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Neurogenic Orthostatic Hypotension

MedGen UID:
1729466
•Concept ID:
C1400301
•
Pathologic Function

Definition

Orthostatic hypotension due to autonomic dysfunction. Primary neurogenic orthostatic hypotension (nOH) may be associated with disorders such as Parkinson disease (PD) and multiple system atrophy (MSA) whereas secondary nOH may be seen in peripheral neuropathies. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeurogenic Orthostatic Hypotension

Professional guidelines

PubMed

Dysautonomia: Diagnosis and Management.
Hovaguimian A
Neurol Clin 2023 Feb;41(1):193-213. Epub 2022 Oct 31 doi: 10.1016/j.ncl.2022.08.002. PMID: 36400555
Diagnosis and treatment of orthostatic hypotension.
Wieling W, Kaufmann H, Claydon VE, van Wijnen VK, Harms MPM, Juraschek SP, Thijs RD
Lancet Neurol 2022 Aug;21(8):735-746. doi: 10.1016/S1474-4422(22)00169-7. PMID: 35841911Free PMC Article
Pharmacologic treatment of orthostatic hypotension.
Park JW, Okamoto LE, Shibao CA, Biaggioni I
Auton Neurosci 2020 Dec;229:102721. Epub 2020 Aug 28 doi: 10.1016/j.autneu.2020.102721. PMID: 32979782Free PMC Article

Recent clinical studies

Therapy

Diagnosis and treatment of orthostatic hypotension.
Wieling W, Kaufmann H, Claydon VE, van Wijnen VK, Harms MPM, Juraschek SP, Thijs RD
Lancet Neurol 2022 Aug;21(8):735-746. doi: 10.1016/S1474-4422(22)00169-7. PMID: 35841911Free PMC Article
Orthostatic hypotension for the cardiologist.
Mar PL, Raj SR
Curr Opin Cardiol 2018 Jan;33(1):66-72. doi: 10.1097/HCO.0000000000000467. PMID: 28984649Free PMC Article
Droxidopa for symptomatic neurogenic orthostatic hypotension: what can we learn?
Kaufmann H
Clin Auton Res 2017 Jul;27(Suppl 1):1-3. Epub 2017 Jun 16 doi: 10.1007/s10286-017-0426-6. PMID: 28623419
Orthostatic hypotension: A review.
Joseph A, Wanono R, Flamant M, Vidal-Petiot E
Nephrol Ther 2017 Apr;13 Suppl 1:S55-S67. doi: 10.1016/j.nephro.2017.01.003. PMID: 28577744
Management of neurogenic orthostatic hypotension.
Arbique D, Cheek D, Welliver M, Vongpatanasin W
J Am Med Dir Assoc 2014 Apr;15(4):234-9. Epub 2014 Jan 2 doi: 10.1016/j.jamda.2013.10.014. PMID: 24388946

Prognosis

Diagnosis and treatment of orthostatic hypotension.
Wieling W, Kaufmann H, Claydon VE, van Wijnen VK, Harms MPM, Juraschek SP, Thijs RD
Lancet Neurol 2022 Aug;21(8):735-746. doi: 10.1016/S1474-4422(22)00169-7. PMID: 35841911Free PMC Article
Dysautonomia: A Forgotten Condition - Part 1.
Rocha EA, Mehta N, Távora-Mehta MZP, Roncari CF, Cidrão AAL, Elias Neto J
Arq Bras Cardiol 2021 Apr;116(4):814-835. doi: 10.36660/abc.20200420. PMID: 33886735Free PMC Article
Differential diagnosis of orthostatic hypotension.
Lei LY, Chew DS, Raj SR
Auton Neurosci 2020 Nov;228:102713. Epub 2020 Aug 1 doi: 10.1016/j.autneu.2020.102713. PMID: 32805514Free PMC Article
Pure Autonomic Failure.
Thaisetthawatkul P
Curr Neurol Neurosci Rep 2016 Aug;16(8):74. doi: 10.1007/s11910-016-0673-2. PMID: 27338613
Neurogenic orthostatic hypotension: pathophysiology and diagnosis.
Low PA
Am J Manag Care 2015 Oct;21(13 Suppl):s248-57. PMID: 26790109

Clinical prediction guides

Mismatch between subjective and objective dysautonomia.
Novak P, Systrom DM, Marciano SP, Knief A, Felsenstein D, Giannetti MP, Hamilton MJ, Nicoloro-SantaBarbara J, Saco TV, Castells M, Farhad K, Pilgrim DM, Mullally WJ
Sci Rep 2024 Jan 30;14(1):2513. doi: 10.1038/s41598-024-52368-x. PMID: 38291116Free PMC Article
Early-onset hereditary isolated non-neurogenic orthostatic hypotension in a Swedish family.
Fagius J, Klar J, Dahl N
Clin Auton Res 2023 Aug;33(4):421-432. Epub 2023 Jul 17 doi: 10.1007/s10286-023-00963-9. PMID: 37460866Free PMC Article
Droxidopa for the treatment of neurogenic orthostatic hypotension in neurodegenerative diseases.
Pérez-Lloret S, Quarracino C, Otero-Losada M, Rascol O
Expert Opin Pharmacother 2019 Apr;20(6):635-645. Epub 2019 Feb 7 doi: 10.1080/14656566.2019.1574746. PMID: 30730771
Diagnosing and treating neurogenic orthostatic hypotension in primary care.
Kuritzky L, Espay AJ, Gelblum J, Payne R, Dietrich E
Postgrad Med 2015;127(7):702-15. Epub 2015 May 27 doi: 10.1080/00325481.2015.1050340. PMID: 26012731
Management of neurogenic orthostatic hypotension.
Arbique D, Cheek D, Welliver M, Vongpatanasin W
J Am Med Dir Assoc 2014 Apr;15(4):234-9. Epub 2014 Jan 2 doi: 10.1016/j.jamda.2013.10.014. PMID: 24388946

Recent systematic reviews

The effects of caffeine in adults with neurogenic orthostatic hypotension: a systematic review.
Gibbon JR, Frith J
Clin Auton Res 2021 Aug;31(4):499-509. Epub 2021 Jun 18 doi: 10.1007/s10286-021-00814-5. PMID: 34143333Free PMC Article
Management of Hypertension and Blood Pressure Dysregulation in Patients with Parkinson's Disease-a Systematic Review.
Katsi V, Papakonstantinou I, Solomou E, Antonopoulos AS, Vlachopoulos C, Tsioufis K
Curr Hypertens Rep 2021 May 7;23(5):26. doi: 10.1007/s11906-021-01146-5. PMID: 33961147
Acute Sensory and Autonomic Neuronopathy: A Devastating Disorder Affecting Sensory and Autonomic Ganglia.
Gutierrez J, Palma JA, Kaufmann H
Semin Neurol 2020 Oct;40(5):580-590. Epub 2020 Sep 9 doi: 10.1055/s-0040-1713843. PMID: 32906171Free PMC Article
The role of autoantibodies in the syndromes of orthostatic intolerance: a systematic review.
Ruzieh M, Batizy L, Dasa O, Oostra C, Grubb B
Scand Cardiovasc J 2017 Oct;51(5):243-247. Epub 2017 Jul 24 doi: 10.1080/14017431.2017.1355068. PMID: 28738696
Droxidopa for orthostatic hypotension: a systematic review and meta-analysis.
Strassheim V, Newton JL, Tan MP, Frith J
J Hypertens 2016 Oct;34(10):1933-41. doi: 10.1097/HJH.0000000000001043. PMID: 27442791

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