U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Neck Carcinoma of Unknown Primary

MedGen UID:
1722873
Concept ID:
C5420280
Neoplastic Process
Synonym: Neck CUP

Definition

A carcinoma that has metastasized to the neck region from an unknown primary anatomic site. [from NCI]

Professional guidelines

PubMed

Podeur F, Pommier P, Crozes C, Monchet E, Ton Van J, Roux PE, Poupart M, Zrounba P, Julieron M, Deneuve S
Head Neck 2020 Feb;42(2):302-311. Epub 2019 Nov 18 doi: 10.1002/hed.26007. PMID: 31737971
Cheraghlou S, Torabi SJ, Husain ZA, Otremba MD, Osborn HA, Mehra S, Yarbrough WG, Burtness BA, Judson BL
Laryngoscope 2019 Mar;129(3):684-691. Epub 2018 Aug 27 doi: 10.1002/lary.27475. PMID: 30151832

Recent clinical studies

Etiology

Ghatasheh H, Huang SH, Su J, Xu W, Bratman SV, Cho J, Giuliani M, Hahn E, Hope A, Kim J, O'Sullivan B, Ringash J, Waldron J, Chepeha DB, Irish JC, Goldstein DP, Spreafico A, Tong L, de Almeida JR, Hosni A
Radiother Oncol 2022 Oct;175:56-64. Epub 2022 Jul 26 doi: 10.1016/j.radonc.2022.07.016. PMID: 35905781
Brenet E, Philouze P, Schiffler C, Pommier P, Crozes C, Benzerdjeb N, Monchet E, Boulagnon-Rombi C, Ton Van J, Podeur F, Servagi-Vernat S, Liem X, Merol JC, Ceruse P, Serre AA, Chabaud S, Julieron M, Deneuve S
Radiother Oncol 2021 Jul;160:1-8. Epub 2021 Apr 27 doi: 10.1016/j.radonc.2021.04.002. PMID: 33845043
Podeur F, Pommier P, Crozes C, Monchet E, Ton Van J, Roux PE, Poupart M, Zrounba P, Julieron M, Deneuve S
Head Neck 2020 Feb;42(2):302-311. Epub 2019 Nov 18 doi: 10.1002/hed.26007. PMID: 31737971
Grewal AS, Rajasekaran K, Cannady SB, Chalian AA, Ghiam AF, Lin A, LiVolsi V, Lukens JN, Mitra N, Montone KT, Newman JG, O'Malley BW Jr,, Rassekh CH, Weinstein GS, Swisher-McClure S
Laryngoscope 2020 Mar;130(3):691-697. Epub 2019 Aug 14 doi: 10.1002/lary.28200. PMID: 31411747
Cheraghlou S, Torabi SJ, Husain ZA, Otremba MD, Osborn HA, Mehra S, Yarbrough WG, Burtness BA, Judson BL
Laryngoscope 2019 Mar;129(3):684-691. Epub 2018 Aug 27 doi: 10.1002/lary.27475. PMID: 30151832

Diagnosis

Mukherjee S, Fischbein NJ, Baugnon KL, Policeni BA, Raghavan P
AJR Am J Roentgenol 2023 Feb;220(2):160-172. Epub 2022 Sep 7 doi: 10.2214/AJR.22.28120. PMID: 36069482
Balk M, Rupp R, Mantsopoulos K, Allner M, Grundtner P, Mueller SK, Traxdorf M, Eckstein M, Speer S, Semrau S, Fietkau R, Iro H, Hecht M, Gostian AO
BMC Cancer 2021 Nov 18;21(1):1236. doi: 10.1186/s12885-021-08885-3. PMID: 34794411Free PMC Article
Kennel T, Garrel R, Costes V, Boisselier P, Crampette L, Favier V
Eur Ann Otorhinolaryngol Head Neck Dis 2019 Jun;136(3):185-192. Epub 2019 Apr 17 doi: 10.1016/j.anorl.2019.04.002. PMID: 31005456
Cheraghlou S, Torabi SJ, Husain ZA, Otremba MD, Osborn HA, Mehra S, Yarbrough WG, Burtness BA, Judson BL
Laryngoscope 2019 Mar;129(3):684-691. Epub 2018 Aug 27 doi: 10.1002/lary.27475. PMID: 30151832
de Ridder M, Klop M, Hamming-Vrieze O, de Boer J, Jasperse B, Smit L, Vogel W, van den Brekel M, Al-Mamgani A
Head Neck 2017 Jul;39(7):1382-1391. Epub 2017 Mar 28 doi: 10.1002/hed.24762. PMID: 28370570

Therapy

Ghatasheh H, Huang SH, Su J, Xu W, Bratman SV, Cho J, Giuliani M, Hahn E, Hope A, Kim J, O'Sullivan B, Ringash J, Waldron J, Chepeha DB, Irish JC, Goldstein DP, Spreafico A, Tong L, de Almeida JR, Hosni A
Radiother Oncol 2022 Oct;175:56-64. Epub 2022 Jul 26 doi: 10.1016/j.radonc.2022.07.016. PMID: 35905781
Mistry R, Walker A, Kim D, Ofo E
Ann R Coll Surg Engl 2020 Jul;102(6):442-450. Epub 2020 Apr 29 doi: 10.1308/rcsann.2020.0071. PMID: 32347742Free PMC Article
Hosni A, Dixon PR, Rishi A, Au M, Xu W, Song Y, Chepeha DB, Goldstein DP, Huang SH, Kim J, O'Sullivan B, Waldron J, Bratman SV, de Almeida JR
JAMA Otolaryngol Head Neck Surg 2016 Dec 1;142(12):1208-1215. doi: 10.1001/jamaoto.2016.3083. PMID: 27812692
Richards TM, Bhide SA, Miah AB, Del Rosario L, Bodla S, Thway K, Gujral DM, Rooney KP, Schick U, McGovern T, Grove L, Newbold KL, Harrington KJ, Nutting CM
Clin Oncol (R Coll Radiol) 2016 Sep;28(9):e77-e84. Epub 2016 May 11 doi: 10.1016/j.clon.2016.04.035. PMID: 27180092
Lu H, Yao M, Tan H
Oral Oncol 2009 Jun;45(6):474-9. Epub 2008 Sep 18 doi: 10.1016/j.oraloncology.2008.06.006. PMID: 18804408

Prognosis

Sittitrai P, Ruenmarkkaew D, Chitapanarux I, Muangwong P, Kangsadarnwiroon K, Benjawongsatien R, Srivanitchapoom C, Donchalermpak S, Asakij T
Asian Pac J Cancer Prev 2024 Feb 1;25(2):699-708. doi: 10.31557/APJCP.2024.25.2.699. PMID: 38415558Free PMC Article
Ghatasheh H, Huang SH, Su J, Xu W, Bratman SV, Cho J, Giuliani M, Hahn E, Hope A, Kim J, O'Sullivan B, Ringash J, Waldron J, Chepeha DB, Irish JC, Goldstein DP, Spreafico A, Tong L, de Almeida JR, Hosni A
Radiother Oncol 2022 Oct;175:56-64. Epub 2022 Jul 26 doi: 10.1016/j.radonc.2022.07.016. PMID: 35905781
Balk M, Rupp R, Mantsopoulos K, Allner M, Grundtner P, Mueller SK, Traxdorf M, Eckstein M, Speer S, Semrau S, Fietkau R, Iro H, Hecht M, Gostian AO
BMC Cancer 2021 Nov 18;21(1):1236. doi: 10.1186/s12885-021-08885-3. PMID: 34794411Free PMC Article
Cheraghlou S, Torabi SJ, Husain ZA, Otremba MD, Osborn HA, Mehra S, Yarbrough WG, Burtness BA, Judson BL
Laryngoscope 2019 Mar;129(3):684-691. Epub 2018 Aug 27 doi: 10.1002/lary.27475. PMID: 30151832
de Ridder M, Klop M, Hamming-Vrieze O, de Boer J, Jasperse B, Smit L, Vogel W, van den Brekel M, Al-Mamgani A
Head Neck 2017 Jul;39(7):1382-1391. Epub 2017 Mar 28 doi: 10.1002/hed.24762. PMID: 28370570

Clinical prediction guides

Sittitrai P, Ruenmarkkaew D, Chitapanarux I, Muangwong P, Kangsadarnwiroon K, Benjawongsatien R, Srivanitchapoom C, Donchalermpak S, Asakij T
Asian Pac J Cancer Prev 2024 Feb 1;25(2):699-708. doi: 10.31557/APJCP.2024.25.2.699. PMID: 38415558Free PMC Article
Ghatasheh H, Huang SH, Su J, Xu W, Bratman SV, Cho J, Giuliani M, Hahn E, Hope A, Kim J, O'Sullivan B, Ringash J, Waldron J, Chepeha DB, Irish JC, Goldstein DP, Spreafico A, Tong L, de Almeida JR, Hosni A
Radiother Oncol 2022 Oct;175:56-64. Epub 2022 Jul 26 doi: 10.1016/j.radonc.2022.07.016. PMID: 35905781
Brenet E, Philouze P, Schiffler C, Pommier P, Crozes C, Benzerdjeb N, Monchet E, Boulagnon-Rombi C, Ton Van J, Podeur F, Servagi-Vernat S, Liem X, Merol JC, Ceruse P, Serre AA, Chabaud S, Julieron M, Deneuve S
Radiother Oncol 2021 Jul;160:1-8. Epub 2021 Apr 27 doi: 10.1016/j.radonc.2021.04.002. PMID: 33845043
Podeur F, Pommier P, Crozes C, Monchet E, Ton Van J, Roux PE, Poupart M, Zrounba P, Julieron M, Deneuve S
Head Neck 2020 Feb;42(2):302-311. Epub 2019 Nov 18 doi: 10.1002/hed.26007. PMID: 31737971
Grewal AS, Rajasekaran K, Cannady SB, Chalian AA, Ghiam AF, Lin A, LiVolsi V, Lukens JN, Mitra N, Montone KT, Newman JG, O'Malley BW Jr,, Rassekh CH, Weinstein GS, Swisher-McClure S
Laryngoscope 2020 Mar;130(3):691-697. Epub 2019 Aug 14 doi: 10.1002/lary.28200. PMID: 31411747

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...