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Recurrent Ganglioneuroblastoma

MedGen UID:
1726489
•Concept ID:
C5420253
•
Neoplastic Process
Synonym: Relapsed Ganglioneuroblastoma

Definition

The reemergence of ganglioneuroblastoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Ganglioneuroblastoma

Professional guidelines

PubMed

Anatomic patterns of relapse and progression following treatment with (131) I-MIBG in relapsed or refractory neuroblastoma.
Fishel Ben Kenan R, Polishchuk AL, Hawkins RA, Braunstein SE, Matthay KK, DuBois SG, Haas-Kogan DA
Pediatr Blood Cancer 2022 Feb;69(2):e29396. Epub 2021 Oct 18 doi: 10.1002/pbc.29396. PMID: 34662499
The clinical management and outcomes of cervical neuroblastic tumors.
Jackson JR, Tran HC, Stein JE, Shimada H, Patel AM, Marachelian A, Kim ES
J Surg Res 2016 Jul;204(1):109-13. Epub 2016 Apr 23 doi: 10.1016/j.jss.2016.04.030. PMID: 27451875Free PMC Article
Diagnosis and follow-up of neuroblastoma by means of iodine-123 metaiodobenzylguanidine scintigraphy and bone scan, and the influence of histology.
Hadj-Djilani NL, Lebtahi NE, Delaloye AB, Laurini R, Beck D
Eur J Nucl Med 1995 Apr;22(4):322-9. doi: 10.1007/BF00941848. PMID: 7607262

Recent clinical studies

Etiology

Ganglioneuroblastoma intermixed: Clinicopathological implications of diagnosis at presentation and genomic correlations.
Nezami BG, Modak S, Cardenas FI, Sarungbam J, Sirintrapun SJ, Gopalan A, Chen Y, Al-Ahmadie H, Fine SW, Reuter VE, Tickoo SK
Pediatr Blood Cancer 2023 Aug;70(8):e30434. Epub 2023 May 26 doi: 10.1002/pbc.30434. PMID: 37243318
Characteristics of benign neuroblastic tumors: Is surgery always necessary?
Whitlock RS, Mehl SC, Larson SK, Foster JH, Hicks J, Nuchtern JG, Sher AC, Vasudevan SA, Naik-Mathuria B
J Pediatr Surg 2022 Aug;57(8):1538-1543. Epub 2021 Jul 7 doi: 10.1016/j.jpedsurg.2021.07.002. PMID: 34281709
Irinotecan-temozolomide with temsirolimus or dinutuximab in children with refractory or relapsed neuroblastoma (COG ANBL1221): an open-label, randomised, phase 2 trial.
Mody R, Naranjo A, Van Ryn C, Yu AL, London WB, Shulkin BL, Parisi MT, Servaes SE, Diccianni MB, Sondel PM, Bender JG, Maris JM, Park JR, Bagatell R
Lancet Oncol 2017 Jul;18(7):946-957. Epub 2017 May 23 doi: 10.1016/S1470-2045(17)30355-8. PMID: 28549783Free PMC Article
Primary cervical ganglioneuroblastoma.
Manjaly JG, Alexander VR, Pepper CM, Ifeacho SN, Hewitt RJ, Hartley BE
Int J Pediatr Otorhinolaryngol 2015 Jul;79(7):1007-12. Epub 2015 Apr 22 doi: 10.1016/j.ijporl.2015.04.012. PMID: 25921075
Laparoscopic adrenalectomy in children.
Lopes RI, Dénes FT, Bissoli J, Mendonca BB, Srougi M
J Pediatr Urol 2012 Aug;8(4):379-85. Epub 2011 Sep 29 doi: 10.1016/j.jpurol.2011.07.012. PMID: 21955529

Diagnosis

Ganglioneuroblastoma intermixed: Clinicopathological implications of diagnosis at presentation and genomic correlations.
Nezami BG, Modak S, Cardenas FI, Sarungbam J, Sirintrapun SJ, Gopalan A, Chen Y, Al-Ahmadie H, Fine SW, Reuter VE, Tickoo SK
Pediatr Blood Cancer 2023 Aug;70(8):e30434. Epub 2023 May 26 doi: 10.1002/pbc.30434. PMID: 37243318
Primary cervical ganglioneuroblastoma, nodular subtype.
McGann EK, Goldberg AM, Lelegren MJ, Pickle JC, Bak MJ, Mark JR
Auris Nasus Larynx 2022 Oct;49(5):889-892. Epub 2021 Apr 16 doi: 10.1016/j.anl.2021.03.010. PMID: 33867181
Irinotecan-temozolomide with temsirolimus or dinutuximab in children with refractory or relapsed neuroblastoma (COG ANBL1221): an open-label, randomised, phase 2 trial.
Mody R, Naranjo A, Van Ryn C, Yu AL, London WB, Shulkin BL, Parisi MT, Servaes SE, Diccianni MB, Sondel PM, Bender JG, Maris JM, Park JR, Bagatell R
Lancet Oncol 2017 Jul;18(7):946-957. Epub 2017 May 23 doi: 10.1016/S1470-2045(17)30355-8. PMID: 28549783Free PMC Article
Primary cervical ganglioneuroblastoma.
Manjaly JG, Alexander VR, Pepper CM, Ifeacho SN, Hewitt RJ, Hartley BE
Int J Pediatr Otorhinolaryngol 2015 Jul;79(7):1007-12. Epub 2015 Apr 22 doi: 10.1016/j.ijporl.2015.04.012. PMID: 25921075
Pleomorphic (anaplastic) neuroblastoma.
Cozzutto C, Carbone A
Arch Pathol Lab Med 1988 Jun;112(6):621-5. PMID: 3377661

Therapy

Clinical features and outcomes of opsoclonus myoclonus ataxia syndrome.
Yıldırım M, Öncel İ, Bektaş Ö, Tanalı G, Şahin S, Kutluk T, Teber S, Anlar B
Eur J Paediatr Neurol 2022 Nov;41:19-26. Epub 2022 Sep 20 doi: 10.1016/j.ejpn.2022.09.002. PMID: 36155293
Irinotecan-temozolomide with temsirolimus or dinutuximab in children with refractory or relapsed neuroblastoma (COG ANBL1221): an open-label, randomised, phase 2 trial.
Mody R, Naranjo A, Van Ryn C, Yu AL, London WB, Shulkin BL, Parisi MT, Servaes SE, Diccianni MB, Sondel PM, Bender JG, Maris JM, Park JR, Bagatell R
Lancet Oncol 2017 Jul;18(7):946-957. Epub 2017 May 23 doi: 10.1016/S1470-2045(17)30355-8. PMID: 28549783Free PMC Article
Laparoscopic adrenalectomy in children.
Lopes RI, Dénes FT, Bissoli J, Mendonca BB, Srougi M
J Pediatr Urol 2012 Aug;8(4):379-85. Epub 2011 Sep 29 doi: 10.1016/j.jpurol.2011.07.012. PMID: 21955529
Sinonasal and nasopharyngeal applications of the hand-held CO2 laser fiber.
Agarwal G, Kupferman ME, Holsinger FC, Hanna EY
Int Forum Allergy Rhinol 2011 Mar-Apr;1(2):109-12. doi: 10.1002/alr.20017. PMID: 22287328
Intrathoracic ganglioneuroblastoma.
Zajtchuk R, Bowen TE, Seyfer AE, Brott WH
J Thorac Cardiovasc Surg 1980 Oct;80(4):605-12. PMID: 7421294

Prognosis

Ganglioneuroblastoma intermixed: Clinicopathological implications of diagnosis at presentation and genomic correlations.
Nezami BG, Modak S, Cardenas FI, Sarungbam J, Sirintrapun SJ, Gopalan A, Chen Y, Al-Ahmadie H, Fine SW, Reuter VE, Tickoo SK
Pediatr Blood Cancer 2023 Aug;70(8):e30434. Epub 2023 May 26 doi: 10.1002/pbc.30434. PMID: 37243318
Primary cervical ganglioneuroblastoma, nodular subtype.
McGann EK, Goldberg AM, Lelegren MJ, Pickle JC, Bak MJ, Mark JR
Auris Nasus Larynx 2022 Oct;49(5):889-892. Epub 2021 Apr 16 doi: 10.1016/j.anl.2021.03.010. PMID: 33867181
Irinotecan-temozolomide with temsirolimus or dinutuximab in children with refractory or relapsed neuroblastoma (COG ANBL1221): an open-label, randomised, phase 2 trial.
Mody R, Naranjo A, Van Ryn C, Yu AL, London WB, Shulkin BL, Parisi MT, Servaes SE, Diccianni MB, Sondel PM, Bender JG, Maris JM, Park JR, Bagatell R
Lancet Oncol 2017 Jul;18(7):946-957. Epub 2017 May 23 doi: 10.1016/S1470-2045(17)30355-8. PMID: 28549783Free PMC Article
Laparoscopic adrenalectomy in children.
Lopes RI, Dénes FT, Bissoli J, Mendonca BB, Srougi M
J Pediatr Urol 2012 Aug;8(4):379-85. Epub 2011 Sep 29 doi: 10.1016/j.jpurol.2011.07.012. PMID: 21955529
Pleomorphic (anaplastic) neuroblastoma.
Cozzutto C, Carbone A
Arch Pathol Lab Med 1988 Jun;112(6):621-5. PMID: 3377661

Clinical prediction guides

Characteristics of benign neuroblastic tumors: Is surgery always necessary?
Whitlock RS, Mehl SC, Larson SK, Foster JH, Hicks J, Nuchtern JG, Sher AC, Vasudevan SA, Naik-Mathuria B
J Pediatr Surg 2022 Aug;57(8):1538-1543. Epub 2021 Jul 7 doi: 10.1016/j.jpedsurg.2021.07.002. PMID: 34281709
Harlequin syndrome associated with ganglioneuroblastoma-induced Horner syndrome.
Miyata K, Akaihata M, Shimomura Y, Hori T, Kaneko K, Okumura A
Childs Nerv Syst 2021 Aug;37(8):2683-2686. Epub 2020 Oct 30 doi: 10.1007/s00381-020-04948-1. PMID: 33125512
Primary cervical ganglioneuroblastoma: A case report.
Lu D, Liu J, Chen Y, Chen F, Yang H
Medicine (Baltimore) 2018 Mar;97(12):e0090. doi: 10.1097/MD.0000000000010090. PMID: 29561407Free PMC Article
The clinical management and outcomes of cervical neuroblastic tumors.
Jackson JR, Tran HC, Stein JE, Shimada H, Patel AM, Marachelian A, Kim ES
J Surg Res 2016 Jul;204(1):109-13. Epub 2016 Apr 23 doi: 10.1016/j.jss.2016.04.030. PMID: 27451875Free PMC Article
ALK amplification and protein expression predict inferior prognosis in neuroblastomas.
Wang M, Zhou C, Sun Q, Cai R, Li Y, Wang D, Gong L
Exp Mol Pathol 2013 Oct;95(2):124-30. Epub 2013 Jun 21 doi: 10.1016/j.yexmp.2013.06.002. PMID: 23797004

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