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USP6 Gene Rearrangement

MedGen UID:
1726277
•Concept ID:
C5418761
•
Cell or Molecular Dysfunction
Synonyms: HRP1 Gene Rearrangement; Tre-2 Gene Rearrangement; TRE17 Gene Rearrangement; TRE2 Gene Rearrangement; TRESMCR Gene Rearrangement; Ubiquitin Specific Peptidase 6 Gene Rearrangement

Definition

A molecular abnormality indicating rearrangement of the USP6 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUSP6 Gene Rearrangement

Professional guidelines

PubMed

Comprehensive genetic profiling of six pulmonary nuclear protein in testis carcinomas with a novel micropapillary histological subtype in two cases.
Chen M, Yang J, Lv L, Li Y, Tang Y, Liu W, Wang W, Jiang L
Hum Pathol 2021 Sep;115:56-66. Epub 2021 Mar 10 doi: 10.1016/j.humpath.2021.02.004. PMID: 33713695

Recent clinical studies

Therapy

Response of an aggressive periosteal aneurysmal bone cyst (ABC) of the radius to denosumab therapy.
Pauli C, Fuchs B, Pfirrmann C, Bridge JA, Hofer S, Bode B
World J Surg Oncol 2014 Jan 20;12:17. doi: 10.1186/1477-7819-12-17. PMID: 24438319Free PMC Article

Prognosis

Sinonasal nodular fasciitis: report of a case with USP6 rearrangement.
Arcovito G, Caporalini C, Palomba A, Maggiore G, Franchi A
Oral Surg Oral Med Oral Pathol Oral Radiol 2023 Nov;136(5):e153-e158. Epub 2023 Jul 11 doi: 10.1016/j.oooo.2023.07.002. PMID: 37735002
Validation of Fluorescence in situ Hybridization Testing of USP6 Gene Rearrangement for Diagnosis of Primary Aneurysmal Bone Cyst.
Li L, Bui MM, Zhang M, Sun X, Han G, Zhang T, Huang X, Ding Y
Ann Clin Lab Sci 2019 Sep;49(5):590-597. PMID: 31611201
USP6 gene rearrangement differentiates primary paranasal sinus solid aneurysmal bone cyst from other giant cell-rich lesions: report of a rare case.
Li HR, Tai CF, Huang HY, Jin YT, Chen YT, Yang SF
Hum Pathol 2018 Jun;76:117-121. Epub 2017 Dec 5 doi: 10.1016/j.humpath.2017.11.018. PMID: 29217425
Paucicellular Fibrointimal Proliferation Characterizes Pediatric Pulmonary Vein Stenosis: Clinicopathologic Analysis of 213 Samples From 97 Patients.
Kovach AE, Magcalas PM, Ireland C, McEnany K, Oliveira AM, Kieran MW, Baird CW, Jenkins K, Vargas SO
Am J Surg Pathol 2017 Sep;41(9):1198-1204. doi: 10.1097/PAS.0000000000000892. PMID: 28622179
USP6 gene rearrangement in nodular fasciitis and histological mimics.
Shin C, Low I, Ng D, Oei P, Miles C, Symmans P
Histopathology 2016 Nov;69(5):784-791. Epub 2016 Aug 16 doi: 10.1111/his.13011. PMID: 27271298

Clinical prediction guides

Infantile Cranial Fasciitis: A Clinicopathologic Evaluation.
Cao J, Yang G, Chen Y, Wang Y, Shan Y, Xu S, Liu Y, Feng X, Liu S
J Craniofac Surg 2023 Jun 1;34(4):1226-1230. Epub 2023 Mar 6 doi: 10.1097/SCS.0000000000009234. PMID: 36872515Free PMC Article
Benign infiltrative myofibroblastic neoplasms of childhood with USP6 gene rearrangement.
Malik F, Wang L, Yu Z, Edelman MC, Miles L, Clay MR, Hedges D, Brennan RC, Nichols KE, Beth McCarville M, Bahrami A
Histopathology 2020 Nov;77(5):760-768. Epub 2020 Sep 12 doi: 10.1111/his.14182. PMID: 32583473
Validation of Fluorescence in situ Hybridization Testing of USP6 Gene Rearrangement for Diagnosis of Primary Aneurysmal Bone Cyst.
Li L, Bui MM, Zhang M, Sun X, Han G, Zhang T, Huang X, Ding Y
Ann Clin Lab Sci 2019 Sep;49(5):590-597. PMID: 31611201
Soft tissue aneurysmal bone cyst: six new cases with imaging details, molecular pathology, and review of the literature.
Song W, Suurmeijer AJH, Bollen SM, Cleton-Jansen AM, Bovée JVMG, Kroon HM
Skeletal Radiol 2019 Jul;48(7):1059-1067. Epub 2019 Jan 2 doi: 10.1007/s00256-018-3135-x. PMID: 30603771
USP6 gene rearrangement in nodular fasciitis and histological mimics.
Shin C, Low I, Ng D, Oei P, Miles C, Symmans P
Histopathology 2016 Nov;69(5):784-791. Epub 2016 Aug 16 doi: 10.1111/his.13011. PMID: 27271298

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