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Pancolitis

MedGen UID:
1720692
Concept ID:
C0868908
Disease or Syndrome
Synonyms: pan-ulcerative colitis; pancolitis; universal colitis
 
HPO: HP:0033256
Monarch Initiative: MONDO:0005536

Definition

Inflammation of the entire colon. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancolitis

Conditions with this feature

Inflammatory bowel disease 25
MedGen UID:
393403
Concept ID:
C2675508
Disease or Syndrome
Any inflammatory bowel disease in which the cause of the disease is a mutation in the IL10RB gene.
Inflammatory bowel disease, immunodeficiency, and encephalopathy
MedGen UID:
1648434
Concept ID:
C4748708
Disease or Syndrome
A rare genetic disease characterized by infantile onset of severe inflammatory bowel disease manifesting with bloody diarrhea and failure to thrive, and central nervous system disease with global developmental delay and regression, impaired speech, hypotonia, hyperreflexia, and epilepsy. Brain imaging shows global cerebral atrophy, thin corpus callosum, delayed myelination, and posterior leukoencephalopathy. Cases with recurrent infections and impaired T-cell responses to stimulation, as well as decreased T-cell subsets, have been reported.
Inflammatory bowel disease 30
MedGen UID:
1737985
Concept ID:
C5436750
Disease or Syndrome
Inflammatory bowel disease-30 (IBD30) is characterized by abdominal pain and watery or bloody diarrhea, with changes in the intestinal tract consistent with Crohn disease (Mao et al., 2018). For a general description and a discussion of genetic heterogeneity of inflammatory bowel disease, including Crohn disease (CD) and ulcerative colitis (UC), see IBD1 (266600).
Dyskeratosis congenita, autosomal recessive 8
MedGen UID:
1824030
Concept ID:
C5774257
Disease or Syndrome
Autosomal recessive dyskeratosis congenita-8 (DKCB8) is characterized by progressive bone marrow failure affecting all lineages apparent from infancy or early childhood. More variable features may include poor growth, mild developmental delay, immunodeficiency, and gastrointestinal manifestations, such as esophageal stricture or inflammatory bowel disease. Some patients may have mucocutaneous features, including oral leukoplakia, nail dystrophy, or pigmentary skin abnormalities, although these features may be absent. Unlike patients with other forms of DKC, those with DKCB8 do not have shortened telomeres, although there is evidence of telomere instability. Hematopoietic stem cell transplant may be curative (Kermasson et al., 2022). For a discussion of genetic heterogeneity of dyskeratosis congenita, see DKCA1 (127550).

Professional guidelines

PubMed

Nahar KJ, Rawson RV, Ahmed T, Tattersall S, Sandanayake N, Kiely CJ, Lo S, Carlino M, Palendira U, Scolyer RA, Long GV, Menzies AM
J Immunother Cancer 2020 Nov;8(2) doi: 10.1136/jitc-2020-001488. PMID: 33234603Free PMC Article
Shah A, Macdonald GA, Morrison M, Holtmann G
Am J Gastroenterol 2020 Jun;115(6):814-822. doi: 10.14309/ajg.0000000000000604. PMID: 32250997Free PMC Article
Langan RC, Gotsch PB, Krafczyk MA, Skillinge DD
Am Fam Physician 2007 Nov 1;76(9):1323-30. PMID: 18019875

Recent clinical studies

Therapy

Kedia S, Virmani S, Bajaj A, Markandey M, Singh N, Madan D, Kaushal K, Sahu P, Vuyyuru SK, Kante B, Kumar P, Thomas DM, Mundhra SK, Singh MK, Verma M, Sharma R, Das P, Dash NR, Monga N, Awasthi A, Makharia G, Ahuja V
Clin Gastroenterol Hepatol 2024 Jun;22(6):1295-1306.e7. Epub 2024 Jan 24 doi: 10.1016/j.cgh.2024.01.013. PMID: 38278200
Ali NM, Shehab MA
Am J Case Rep 2023 Nov 6;24:e940966. doi: 10.12659/AJCR.940966. PMID: 37926993Free PMC Article
Kedia S, Virmani S, K Vuyyuru S, Kumar P, Kante B, Sahu P, Kaushal K, Farooqui M, Singh M, Verma M, Bajaj A, Markandey M, Sachdeva K, Das P, Makharia GK, Ahuja V
Gut 2022 Dec;71(12):2401-2413. Epub 2022 Aug 16 doi: 10.1136/gutjnl-2022-327811. PMID: 35973787
Hiraoka S, Fujiwara A, Toyokawa T, Higashi R, Moritou Y, Takagi S, Matsueda K, Suzuki S, Miyaike J, Inokuchi T, Takahara M, Kato J, Okada H
J Gastroenterol Hepatol 2021 Jan;36(1):137-143. Epub 2020 Jun 27 doi: 10.1111/jgh.15138. PMID: 32525567
Wollina U, Haroske G
Curr Opin Rheumatol 2011 Jan;23(1):50-6. doi: 10.1097/BOR.0b013e328341152f. PMID: 21037478

Prognosis

Grassi E, Zingaretti C, Petracci E, Corbelli J, Papiani G, Banchelli I, Valli I, Frassineti GL, Passardi A, Di Bartolomeo M, Pietrantonio F, Gelsomino F, Carandina I, Banzi M, Martella L, Bonetti AV, Boccaccino A, Molinari C, Marisi G, Ugolini G, Nanni O, Tamberi S
ESMO Open 2023 Oct;8(5):101824. Epub 2023 Sep 27 doi: 10.1016/j.esmoop.2023.101824. PMID: 37774508Free PMC Article
Gaweł K, Dąbkowski K, Zawada I, Starzyńska T
Scand J Gastroenterol 2022 Dec;57(12):1406-1411. Epub 2022 Jul 6 doi: 10.1080/00365521.2022.2094726. PMID: 35793351
Hiraoka S, Fujiwara A, Toyokawa T, Higashi R, Moritou Y, Takagi S, Matsueda K, Suzuki S, Miyaike J, Inokuchi T, Takahara M, Kato J, Okada H
J Gastroenterol Hepatol 2021 Jan;36(1):137-143. Epub 2020 Jun 27 doi: 10.1111/jgh.15138. PMID: 32525567
Goenka MK, Nag S, Kumar A, Pai CG
Trop Gastroenterol 2014 Aug;35 Suppl 1:S1-8. doi: 10.7869/tg.175. PMID: 25735119
Cuffari C, Present DH, Bayless TM, Lichtenstein GR
Inflamm Bowel Dis 2005 Oct;11(10):937-46. doi: 10.1097/01.mib.0000179469.86500.ac. PMID: 16189424

Clinical prediction guides

Grassi E, Zingaretti C, Petracci E, Corbelli J, Papiani G, Banchelli I, Valli I, Frassineti GL, Passardi A, Di Bartolomeo M, Pietrantonio F, Gelsomino F, Carandina I, Banzi M, Martella L, Bonetti AV, Boccaccino A, Molinari C, Marisi G, Ugolini G, Nanni O, Tamberi S
ESMO Open 2023 Oct;8(5):101824. Epub 2023 Sep 27 doi: 10.1016/j.esmoop.2023.101824. PMID: 37774508Free PMC Article
Ricciuto A, Kamath BM, Griffiths AM
Curr Gastroenterol Rep 2018 Mar 28;20(4):16. doi: 10.1007/s11894-018-0620-2. PMID: 29594739
de Vries AB, Janse M, Blokzijl H, Weersma RK
World J Gastroenterol 2015 Feb 14;21(6):1956-71. doi: 10.3748/wjg.v21.i6.1956. PMID: 25684965Free PMC Article
Goenka MK, Nag S, Kumar A, Pai CG
Trop Gastroenterol 2014 Aug;35 Suppl 1:S1-8. doi: 10.7869/tg.175. PMID: 25735119
Wollina U, Haroske G
Curr Opin Rheumatol 2011 Jan;23(1):50-6. doi: 10.1097/BOR.0b013e328341152f. PMID: 21037478

Recent systematic reviews

Sanat ZM, Vahedi H, Malekzadeh R, Fanni Z
BMC Public Health 2024 May 24;24(1):1395. doi: 10.1186/s12889-024-18816-z. PMID: 38789987Free PMC Article
Papadopoulos VP, Antoniadou C, Ritis K, Skendros P
J Gastrointestin Liver Dis 2022 Mar 19;31(1):85-97. doi: 10.15403/jgld-4070. PMID: 35306551
Attauabi M, Zhao M, Bendtsen F, Burisch J
Inflamm Bowel Dis 2021 May 17;27(6):927-939. doi: 10.1093/ibd/izaa167. PMID: 32628745
Pezold M, Pergamo M, Rockman C, Lugo J
Ann Vasc Surg 2020 Aug;67:532-541.e3. Epub 2020 Mar 24 doi: 10.1016/j.avsg.2020.02.025. PMID: 32220617
Selvaratnam S, Gullino S, Shim L, Lee E, Lee A, Paramsothy S, Leong RW
World J Gastroenterol 2019 Dec 21;25(47):6866-6875. doi: 10.3748/wjg.v25.i47.6866. PMID: 31885427Free PMC Article

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