U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Unresectable Vulvar Carcinoma

MedGen UID:
1734345
•Concept ID:
C5420646
•
Neoplastic Process

Definition

Vulvar carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Vulvar Carcinoma

Professional guidelines

PubMed

Management of inguinal lymph nodes in locally advanced, surgically unresectable, squamous cell carcinoma of the vulva.
Swift BE, Khoja L, Matthews J, Croke J, Laframboise S, Leung E, Gien LT
Gynecol Oncol 2024 Aug;187:46-50. Epub 2024 May 8 doi: 10.1016/j.ygyno.2024.04.025. PMID: 38723339
Carcinoma of the vulva: combined modality treatment.
Montana GS
Curr Treat Options Oncol 2004 Apr;5(2):85-95. doi: 10.1007/s11864-004-0041-3. PMID: 14990203
Management of locally advanced squamous cell carcinoma of the vulva.
Hoffman MS, Greenberg H, Roberts WS, Fiorica JV, LaPolla JP, Barton DP, Cavanagh D
J Gynecol Surg 1991 Fall;7(3):175-82. doi: 10.1089/gyn.1991.7.175. PMID: 10149781

Recent clinical studies

Etiology

NOTCH1 and PIK3CA mutation are related to HPV-associated vulvar squamous cell carcinoma.
Choschzick M, Stergiou C, Gut A, Zoche M, Ross JS, Moch H
Pathol Res Pract 2023 Nov;251:154877. Epub 2023 Oct 7 doi: 10.1016/j.prp.2023.154877. PMID: 37839360
High-dose intensity-modulated chemoradiotherapy in vulvar squamous cell carcinoma: Outcome and toxicity.
Rishi A, Rollins M, Ahmed KA, Hunt DC, Sarkar P, Fernandez DC, Hoffman MS, Apte SM, Shahzad MMK, Chon HS, Chern JY, Wenham RM, Montejo ME
Gynecol Oncol 2020 Feb;156(2):349-356. Epub 2019 Nov 23 doi: 10.1016/j.ygyno.2019.11.027. PMID: 31771865
Human papillomavirus and nonhuman papillomavirus pathways to vulvar squamous cell carcinoma: A review.
Nitecki R, Feltmate CM
Curr Probl Cancer 2018 Sep;42(5):476-485. Epub 2018 Jul 5 doi: 10.1016/j.currproblcancer.2018.06.008. PMID: 30093165
Chemoradiation for advanced primary vulval cancer.
Shylasree TS, Bryant A, Howells RE
Cochrane Database Syst Rev 2011 Apr 13;2011(4):CD003752. doi: 10.1002/14651858.CD003752.pub3. PMID: 21491387Free PMC Article
Vulvar carcinoma.
Coleman RL, Santoso JT
Curr Treat Options Oncol 2000 Jun;1(2):177-90. doi: 10.1007/s11864-000-0063-4. PMID: 12057056

Diagnosis

Human papillomavirus and nonhuman papillomavirus pathways to vulvar squamous cell carcinoma: A review.
Nitecki R, Feltmate CM
Curr Probl Cancer 2018 Sep;42(5):476-485. Epub 2018 Jul 5 doi: 10.1016/j.currproblcancer.2018.06.008. PMID: 30093165
Basal cell carcinoma of the vulva: a case series.
Mulvany NJ, Rayoo M, Allen DG
Pathology 2012 Oct;44(6):528-33. doi: 10.1097/PAT.0b013e328357a001. PMID: 22935972
Comparison of outcome measures in patients with advanced squamous cell carcinoma of the vulva treated with surgery or primary chemoradiation.
Landrum LM, Skaggs V, Gould N, Walker JL, McMeekin DS
Gynecol Oncol 2008 Mar;108(3):584-90. Epub 2007 Dec 26 doi: 10.1016/j.ygyno.2007.11.010. PMID: 18155755
Groin recurrence in patients with vulvar cancer with negative nodes on superficial inguinal lymphadenectomy.
Gordinier ME, Malpica A, Burke TW, Bodurka DC, Wolf JK, Jhingran A, Ramirez PT, Levenback C
Gynecol Oncol 2003 Sep;90(3):625-8. doi: 10.1016/s0090-8258(03)00374-3. PMID: 13678736
Vulvar carcinoma.
Coleman RL, Santoso JT
Curr Treat Options Oncol 2000 Jun;1(2):177-90. doi: 10.1007/s11864-000-0063-4. PMID: 12057056

Therapy

A phase 2 study of combined chemo-immunotherapy with cisplatin-pembrolizumab and radiation for unresectable vulvar squamous cell carcinoma.
Yeku O, Russo AL, Lee H, Spriggs D
J Transl Med 2020 Sep 14;18(1):350. doi: 10.1186/s12967-020-02523-5. PMID: 32928237Free PMC Article
High-dose intensity-modulated chemoradiotherapy in vulvar squamous cell carcinoma: Outcome and toxicity.
Rishi A, Rollins M, Ahmed KA, Hunt DC, Sarkar P, Fernandez DC, Hoffman MS, Apte SM, Shahzad MMK, Chon HS, Chern JY, Wenham RM, Montejo ME
Gynecol Oncol 2020 Feb;156(2):349-356. Epub 2019 Nov 23 doi: 10.1016/j.ygyno.2019.11.027. PMID: 31771865
Chemoradiation for advanced primary vulval cancer.
Shylasree TS, Bryant A, Howells RE
Cochrane Database Syst Rev 2011 Apr 13;2011(4):CD003752. doi: 10.1002/14651858.CD003752.pub3. PMID: 21491387Free PMC Article
Vulvar carcinoma.
Coleman RL, Santoso JT
Curr Treat Options Oncol 2000 Jun;1(2):177-90. doi: 10.1007/s11864-000-0063-4. PMID: 12057056
Prolonged continuous infusion cisplatin and 5-fluorouracil with radiation for locally advanced carcinoma of the vulva.
Eifel PJ, Morris M, Burke TW, Levenback C, Gershenson DM
Gynecol Oncol 1995 Oct;59(1):51-6. doi: 10.1006/gyno.1995.1267. PMID: 7557615

Prognosis

Surgery after upfront chemoradiation in locally advanced squamous cell vulvar cancer: Analysis of postoperative outcomes and survival.
Federico A, Lancellotta V, Fragomeni SM, Macchia G, Ammar S, Pasciuto T, Santoro A, Corrado G, Piermattei A, Gallotta V, Tagliaferri L, Zannoni G, Gambacorta MA, Scambia G, Garganese G
Gynecol Oncol 2024 Dec;191:106-113. Epub 2024 Oct 16 doi: 10.1016/j.ygyno.2024.10.005. PMID: 39413556
High-dose intensity-modulated chemoradiotherapy in vulvar squamous cell carcinoma: Outcome and toxicity.
Rishi A, Rollins M, Ahmed KA, Hunt DC, Sarkar P, Fernandez DC, Hoffman MS, Apte SM, Shahzad MMK, Chon HS, Chern JY, Wenham RM, Montejo ME
Gynecol Oncol 2020 Feb;156(2):349-356. Epub 2019 Nov 23 doi: 10.1016/j.ygyno.2019.11.027. PMID: 31771865
Human papillomavirus and nonhuman papillomavirus pathways to vulvar squamous cell carcinoma: A review.
Nitecki R, Feltmate CM
Curr Probl Cancer 2018 Sep;42(5):476-485. Epub 2018 Jul 5 doi: 10.1016/j.currproblcancer.2018.06.008. PMID: 30093165
Carcinoma of the vulva.
Stehman FB, Look KY
Obstet Gynecol 2006 Mar;107(3):719-33. doi: 10.1097/01.AOG.0000202404.55215.72. PMID: 16507947
Preoperative chemoradiation for advanced vulvar cancer: a phase II study of the Gynecologic Oncology Group.
Moore DH, Thomas GM, Montana GS, Saxer A, Gallup DG, Olt G
Int J Radiat Oncol Biol Phys 1998 Aug 1;42(1):79-85. doi: 10.1016/s0360-3016(98)00193-x. PMID: 9747823

Clinical prediction guides

Surgery after upfront chemoradiation in locally advanced squamous cell vulvar cancer: Analysis of postoperative outcomes and survival.
Federico A, Lancellotta V, Fragomeni SM, Macchia G, Ammar S, Pasciuto T, Santoro A, Corrado G, Piermattei A, Gallotta V, Tagliaferri L, Zannoni G, Gambacorta MA, Scambia G, Garganese G
Gynecol Oncol 2024 Dec;191:106-113. Epub 2024 Oct 16 doi: 10.1016/j.ygyno.2024.10.005. PMID: 39413556
High-dose intensity-modulated chemoradiotherapy in vulvar squamous cell carcinoma: Outcome and toxicity.
Rishi A, Rollins M, Ahmed KA, Hunt DC, Sarkar P, Fernandez DC, Hoffman MS, Apte SM, Shahzad MMK, Chon HS, Chern JY, Wenham RM, Montejo ME
Gynecol Oncol 2020 Feb;156(2):349-356. Epub 2019 Nov 23 doi: 10.1016/j.ygyno.2019.11.027. PMID: 31771865
Chemoradiation for advanced primary vulval cancer.
Shylasree TS, Bryant A, Howells RE
Cochrane Database Syst Rev 2011 Apr 13;2011(4):CD003752. doi: 10.1002/14651858.CD003752.pub3. PMID: 21491387Free PMC Article
Comparison of outcome measures in patients with advanced squamous cell carcinoma of the vulva treated with surgery or primary chemoradiation.
Landrum LM, Skaggs V, Gould N, Walker JL, McMeekin DS
Gynecol Oncol 2008 Mar;108(3):584-90. Epub 2007 Dec 26 doi: 10.1016/j.ygyno.2007.11.010. PMID: 18155755
Synchronous radiation and cytotoxic chemotherapy for locally advanced or recurrent squamous cancer of the vulva.
Russell AH, Mesic JB, Scudder SA, Rosenberg PJ, Smith LH, Kinney WK, Townsend DE, Trelford JD, Taylor MH, Zukowski CL
Gynecol Oncol 1992 Oct;47(1):14-20. doi: 10.1016/0090-8258(92)90068-t. PMID: 1427394

Recent systematic reviews

Chemoradiation for advanced primary vulval cancer.
Shylasree TS, Bryant A, Howells RE
Cochrane Database Syst Rev 2011 Apr 13;2011(4):CD003752. doi: 10.1002/14651858.CD003752.pub3. PMID: 21491387Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...