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Weak grip

MedGen UID:
1720697
Concept ID:
C2126089
Sign or Symptom
HPO: HP:0033466

Definition

Reduced grip strength. Gripping is the motion by which the hand tightly grasps an object or other hand. [from HPO]

Conditions with this feature

Charcot-Marie-Tooth disease, axonal, type 2FF
MedGen UID:
1794191
Concept ID:
C5561981
Disease or Syndrome
Charcot-Marie-Tooth disease type 2FF (CMT2FF) is an autosomal dominant progressive axonal sensorimotor peripheral neuropathy characterized by early-childhood onset of difficulties walking or running due to atrophy and weakness of the lower limbs. Most patients have foot and ankle deformities, requiring surgery or walking aids. Some patients lose independent ambulation. There is also prominent involvement of the upper limbs, with weakness and atrophy of the forearm, wrist, and intrinsic hand muscles. Proximal muscle function is preserved. Affected individuals have variable distal sensory impairment. Most patients have hyporeflexia, although brisk reflexes, suggesting upper motor involvement, have been described in 1 family. Sural nerve biopsy showed abnormal myelination (Rebelo et al., 2021). For a phenotypic description and a discussion of genetic heterogeneity of axonal CMT type 2, see CMT2A (118210).

Professional guidelines

PubMed

Brown PJ, Ciarleglio A, Roose SP, Garcia CM, Chung S, Alvarez J, Stein A, Gomez S, Rutherford BR
Am J Geriatr Psychiatry 2021 Sep;29(9):944-955. Epub 2020 Dec 25 doi: 10.1016/j.jagp.2020.12.024. PMID: 33388223Free PMC Article
Abdul Aziz SA, Mcstea M, Ahmad Bashah NS, Chong ML, Ponnampalavanar S, Syed Omar SF, Sulaiman H, Azwa I, Tan MP, Kamarulzaman A, Rajasuriar R, Kamaruzzaman SB
AIDS 2018 May 15;32(8):1025-1034. doi: 10.1097/QAD.0000000000001798. PMID: 29547442
Kittiskulnam P, Chertow GM, Carrero JJ, Delgado C, Kaysen GA, Johansen KL
Kidney Int 2017 Jul;92(1):238-247. Epub 2017 Mar 17 doi: 10.1016/j.kint.2017.01.024. PMID: 28318630Free PMC Article

Recent clinical studies

Etiology

Liu H, Hou Y, Li H, Lin J
BMC Public Health 2022 Dec 13;22(1):2337. doi: 10.1186/s12889-022-14753-x. PMID: 36514090Free PMC Article
Erlandson KM, Bradford Y, Samuels DC, Brown TT, Sun J, Wu K, Tassiopoulos K, Ritchie MD, Haas DW, Hulgan T
AIDS Res Hum Retroviruses 2020 Mar;36(3):214-219. Epub 2020 Jan 14 doi: 10.1089/AID.2019.0233. PMID: 31822125Free PMC Article
Wang T, Wu Y, Li W, Li S, Sun Y, Li S, Zhang D, Tan Q
J Am Geriatr Soc 2019 Jan;67(1):93-99. Epub 2018 Oct 25 doi: 10.1111/jgs.15611. PMID: 30357802
Kim JH, Hong AR, Choi HJ, Ku EJ, Lee JH, Cho NH, Shin CS
Arch Osteoporos 2018 Sep 20;13(1):100. doi: 10.1007/s11657-018-0511-z. PMID: 30238222
Dodds RM, Syddall HE, Cooper R, Benzeval M, Deary IJ, Dennison EM, Der G, Gale CR, Inskip HM, Jagger C, Kirkwood TB, Lawlor DA, Robinson SM, Starr JM, Steptoe A, Tilling K, Kuh D, Cooper C, Sayer AA
PLoS One 2014;9(12):e113637. Epub 2014 Dec 4 doi: 10.1371/journal.pone.0113637. PMID: 25474696Free PMC Article

Diagnosis

Lee K
Nutr Res 2021 Mar;87:41-48. Epub 2020 Dec 24 doi: 10.1016/j.nutres.2020.12.016. PMID: 33596510
Kim JH, Hong AR, Choi HJ, Ku EJ, Lee JH, Cho NH, Shin CS
Arch Osteoporos 2018 Sep 20;13(1):100. doi: 10.1007/s11657-018-0511-z. PMID: 30238222
Granic A, Davies K, Martin-Ruiz C, Jagger C, Kirkwood TBL, von Zglinicki T, Aihie Sayer A
Age Ageing 2017 Nov 1;46(6):976-982. doi: 10.1093/ageing/afx088. PMID: 28541423Free PMC Article
Dodds RM, Syddall HE, Cooper R, Kuh D, Cooper C, Sayer AA
Age Ageing 2016 Mar;45(2):209-16. Epub 2016 Jan 19 doi: 10.1093/ageing/afv192. PMID: 26790455Free PMC Article
Dodds RM, Syddall HE, Cooper R, Benzeval M, Deary IJ, Dennison EM, Der G, Gale CR, Inskip HM, Jagger C, Kirkwood TB, Lawlor DA, Robinson SM, Starr JM, Steptoe A, Tilling K, Kuh D, Cooper C, Sayer AA
PLoS One 2014;9(12):e113637. Epub 2014 Dec 4 doi: 10.1371/journal.pone.0113637. PMID: 25474696Free PMC Article

Therapy

Kelly SG, Wu K, Tassiopoulos K, Erlandson KM, Koletar SL, Palella FJ Jr; ACTG A5322 Study Team
J Acquir Immune Defic Syndr 2021 Jul 1;87(3):971-977. doi: 10.1097/QAI.0000000000002662. PMID: 33625065Free PMC Article
Brown PJ, Ciarleglio A, Roose SP, Garcia CM, Chung S, Alvarez J, Stein A, Gomez S, Rutherford BR
Am J Geriatr Psychiatry 2021 Sep;29(9):944-955. Epub 2020 Dec 25 doi: 10.1016/j.jagp.2020.12.024. PMID: 33388223Free PMC Article
Sim M, Lewis JR, Blekkenhorst LC, Bondonno CP, Devine A, Zhu K, Peeling P, Prince RL, Hodgson JM
J Cachexia Sarcopenia Muscle 2019 Jun;10(3):601-610. Epub 2019 Mar 24 doi: 10.1002/jcsm.12413. PMID: 30907070Free PMC Article
Abdul Aziz SA, Mcstea M, Ahmad Bashah NS, Chong ML, Ponnampalavanar S, Syed Omar SF, Sulaiman H, Azwa I, Tan MP, Kamarulzaman A, Rajasuriar R, Kamaruzzaman SB
AIDS 2018 May 15;32(8):1025-1034. doi: 10.1097/QAD.0000000000001798. PMID: 29547442
Kittiskulnam P, Chertow GM, Carrero JJ, Delgado C, Kaysen GA, Johansen KL
Kidney Int 2017 Jul;92(1):238-247. Epub 2017 Mar 17 doi: 10.1016/j.kint.2017.01.024. PMID: 28318630Free PMC Article

Prognosis

Wang T, Wu Y, Li W, Li S, Sun Y, Li S, Zhang D, Tan Q
J Am Geriatr Soc 2019 Jan;67(1):93-99. Epub 2018 Oct 25 doi: 10.1111/jgs.15611. PMID: 30357802
Kim JH, Kim JM
Int Psychogeriatr 2019 May;31(5):723-734. Epub 2018 Oct 9 doi: 10.1017/S1041610218001175. PMID: 30298800
Kim JH, Hong AR, Choi HJ, Ku EJ, Lee JH, Cho NH, Shin CS
Arch Osteoporos 2018 Sep 20;13(1):100. doi: 10.1007/s11657-018-0511-z. PMID: 30238222
Dodds RM, Syddall HE, Cooper R, Kuh D, Cooper C, Sayer AA
Age Ageing 2016 Mar;45(2):209-16. Epub 2016 Jan 19 doi: 10.1093/ageing/afv192. PMID: 26790455Free PMC Article
Dodds RM, Syddall HE, Cooper R, Benzeval M, Deary IJ, Dennison EM, Der G, Gale CR, Inskip HM, Jagger C, Kirkwood TB, Lawlor DA, Robinson SM, Starr JM, Steptoe A, Tilling K, Kuh D, Cooper C, Sayer AA
PLoS One 2014;9(12):e113637. Epub 2014 Dec 4 doi: 10.1371/journal.pone.0113637. PMID: 25474696Free PMC Article

Clinical prediction guides

Goldstein DW, Hajduk AM, Song X, Tsang S, Geda M, McClurken JB, Tinetti ME, Krumholz HM, Chaudhry SI
J Am Geriatr Soc 2021 Dec;69(12):3476-3485. Epub 2021 Aug 12 doi: 10.1111/jgs.17398. PMID: 34383963Free PMC Article
Wang T, Wu Y, Li W, Li S, Sun Y, Li S, Zhang D, Tan Q
J Am Geriatr Soc 2019 Jan;67(1):93-99. Epub 2018 Oct 25 doi: 10.1111/jgs.15611. PMID: 30357802
Kim JH, Hong AR, Choi HJ, Ku EJ, Lee JH, Cho NH, Shin CS
Arch Osteoporos 2018 Sep 20;13(1):100. doi: 10.1007/s11657-018-0511-z. PMID: 30238222
Dodds RM, Syddall HE, Cooper R, Kuh D, Cooper C, Sayer AA
Age Ageing 2016 Mar;45(2):209-16. Epub 2016 Jan 19 doi: 10.1093/ageing/afv192. PMID: 26790455Free PMC Article
Dodds RM, Syddall HE, Cooper R, Benzeval M, Deary IJ, Dennison EM, Der G, Gale CR, Inskip HM, Jagger C, Kirkwood TB, Lawlor DA, Robinson SM, Starr JM, Steptoe A, Tilling K, Kuh D, Cooper C, Sayer AA
PLoS One 2014;9(12):e113637. Epub 2014 Dec 4 doi: 10.1371/journal.pone.0113637. PMID: 25474696Free PMC Article

Recent systematic reviews

Dodds RM, Syddall HE, Cooper R, Kuh D, Cooper C, Sayer AA
Age Ageing 2016 Mar;45(2):209-16. Epub 2016 Jan 19 doi: 10.1093/ageing/afv192. PMID: 26790455Free PMC Article

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