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Refractory Neuroendocrine Carcinoma

MedGen UID:
1719330
•Concept ID:
C5237419
•
Neoplastic Process

Definition

Neuroendocrine carcinoma that does not respond to treatment. [from NCI]

Professional guidelines

PubMed

Treatment of Aggressive Thyroid Cancer.
Huang J, Harris EJ, Lorch JH
Surg Pathol Clin 2019 Dec;12(4):943-950. doi: 10.1016/j.path.2019.08.004. PMID: 31672300
Avelumab for the treatment of metastatic Merkel cell carcinoma.
Cordes LM, Gulley JL
Drugs Today (Barc) 2017 Jul;53(7):377-383. doi: 10.1358/dot.2017.53.7.2654888. PMID: 28837181Free PMC Article
Update on thyroid cancer treatment.
Regalbuto C, Frasca F, Pellegriti G, Malandrino P, Marturano I, Di Carlo I, Pezzino V
Future Oncol 2012 Oct;8(10):1331-48. doi: 10.2217/fon.12.123. PMID: 23130931

Recent clinical studies

Etiology

Merkel Cell Carcinoma.
Strong J, Hallaert P, Brownell I
Hematol Oncol Clin North Am 2024 Oct;38(5):1133-1147. Epub 2024 Jul 26 doi: 10.1016/j.hoc.2024.05.013. PMID: 39060119Free PMC Article
Theranostics of Thyroid Cancer.
Giovanella L, Tuncel M, Aghaee A, Campenni A, De Virgilio A, Petranović Ovčariček P
Semin Nucl Med 2024 Jul;54(4):470-487. Epub 2024 Mar 19 doi: 10.1053/j.semnuclmed.2024.01.011. PMID: 38503602
Molecular targets of tyrosine kinase inhibitors in thyroid cancer.
Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
Treatment of Aggressive Thyroid Cancer.
Huang J, Harris EJ, Lorch JH
Surg Pathol Clin 2019 Dec;12(4):943-950. doi: 10.1016/j.path.2019.08.004. PMID: 31672300
Everolimus.
Hasskarl J
Recent Results Cancer Res 2018;211:101-123. doi: 10.1007/978-3-319-91442-8_8. PMID: 30069763

Diagnosis

Merkel Cell Carcinoma.
Strong J, Hallaert P, Brownell I
Hematol Oncol Clin North Am 2024 Oct;38(5):1133-1147. Epub 2024 Jul 26 doi: 10.1016/j.hoc.2024.05.013. PMID: 39060119Free PMC Article
TROP2 Expression Across Molecular Subtypes of Urothelial Carcinoma and Enfortumab Vedotin-resistant Cells.
Chou J, Trepka K, Sjöström M, Egusa EA, Chu CE, Zhu J, Chan E, Gibb EA, Badura ML, Contreras-Sanz A, Stohr BA, Meng MV, Pruthi RS, Lotan Y, Black PC, Porten SP, Koshkin VS, Friedlander TW, Feng FY
Eur Urol Oncol 2022 Dec;5(6):714-718. Epub 2022 Feb 23 doi: 10.1016/j.euo.2021.11.005. PMID: 35216942Free PMC Article
Molecular targets of tyrosine kinase inhibitors in thyroid cancer.
Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
DLL3: an emerging target in small cell lung cancer.
Owen DH, Giffin MJ, Bailis JM, Smit MD, Carbone DP, He K
J Hematol Oncol 2019 Jun 18;12(1):61. doi: 10.1186/s13045-019-0745-2. PMID: 31215500Free PMC Article
Merkel cell carcinoma.
Becker JC, Stang A, DeCaprio JA, Cerroni L, Lebbé C, Veness M, Nghiem P
Nat Rev Dis Primers 2017 Oct 26;3:17077. doi: 10.1038/nrdp.2017.77. PMID: 29072302Free PMC Article

Therapy

Molecular basis and targeted therapy in thyroid cancer: Progress and opportunities.
Zhang L, Feng Q, Wang J, Tan Z, Li Q, Ge M
Biochim Biophys Acta Rev Cancer 2023 Jul;1878(4):188928. Epub 2023 May 29 doi: 10.1016/j.bbcan.2023.188928. PMID: 37257629
Molecular targets of tyrosine kinase inhibitors in thyroid cancer.
Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
Immunotherapy for Non-melanoma Skin Cancer.
Shalhout SZ, Emerick KS, Kaufman HL, Miller DM
Curr Oncol Rep 2021 Aug 27;23(11):125. doi: 10.1007/s11912-021-01120-z. PMID: 34448958Free PMC Article
Treatment of Aggressive Thyroid Cancer.
Huang J, Harris EJ, Lorch JH
Surg Pathol Clin 2019 Dec;12(4):943-950. doi: 10.1016/j.path.2019.08.004. PMID: 31672300
DLL3: an emerging target in small cell lung cancer.
Owen DH, Giffin MJ, Bailis JM, Smit MD, Carbone DP, He K
J Hematol Oncol 2019 Jun 18;12(1):61. doi: 10.1186/s13045-019-0745-2. PMID: 31215500Free PMC Article

Prognosis

Molecular targets of tyrosine kinase inhibitors in thyroid cancer.
Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
Immune checkpoint inhibitors to treat cutaneous malignancies.
Barrios DM, Do MH, Phillips GS, Postow MA, Akaike T, Nghiem P, Lacouture ME
J Am Acad Dermatol 2020 Nov;83(5):1239-1253. Epub 2020 May 24 doi: 10.1016/j.jaad.2020.03.131. PMID: 32461079Free PMC Article
Treatment of Aggressive Thyroid Cancer.
Huang J, Harris EJ, Lorch JH
Surg Pathol Clin 2019 Dec;12(4):943-950. doi: 10.1016/j.path.2019.08.004. PMID: 31672300
Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma.
Saito Y, Muramatsu T, Kanai Y, Ojima H, Sukeda A, Hiraoka N, Arai E, Sugiyama Y, Matsuzaki J, Uchida R, Yoshikawa N, Furukawa R, Saito H
Cell Rep 2019 Apr 23;27(4):1265-1276.e4. doi: 10.1016/j.celrep.2019.03.088. PMID: 31018139
Merkel cell carcinoma.
Becker JC, Stang A, DeCaprio JA, Cerroni L, Lebbé C, Veness M, Nghiem P
Nat Rev Dis Primers 2017 Oct 26;3:17077. doi: 10.1038/nrdp.2017.77. PMID: 29072302Free PMC Article

Clinical prediction guides

Narrative Review of Immunotherapy in Gastroentero-Pancreatic Neuroendocrine Neoplasms.
Kaur J, Vijayvergia N
Curr Oncol 2023 Sep 21;30(9):8653-8664. doi: 10.3390/curroncol30090627. PMID: 37754542Free PMC Article
Aggressive pituitary tumors (PitNETs).
Nishioka H
Endocr J 2023 Mar 28;70(3):241-248. Epub 2023 Mar 3 doi: 10.1507/endocrj.EJ23-0007. PMID: 36858483
Immune checkpoint inhibitors to treat cutaneous malignancies.
Barrios DM, Do MH, Phillips GS, Postow MA, Akaike T, Nghiem P, Lacouture ME
J Am Acad Dermatol 2020 Nov;83(5):1239-1253. Epub 2020 May 24 doi: 10.1016/j.jaad.2020.03.131. PMID: 32461079Free PMC Article
Merkel Cell Carcinoma - Current Controversies and Future Directions.
Steven N, Lawton P, Poulsen M
Clin Oncol (R Coll Radiol) 2019 Nov;31(11):789-796. doi: 10.1016/j.clon.2019.08.012. PMID: 31594644
Neuroendocrine transdifferentiation of prostate carcinoma cells and its prognostic significance.
Marcu M, Radu E, Sajin M
Rom J Morphol Embryol 2010;51(1):7-12. PMID: 20191113

Recent systematic reviews

Efficacy and Safety of Multikinase Inhibitors for Patients With Refractory Thyroid Cancer: Systematic Review and Network Meta-Analysis.
Jing R, Wu N, Wu Y, Zhang Q, Liang Q, Huang P, Yi S
J Clin Endocrinol Metab 2024 Sep 16;109(10):2658-2672. doi: 10.1210/clinem/dgae454. PMID: 38970485
Efficacy and safety of peptide receptor radionuclide therapy in advanced radioiodine-refractory differentiated thyroid cancer and metastatic medullary thyroid cancer: a systematic review.
Maghsoomi Z, Emami Z, Malboosbaf R, Malek M, Khamseh ME
BMC Cancer 2021 May 20;21(1):579. doi: 10.1186/s12885-021-08257-x. PMID: 34016077Free PMC Article
Clinicopathological data and treatment modalities for pancreatic vipomas: a systematic review.
Schizas D, Mastoraki A, Bagias G, Patras R, Moris D, Lazaridis II, Arkadopoulos N, Felekouras E
J BUON 2019 Mar-Apr;24(2):415-423. PMID: 31127985
Gastrointestinal neuroendocrine tumors treated with high dose octreotide-LAR: a systematic literature review.
Broder MS, Beenhouwer D, Strosberg JR, Neary MP, Cherepanov D
World J Gastroenterol 2015 Feb 14;21(6):1945-55. doi: 10.3748/wjg.v21.i6.1945. PMID: 25684964Free PMC Article
New therapeutic options for advanced forms of thyroid cancer.
Bernet V, Smallridge R
Expert Opin Emerg Drugs 2014 Jun;19(2):225-41. Epub 2014 Mar 3 doi: 10.1517/14728214.2014.894017. PMID: 24588376

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