044-54. Epub 2016 Feb 3 doi: 10.1038/leu.2016.5. PMID: 26837842Free PMC Article

Clinical prediction guides

Iezza M, Cortesi S, Ottaviani E, Mancini M, Venturi C, Monaldi C, De Santis S, Testoni N, Soverini S, Rosti G, Cavo M, Castagnetti F
Cells 2023 Jun 23;12(13) doi: 10.3390/cells12131703. PMID: 37443737Free PMC Article
Shahin OA, Chifotides HT, Bose P, Masarova L, Verstovsek S
Acta Haematol 2021;144(5):484-499. Epub 2021 Apr 21 doi: 10.1159/000512929. PMID: 33882481Free PMC Article
Xiao W, Chan A, Waarts MR, Mishra T, Liu Y, Cai SF, Yao J, Gao Q, Bowman RL, Koche RP, Csete IS, DelGaudio NL, Derkach A, Baik J, Yanis S, Famulare CA, Patel M, Arcila ME, Stahl M, Rampal RK, Tallman MS, Zhang Y, Dogan A, Goldberg AD, Roshal M, Levine RL
Blood 2021 Mar 11;137(10):1377-1391. doi: 10.1182/blood.2020007897. PMID: 32871587Free PMC Article
Raetz EA, Teachey DT
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):580-588. doi: 10.1182/asheducation-2016.1.580. PMID: 27913532Free PMC Article
Hochhaus A, Saglio G, Hughes TP, Larson RA, Kim DW, Issaragrisil S, le Coutre PD, Etienne G, Dorlhiac-Llacer PE, Clark RE, Flinn IW, Nakamae H, Donohue B, Deng W, Dalal D, Menssen HD, Kantarjian HM
Leukemia 2016 May;30(5):1044-54. Epub 2016 Feb 3 doi: 10.1038/leu.2016.5. PMID: 26837842Free PMC Article

Recent systematic reviews

Cha SH, Kim K, Song YK
Acta Oncol 2023 Dec;62(12):1767-1774. Epub 2023 Nov 25 doi: 10.1080/0284186X.2023.2263152. PMID: 37787749
Vener C, Banzi R, Ambrogi F, Ferrero A, Saglio G, Pravettoni G, Sant M
Blood Adv 2020 Jun 23;4(12):2723-2735. doi: 10.1182/bloodadvances.2019001329. PMID: 32559295Free PMC Article
Yun S, Vincelette ND, Segar JM, Dong Y, Shen Y, Kim DW, Abraham I
Clin Lymphoma Myeloma Leuk 2016 Jun;16(6):e85-94. Epub 2016 Mar 30 doi: 10.1016/j.clml.2016.03.003. PMID: 27101984
Breccia M, Efficace F, Alimena G
Cancer Lett 2011 Jan 28;300(2):115-21. Epub 2010 Nov 12 doi: 10.1016/j.canlet.2010.10.018. PMID: 21074936
Khalade A, Jaakkola MS, Pukkala E, Jaakkola JJ
Environ Health 2010 Jun 28;9:31. doi: 10.1186/1476-069X-9-31. PMID: 20584305Free PMC Article

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