U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Very High Risk Myelodysplastic Syndrome

MedGen UID:
1720312
Concept ID:
C5237066
Neoplastic Process

Definition

Myelodysplastic syndrome with more than 6 points, according to the revised International Prognostic Scoring System (IPSS-R). [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Bazinet A, Bravo GM
Curr Treat Options Oncol 2022 May;23(5):668-687. Epub 2022 Mar 23 doi: 10.1007/s11864-022-00965-1. PMID: 35320468
Patnaik MM, Tefferi A
Am J Hematol 2022 Mar 1;97(3):352-372. Epub 2022 Jan 27 doi: 10.1002/ajh.26455. PMID: 34985762
Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Lass-Flörl C, Lewis RE, Munoz P, Verweij PE, Warris A, Ader F, Akova M, Arendrup MC, Barnes RA, Beigelman-Aubry C, Blot S, Bouza E, Brüggemann RJM, Buchheidt D, Cadranel J, Castagnola E, Chakrabarti A, Cuenca-Estrella M, Dimopoulos G, Fortun J, Gangneux JP, Garbino J, Heinz WJ, Herbrecht R, Heussel CP, Kibbler CC, Klimko N, Kullberg BJ, Lange C, Lehrnbecher T, Löffler J, Lortholary O, Maertens J, Marchetti O, Meis JF, Pagano L, Ribaud P, Richardson M, Roilides E, Ruhnke M, Sanguinetti M, Sheppard DC, Sinkó J, Skiada A, Vehreschild MJGT, Viscoli C, Cornely OA
Clin Microbiol Infect 2018 May;24 Suppl 1:e1-e38. Epub 2018 Mar 12 doi: 10.1016/j.cmi.2018.01.002. PMID: 29544767

Recent clinical studies

Etiology

DeFilipp Z, Ciurea SO, Cutler C, Robin M, Warlick ED, Nakamura R, Brunner AM, Dholaria B, Walker AR, Kröger N, Bejanyan N, Atallah E, Tamari R, Solh MM, Percival ME, de Lima M, Scott B, Oran B, Garcia-Manero G, Hamadani M, Carpenter P, DeZern AE
Transplant Cell Ther 2023 Feb;29(2):71-81. Epub 2022 Nov 25 doi: 10.1016/j.jtct.2022.11.014. PMID: 36436780
Bazinet A, Bravo GM
Curr Treat Options Oncol 2022 May;23(5):668-687. Epub 2022 Mar 23 doi: 10.1007/s11864-022-00965-1. PMID: 35320468
Malcovati L, Hellström-Lindberg E, Bowen D, Adès L, Cermak J, Del Cañizo C, Della Porta MG, Fenaux P, Gattermann N, Germing U, Jansen JH, Mittelman M, Mufti G, Platzbecker U, Sanz GF, Selleslag D, Skov-Holm M, Stauder R, Symeonidis A, van de Loosdrecht AA, de Witte T, Cazzola M; European Leukemia Net
Blood 2013 Oct 24;122(17):2943-64. Epub 2013 Aug 26 doi: 10.1182/blood-2013-03-492884. PMID: 23980065Free PMC Article
Hofmann WK, Koeffler HP
Annu Rev Med 2005;56:1-16. doi: 10.1146/annurev.med.56.082103.104704. PMID: 15660498
Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz G, Sanz M, Vallespi T, Hamblin T, Oscier D, Ohyashiki K, Toyama K, Aul C, Mufti G, Bennett J
Blood 1997 Mar 15;89(6):2079-88. PMID: 9058730

Diagnosis

Bazinet A, Bravo GM
Curr Treat Options Oncol 2022 May;23(5):668-687. Epub 2022 Mar 23 doi: 10.1007/s11864-022-00965-1. PMID: 35320468
Greenberg PL, Stone RM, Al-Kali A, Bennett JM, Borate U, Brunner AM, Chai-Ho W, Curtin P, de Castro CM, Deeg HJ, DeZern AE, Dinner S, Foucar C, Gaensler K, Garcia-Manero G, Griffiths EA, Head D, Jonas BA, Keel S, Madanat Y, Maness LJ, Mangan J, McCurdy S, McMahon C, Patel B, Reddy VV, Sallman DA, Shallis R, Shami PJ, Thota S, Varshavsky-Yanovsky AN, Westervelt P, Hollinger E, Shead DA, Hochstetler C
J Natl Compr Canc Netw 2022 Feb;20(2):106-117. doi: 10.6004/jnccn.2022.0009. PMID: 35130502
Grob T, Al Hinai ASA, Sanders MA, Kavelaars FG, Rijken M, Gradowska PL, Biemond BJ, Breems DA, Maertens J, van Marwijk Kooy M, Pabst T, de Weerdt O, Ossenkoppele GJ, van de Loosdrecht AA, Huls GA, Cornelissen JJ, Beverloo HB, Löwenberg B, Jongen-Lavrencic M, Valk PJM
Blood 2022 Apr 14;139(15):2347-2354. doi: 10.1182/blood.2021014472. PMID: 35108372
Kadia TM, Reville PK, Borthakur G, Yilmaz M, Kornblau S, Alvarado Y, Dinardo CD, Daver N, Jain N, Pemmaraju N, Short N, Wang SA, Tidwell RSS, Islam R, Konopleva M, Garcia-Manero G, Ravandi F, Kantarjian HM
Lancet Haematol 2021 Aug;8(8):e552-e561. doi: 10.1016/S2352-3026(21)00192-7. PMID: 34329576Free PMC Article
Keng MK, Sekeres MA
Curr Hematol Malig Rep 2013 Dec;8(4):370-8. doi: 10.1007/s11899-013-0171-4. PMID: 23990311

Therapy

Watts JM, Baer MR, Yang J, Prebet T, Lee S, Schiller GJ, Dinner SN, Pigneux A, Montesinos P, Wang ES, Seiter KP, Wei AH, De Botton S, Arnan M, Donnellan W, Schwarer AP, Récher C, Jonas BA, Ferrell PB Jr, Marzac C, Kelly P, Sweeney J, Forsyth S, Guichard SM, Brevard J, Henrick P, Mohamed H, Cortes JE
Lancet Haematol 2023 Jan;10(1):e46-e58. Epub 2022 Nov 10 doi: 10.1016/S2352-3026(22)00292-7. PMID: 36370742
Bazinet A, Bravo GM
Curr Treat Options Oncol 2022 May;23(5):668-687. Epub 2022 Mar 23 doi: 10.1007/s11864-022-00965-1. PMID: 35320468
Kadia TM, Reville PK, Borthakur G, Yilmaz M, Kornblau S, Alvarado Y, Dinardo CD, Daver N, Jain N, Pemmaraju N, Short N, Wang SA, Tidwell RSS, Islam R, Konopleva M, Garcia-Manero G, Ravandi F, Kantarjian HM
Lancet Haematol 2021 Aug;8(8):e552-e561. doi: 10.1016/S2352-3026(21)00192-7. PMID: 34329576Free PMC Article
Sun L, Babushok DV
Blood 2020 Jul 2;136(1):36-49. doi: 10.1182/blood.2019000940. PMID: 32430502Free PMC Article
de Witte T, Bowen D, Robin M, Malcovati L, Niederwieser D, Yakoub-Agha I, Mufti GJ, Fenaux P, Sanz G, Martino R, Alessandrino EP, Onida F, Symeonidis A, Passweg J, Kobbe G, Ganser A, Platzbecker U, Finke J, van Gelder M, van de Loosdrecht AA, Ljungman P, Stauder R, Volin L, Deeg HJ, Cutler C, Saber W, Champlin R, Giralt S, Anasetti C, Kröger N
Blood 2017 Mar 30;129(13):1753-1762. Epub 2017 Jan 17 doi: 10.1182/blood-2016-06-724500. PMID: 28096091Free PMC Article

Prognosis

Bazinet A, Bravo GM
Curr Treat Options Oncol 2022 May;23(5):668-687. Epub 2022 Mar 23 doi: 10.1007/s11864-022-00965-1. PMID: 35320468
Volpe VO, Garcia-Manero G, Komrokji RS
Clin Lymphoma Myeloma Leuk 2022 Jan;22(1):1-16. Epub 2021 Aug 2 doi: 10.1016/j.clml.2021.07.031. PMID: 34544674
Kadia TM, Reville PK, Borthakur G, Yilmaz M, Kornblau S, Alvarado Y, Dinardo CD, Daver N, Jain N, Pemmaraju N, Short N, Wang SA, Tidwell RSS, Islam R, Konopleva M, Garcia-Manero G, Ravandi F, Kantarjian HM
Lancet Haematol 2021 Aug;8(8):e552-e561. doi: 10.1016/S2352-3026(21)00192-7. PMID: 34329576Free PMC Article
Cortes JE, Heidel FH, Hellmann A, Fiedler W, Smith BD, Robak T, Montesinos P, Pollyea DA, DesJardins P, Ottmann O, Ma WW, Shaik MN, Laird AD, Zeremski M, O'Connell A, Chan G, Heuser M
Leukemia 2019 Feb;33(2):379-389. Epub 2018 Dec 16 doi: 10.1038/s41375-018-0312-9. PMID: 30555165Free PMC Article
Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz G, Sanz M, Vallespi T, Hamblin T, Oscier D, Ohyashiki K, Toyama K, Aul C, Mufti G, Bennett J
Blood 1997 Mar 15;89(6):2079-88. PMID: 9058730

Clinical prediction guides

Sauta E, Robin M, Bersanelli M, Travaglino E, Meggendorfer M, Zhao LP, Caballero Berrocal JC, Sala C, Maggioni G, Bernardi M, Di Grazia C, Vago L, Rivoli G, Borin L, D'Amico S, Tentori CA, Ubezio M, Campagna A, Russo A, Mannina D, Lanino L, Chiusolo P, Giaccone L, Voso MT, Riva M, Oliva EN, Zampini M, Riva E, Nibourel O, Bicchieri M, Bolli N, Rambaldi A, Passamonti F, Savevski V, Santoro A, Germing U, Kordasti S, Santini V, Diez-Campelo M, Sanz G, Sole F, Kern W, Platzbecker U, Ades L, Fenaux P, Haferlach T, Castellani G, Della Porta MG
J Clin Oncol 2023 May 20;41(15):2827-2842. Epub 2023 Mar 17 doi: 10.1200/JCO.22.01784. PMID: 36930857Free PMC Article
Nachtkamp K, Kobbe G, Gattermann N, Germing U
Dtsch Arztebl Int 2023 Mar 24;120(12):203-210. doi: 10.3238/arztebl.m2023.0005. PMID: 36718105Free PMC Article
Bazinet A, Bravo GM
Curr Treat Options Oncol 2022 May;23(5):668-687. Epub 2022 Mar 23 doi: 10.1007/s11864-022-00965-1. PMID: 35320468
Kadia TM, Reville PK, Borthakur G, Yilmaz M, Kornblau S, Alvarado Y, Dinardo CD, Daver N, Jain N, Pemmaraju N, Short N, Wang SA, Tidwell RSS, Islam R, Konopleva M, Garcia-Manero G, Ravandi F, Kantarjian HM
Lancet Haematol 2021 Aug;8(8):e552-e561. doi: 10.1016/S2352-3026(21)00192-7. PMID: 34329576Free PMC Article
Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz G, Sanz M, Vallespi T, Hamblin T, Oscier D, Ohyashiki K, Toyama K, Aul C, Mufti G, Bennett J
Blood 1997 Mar 15;89(6):2079-88. PMID: 9058730

Recent systematic reviews

Gao C, Wang J, Li Y, Zhao H, Li R, Hou L, Zhang Y, Tian S, Liang H, Wang C, Chen X, Wang J
Medicine (Baltimore) 2018 Aug;97(34):e11860. doi: 10.1097/MD.0000000000011860. PMID: 30142779Free PMC Article
Dodillet H, Kreuzer KA, Monsef I, Skoetz N
Cochrane Database Syst Rev 2017 Sep 30;9(9):CD009883. doi: 10.1002/14651858.CD009883.pub2. PMID: 28962071Free PMC Article
Smith TJ, Bohlke K, Lyman GH, Carson KR, Crawford J, Cross SJ, Goldberg JM, Khatcheressian JL, Leighl NB, Perkins CL, Somlo G, Wade JL, Wozniak AJ, Armitage JO; American Society of Clinical Oncology
J Clin Oncol 2015 Oct 1;33(28):3199-212. Epub 2015 Jul 13 doi: 10.1200/JCO.2015.62.3488. PMID: 26169616
Vaxman I, Ram R, Gafter-Gvili A, Vidal L, Yeshurun M, Lahav M, Shpilberg O
Bone Marrow Transplant 2015 May;50(5):706-14. Epub 2015 Feb 9 doi: 10.1038/bmt.2014.325. PMID: 25665042
Esatoglu SN, Hatemi G, Salihoglu A, Hatemi I, Soysal T, Celik AF
Clin Exp Rheumatol 2015 Nov-Dec;33(6 Suppl 94):S145-51. Epub 2015 Feb 9 PMID: 25664843

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...