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IDH Inhibitor Associated Differentiation Syndrome

MedGen UID:
1719763
Concept ID:
C5238955
Disease or Syndrome
Synonym: IDH-DS

Definition

A constellation of signs and symptoms occurring in the context of administration of isocitrate dehydrogenase (IDH) inhibitors in hematologic malignancies. It is characterized by dyspnea, unexplained fever, pulmonary infiltrates, hypoxia, pleural effusion, acute kidney injury, pericardial effusion, arthralgia, lymphadenopathy, edema and weight gain. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIDH Inhibitor Associated Differentiation Syndrome

Professional guidelines

PubMed

Montesinos P, Fathi AT, de Botton S, Stein EM, Zeidan AM, Zhu Y, Prebet T, Vigil CE, Bluemmert I, Yu X, DiNardo CD
Blood Adv 2024 May 28;8(10):2509-2519. doi: 10.1182/bloodadvances.2023011914. PMID: 38507688Free PMC Article
Parisi R, Cowen EA, Stoll JR, Zhu H, Dusza S, Pulitzer MP, Stein EM, Markova A
Leuk Res 2022 Dec;123:106970. Epub 2022 Oct 22 doi: 10.1016/j.leukres.2022.106970. PMID: 36308802Free PMC Article
Norsworthy KJ, Mulkey F, Scott EC, Ward AF, Przepiorka D, Charlab R, Dorff SE, Deisseroth A, Kazandjian D, Sridhara R, Beaver JA, Farrell AT, de Claro RA, Pazdur R
Clin Cancer Res 2020 Aug 15;26(16):4280-4288. Epub 2020 May 11 doi: 10.1158/1078-0432.CCR-20-0834. PMID: 32393603Free PMC Article

Recent clinical studies

Etiology

Montesinos P, Fathi AT, de Botton S, Stein EM, Zeidan AM, Zhu Y, Prebet T, Vigil CE, Bluemmert I, Yu X, DiNardo CD
Blood Adv 2024 May 28;8(10):2509-2519. doi: 10.1182/bloodadvances.2023011914. PMID: 38507688Free PMC Article
DiNardo CD, Venugopal S, Lachowiez C, Takahashi K, Loghavi S, Montalban-Bravo G, Wang X, Carraway H, Sekeres M, Sukkur A, Hammond D, Chien K, Maiti A, Masarova L, Sasaki K, Alvarado Y, Kadia T, Short NJ, Daver N, Borthakur G, Ravandi F, Kantarjian HM, Patel B, Dezern A, Roboz G, Garcia-Manero G
Blood Adv 2023 Jun 13;7(11):2378-2387. doi: 10.1182/bloodadvances.2022008378. PMID: 35973199Free PMC Article
Megherea O, Janes C, Kowalski A, Baron J, Ahn E, Soule A, Newman M
Leuk Lymphoma 2021 Dec;62(13):3219-3225. Epub 2021 Jul 27 doi: 10.1080/10428194.2021.1957868. PMID: 34313176
Stein EM, DiNardo CD, Fathi AT, Pollyea DA, Stone RM, Altman JK, Roboz GJ, Patel MR, Collins R, Flinn IW, Sekeres MA, Stein AS, Kantarjian HM, Levine RL, Vyas P, MacBeth KJ, Tosolini A, VanOostendorp J, Xu Q, Gupta I, Lila T, Risueno A, Yen KE, Wu B, Attar EC, Tallman MS, de Botton S
Blood 2019 Feb 14;133(7):676-687. Epub 2018 Dec 3 doi: 10.1182/blood-2018-08-869008. PMID: 30510081Free PMC Article
DiNardo CD, Stein EM, de Botton S, Roboz GJ, Altman JK, Mims AS, Swords R, Collins RH, Mannis GN, Pollyea DA, Donnellan W, Fathi AT, Pigneux A, Erba HP, Prince GT, Stein AS, Uy GL, Foran JM, Traer E, Stuart RK, Arellano ML, Slack JL, Sekeres MA, Willekens C, Choe S, Wang H, Zhang V, Yen KE, Kapsalis SM, Yang H, Dai D, Fan B, Goldwasser M, Liu H, Agresta S, Wu B, Attar EC, Tallman MS, Stone RM, Kantarjian HM
N Engl J Med 2018 Jun 21;378(25):2386-2398. Epub 2018 Jun 2 doi: 10.1056/NEJMoa1716984. PMID: 29860938

Diagnosis

Montesinos P, Fathi AT, de Botton S, Stein EM, Zeidan AM, Zhu Y, Prebet T, Vigil CE, Bluemmert I, Yu X, DiNardo CD
Blood Adv 2024 May 28;8(10):2509-2519. doi: 10.1182/bloodadvances.2023011914. PMID: 38507688Free PMC Article
DiNardo CD, Venugopal S, Lachowiez C, Takahashi K, Loghavi S, Montalban-Bravo G, Wang X, Carraway H, Sekeres M, Sukkur A, Hammond D, Chien K, Maiti A, Masarova L, Sasaki K, Alvarado Y, Kadia T, Short NJ, Daver N, Borthakur G, Ravandi F, Kantarjian HM, Patel B, Dezern A, Roboz G, Garcia-Manero G
Blood Adv 2023 Jun 13;7(11):2378-2387. doi: 10.1182/bloodadvances.2022008378. PMID: 35973199Free PMC Article
Megherea O, Janes C, Kowalski A, Baron J, Ahn E, Soule A, Newman M
Leuk Lymphoma 2021 Dec;62(13):3219-3225. Epub 2021 Jul 27 doi: 10.1080/10428194.2021.1957868. PMID: 34313176
Medeiros BC, Fathi AT, DiNardo CD, Pollyea DA, Chan SM, Swords R
Leukemia 2017 Feb;31(2):272-281. Epub 2016 Oct 10 doi: 10.1038/leu.2016.275. PMID: 27721426Free PMC Article

Therapy

DiNardo CD, Venugopal S, Lachowiez C, Takahashi K, Loghavi S, Montalban-Bravo G, Wang X, Carraway H, Sekeres M, Sukkur A, Hammond D, Chien K, Maiti A, Masarova L, Sasaki K, Alvarado Y, Kadia T, Short NJ, Daver N, Borthakur G, Ravandi F, Kantarjian HM, Patel B, Dezern A, Roboz G, Garcia-Manero G
Blood Adv 2023 Jun 13;7(11):2378-2387. doi: 10.1182/bloodadvances.2022008378. PMID: 35973199Free PMC Article
Megherea O, Janes C, Kowalski A, Baron J, Ahn E, Soule A, Newman M
Leuk Lymphoma 2021 Dec;62(13):3219-3225. Epub 2021 Jul 27 doi: 10.1080/10428194.2021.1957868. PMID: 34313176
Stein EM, DiNardo CD, Fathi AT, Pollyea DA, Stone RM, Altman JK, Roboz GJ, Patel MR, Collins R, Flinn IW, Sekeres MA, Stein AS, Kantarjian HM, Levine RL, Vyas P, MacBeth KJ, Tosolini A, VanOostendorp J, Xu Q, Gupta I, Lila T, Risueno A, Yen KE, Wu B, Attar EC, Tallman MS, de Botton S
Blood 2019 Feb 14;133(7):676-687. Epub 2018 Dec 3 doi: 10.1182/blood-2018-08-869008. PMID: 30510081Free PMC Article
DiNardo CD, Stein EM, de Botton S, Roboz GJ, Altman JK, Mims AS, Swords R, Collins RH, Mannis GN, Pollyea DA, Donnellan W, Fathi AT, Pigneux A, Erba HP, Prince GT, Stein AS, Uy GL, Foran JM, Traer E, Stuart RK, Arellano ML, Slack JL, Sekeres MA, Willekens C, Choe S, Wang H, Zhang V, Yen KE, Kapsalis SM, Yang H, Dai D, Fan B, Goldwasser M, Liu H, Agresta S, Wu B, Attar EC, Tallman MS, Stone RM, Kantarjian HM
N Engl J Med 2018 Jun 21;378(25):2386-2398. Epub 2018 Jun 2 doi: 10.1056/NEJMoa1716984. PMID: 29860938
Stein EM, DiNardo CD, Pollyea DA, Fathi AT, Roboz GJ, Altman JK, Stone RM, DeAngelo DJ, Levine RL, Flinn IW, Kantarjian HM, Collins R, Patel MR, Frankel AE, Stein A, Sekeres MA, Swords RT, Medeiros BC, Willekens C, Vyas P, Tosolini A, Xu Q, Knight RD, Yen KE, Agresta S, de Botton S, Tallman MS
Blood 2017 Aug 10;130(6):722-731. Epub 2017 Jun 6 doi: 10.1182/blood-2017-04-779405. PMID: 28588020Free PMC Article

Prognosis

Stein EM, DiNardo CD, Fathi AT, Pollyea DA, Stone RM, Altman JK, Roboz GJ, Patel MR, Collins R, Flinn IW, Sekeres MA, Stein AS, Kantarjian HM, Levine RL, Vyas P, MacBeth KJ, Tosolini A, VanOostendorp J, Xu Q, Gupta I, Lila T, Risueno A, Yen KE, Wu B, Attar EC, Tallman MS, de Botton S
Blood 2019 Feb 14;133(7):676-687. Epub 2018 Dec 3 doi: 10.1182/blood-2018-08-869008. PMID: 30510081Free PMC Article
DiNardo CD, Stein EM, de Botton S, Roboz GJ, Altman JK, Mims AS, Swords R, Collins RH, Mannis GN, Pollyea DA, Donnellan W, Fathi AT, Pigneux A, Erba HP, Prince GT, Stein AS, Uy GL, Foran JM, Traer E, Stuart RK, Arellano ML, Slack JL, Sekeres MA, Willekens C, Choe S, Wang H, Zhang V, Yen KE, Kapsalis SM, Yang H, Dai D, Fan B, Goldwasser M, Liu H, Agresta S, Wu B, Attar EC, Tallman MS, Stone RM, Kantarjian HM
N Engl J Med 2018 Jun 21;378(25):2386-2398. Epub 2018 Jun 2 doi: 10.1056/NEJMoa1716984. PMID: 29860938
Fathi AT, DiNardo CD, Kline I, Kenvin L, Gupta I, Attar EC, Stein EM, de Botton S; AG221-C-001 Study Investigators
JAMA Oncol 2018 Aug 1;4(8):1106-1110. doi: 10.1001/jamaoncol.2017.4695. PMID: 29346478Free PMC Article
Medeiros BC, Fathi AT, DiNardo CD, Pollyea DA, Chan SM, Swords R
Leukemia 2017 Feb;31(2):272-281. Epub 2016 Oct 10 doi: 10.1038/leu.2016.275. PMID: 27721426Free PMC Article

Clinical prediction guides

Parisi R, Cowen EA, Stoll JR, Zhu H, Dusza S, Pulitzer MP, Stein EM, Markova A
Leuk Res 2022 Dec;123:106970. Epub 2022 Oct 22 doi: 10.1016/j.leukres.2022.106970. PMID: 36308802Free PMC Article
Förster A, Brand F, Banan R, Hüneburg R, Weber CAM, Ewert W, Kronenberg J, Previti C, Elyan N, Beyer U, Martens H, Hong B, Bräsen JH, Erbersdobler A, Krauss JK, Stangel M, Samii A, Wolf S, Preller M, Aretz S, Wiese B, Hartmann C, Weber RG
Acta Neuropathol 2021 Jul;142(1):191-210. Epub 2021 Apr 30 doi: 10.1007/s00401-021-02307-1. PMID: 33929593Free PMC Article
DiNardo CD, Stein EM, de Botton S, Roboz GJ, Altman JK, Mims AS, Swords R, Collins RH, Mannis GN, Pollyea DA, Donnellan W, Fathi AT, Pigneux A, Erba HP, Prince GT, Stein AS, Uy GL, Foran JM, Traer E, Stuart RK, Arellano ML, Slack JL, Sekeres MA, Willekens C, Choe S, Wang H, Zhang V, Yen KE, Kapsalis SM, Yang H, Dai D, Fan B, Goldwasser M, Liu H, Agresta S, Wu B, Attar EC, Tallman MS, Stone RM, Kantarjian HM
N Engl J Med 2018 Jun 21;378(25):2386-2398. Epub 2018 Jun 2 doi: 10.1056/NEJMoa1716984. PMID: 29860938

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