U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Very High Risk Myelodysplastic Syndrome

MedGen UID:
1720312
Concept ID:
C5237066
Neoplastic Process

Definition

Myelodysplastic syndrome with more than 6 points, according to the revised International Prognostic Scoring System (IPSS-R). [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Bazinet A, Bravo GM
Curr Treat Options Oncol 2022 May;23(5):668-687. Epub 2022 Mar 23 doi: 10.1007/s11864-022-00965-1. PMID: 35320468
Patnaik MM, Tefferi A
Am J Hematol 2022 Mar 1;97(3):352-372. Epub 2022 Jan 27 doi: 10.1002/ajh.26455. PMID: 34985762
Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Lass-Flörl C, Lewis RE, Munoz P, Verweij PE, Warris A, Ader F, Akova M, Arendrup MC, Barnes RA, Beigelman-Aubry C, Blot S, Bouza E, Brüggemann RJM, Buchheidt D, Cadranel J, Castagnola E, Chakrabarti A, Cuenca-Estrella M, Dimopoulos G, Fortun J, Gangneux JP, Garbino J, Heinz WJ, Herbrecht R, Heussel CP, Kibbler CC, Klimko N, Kullberg BJ, Lange C, Lehrnbecher T, Löffler J, Lortholary O, Maertens J, Marchetti O, Meis JF, Pagano L, Ribaud P, Richardson M, Roilides E, Ruhnke M, Sanguinetti M, Sheppard DC, Sinkó J, Skiada A, Vehreschild MJGT, Viscoli C, Cornely OA
Clin Microbiol Infect 2018 May;24 Suppl 1:e1-e38. Epub 2018 Mar 12 doi: 10.1016/j.cmi.2018.01.002. PMID: 29544767

Recent clinical studies

Etiology

Versluis J, Saber W, Tsai HK, Gibson CJ, Dillon LW, Mishra A, McGuirk J, Maziarz RT, Westervelt P, Hegde P, Mukherjee D, Martens MJ, Logan B, Horowitz M, Hourigan CS, Nakamura R, Cutler C, Lindsley RC; Blood and Marrow Transplant Clinical Trials Network
J Clin Oncol 2023 Oct 1;41(28):4497-4510. Epub 2023 Aug 22 doi: 10.1200/JCO.23.00866. PMID: 37607457Free PMC Article
DeFilipp Z, Ciurea SO, Cutler C, Robin M, Warlick ED, Nakamura R, Brunner AM, Dholaria B, Walker AR, Kröger N, Bejanyan N, Atallah E, Tamari R, Solh MM, Percival ME, de Lima M, Scott B, Oran B, Garcia-Manero G, Hamadani M, Carpenter P, DeZern AE
Transplant Cell Ther 2023 Feb;29(2):71-81. Epub 2022 Nov 25 doi: 10.1016/j.jtct.2022.11.014. PMID: 36436780
Bazinet A, Bravo GM
Curr Treat Options Oncol 2022 May;23(5):668-687. Epub 2022 Mar 23 doi: 10.1007/s11864-022-00965-1. PMID: 35320468
Hofmann WK, Koeffler HP
Annu Rev Med 2005;56:1-16. doi: 10.1146/annurev.med.56.082103.104704. PMID: 15660498
Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz G, Sanz M, Vallespi T, Hamblin T, Oscier D, Ohyashiki K, Toyama K, Aul C, Mufti G, Bennett J
Blood 1997 Mar 15;89(6):2079-88. PMID: 9058730

Diagnosis

Nachtkamp K, Kobbe G, Gattermann N, Germing U
Dtsch Arztebl Int 2023 Mar 24;120(12):203-210. doi: 10.3238/arztebl.m2023.0005. PMID: 36718105Free PMC Article
Bazinet A, Bravo GM
Curr Treat Options Oncol 2022 May;23(5):668-687. Epub 2022 Mar 23 doi: 10.1007/s11864-022-00965-1. PMID: 35320468
Greenberg PL, Stone RM, Al-Kali A, Bennett JM, Borate U, Brunner AM, Chai-Ho W, Curtin P, de Castro CM, Deeg HJ, DeZern AE, Dinner S, Foucar C, Gaensler K, Garcia-Manero G, Griffiths EA, Head D, Jonas BA, Keel S, Madanat Y, Maness LJ, Mangan J, McCurdy S, McMahon C, Patel B, Reddy VV, Sallman DA, Shallis R, Shami PJ, Thota S, Varshavsky-Yanovsky AN, Westervelt P, Hollinger E, Shead DA, Hochstetler C
J Natl Compr Canc Netw 2022 Feb;20(2):106-117. doi: 10.6004/jnccn.2022.0009. PMID: 35130502
Grob T, Al Hinai ASA, Sanders MA, Kavelaars FG, Rijken M, Gradowska PL, Biemond BJ, Breems DA, Maertens J, van Marwijk Kooy M, Pabst T, de Weerdt O, Ossenkoppele GJ, van de Loosdrecht AA, Huls GA, Cornelissen JJ, Beverloo HB, Löwenberg B, Jongen-Lavrencic M, Valk PJM
Blood 2022 Apr 14;139(15):2347-2354. doi: 10.1182/blood.2021014472. PMID: 35108372Free PMC Article
Kadia TM, Reville PK, Borthakur G, Yilmaz M, Kornblau S, Alvarado Y, Dinardo CD, Daver N, Jain N, Pemmaraju N, Short N, Wang SA, Tidwell RSS, Islam R, Konopleva M, Garcia-Manero G, Ravandi F, Kantarjian HM
Lancet Haematol 2021 Aug;8(8):e552-e561. doi: 10.1016/S2352-3026(21)00192-7. PMID: 34329576Free PMC Article

Therapy

Bazinet A, Bravo GM
Curr Treat Options Oncol 2022 May;23(5):668-687. Epub 2022 Mar 23 doi: 10.1007/s11864-022-00965-1. PMID: 35320468
Kadia TM, Reville PK, Borthakur G, Yilmaz M, Kornblau S, Alvarado Y, Dinardo CD, Daver N, Jain N, Pemmaraju N, Short N, Wang SA, Tidwell RSS, Islam R, Konopleva M, Garcia-Manero G, Ravandi F, Kantarjian HM
Lancet Haematol 2021 Aug;8(8):e552-e561. doi: 10.1016/S2352-3026(21)00192-7. PMID: 34329576Free PMC Article
Sun L, Babushok DV
Blood 2020 Jul 2;136(1):36-49. doi: 10.1182/blood.2019000940. PMID: 32430502Free PMC Article
Mellinghoff SC, Panse J, Alakel N, Behre G, Buchheidt D, Christopeit M, Hasenkamp J, Kiehl M, Koldehoff M, Krause SW, Lehners N, von Lilienfeld-Toal M, Löhnert AY, Maschmeyer G, Teschner D, Ullmann AJ, Penack O, Ruhnke M, Mayer K, Ostermann H, Wolf HH, Cornely OA
Ann Hematol 2018 Feb;97(2):197-207. Epub 2017 Dec 7 doi: 10.1007/s00277-017-3196-2. PMID: 29218389Free PMC Article
Cornely OA, Maertens J, Winston DJ, Perfect J, Ullmann AJ, Walsh TJ, Helfgott D, Holowiecki J, Stockelberg D, Goh YT, Petrini M, Hardalo C, Suresh R, Angulo-Gonzalez D
N Engl J Med 2007 Jan 25;356(4):348-59. doi: 10.1056/NEJMoa061094. PMID: 17251531

Prognosis

Versluis J, Saber W, Tsai HK, Gibson CJ, Dillon LW, Mishra A, McGuirk J, Maziarz RT, Westervelt P, Hegde P, Mukherjee D, Martens MJ, Logan B, Horowitz M, Hourigan CS, Nakamura R, Cutler C, Lindsley RC; Blood and Marrow Transplant Clinical Trials Network
J Clin Oncol 2023 Oct 1;41(28):4497-4510. Epub 2023 Aug 22 doi: 10.1200/JCO.23.00866. PMID: 37607457Free PMC Article
Bazinet A, Bravo GM
Curr Treat Options Oncol 2022 May;23(5):668-687. Epub 2022 Mar 23 doi: 10.1007/s11864-022-00965-1. PMID: 35320468
Kadia TM, Reville PK, Borthakur G, Yilmaz M, Kornblau S, Alvarado Y, Dinardo CD, Daver N, Jain N, Pemmaraju N, Short N, Wang SA, Tidwell RSS, Islam R, Konopleva M, Garcia-Manero G, Ravandi F, Kantarjian HM
Lancet Haematol 2021 Aug;8(8):e552-e561. doi: 10.1016/S2352-3026(21)00192-7. PMID: 34329576Free PMC Article
Hofmann WK, Koeffler HP
Annu Rev Med 2005;56:1-16. doi: 10.1146/annurev.med.56.082103.104704. PMID: 15660498
Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz G, Sanz M, Vallespi T, Hamblin T, Oscier D, Ohyashiki K, Toyama K, Aul C, Mufti G, Bennett J
Blood 1997 Mar 15;89(6):2079-88. PMID: 9058730

Clinical prediction guides

Versluis J, Saber W, Tsai HK, Gibson CJ, Dillon LW, Mishra A, McGuirk J, Maziarz RT, Westervelt P, Hegde P, Mukherjee D, Martens MJ, Logan B, Horowitz M, Hourigan CS, Nakamura R, Cutler C, Lindsley RC; Blood and Marrow Transplant Clinical Trials Network
J Clin Oncol 2023 Oct 1;41(28):4497-4510. Epub 2023 Aug 22 doi: 10.1200/JCO.23.00866. PMID: 37607457Free PMC Article
Sauta E, Robin M, Bersanelli M, Travaglino E, Meggendorfer M, Zhao LP, Caballero Berrocal JC, Sala C, Maggioni G, Bernardi M, Di Grazia C, Vago L, Rivoli G, Borin L, D'Amico S, Tentori CA, Ubezio M, Campagna A, Russo A, Mannina D, Lanino L, Chiusolo P, Giaccone L, Voso MT, Riva M, Oliva EN, Zampini M, Riva E, Nibourel O, Bicchieri M, Bolli N, Rambaldi A, Passamonti F, Savevski V, Santoro A, Germing U, Kordasti S, Santini V, Diez-Campelo M, Sanz G, Sole F, Kern W, Platzbecker U, Ades L, Fenaux P, Haferlach T, Castellani G, Della Porta MG
J Clin Oncol 2023 May 20;41(15):2827-2842. Epub 2023 Mar 17 doi: 10.1200/JCO.22.01784. PMID: 36930857Free PMC Article
Bazinet A, Bravo GM
Curr Treat Options Oncol 2022 May;23(5):668-687. Epub 2022 Mar 23 doi: 10.1007/s11864-022-00965-1. PMID: 35320468
Grob T, Al Hinai ASA, Sanders MA, Kavelaars FG, Rijken M, Gradowska PL, Biemond BJ, Breems DA, Maertens J, van Marwijk Kooy M, Pabst T, de Weerdt O, Ossenkoppele GJ, van de Loosdrecht AA, Huls GA, Cornelissen JJ, Beverloo HB, Löwenberg B, Jongen-Lavrencic M, Valk PJM
Blood 2022 Apr 14;139(15):2347-2354. doi: 10.1182/blood.2021014472. PMID: 35108372Free PMC Article
Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz G, Sanz M, Vallespi T, Hamblin T, Oscier D, Ohyashiki K, Toyama K, Aul C, Mufti G, Bennett J
Blood 1997 Mar 15;89(6):2079-88. PMID: 9058730

Recent systematic reviews

Saleem K, Franz J, Klem ML, Yabes JG, Boyiadzis M, Jones JR, Shaikh N, Lontos K
Lancet Haematol 2022 Dec;9(12):e906-e918. Epub 2022 Oct 27 doi: 10.1016/S2352-3026(22)00289-7. PMID: 36354020
Lyman GH, Yau L, Nakov R, Krendyukov A
Ann Oncol 2018 Sep 1;29(9):1903-1910. doi: 10.1093/annonc/mdy311. PMID: 30099478
Smith TJ, Bohlke K, Lyman GH, Carson KR, Crawford J, Cross SJ, Goldberg JM, Khatcheressian JL, Leighl NB, Perkins CL, Somlo G, Wade JL, Wozniak AJ, Armitage JO; American Society of Clinical Oncology
J Clin Oncol 2015 Oct 1;33(28):3199-212. Epub 2015 Jul 13 doi: 10.1200/JCO.2015.62.3488. PMID: 26169616
Vaxman I, Ram R, Gafter-Gvili A, Vidal L, Yeshurun M, Lahav M, Shpilberg O
Bone Marrow Transplant 2015 May;50(5):706-14. Epub 2015 Feb 9 doi: 10.1038/bmt.2014.325. PMID: 25665042
Nardone B, Wu S, Garden BC, West DP, Reich LM, Lacouture ME
Clin Lymphoma Myeloma Leuk 2013 Aug;13(4):424-9. Epub 2013 Jun 13 doi: 10.1016/j.clml.2013.03.006. PMID: 23769670

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...