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Skin Spindle Cell Lipoma

MedGen UID:
1732074
•Concept ID:
C5418577
•
Neoplastic Process

Definition

A spindle cell lipoma arising from the skin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin Spindle Cell Lipoma

Professional guidelines

PubMed

Cutaneous side effects in a cohort of patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: General description and further characterization, correlation with photoexposition and study of hypopigmentation as treatment's prognostic factor.
Llamas-Velasco M, Ovejero-Merino E, García-Diez A, Requena L, Daudén E, Steegmann JL
Dermatol Ther 2020 Nov;33(6):e14428. Epub 2020 Nov 3 doi: 10.1111/dth.14428. PMID: 33073453

Recent clinical studies

Etiology

Histopathologic and genetic findings in atypical spindle cell/pleomorphic lipomatous tumors and atypical pleomorphic fibromas.
Kouhsari LM, LeBoit PE, McCalmont TH, Hinds B, North JP
J Cutan Pathol 2022 Jul;49(7):623-631. Epub 2022 Apr 5 doi: 10.1111/cup.14230. PMID: 35332938
Cutaneous CD34+ spindle cell neoplasms: Histopathologic features distinguish spindle cell lipoma, solitary fibrous tumor, and dermatofibrosarcoma protuberans.
Wood L, Fountaine TJ, Rosamilia L, Helm KF, Clarke LE
Am J Dermatopathol 2010 Dec;32(8):764-8. doi: 10.1097/DAD.0b013e3181d0c587. PMID: 20559119
Coexistence of spindle cell lipoma and ordinary lipoma.
Sakai H, Kuroda K, Hara D, Tajima S
J Dermatol 2004 Oct;31(10):831-4. doi: 10.1111/j.1346-8138.2004.tb00610.x. PMID: 15672714
Intradermal spindle cell/pleomorphic lipoma: a distinct subset.
French CA, Mentzel T, Kutzner H, Fletcher CD
Am J Dermatopathol 2000 Dec;22(6):496-502. doi: 10.1097/00000372-200012000-00003. PMID: 11190440
Liposarcoma: new entities and evolving concepts.
Dei Tos AP
Ann Diagn Pathol 2000 Aug;4(4):252-66. doi: 10.1053/adpa.2000.8133. PMID: 10982304

Diagnosis

PRAME immunohistochemistry in soft tissue tumors and mimics: a study of 350 cases highlighting its imperfect specificity but potentially useful diagnostic applications.
Cammareri C, Beltzung F, Michal M, Vanhersecke L, Coindre JM, Velasco V, Le Loarer F, Vergier B, Perret R
Virchows Arch 2023 Aug;483(2):145-156. Epub 2023 Jul 21 doi: 10.1007/s00428-023-03606-6. PMID: 37477762
Practical approach to diagnosis of bland-looking spindle cell lesions of the breast.
Magro G, Salvatorelli L, Puzzo L, Piombino E, Bartoloni G, Broggi G, Vecchio GM
Pathologica 2019 Dec;111(4):344-360. doi: 10.32074/1591-951X-31-19. PMID: 31965112Free PMC Article
Dermal plexiform spindle cell lipoma.
Val-Bernal JF, Hermana S
Rom J Morphol Embryol 2016;57(2 Suppl):875-878. PMID: 27833986
Uncommon Tumor, Uncommon Location: A Dermal-Based Spindle Cell/Pleomorphic Lipoma.
Lincoln M, Royer M
Am J Dermatopathol 2016 Aug;38(8):e122-4. doi: 10.1097/DAD.0000000000000546. PMID: 26913848
Spindle-cell lipoma of the skin.
Duve S, Müller-Höcker J, Worret WI
Am J Dermatopathol 1995 Oct;17(5):529-33. doi: 10.1097/00000372-199510000-00017. PMID: 8599462

Therapy

Cutaneous side effects in a cohort of patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: General description and further characterization, correlation with photoexposition and study of hypopigmentation as treatment's prognostic factor.
Llamas-Velasco M, Ovejero-Merino E, García-Diez A, Requena L, Daudén E, Steegmann JL
Dermatol Ther 2020 Nov;33(6):e14428. Epub 2020 Nov 3 doi: 10.1111/dth.14428. PMID: 33073453
Loss of retinoblastoma in pleomorphic fibroma: An immunohistochemical and genomic analysis.
Hinds B, Agulló Pérez AD, LeBoit PE, McCalmont TH, North JP
J Cutan Pathol 2017 Aug;44(8):665-671. Epub 2017 Jun 13 doi: 10.1111/cup.12965. PMID: 28543636
CD34-positive superficial myxofibrosarcoma: a potential diagnostic pitfall.
Smith SC, Poznanski AA, Fullen DR, Ma L, McHugh JB, Lucas DR, Patel RM
J Cutan Pathol 2013 Jul;40(7):639-45. Epub 2013 Apr 19 doi: 10.1111/cup.12158. PMID: 23600956
Selected case from the Arkadi M. Rywlin International Pathology Slide Seminar: sclerotic (fibroma-like) lipoma, dorsum of right hand.
Allen PW
Adv Anat Pathol 2013 Jan;20(1):68-72. doi: 10.1097/PAP.0b013e31827b65e3. PMID: 23232574
Sclerotic (fibroma-like) lipoma: a distinctive lipoma variant with a predilection for the distal extremities.
Laskin WB, Fetsch JF, Michal M, Miettinen M
Am J Dermatopathol 2006 Aug;28(4):308-16. doi: 10.1097/00000372-200608000-00003. PMID: 16871033

Prognosis

Practical approach to diagnosis of bland-looking spindle cell lesions of the breast.
Magro G, Salvatorelli L, Puzzo L, Piombino E, Bartoloni G, Broggi G, Vecchio GM
Pathologica 2019 Dec;111(4):344-360. doi: 10.32074/1591-951X-31-19. PMID: 31965112Free PMC Article
Uncommon Tumor, Uncommon Location: A Dermal-Based Spindle Cell/Pleomorphic Lipoma.
Lincoln M, Royer M
Am J Dermatopathol 2016 Aug;38(8):e122-4. doi: 10.1097/DAD.0000000000000546. PMID: 26913848
Cutaneous CD34+ spindle cell neoplasms: Histopathologic features distinguish spindle cell lipoma, solitary fibrous tumor, and dermatofibrosarcoma protuberans.
Wood L, Fountaine TJ, Rosamilia L, Helm KF, Clarke LE
Am J Dermatopathol 2010 Dec;32(8):764-8. doi: 10.1097/DAD.0b013e3181d0c587. PMID: 20559119
Cutaneous lipomatous neoplasms.
Mentzel T
Semin Diagn Pathol 2001 Nov;18(4):250-7. PMID: 11757864
Liposarcoma: new entities and evolving concepts.
Dei Tos AP
Ann Diagn Pathol 2000 Aug;4(4):252-66. doi: 10.1053/adpa.2000.8133. PMID: 10982304

Clinical prediction guides

Histopathologic and genetic findings in atypical spindle cell/pleomorphic lipomatous tumors and atypical pleomorphic fibromas.
Kouhsari LM, LeBoit PE, McCalmont TH, Hinds B, North JP
J Cutan Pathol 2022 Jul;49(7):623-631. Epub 2022 Apr 5 doi: 10.1111/cup.14230. PMID: 35332938
Uncommon Tumor, Uncommon Location: A Dermal-Based Spindle Cell/Pleomorphic Lipoma.
Lincoln M, Royer M
Am J Dermatopathol 2016 Aug;38(8):e122-4. doi: 10.1097/DAD.0000000000000546. PMID: 26913848
Cutaneous CD34+ spindle cell neoplasms: Histopathologic features distinguish spindle cell lipoma, solitary fibrous tumor, and dermatofibrosarcoma protuberans.
Wood L, Fountaine TJ, Rosamilia L, Helm KF, Clarke LE
Am J Dermatopathol 2010 Dec;32(8):764-8. doi: 10.1097/DAD.0b013e3181d0c587. PMID: 20559119
Liposarcoma: new entities and evolving concepts.
Dei Tos AP
Ann Diagn Pathol 2000 Aug;4(4):252-66. doi: 10.1053/adpa.2000.8133. PMID: 10982304
Spindle-cell lipoma of the skin.
Duve S, Müller-Höcker J, Worret WI
Am J Dermatopathol 1995 Oct;17(5):529-33. doi: 10.1097/00000372-199510000-00017. PMID: 8599462

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