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Parotid Gland Diffuse Large B-Cell Lymphoma

MedGen UID:: 1722104
•Concept ID:: C5420355
•: Neoplastic Process

Synonym:

Primary Parotid Gland Diffuse Large B-Cell Lymphoma

Definition

A diffuse large B-cell lymphoma that manifests initially in the parotid gland. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVParotid Gland Diffuse Large B-Cell Lymphoma

Head and neck neoplasm
- Head and neck cancer
  - Malignant Salivary Gland Neoplasm
    - Major salivary gland cancer
      - Major Salivary Gland Non-Hodgkin Lymphoma
        Parotid Gland Non-Hodgkin Lymphoma
        Parotid Gland Diffuse Large B-Cell Lymphoma

Professional guidelines

PubMed

Current evidence on diagnosis and treatment of parotid gland lymphomas: a systematic review.

Di Santo D, Bramati C, Festa BM, Pace GM, Comini LV, Luparello P, Cascardi E, Galizia D, Galli A, De Virgilio A, Giordano L, Bondi S
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5219-5227. Epub 2023 Aug 28 doi: 10.1007/s00405-023-08206-3. PMID: 37638999

See all (1)

Recent clinical studies

Etiology

Current evidence on diagnosis and treatment of parotid gland lymphomas: a systematic review.

Lymphomas of the salivary glands: a systematic review.

Al-Khafaf AE, Al-Shahrestani F, Baysal Y, Rahbek Gjerdrum LM, Heegaard S, Pedersen LM, Homøe P
Acta Otolaryngol 2023 Jul-Aug;143(7):610-616. Epub 2023 Aug 12 doi: 10.1080/00016489.2023.2226689. PMID: 37572309

Primary diffuse large B-cell lymphoma of the major salivary glands: Increasing incidence and survival.

Gupta A, Lee JA, Nguyen SA, Lentsch EJ
Am J Otolaryngol 2021 May-Jun;42(3):102938. Epub 2021 Jan 28 doi: 10.1016/j.amjoto.2021.102938. PMID: 33524741

Primary parotid gland lymphoma: pitfalls in the use of ultrasound imaging by a great pretender.

Mantsopoulos K, Koch M, Fauck V, Schinz K, Schapher M, Constantinidis J, Rösler W, Iro H
Int J Oral Maxillofac Surg 2021 May;50(5):573-578. Epub 2020 Sep 13 doi: 10.1016/j.ijom.2020.08.008. PMID: 32938567

Parotid gland lymphoma: prognostic analysis of 2140 patients.

Feinstein AJ, Ciarleglio MM, Cong X, Otremba MD, Judson BL
Laryngoscope 2013 May;123(5):1199-203. Epub 2013 Apr 10 doi: 10.1002/lary.23901. PMID: 23576299

See all (21)

Diagnosis

Current evidence on diagnosis and treatment of parotid gland lymphomas: a systematic review.

Cutaneous Ossifying Amyloidoma.

Requena C, Diago A, Traves V, Llombart B, Nagore E, Sanmartin O
Am J Dermatopathol 2022 Oct 1;44(10):760-763. Epub 2022 Jul 19 doi: 10.1097/DAD.0000000000002263. PMID: 35925553

Primary diffuse large B-cell lymphoma of the major salivary glands: Increasing incidence and survival.

Gupta A, Lee JA, Nguyen SA, Lentsch EJ
Am J Otolaryngol 2021 May-Jun;42(3):102938. Epub 2021 Jan 28 doi: 10.1016/j.amjoto.2021.102938. PMID: 33524741

11C-Methionine-Avid Plasmablastic Lymphoma.

Annunziata S, Cuccaro A, Caldarella C, Leccisotti L, Hohaus S
Clin Nucl Med 2017 Nov;42(11):872-873. doi: 10.1097/RLU.0000000000001803. PMID: 28825948

Diffuse large B cell lymphoma in hyper-IgE syndrome due to STAT3 mutation.

Kumánovics A, Perkins SL, Gilbert H, Cessna MH, Augustine NH, Hill HR
J Clin Immunol 2010 Nov;30(6):886-93. Epub 2010 Sep 22 doi: 10.1007/s10875-010-9452-z. PMID: 20859667

See all (41)

Therapy

Sequential development of multifocal recurrent non-Hodgkin's lymphoma of mucosa-associated lymphoid tissue and diffuse large B-Cell lymphoma in a single patient: A case report.

Yang X, Min X, He W
Medicine (Baltimore) 2018 May;97(21):e10845. doi: 10.1097/MD.0000000000010845. PMID: 29794780 Free PMC Article

Parotid lymphoma: a review of clinical presentation and management.

Shum JW, Emmerling M, Lubek JE, Ord RA
Oral Surg Oral Med Oral Pathol Oral Radiol 2014 Jul;118(1):e1-5. Epub 2013 Nov 6 doi: 10.1016/j.oooo.2013.10.013. PMID: 24405648

Rare manifestation of the thrombotic microangiopathy in a patient with sarcoidosis, common variable immunodeficiency and large B-cell non-hodgkin lymphoma: case report.

Ekart R, Grobelšek VK, Dai K, Cernelč P, Hojs R
Transfus Apher Sci 2013 Jun;48(3):345-7. Epub 2013 Apr 22 doi: 10.1016/j.transci.2013.04.014. PMID: 23619325

Large cell lymphoma associated with prosthetic joint debris.

Ong MG, Ghali GE, Veillon D, Cotelingam J
J La State Med Soc 2012 Jan-Feb;164(1):31-2. doi: 10.1002/sta4.4. PMID: 22533111

Parotid gland non-Hodgkin lymphoma in primary Sjögren syndrome.

Zenone T
Rheumatol Int 2012 May;32(5):1387-90. Epub 2011 Mar 23 doi: 10.1007/s00296-011-1851-9. PMID: 21431292

See all (7)

Prognosis

Lymphomas of the salivary glands: a systematic review.

Primary diffuse large B-cell lymphoma of the major salivary glands: Increasing incidence and survival.

Gupta A, Lee JA, Nguyen SA, Lentsch EJ
Am J Otolaryngol 2021 May-Jun;42(3):102938. Epub 2021 Jan 28 doi: 10.1016/j.amjoto.2021.102938. PMID: 33524741

A Case of Transformation of Primary Cutaneous Follicle Center Lymphoma to Diffuse Large B-Cell Lymphoma Involving the Parotid Gland and Cervical Lymph Nodes.

King ML, Vengaloor Thomas T, Albert AA, Joseph S, Ramachandran Nair L, Lam JT, Woods WC, Nittala M, Vijayakumar S
Am J Case Rep 2019 Aug 29;20:1273-1278. doi: 10.12659/AJCR.917389. PMID: 31462626 Free PMC Article

11C-Methionine-Avid Plasmablastic Lymphoma.

Annunziata S, Cuccaro A, Caldarella C, Leccisotti L, Hohaus S
Clin Nucl Med 2017 Nov;42(11):872-873. doi: 10.1097/RLU.0000000000001803. PMID: 28825948

Parotid gland lymphoma: prognostic analysis of 2140 patients.

Feinstein AJ, Ciarleglio MM, Cong X, Otremba MD, Judson BL
Laryngoscope 2013 May;123(5):1199-203. Epub 2013 Apr 10 doi: 10.1002/lary.23901. PMID: 23576299

See all (22)

Clinical prediction guides

Parotid gland non-Hodgkin lymphoma in primary Sjögren syndrome.

Zenone T
Rheumatol Int 2012 May;32(5):1387-90. Epub 2011 Mar 23 doi: 10.1007/s00296-011-1851-9. PMID: 21431292

Hematologic manifestations and predictors of lymphoma development in primary Sjögren syndrome: clinical and pathophysiologic aspects.

Baimpa E, Dahabreh IJ, Voulgarelis M, Moutsopoulos HM
Medicine (Baltimore) 2009 Sep;88(5):284-293. doi: 10.1097/MD.0b013e3181b76ab5. PMID: 19745687

Xerostomia in long-term survivors of aggressive non-Hodgkin's lymphoma of Waldeyer's ring: a potential role for parotid-sparing techniques?

Chang DT, Amdur RJ, Pacholke H, Mendenhall NP, Morris CG, Byer GA, Olivier KR
Am J Clin Oncol 2009 Apr;32(2):145-9. doi: 10.1097/COC.0b013e3181841f42. PMID: 19307951

Parotid gland involvement, the presenting sign of high grade non-Hodgkin lymphoma in two patients with Gaucher disease and sicca syndrome.

Shvidel L, Sigler E, Shtalrid M, Feldberg E, Berrebi A
J Inherit Metab Dis 2007 Oct;30(5):825. Epub 2007 Aug 20 doi: 10.1007/s10545-007-0610-2. PMID: 17703372

Potential clinical role of fluorodeoxyglucose-positron emission tomography in assessing primary or secondary lymphomas of the parotid gland.

Basu S, Mahne A, Iruvuri S, Alavi A
Clin Lymphoma Myeloma 2007 Jan;7(4):309-14. doi: 10.3816/CLM.2007.n.008. PMID: 17324340

See all (6)