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Salivary Gland Diffuse Large B-Cell Lymphoma

MedGen UID:
1730404
•Concept ID:
C2204355
•
Neoplastic Process
Synonym: Primary Salivary Gland Diffuse Large B-Cell Lymphoma

Definition

A diffuse large B-cell lymphoma that manifests initially in a salivary gland. It usually occurs in the parotid gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSalivary Gland Diffuse Large B-Cell Lymphoma

Professional guidelines

PubMed

Current evidence on diagnosis and treatment of parotid gland lymphomas: a systematic review.
Di Santo D, Bramati C, Festa BM, Pace GM, Comini LV, Luparello P, Cascardi E, Galizia D, Galli A, De Virgilio A, Giordano L, Bondi S
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5219-5227. Epub 2023 Aug 28 doi: 10.1007/s00405-023-08206-3. PMID: 37638999
Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.
Luk PP, Selinger CI, Cooper WA, Mahar A, Palme CE, O'Toole SA, Clark JR, Gupta R
Head Neck Pathol 2019 Sep;13(3):397-414. Epub 2018 Nov 22 doi: 10.1007/s12105-018-0988-1. PMID: 30467669Free PMC Article
Influence of differing radiotherapy strategies on treatment results in diffuse large-cell lymphoma: a review.
Nieder C, Licht T, Andratschke N, Peschel C, Molls M
Cancer Treat Rev 2003 Feb;29(1):11-9. doi: 10.1016/s0305-7372(02)00094-4. PMID: 12633576

Recent clinical studies

Etiology

Current evidence on diagnosis and treatment of parotid gland lymphomas: a systematic review.
Di Santo D, Bramati C, Festa BM, Pace GM, Comini LV, Luparello P, Cascardi E, Galizia D, Galli A, De Virgilio A, Giordano L, Bondi S
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5219-5227. Epub 2023 Aug 28 doi: 10.1007/s00405-023-08206-3. PMID: 37638999
Lymphomas of the salivary glands: a systematic review.
Al-Khafaf AE, Al-Shahrestani F, Baysal Y, Rahbek Gjerdrum LM, Heegaard S, Pedersen LM, Homøe P
Acta Otolaryngol 2023 Jul-Aug;143(7):610-616. Epub 2023 Aug 12 doi: 10.1080/00016489.2023.2226689. PMID: 37572309
Primary diffuse large B-cell lymphoma of the major salivary glands: Increasing incidence and survival.
Gupta A, Lee JA, Nguyen SA, Lentsch EJ
Am J Otolaryngol 2021 May-Jun;42(3):102938. Epub 2021 Jan 28 doi: 10.1016/j.amjoto.2021.102938. PMID: 33524741
Predictive markers of lymphomagenesis in Sjögren's syndrome: From clinical data to molecular stratification.
Kapsogeorgou EK, Voulgarelis M, Tzioufas AG
J Autoimmun 2019 Nov;104:102316. Epub 2019 Aug 17 doi: 10.1016/j.jaut.2019.102316. PMID: 31431317
The aetiology of B-cell lymphoid malignancies with a focus on chronic inflammation and infections.
Smedby KE, Ponzoni M
J Intern Med 2017 Nov;282(5):360-370. Epub 2017 Sep 27 doi: 10.1111/joim.12684. PMID: 28875507

Diagnosis

Current evidence on diagnosis and treatment of parotid gland lymphomas: a systematic review.
Di Santo D, Bramati C, Festa BM, Pace GM, Comini LV, Luparello P, Cascardi E, Galizia D, Galli A, De Virgilio A, Giordano L, Bondi S
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5219-5227. Epub 2023 Aug 28 doi: 10.1007/s00405-023-08206-3. PMID: 37638999
Primary diffuse large B-cell lymphoma of the major salivary glands: Increasing incidence and survival.
Gupta A, Lee JA, Nguyen SA, Lentsch EJ
Am J Otolaryngol 2021 May-Jun;42(3):102938. Epub 2021 Jan 28 doi: 10.1016/j.amjoto.2021.102938. PMID: 33524741
Predictive markers of lymphomagenesis in Sjögren's syndrome: From clinical data to molecular stratification.
Kapsogeorgou EK, Voulgarelis M, Tzioufas AG
J Autoimmun 2019 Nov;104:102316. Epub 2019 Aug 17 doi: 10.1016/j.jaut.2019.102316. PMID: 31431317
Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.
Luk PP, Selinger CI, Cooper WA, Mahar A, Palme CE, O'Toole SA, Clark JR, Gupta R
Head Neck Pathol 2019 Sep;13(3):397-414. Epub 2018 Nov 22 doi: 10.1007/s12105-018-0988-1. PMID: 30467669Free PMC Article
Extranodal Lymphoproliferative Processes.
Zeppa P, Cozzolino I
Monogr Clin Cytol 2018;23:81-92. Epub 2017 Nov 13 doi: 10.1159/000478884. PMID: 29130993

Therapy

Lymphoma-associated mutations in autoreactive memory B cells of patients with Sjögren's syndrome.
Bende RJ, Slot LM, Kwakkenbos MJ, Wormhoudt TA, Jongejan A, Verstappen GM, van Kampen AC, Guikema JE, Kroese FG, van Noesel CJ
J Pathol 2023 Mar;259(3):264-275. Epub 2023 Jan 12 doi: 10.1002/path.6039. PMID: 36426826Free PMC Article
Sequential development of multifocal recurrent non-Hodgkin's lymphoma of mucosa-associated lymphoid tissue and diffuse large B-Cell lymphoma in a single patient: A case report.
Yang X, Min X, He W
Medicine (Baltimore) 2018 May;97(21):e10845. doi: 10.1097/MD.0000000000010845. PMID: 29794780Free PMC Article
Rheumatoid Factor and Disease Activity Are Independent Predictors of Lymphoma in Primary Sjögren's Syndrome.
Nocturne G, Virone A, Ng WF, Le Guern V, Hachulla E, Cornec D, Daien C, Vittecoq O, Bienvenu B, Marcelli C, Wendling D, Amoura Z, Dhote R, Lavigne C, Fior R, Gottenberg JE, Seror R, Mariette X
Arthritis Rheumatol 2016 Apr;68(4):977-85. doi: 10.1002/art.39518. PMID: 26606524
Large cell lymphoma associated with prosthetic joint debris.
Ong MG, Ghali GE, Veillon D, Cotelingam J
J La State Med Soc 2012 Jan-Feb;164(1):31-2. doi: 10.1002/sta4.4. PMID: 22533111
Influence of differing radiotherapy strategies on treatment results in diffuse large-cell lymphoma: a review.
Nieder C, Licht T, Andratschke N, Peschel C, Molls M
Cancer Treat Rev 2003 Feb;29(1):11-9. doi: 10.1016/s0305-7372(02)00094-4. PMID: 12633576

Prognosis

Lymphomas of the salivary glands: a systematic review.
Al-Khafaf AE, Al-Shahrestani F, Baysal Y, Rahbek Gjerdrum LM, Heegaard S, Pedersen LM, Homøe P
Acta Otolaryngol 2023 Jul-Aug;143(7):610-616. Epub 2023 Aug 12 doi: 10.1080/00016489.2023.2226689. PMID: 37572309
EBV Association with Lymphomas and Carcinomas in the Oral Compartment.
Ward BJH, Schaal DL, Nkadi EH, Scott RS
Viruses 2022 Dec 1;14(12) doi: 10.3390/v14122700. PMID: 36560704Free PMC Article
Primary diffuse large B-cell lymphoma of the major salivary glands: Increasing incidence and survival.
Gupta A, Lee JA, Nguyen SA, Lentsch EJ
Am J Otolaryngol 2021 May-Jun;42(3):102938. Epub 2021 Jan 28 doi: 10.1016/j.amjoto.2021.102938. PMID: 33524741
Predictive markers of lymphomagenesis in Sjögren's syndrome: From clinical data to molecular stratification.
Kapsogeorgou EK, Voulgarelis M, Tzioufas AG
J Autoimmun 2019 Nov;104:102316. Epub 2019 Aug 17 doi: 10.1016/j.jaut.2019.102316. PMID: 31431317
The aetiology of B-cell lymphoid malignancies with a focus on chronic inflammation and infections.
Smedby KE, Ponzoni M
J Intern Med 2017 Nov;282(5):360-370. Epub 2017 Sep 27 doi: 10.1111/joim.12684. PMID: 28875507

Clinical prediction guides

EBV Association with Lymphomas and Carcinomas in the Oral Compartment.
Ward BJH, Schaal DL, Nkadi EH, Scott RS
Viruses 2022 Dec 1;14(12) doi: 10.3390/v14122700. PMID: 36560704Free PMC Article
Clinical picture, outcome and predictive factors of lymphoma in primary Sjögren's syndrome: results from a harmonized dataset (1981-2021).
Chatzis LG, Stergiou IE, Goules AV, Pezoulas V, Tsourouflis G, Fotiadis D, Tzioufas AG, Voulgarelis M
Rheumatology (Oxford) 2022 Aug 30;61(9):3576-3585. doi: 10.1093/rheumatology/keab939. PMID: 34940812
Predictive markers of lymphomagenesis in Sjögren's syndrome: From clinical data to molecular stratification.
Kapsogeorgou EK, Voulgarelis M, Tzioufas AG
J Autoimmun 2019 Nov;104:102316. Epub 2019 Aug 17 doi: 10.1016/j.jaut.2019.102316. PMID: 31431317
Localized B-cell non-Hodgkin's lymphoma of oral cavity and maxillofacial region: a clinical study.
Kolokotronis A, Konstantinou N, Christakis I, Papadimitriou P, Matiakis A, Zaraboukas T, Antoniades D
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005 Mar;99(3):303-10. doi: 10.1016/j.tripleo.2004.03.028. PMID: 15716836
Influence of differing radiotherapy strategies on treatment results in diffuse large-cell lymphoma: a review.
Nieder C, Licht T, Andratschke N, Peschel C, Molls M
Cancer Treat Rev 2003 Feb;29(1):11-9. doi: 10.1016/s0305-7372(02)00094-4. PMID: 12633576

Recent systematic reviews

Current evidence on diagnosis and treatment of parotid gland lymphomas: a systematic review.
Di Santo D, Bramati C, Festa BM, Pace GM, Comini LV, Luparello P, Cascardi E, Galizia D, Galli A, De Virgilio A, Giordano L, Bondi S
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5219-5227. Epub 2023 Aug 28 doi: 10.1007/s00405-023-08206-3. PMID: 37638999
Lymphomas of the salivary glands: a systematic review.
Al-Khafaf AE, Al-Shahrestani F, Baysal Y, Rahbek Gjerdrum LM, Heegaard S, Pedersen LM, Homøe P
Acta Otolaryngol 2023 Jul-Aug;143(7):610-616. Epub 2023 Aug 12 doi: 10.1080/00016489.2023.2226689. PMID: 37572309

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