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Salivary Gland Poorly Differentiated Carcinoma

MedGen UID:
1724431
•Concept ID:
C5400765
•
Neoplastic Process

Definition

A high-grade carcinoma that arises from the salivary glands. This category includes large and small cell types with or without neuroendocrine differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSalivary Gland Poorly Differentiated Carcinoma

Professional guidelines

PubMed

Treatment Efficacy of PD-1 Inhibitor Therapy in Patients With Recurrent and/or Metastatic Salivary Gland Carcinoma.
Hashimoto K, Yasumatsu R, Kuga R, Hongo T, Yamamoto H, Matsuo M, Wakasaki T, Jiromaru R, Manako T, Toh S, Masuda M, Yamauchi M, Kuratomi Y, Uryu H, Nakashima T, Tamae A, Tanaka R, Taura M, Takeuchi T, Yoshida T, Nakagawa T
Anticancer Res 2022 Feb;42(2):981-989. doi: 10.21873/anticanres.15558. PMID: 35093898
The diagnosis and treatment of oncocytic carcinoma.
Wei H, Xiaofeng H, Yang Z, Zhiyong W
J Craniofac Surg 2014 Jul;25(4):e326-8. doi: 10.1097/SCS.0000000000000592. PMID: 25006936
Long-term treatment outcome of minor salivary gland carcinoma of the hard palate.
Li Q, Zhang XR, Liu XK, Liu ZM, Liu WW, Li H, Guo ZM
Oral Oncol 2012 May;48(5):456-62. Epub 2012 Jan 16 doi: 10.1016/j.oraloncology.2011.12.005. PMID: 22248739

Recent clinical studies

Etiology

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.
Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Treatment Efficacy of PD-1 Inhibitor Therapy in Patients With Recurrent and/or Metastatic Salivary Gland Carcinoma.
Hashimoto K, Yasumatsu R, Kuga R, Hongo T, Yamamoto H, Matsuo M, Wakasaki T, Jiromaru R, Manako T, Toh S, Masuda M, Yamauchi M, Kuratomi Y, Uryu H, Nakashima T, Tamae A, Tanaka R, Taura M, Takeuchi T, Yoshida T, Nakagawa T
Anticancer Res 2022 Feb;42(2):981-989. doi: 10.21873/anticanres.15558. PMID: 35093898
Fine needle aspiration of salivary gland carcinomas with high-grade transformation: A multi-institutional study of 22 cases and review of the literature.
Nakaguro M, Faquin WC, Baloch ZW, Cantley RL, Compton ML, Ely KA, Holmes BJ, Hu R, Kerr DA, Montone KT, Nishino M, Pantanowitz L, Rossi ED, Sadow PM
Cancer Cytopathol 2021 Apr;129(4):318-325. Epub 2020 Nov 19 doi: 10.1002/cncy.22388. PMID: 33211402Free PMC Article
The diagnosis and treatment of oncocytic carcinoma.
Wei H, Xiaofeng H, Yang Z, Zhiyong W
J Craniofac Surg 2014 Jul;25(4):e326-8. doi: 10.1097/SCS.0000000000000592. PMID: 25006936

Diagnosis

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Overview of the 2022 WHO Classification of Head and Neck Neuroendocrine Neoplasms.
Mete O, Wenig BM
Head Neck Pathol 2022 Mar;16(1):123-142. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01435-8. PMID: 35312985Free PMC Article
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.
Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Fine needle aspiration of salivary gland carcinomas with high-grade transformation: A multi-institutional study of 22 cases and review of the literature.
Nakaguro M, Faquin WC, Baloch ZW, Cantley RL, Compton ML, Ely KA, Holmes BJ, Hu R, Kerr DA, Montone KT, Nishino M, Pantanowitz L, Rossi ED, Sadow PM
Cancer Cytopathol 2021 Apr;129(4):318-325. Epub 2020 Nov 19 doi: 10.1002/cncy.22388. PMID: 33211402Free PMC Article
The diagnosis and treatment of oncocytic carcinoma.
Wei H, Xiaofeng H, Yang Z, Zhiyong W
J Craniofac Surg 2014 Jul;25(4):e326-8. doi: 10.1097/SCS.0000000000000592. PMID: 25006936

Therapy

Submandibular gland in squamous cell carcinoma of the tongue: Can preservation during neck dissection be a pragmatic option?
Joshi KD, Joshi P, Bhati M, Nair S, Chaturvedi P
J Cancer Res Ther 2022 Apr-Jun;18(3):612-616. doi: 10.4103/jcrt.JCRT_1661_20. PMID: 35900530
Treatment Efficacy of PD-1 Inhibitor Therapy in Patients With Recurrent and/or Metastatic Salivary Gland Carcinoma.
Hashimoto K, Yasumatsu R, Kuga R, Hongo T, Yamamoto H, Matsuo M, Wakasaki T, Jiromaru R, Manako T, Toh S, Masuda M, Yamauchi M, Kuratomi Y, Uryu H, Nakashima T, Tamae A, Tanaka R, Taura M, Takeuchi T, Yoshida T, Nakagawa T
Anticancer Res 2022 Feb;42(2):981-989. doi: 10.21873/anticanres.15558. PMID: 35093898
NUT Midline Carcinoma of the Sublingual Gland: Clinical Presentation and Review.
Seim NB, Philips RHW, Schoenfield L, Teknos TN, Rocco JW, Agrawal A, Ozer E, Carrau RL, Kang SY, Old MO
Head Neck Pathol 2017 Dec;11(4):460-468. Epub 2017 Mar 27 doi: 10.1007/s12105-017-0809-y. PMID: 28349372Free PMC Article
A phase II study of sorafenib in recurrent and/or metastatic salivary gland carcinomas: Translational analyses and clinical impact.
Locati LD, Perrone F, Cortelazzi B, Bergamini C, Bossi P, Civelli E, Morosi C, Lo Vullo S, Imbimbo M, Quattrone P, Dagrada GP, Granata R, Resteghini C, Mirabile A, Alfieri S, Orlandi E, Mariani L, Saibene G, Pilotti S, Licitra L
Eur J Cancer 2016 Dec;69:158-165. Epub 2016 Nov 5 doi: 10.1016/j.ejca.2016.09.022. PMID: 27821319
Treatment of advanced differentiated thyroid carcinoma with high activity radioiodine therapy.
Haq MS, McCready RV, Harmer CL
Nucl Med Commun 2004 Aug;25(8):799-805. doi: 10.1097/01.mnm.0000136693.94761.5c. PMID: 15266174

Prognosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
High-grade Transformation/Dedifferentiation in Salivary Gland Carcinomas: Occurrence Across Subtypes and Clinical Significance.
Skalova A, Leivo I, Hellquist H, Agaimy A, Simpson RHW, Stenman G, Vander Poorten V, Bishop JA, Franchi A, Hernandez-Prera JC, Slouka D, Willems SM, Olsen KD, Ferlito A
Adv Anat Pathol 2021 May 1;28(3):107-118. doi: 10.1097/PAP.0000000000000298. PMID: 33825717
Fine needle aspiration of salivary gland carcinomas with high-grade transformation: A multi-institutional study of 22 cases and review of the literature.
Nakaguro M, Faquin WC, Baloch ZW, Cantley RL, Compton ML, Ely KA, Holmes BJ, Hu R, Kerr DA, Montone KT, Nishino M, Pantanowitz L, Rossi ED, Sadow PM
Cancer Cytopathol 2021 Apr;129(4):318-325. Epub 2020 Nov 19 doi: 10.1002/cncy.22388. PMID: 33211402Free PMC Article
The diagnosis and treatment of oncocytic carcinoma.
Wei H, Xiaofeng H, Yang Z, Zhiyong W
J Craniofac Surg 2014 Jul;25(4):e326-8. doi: 10.1097/SCS.0000000000000592. PMID: 25006936
"Dedifferentiation" and high-grade transformation in salivary gland carcinomas.
Nagao T
Head Neck Pathol 2013 Jul;7 Suppl 1(Suppl 1):S37-47. Epub 2013 Jul 3 doi: 10.1007/s12105-013-0458-8. PMID: 23821210Free PMC Article

Clinical prediction guides

Histopathological evaluation of minor salivary gland aberrations in oral squamous cell carcinoma.
Bhola R, Narwal A, Kamboj M, Devi A, Anand R, Chatterjee S
J Cancer Res Ther 2023 Jan-Mar;19(2):299-303. doi: 10.4103/jcrt.jcrt_1832_21. PMID: 37313908
Clinical, pathological and treatment factors associated with the survival of patients with primary pulmonary salivary gland-type tumors.
Qin BD, Jiao XD, Liu K, Wu Y, He X, Liu J, Zang YS
Lung Cancer 2018 Dec;126:174-181. Epub 2018 Nov 10 doi: 10.1016/j.lungcan.2018.11.010. PMID: 30527184
Clinical features of brain metastasis from salivary gland tumors.
Venteicher AS, Walcott BP, Sheth SA, Snuderl M, Patel AP, Curry WT, Nahed BV
J Clin Neurosci 2013 Nov;20(11):1533-7. Epub 2013 May 16 doi: 10.1016/j.jocn.2012.11.024. PMID: 23685104Free PMC Article
Adenoid cystic carcinoma with high-grade transformation: a report of 11 cases and a review of the literature.
Seethala RR, Hunt JL, Baloch ZW, Livolsi VA, Leon Barnes E
Am J Surg Pathol 2007 Nov;31(11):1683-94. doi: 10.1097/PAS.0b013e3180dc928c. PMID: 18059225
Nonsalivary sinonasal adenocarcinoma.
Alessi DM, Trapp TK, Fu YS, Calcaterra TC
Arch Otolaryngol Head Neck Surg 1988 Sep;114(9):996-9. doi: 10.1001/archotol.1988.01860210062016. PMID: 3408582

Recent systematic reviews

Salivary Gland NUT Carcinoma with Prolonged Survival in Children: Case Illustration and Systematic Review of Literature.
Wang H, Weiss VL, Hoffman RD, Abel T, Ho RH, Borinstein SC, Mannion K, Bridge JA, Black J, Liang J
Head Neck Pathol 2021 Mar;15(1):236-243. Epub 2020 Feb 19 doi: 10.1007/s12105-020-01141-3. PMID: 32077054Free PMC Article

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