U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Calcifying Odontogenic Cyst

MedGen UID:
1724801
•Concept ID:
C5400837
•
Finding

Definition

A simple odontogenic cyst lined by ameloblastoma-like epithelium, which contains focal accumulations of ghost cells. (WHO 2017) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCalcifying Odontogenic Cyst

Professional guidelines

PubMed

Differential diagnosis between calcifying odontogenic cyst and adenomatoid odontogenic tumor by computed tomography images.
Okura S, Igarashi C, Wakae-Morita S, Eda T, Ito H, Nakashima K, Sugisaki M, Ito Y, Kobayashi K
Oral Radiol 2022 Jan;38(1):99-104. Epub 2021 Apr 27 doi: 10.1007/s11282-021-00531-9. PMID: 33907948
Peripheral odontogenic tumours--differential diagnosis in gingival lesions.
Manor Y, Mardinger O, Katz J, Taicher S, Hirshberg A
Int J Oral Maxillofac Surg 2004 Apr;33(3):268-73. doi: 10.1006/ijom.2003.0508. PMID: 15287310

Recent clinical studies

Etiology

Odontogenic Cysts.
Rajendra Santosh AB
Dent Clin North Am 2020 Jan;64(1):105-119. Epub 2019 Oct 18 doi: 10.1016/j.cden.2019.08.002. PMID: 31735221
Calcifying cystic odontogenic tumor associated with ameloblastoma - A rare histological variant.
Muddana K, Maloth AK, Dorankula SPR, Kulkarni PG
Indian J Dent Res 2019 Jan-Feb;30(1):144-148. doi: 10.4103/ijdr.IJDR_105_17. PMID: 30900676
Ameloblastomatous Gorlin's cyst.
Kamboj M, Juneja M
J Oral Sci 2007 Dec;49(4):319-23. doi: 10.2334/josnusd.49.319. PMID: 18195516
Pindborg tumor in children.
Ungari C, Poladas G, Giovannetti F, Carnevale C, Iannetti G
J Craniofac Surg 2006 Mar;17(2):365-9. doi: 10.1097/00001665-200603000-00029. PMID: 16633191
Odontogenic tumors: a study of 340 cases in a Brazilian population.
Fernandes AM, Duarte EC, Pimenta FJ, Souza LN, Santos VR, Mesquita RA, de Aguiar MC
J Oral Pathol Med 2005 Nov;34(10):583-7. doi: 10.1111/j.1600-0714.2005.00357.x. PMID: 16202077

Diagnosis

Calcifying odontogenic cysts.
Rojo R, Prados-Frutos JC, Gutierrez Lázaro I, Herguedas Alonso JA
J Stomatol Oral Maxillofac Surg 2017 Apr;118(2):122-124. Epub 2017 Feb 11 doi: 10.1016/j.jormas.2016.10.007. PMID: 28345512
Nevoid basal cell carcinoma syndrome.
Leger M, Quintana A, Tzu J, Yee H, Kamino H, Sanchez M
Dermatol Online J 2011 Oct 15;17(10):23. PMID: 22031649
Pindborg tumor in children.
Ungari C, Poladas G, Giovannetti F, Carnevale C, Iannetti G
J Craniofac Surg 2006 Mar;17(2):365-9. doi: 10.1097/00001665-200603000-00029. PMID: 16633191
Calcifying epithelial odontogenic tumor (Pindborg tumor).
Belmonte-Caro R, Torres-Lagares D, Mayorga-Jimenez F, Garcia-Perla García A, Infante-Cossio P, Gutierrez-Perez JL
Med Oral 2002 Jul-Oct;7(4):309-15. PMID: 12134133
The dentinogenic ghost cell tumor.
Tajima Y, Ohno J, Utsumi N
J Oral Pathol 1986 Jul;15(6):359-62. doi: 10.1111/j.1600-0714.1986.tb00640.x. PMID: 3093655

Therapy

Genetic screening for nevoid basal cell carcinoma syndrome in patients with a solitary keratocystic odontogenic tumour is not useful.
Karagozoglu KH, Van Hagen JM, Baart JA, Van Der Waal I
Minerva Stomatol 2011 Jan-Feb;60(1-2):1-4. PMID: 21252844
Persistent apical periodontitis associated with a calcifying odontogenic cyst.
Estrela C, Decurcio DA, Silva JA, Mendonça EF, Estrela CR
Int Endod J 2009 Jun;42(6):539-45. Epub 2008 Oct 23 doi: 10.1111/j.1365-2591.2008.01477.x. PMID: 19178595
Malignant calcifying epithelial odontogenic tumor of the mandible: report of a case with pulmonary metastasis showing remarkable response to platinum derivatives.
Kawano K, Ono K, Yada N, Takahashi Y, Kashima K, Yokoyama S, Yanagisawa S
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007 Jul;104(1):76-81. Epub 2006 Sep 25 doi: 10.1016/j.tripleo.2006.04.014. PMID: 17577547
Case challenge. Chronic maxillary inflammation.
Omnell KA, Rohlin M
J Contemp Dent Pract 2000 Feb 15;1(2):100-5. PMID: 12167893

Prognosis

Ghost cells unveiled: A comprehensive review.
Garg A, Malhotra R, Urs AB
J Oral Biosci 2022 Jun;64(2):202-209. Epub 2022 Apr 6 doi: 10.1016/j.job.2022.03.005. PMID: 35398253
Exophytic gingival growth of the maxillary canine region in a young individual: Extremely rare case report of peripheral dentinogenic ghost cell tumor.
Nahid R, Bansal M, Gupta K, Pandey S, Tiwari P, Agarwal R
J Cancer Res Ther 2020 Apr-Jun;16(3):661-664. doi: 10.4103/jcrt.JCRT_180_19. PMID: 32719286
Custom-made implant for maxillofacial defects using rapid prototype models.
Arora A, Datarkar AN, Borle RM, Rai A, Adwani DG
J Oral Maxillofac Surg 2013 Feb;71(2):e104-10. doi: 10.1016/j.joms.2012.10.015. PMID: 23351764
Genetic screening for nevoid basal cell carcinoma syndrome in patients with a solitary keratocystic odontogenic tumour is not useful.
Karagozoglu KH, Van Hagen JM, Baart JA, Van Der Waal I
Minerva Stomatol 2011 Jan-Feb;60(1-2):1-4. PMID: 21252844
Two maxillary lesions containing bony/calcified shells.
Gurel K, Sanal S, Gurel S, Kalfaoglu M, Boran C
Dentomaxillofac Radiol 2009 Jul;38(5):296-300. doi: 10.1259/dmfr/33360963. PMID: 19474258

Clinical prediction guides

Calcifying odontogenic cysts.
Rojo R, Prados-Frutos JC, Gutierrez Lázaro I, Herguedas Alonso JA
J Stomatol Oral Maxillofac Surg 2017 Apr;118(2):122-124. Epub 2017 Feb 11 doi: 10.1016/j.jormas.2016.10.007. PMID: 28345512
Ectopic production of hair keratin constitutes Rushton's hyaline bodies in association with hematogenous deposits.
Sakamoto K, Khanom R, Hamagaki M, Yamaguchi A
J Oral Pathol Med 2012 Sep;41(8):637-41. Epub 2012 Apr 6 doi: 10.1111/j.1600-0714.2012.01150.x. PMID: 22486945
Histopathological features of keratocystic odontogenic tumor: a descriptive study of 177 cases from a Brazilian population.
Azevedo RS, Cabral MG, dos Santos TC, de Oliveira AV, de Almeida OP, Pires FR
Int J Surg Pathol 2012 Apr;20(2):154-60. Epub 2011 Nov 21 doi: 10.1177/1066896911428072. PMID: 22108498
Two maxillary lesions containing bony/calcified shells.
Gurel K, Sanal S, Gurel S, Kalfaoglu M, Boran C
Dentomaxillofac Radiol 2009 Jul;38(5):296-300. doi: 10.1259/dmfr/33360963. PMID: 19474258
Immunohistochemical analysis of a dentinogenic ghost cell tumour.
Piattelli A, Fioroni M, Di Alberti L, Rubini C
Oral Oncol 1998 Nov;34(6):502-7. doi: 10.1016/s1368-8375(98)00034-7. PMID: 9930362

Recent systematic reviews

Localization of beta catenin across the domain of odontogenic lesions: A systematic review.
Chatterjee S, Devi A, Kamboj M, Narwal A
J Oral Pathol Med 2023 Nov;52(10):904-910. Epub 2023 Oct 15 doi: 10.1111/jop.13487. PMID: 37840228
Compound odontoma associated with a calcifying odontogenic cyst. Case report and systematic review.
Vizuete-Bolaños MX, Salgado-Chavarria F, Ramírez-Martínez CM, Ramos-Nieto JJ, Vazquez-Dávalos NM
J Stomatol Oral Maxillofac Surg 2022 Jun;123(3):e97-e105. Epub 2021 Oct 21 doi: 10.1016/j.jormas.2021.10.008. PMID: 34687949
Hybrid odontogenic lesions: A systematic review of 203 cases reported in the literature.
Pontes FSC, Mosqueda-Taylor A, de Souza LL, de Paula LP, Batista LAL, Rodrigues-Fernandes CI, Paiva E Costa AM, de Abreu MC, Gomez RS, de Oliveira EM, Fonseca FP, Rahimi S, Brennan PA, Pontes HAR
J Oral Pathol Med 2022 Jan;51(1):5-12. Epub 2021 Sep 20 doi: 10.1111/jop.13238. PMID: 34469012
Calcifying odontogenic cyst, dentinogenic ghost cell tumor, and ghost cell odontogenic carcinoma: A systematic review.
de Arruda JAA, Monteiro JLGC, Abreu LG, de Oliveira Silva LV, Schuch LF, de Noronha MS, Callou G, Moreno A, Mesquita RA
J Oral Pathol Med 2018 Sep;47(8):721-730. Epub 2018 May 25 doi: 10.1111/jop.12727. PMID: 29738629
Peripheral calcifying cystic odontogenic tumour and peripheral dentinogenic ghost cell tumour: an updated systematic review of 117 cases reported in the literature.
Chrcanovic BR, Gomez RS
Acta Odontol Scand 2016 Nov;74(8):591-597. Epub 2016 Sep 27 doi: 10.1080/00016357.2016.1236986. PMID: 27669959

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...