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Colon Large Cell Neuroendocrine Carcinoma

MedGen UID:
1730673
•Concept ID:
C5418920
•
Neoplastic Process

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the colon. It is characterized by the presence of malignant large cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColon Large Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Survival According to Primary Tumor Location, Stage, and Treatment Patterns in Locoregional Gastroenteropancreatic High-grade Neuroendocrine Carcinomas.
Dasari A, Shen C, Devabhaktuni A, Nighot R, Sorbye H
Oncologist 2022 Apr 5;27(4):299-306. doi: 10.1093/oncolo/oyab039. PMID: 35380711Free PMC Article
Current concepts in the diagnosis and management of poorly differentiated gastrointestinal neuroendocrine carcinomas.
Koumarianou A, Chatzellis E, Boutzios G, Tsavaris N, Kaltsas G
Endokrynol Pol 2013;64(1):60-72. PMID: 23450449

Recent clinical studies

Etiology

Site-specific trends in gastroenteropancreatic neuroendocrine neoplasms in Bavaria, Germany.
Grundmann N, Voigtländer S, Hakimhashemi A, Pape UF, Meyer M, Müller-Nordhorn J
Cancer Med 2023 Oct;12(19):19949-19958. Epub 2023 Sep 22 doi: 10.1002/cam4.6510. PMID: 37737059Free PMC Article
Patient-Derived Organoid Models of Human Neuroendocrine Carcinoma.
Dijkstra KK, van den Berg JG, Weeber F, van de Haar J, Velds A, Kaing S, Peters DDGC, Eskens FALM, de Groot DA, Tesselaar MET, Voest EE
Front Endocrinol (Lausanne) 2021;12:627819. Epub 2021 Mar 11 doi: 10.3389/fendo.2021.627819. PMID: 33776923Free PMC Article
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Composite intestinal adenoma-microcarcinoid.
Lin J, Goldblum JR, Bennett AE, Bronner MP, Liu X
Am J Surg Pathol 2012 Feb;36(2):292-5. doi: 10.1097/PAS.0b013e318236e4d2. PMID: 22082602
The epidemiology and pathogenesis of neoplasia in the small intestine.
Schottenfeld D, Beebe-Dimmer JL, Vigneau FD
Ann Epidemiol 2009 Jan;19(1):58-69. doi: 10.1016/j.annepidem.2008.10.004. PMID: 19064190Free PMC Article

Diagnosis

Site-specific trends in gastroenteropancreatic neuroendocrine neoplasms in Bavaria, Germany.
Grundmann N, Voigtländer S, Hakimhashemi A, Pape UF, Meyer M, Müller-Nordhorn J
Cancer Med 2023 Oct;12(19):19949-19958. Epub 2023 Sep 22 doi: 10.1002/cam4.6510. PMID: 37737059Free PMC Article
Multiple large cell neuroendocrine carcinomas in the rectum and descending colon presented with liver metastasis: A case report.
Fukushima N, Furukawa K, Takano Y, Suzuki T, Yoshinobu M, Hanyu K, Kobayashi S
Asian J Endosc Surg 2022 Apr;15(2):405-409. Epub 2022 Jan 9 doi: 10.1111/ases.13025. PMID: 35001529
Establishment, functional and genetic characterization of a colon derived large cell neuroendocrine carcinoma cell line.
Gock M, Mullins CS, Harnack C, Prall F, Ramer R, Göder A, Krämer OH, Klar E, Linnebacher M
World J Gastroenterol 2018 Sep 7;24(33):3749-3759. doi: 10.3748/wjg.v24.i33.3749. PMID: 30197480Free PMC Article
Primary Biliary Mixed Adenoneuroendocrine Carcinoma (MANEC): A Short Review.
Acosta AM, Wiley EL
Arch Pathol Lab Med 2016 Oct;140(10):1157-62. doi: 10.5858/arpa.2015-0102-RS. PMID: 27684986
Current concepts in the diagnosis and management of poorly differentiated gastrointestinal neuroendocrine carcinomas.
Koumarianou A, Chatzellis E, Boutzios G, Tsavaris N, Kaltsas G
Endokrynol Pol 2013;64(1):60-72. PMID: 23450449

Therapy

Patient-Derived Organoid Models of Human Neuroendocrine Carcinoma.
Dijkstra KK, van den Berg JG, Weeber F, van de Haar J, Velds A, Kaing S, Peters DDGC, Eskens FALM, de Groot DA, Tesselaar MET, Voest EE
Front Endocrinol (Lausanne) 2021;12:627819. Epub 2021 Mar 11 doi: 10.3389/fendo.2021.627819. PMID: 33776923Free PMC Article
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Colorectal Large-Cell Neuroendocrine Carcinoma: Case Report and Literature Review for Potential Novel Therapeutic Options.
Chen X, Wang X, Abadi M, Kumar A
Clin Colorectal Cancer 2020 Mar;19(1):61-64. Epub 2019 Oct 31 doi: 10.1016/j.clcc.2019.10.005. PMID: 31761668
Aggressive large-cell neuroendocrine carcinoma of the sigmoid colon in a patient with ulcerative colitis.
Stoner P, Ghaffaripour T, Cohen D
BMJ Case Rep 2017 Aug 7;2017 doi: 10.1136/bcr-2017-220093. PMID: 28790093Free PMC Article
Current concepts in the diagnosis and management of poorly differentiated gastrointestinal neuroendocrine carcinomas.
Koumarianou A, Chatzellis E, Boutzios G, Tsavaris N, Kaltsas G
Endokrynol Pol 2013;64(1):60-72. PMID: 23450449

Prognosis

Neuroendocrine tumor G3 of bronchopulmonary origin and its classification.
Kasajima A, Klöppel G
Pathol Int 2022 Oct;72(10):488-495. Epub 2022 Aug 19 doi: 10.1111/pin.13266. PMID: 35983917
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Primary Biliary Mixed Adenoneuroendocrine Carcinoma (MANEC): A Short Review.
Acosta AM, Wiley EL
Arch Pathol Lab Med 2016 Oct;140(10):1157-62. doi: 10.5858/arpa.2015-0102-RS. PMID: 27684986
Composite intestinal adenoma-microcarcinoid.
Lin J, Goldblum JR, Bennett AE, Bronner MP, Liu X
Am J Surg Pathol 2012 Feb;36(2):292-5. doi: 10.1097/PAS.0b013e318236e4d2. PMID: 22082602
The epidemiology and pathogenesis of neoplasia in the small intestine.
Schottenfeld D, Beebe-Dimmer JL, Vigneau FD
Ann Epidemiol 2009 Jan;19(1):58-69. doi: 10.1016/j.annepidem.2008.10.004. PMID: 19064190Free PMC Article

Clinical prediction guides

Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Establishment, functional and genetic characterization of a colon derived large cell neuroendocrine carcinoma cell line.
Gock M, Mullins CS, Harnack C, Prall F, Ramer R, Göder A, Krämer OH, Klar E, Linnebacher M
World J Gastroenterol 2018 Sep 7;24(33):3749-3759. doi: 10.3748/wjg.v24.i33.3749. PMID: 30197480Free PMC Article
Neuroendocrine carcinoma of unknown primary site.
Spigel DR, Hainsworth JD, Greco FA
Semin Oncol 2009 Feb;36(1):52-9. doi: 10.1053/j.seminoncol.2008.10.003. PMID: 19179188
Biology of colorectal and gastric cancer cell lines.
Park JG, Gazdar AF
J Cell Biochem Suppl 1996;24:131-41. doi: 10.1002/jcb.240630508. PMID: 8806095
Neuroendocrine tumors of the gastrointestinal tract.
Chejfec G, Falkmer S, Askensten U, Grimelius L, Gould VE
Pathol Res Pract 1988 Apr;183(2):143-54. doi: 10.1016/S0344-0338(88)80042-6. PMID: 3290866

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