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Salivary Gland Lymphoma

MedGen UID:
1727252
•Concept ID:
C5420341
•
Neoplastic Process
Synonym: Primary Salivary Gland Lymphoma

Definition

A lymphoma that manifests initially in a salivary gland. It usually occurs in the parotid gland. [from NCI]

Professional guidelines

PubMed

Current evidence on diagnosis and treatment of parotid gland lymphomas: a systematic review.
Di Santo D, Bramati C, Festa BM, Pace GM, Comini LV, Luparello P, Cascardi E, Galizia D, Galli A, De Virgilio A, Giordano L, Bondi S
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5219-5227. Epub 2023 Aug 28 doi: 10.1007/s00405-023-08206-3. PMID: 37638999

Recent clinical studies

Etiology

Current evidence on diagnosis and treatment of parotid gland lymphomas: a systematic review.
Di Santo D, Bramati C, Festa BM, Pace GM, Comini LV, Luparello P, Cascardi E, Galizia D, Galli A, De Virgilio A, Giordano L, Bondi S
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5219-5227. Epub 2023 Aug 28 doi: 10.1007/s00405-023-08206-3. PMID: 37638999
Safety, patient acceptance and diagnostic accuracy of ultrasound core needle biopsy of parotid or submandibular glands in primary Sjögren's syndrome with suspected salivary gland lymphoma.
Giovannini I, Lorenzon M, Manfrè V, Zandonella Callegher S, Pegolo E, Zuiani C, Girometti R, Hocevar A, Dejaco C, Luca Q, De Vita S, Zabotti A
RMD Open 2022 Feb;8(1) doi: 10.1136/rmdopen-2021-001901. PMID: 35131750Free PMC Article
Primary salivary gland lymphoma among Japanese: A clinicopathological study of 30 cases.
Kojima M, Shimizu K, Nishikawa M, Tamaki Y, Ito H, Tsukamoto N, Masawa N
Leuk Lymphoma 2007 Sep;48(9):1793-8. doi: 10.1080/10428190701528509. PMID: 17786716
Lymphoid infiltrates of the salivary glands: pathology, biology and clinical significance.
DiGiuseppe JA, Corio RL, Westra WH
Curr Opin Oncol 1996 May;8(3):232-7. doi: 10.1097/00001622-199605000-00011. PMID: 8804813
Non-Hodgkin's lymphoma of the major salivary gland: a morphologic and immunohistochemical study of 15 cases.
Takahashi H, Tsuda N, Tezuka F, Fujita S, Okabe H
J Oral Pathol Med 1990 Aug;19(7):306-12. doi: 10.1111/j.1600-0714.1990.tb00850.x. PMID: 2121963

Diagnosis

Current evidence on diagnosis and treatment of parotid gland lymphomas: a systematic review.
Di Santo D, Bramati C, Festa BM, Pace GM, Comini LV, Luparello P, Cascardi E, Galizia D, Galli A, De Virgilio A, Giordano L, Bondi S
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5219-5227. Epub 2023 Aug 28 doi: 10.1007/s00405-023-08206-3. PMID: 37638999
Safety, patient acceptance and diagnostic accuracy of ultrasound core needle biopsy of parotid or submandibular glands in primary Sjögren's syndrome with suspected salivary gland lymphoma.
Giovannini I, Lorenzon M, Manfrè V, Zandonella Callegher S, Pegolo E, Zuiani C, Girometti R, Hocevar A, Dejaco C, Luca Q, De Vita S, Zabotti A
RMD Open 2022 Feb;8(1) doi: 10.1136/rmdopen-2021-001901. PMID: 35131750Free PMC Article
Ultrasound-Guided Biopsy of Suspected Salivary Gland Lymphoma in Sjögren's Syndrome.
Baer AN, Grader-Beck T, Antiochos B, Birnbaum J, Fradin JM
Arthritis Care Res (Hoboken) 2021 Jun;73(6):849-855. doi: 10.1002/acr.24203. PMID: 32248649Free PMC Article
Comparison of patients with and without pre-existing lymphoma at diagnosis of primary Sjögren's syndrome.
Vasaitis L, Nordmark G, Theander E, Backlin C, Smedby KE, Askling J, Rönnblom L, Sundström C, Baecklund E
Scand J Rheumatol 2019 May;48(3):207-212. Epub 2018 Nov 13 doi: 10.1080/03009742.2018.1523456. PMID: 30422723
Primary lymphoma in the salivary glands: report of five cases and review of the literature.
Shikhani A, Samara M, Allam C, Salem P, Lenhard R
Laryngoscope 1987 Dec;97(12):1438-42. doi: 10.1288/00005537-198712000-00011. PMID: 3316887

Therapy

Safety, patient acceptance and diagnostic accuracy of ultrasound core needle biopsy of parotid or submandibular glands in primary Sjögren's syndrome with suspected salivary gland lymphoma.
Giovannini I, Lorenzon M, Manfrè V, Zandonella Callegher S, Pegolo E, Zuiani C, Girometti R, Hocevar A, Dejaco C, Luca Q, De Vita S, Zabotti A
RMD Open 2022 Feb;8(1) doi: 10.1136/rmdopen-2021-001901. PMID: 35131750Free PMC Article
Two cases of lymphoma of the parotid gland following ablative radioiodine therapy for thyroid carcinoma.
Wiseman JC, Hales IB, Joasoo A
Clin Endocrinol (Oxf) 1982 Jul 1;17(1):85-9. doi: 10.1111/j.1365-2265.1982.tb02637.x. PMID: 7116654

Prognosis

Ultrasound-Guided Biopsy of Suspected Salivary Gland Lymphoma in Sjögren's Syndrome.
Baer AN, Grader-Beck T, Antiochos B, Birnbaum J, Fradin JM
Arthritis Care Res (Hoboken) 2021 Jun;73(6):849-855. doi: 10.1002/acr.24203. PMID: 32248649Free PMC Article
Primary salivary gland lymphoma among Japanese: A clinicopathological study of 30 cases.
Kojima M, Shimizu K, Nishikawa M, Tamaki Y, Ito H, Tsukamoto N, Masawa N
Leuk Lymphoma 2007 Sep;48(9):1793-8. doi: 10.1080/10428190701528509. PMID: 17786716
Primary salivary gland lymphoma: a clinicopathologic study of 23 cases in Taiwan.
Dunn P, Kuo TT, Shih LY, Lin TL, Wang PN, Kuo MC, Tang CC
Acta Haematol 2004;112(4):203-8. doi: 10.1159/000081273. PMID: 15564732
Follicular lymphoma of the salivary gland: a clinicopathological and molecular study of six cases.
Kojima M, Nakamura S, Ichimura K, Shimizu K, Itoh H, Masawa N
Int J Surg Pathol 2001 Oct;9(4):287-93. doi: 10.1177/106689690100900405. PMID: 12574844
Lymphoid infiltrates of the salivary glands: pathology, biology and clinical significance.
DiGiuseppe JA, Corio RL, Westra WH
Curr Opin Oncol 1996 May;8(3):232-7. doi: 10.1097/00001622-199605000-00011. PMID: 8804813

Clinical prediction guides

Safety, patient acceptance and diagnostic accuracy of ultrasound core needle biopsy of parotid or submandibular glands in primary Sjögren's syndrome with suspected salivary gland lymphoma.
Giovannini I, Lorenzon M, Manfrè V, Zandonella Callegher S, Pegolo E, Zuiani C, Girometti R, Hocevar A, Dejaco C, Luca Q, De Vita S, Zabotti A
RMD Open 2022 Feb;8(1) doi: 10.1136/rmdopen-2021-001901. PMID: 35131750Free PMC Article
Ultrasound-Guided Biopsy of Suspected Salivary Gland Lymphoma in Sjögren's Syndrome.
Baer AN, Grader-Beck T, Antiochos B, Birnbaum J, Fradin JM
Arthritis Care Res (Hoboken) 2021 Jun;73(6):849-855. doi: 10.1002/acr.24203. PMID: 32248649Free PMC Article
EBV-associated primary lymphomas in salivary glands of HIV-infected patients.
Ioachim HL, Antonescu C, Giancotti F, Dorsett B
Pathol Res Pract 1998;194(2):87-95. doi: 10.1016/S0344-0338(98)80075-7. PMID: 9584321
Analysis of TH1 and TH2 cytokine production in low grade B cell gastric MALT-type lymphomas stimulated in vitro with Helicobacter pylori.
Hauer AC, Finn TM, MacDonald TT, Spencer J, Isaacson PG
J Clin Pathol 1997 Nov;50(11):957-9. doi: 10.1136/jcp.50.11.957. PMID: 9462249Free PMC Article
Familial Sjögren's syndrome with associated primary salivary gland lymphoma.
Lichtenfeld JL, Kirschner RH, Wiernik PH
Am J Med 1976 Feb;60(2):286-92. doi: 10.1016/0002-9343(76)90439-3. PMID: 766625

Recent systematic reviews

Current evidence on diagnosis and treatment of parotid gland lymphomas: a systematic review.
Di Santo D, Bramati C, Festa BM, Pace GM, Comini LV, Luparello P, Cascardi E, Galizia D, Galli A, De Virgilio A, Giordano L, Bondi S
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5219-5227. Epub 2023 Aug 28 doi: 10.1007/s00405-023-08206-3. PMID: 37638999
Sjögren Syndrome in Primary Salivary Gland Lymphoma.
Travaglino A, Giordano C, Pace M, Varricchio S, Picardi M, Pane F, Staibano S, Mascolo M
Am J Clin Pathol 2020 May 5;153(6):719-724. doi: 10.1093/ajcp/aqaa005. PMID: 32076706

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