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Unresectable Primary Peritoneal Adenocarcinoma

MedGen UID:
1734723
•Concept ID:
C5418917
•
Neoplastic Process

Definition

Primary peritoneal adenocarcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Primary Peritoneal Adenocarcinoma

Professional guidelines

PubMed

Intraperitoneal chemotherapy in the management of pancreatic adenocarcinoma: A systematic review and meta-analysis.
Frassini S, Calabretto F, Granieri S, Fugazzola P, Viganò J, Fazzini N, Ansaloni L, Cobianchi L
Eur J Surg Oncol 2022 Sep;48(9):1911-1921. Epub 2022 Jun 2 doi: 10.1016/j.ejso.2022.05.030. PMID: 35688711
Clinicopathological features and treatment outcomes of metastatic or locally unresectable small bowel adenocarcinoma.
Li X, Ying H, Cheng Y, Zhao L, Zhao S, Bai C, Zhou J
J BUON 2019 Nov-Dec;24(6):2539-2545. PMID: 31983130
Multidisciplinary management of intrahepatic cholangiocarcinoma: Current approaches.
Guro H, Kim JW, Choi Y, Cho JY, Yoon YS, Han HS
Surg Oncol 2017 Jun;26(2):146-152. Epub 2017 Mar 7 doi: 10.1016/j.suronc.2017.03.001. PMID: 28577720

Recent clinical studies

Etiology

Intraperitoneal chemotherapy in the management of pancreatic adenocarcinoma: A systematic review and meta-analysis.
Frassini S, Calabretto F, Granieri S, Fugazzola P, Viganò J, Fazzini N, Ansaloni L, Cobianchi L
Eur J Surg Oncol 2022 Sep;48(9):1911-1921. Epub 2022 Jun 2 doi: 10.1016/j.ejso.2022.05.030. PMID: 35688711
Clinical impact of primary tumor sidedness and sex on unresectable post-recurrence survival in resected pathological stage II-III colorectal cancers: a nationwide multicenter retrospective study.
Abe S, Kawai K, Nozawa H, Sasaki K, Murono K, Emoto S, Ozawa T, Yokoyama Y, Nagai Y, Anzai H, Sonoda H, Yamauchi S, Sugihara K, Ishihara S
BMC Cancer 2022 May 2;22(1):486. doi: 10.1186/s12885-022-09615-z. PMID: 35501727Free PMC Article
Efficacy and safety of weekly paclitaxel with or without ramucirumab as second-line therapy for the treatment of advanced gastric or gastroesophageal junction adenocarcinoma (RAINBOW-Asia): a randomised, multicentre, double-blind, phase 3 trial.
Xu RH, Zhang Y, Pan H, Feng J, Zhang T, Liu T, Qin Y, Qin S, Yin X, Liu B, Ba Y, Yang N, Voon PJ, Tanasanvimon S, Zhou C, Zhang WL, Shen L
Lancet Gastroenterol Hepatol 2021 Dec;6(12):1015-1024. Epub 2021 Oct 7 doi: 10.1016/S2468-1253(21)00313-7. PMID: 34626550
Clinicopathological features and treatment outcomes of metastatic or locally unresectable small bowel adenocarcinoma.
Li X, Ying H, Cheng Y, Zhao L, Zhao S, Bai C, Zhou J
J BUON 2019 Nov-Dec;24(6):2539-2545. PMID: 31983130
Efficacy of palliative radiotherapy and chemo-radiotherapy for unresectable gastric cancer demonstrating bleeding and obstruction.
Hiramoto S, Kikuchi A, Tetsuso H, Yoshioka A, Kohigashi Y, Maeda I
Int J Clin Oncol 2018 Dec;23(6):1090-1094. Epub 2018 Jul 17 doi: 10.1007/s10147-018-1317-0. PMID: 30019177

Diagnosis

Is surgical resection justified for pancreatic ductal adenocarcinoma with distant abdominal organ metastasis? A position paper by experts in pancreatic surgery at the Joint Meeting of the International Association of Pancreatology (IAP) & the Japan Pancreas Society (JPS) 2022 in Kyoto.
Hashimoto D, Satoi S, Fujii T, Sho M, He J, Hackert T, Del Chiaro M, Jang JY, Gulla A, Yoon YS, Shan YS, Lou W, Valente R, Furuse J, Oba A, Nagai M, Terai T, Tanaka H, Sakai A, Yamamoto T, Yamaki S, Matsumoto I, Murakami Y, Takaori K, Takeyama Y
Pancreatology 2023 Sep;23(6):682-688. Epub 2023 Jul 20 doi: 10.1016/j.pan.2023.07.005. PMID: 37507301
Neoadjuvant concurrent chemoradiotherapy using infusional gemcitabine in locally advanced rectal cancer: A phase II trial.
Bazarbashi S, Elshenawy MA, Badran A, Aljubran A, Alzahrani A, Almanea H, Alsuhaibani A, Alashwah A, Neimatallah M, Abduljabbar A, Ashari L, Alhomoud S, Ghebeh H, Elhassan T, Alsanea N, Mohiuddin M
Cancer Med 2022 May;11(10):2056-2066. Epub 2022 Feb 10 doi: 10.1002/cam4.4590. PMID: 35146939Free PMC Article
Efficacy and safety of weekly paclitaxel with or without ramucirumab as second-line therapy for the treatment of advanced gastric or gastroesophageal junction adenocarcinoma (RAINBOW-Asia): a randomised, multicentre, double-blind, phase 3 trial.
Xu RH, Zhang Y, Pan H, Feng J, Zhang T, Liu T, Qin Y, Qin S, Yin X, Liu B, Ba Y, Yang N, Voon PJ, Tanasanvimon S, Zhou C, Zhang WL, Shen L
Lancet Gastroenterol Hepatol 2021 Dec;6(12):1015-1024. Epub 2021 Oct 7 doi: 10.1016/S2468-1253(21)00313-7. PMID: 34626550
Exploring the role of resection of extrahepatic metastases from hepatocellular carcinoma.
Chua TC, Morris DL
Surg Oncol 2012 Jun;21(2):95-101. Epub 2011 Mar 11 doi: 10.1016/j.suronc.2011.01.005. PMID: 21397495
Pancreatic adenocarcinoma.
Howard TJ
Curr Probl Cancer 1996 Sep-Oct;20(5):281-328. doi: 10.1016/s0147-0272(96)80001-8. PMID: 8902402

Therapy

Intraperitoneal chemotherapy in the management of pancreatic adenocarcinoma: A systematic review and meta-analysis.
Frassini S, Calabretto F, Granieri S, Fugazzola P, Viganò J, Fazzini N, Ansaloni L, Cobianchi L
Eur J Surg Oncol 2022 Sep;48(9):1911-1921. Epub 2022 Jun 2 doi: 10.1016/j.ejso.2022.05.030. PMID: 35688711
Neoadjuvant concurrent chemoradiotherapy using infusional gemcitabine in locally advanced rectal cancer: A phase II trial.
Bazarbashi S, Elshenawy MA, Badran A, Aljubran A, Alzahrani A, Almanea H, Alsuhaibani A, Alashwah A, Neimatallah M, Abduljabbar A, Ashari L, Alhomoud S, Ghebeh H, Elhassan T, Alsanea N, Mohiuddin M
Cancer Med 2022 May;11(10):2056-2066. Epub 2022 Feb 10 doi: 10.1002/cam4.4590. PMID: 35146939Free PMC Article
Efficacy and safety of weekly paclitaxel with or without ramucirumab as second-line therapy for the treatment of advanced gastric or gastroesophageal junction adenocarcinoma (RAINBOW-Asia): a randomised, multicentre, double-blind, phase 3 trial.
Xu RH, Zhang Y, Pan H, Feng J, Zhang T, Liu T, Qin Y, Qin S, Yin X, Liu B, Ba Y, Yang N, Voon PJ, Tanasanvimon S, Zhou C, Zhang WL, Shen L
Lancet Gastroenterol Hepatol 2021 Dec;6(12):1015-1024. Epub 2021 Oct 7 doi: 10.1016/S2468-1253(21)00313-7. PMID: 34626550
Clinicopathological features and treatment outcomes of metastatic or locally unresectable small bowel adenocarcinoma.
Li X, Ying H, Cheng Y, Zhao L, Zhao S, Bai C, Zhou J
J BUON 2019 Nov-Dec;24(6):2539-2545. PMID: 31983130
Multidisciplinary management of intrahepatic cholangiocarcinoma: Current approaches.
Guro H, Kim JW, Choi Y, Cho JY, Yoon YS, Han HS
Surg Oncol 2017 Jun;26(2):146-152. Epub 2017 Mar 7 doi: 10.1016/j.suronc.2017.03.001. PMID: 28577720

Prognosis

Is surgical resection justified for pancreatic ductal adenocarcinoma with distant abdominal organ metastasis? A position paper by experts in pancreatic surgery at the Joint Meeting of the International Association of Pancreatology (IAP) & the Japan Pancreas Society (JPS) 2022 in Kyoto.
Hashimoto D, Satoi S, Fujii T, Sho M, He J, Hackert T, Del Chiaro M, Jang JY, Gulla A, Yoon YS, Shan YS, Lou W, Valente R, Furuse J, Oba A, Nagai M, Terai T, Tanaka H, Sakai A, Yamamoto T, Yamaki S, Matsumoto I, Murakami Y, Takaori K, Takeyama Y
Pancreatology 2023 Sep;23(6):682-688. Epub 2023 Jul 20 doi: 10.1016/j.pan.2023.07.005. PMID: 37507301
Clinical impact of primary tumor sidedness and sex on unresectable post-recurrence survival in resected pathological stage II-III colorectal cancers: a nationwide multicenter retrospective study.
Abe S, Kawai K, Nozawa H, Sasaki K, Murono K, Emoto S, Ozawa T, Yokoyama Y, Nagai Y, Anzai H, Sonoda H, Yamauchi S, Sugihara K, Ishihara S
BMC Cancer 2022 May 2;22(1):486. doi: 10.1186/s12885-022-09615-z. PMID: 35501727Free PMC Article
Neoadjuvant concurrent chemoradiotherapy using infusional gemcitabine in locally advanced rectal cancer: A phase II trial.
Bazarbashi S, Elshenawy MA, Badran A, Aljubran A, Alzahrani A, Almanea H, Alsuhaibani A, Alashwah A, Neimatallah M, Abduljabbar A, Ashari L, Alhomoud S, Ghebeh H, Elhassan T, Alsanea N, Mohiuddin M
Cancer Med 2022 May;11(10):2056-2066. Epub 2022 Feb 10 doi: 10.1002/cam4.4590. PMID: 35146939Free PMC Article
Clinicopathological features and treatment outcomes of metastatic or locally unresectable small bowel adenocarcinoma.
Li X, Ying H, Cheng Y, Zhao L, Zhao S, Bai C, Zhou J
J BUON 2019 Nov-Dec;24(6):2539-2545. PMID: 31983130
Multidisciplinary management of intrahepatic cholangiocarcinoma: Current approaches.
Guro H, Kim JW, Choi Y, Cho JY, Yoon YS, Han HS
Surg Oncol 2017 Jun;26(2):146-152. Epub 2017 Mar 7 doi: 10.1016/j.suronc.2017.03.001. PMID: 28577720

Clinical prediction guides

Intraperitoneal chemotherapy in the management of pancreatic adenocarcinoma: A systematic review and meta-analysis.
Frassini S, Calabretto F, Granieri S, Fugazzola P, Viganò J, Fazzini N, Ansaloni L, Cobianchi L
Eur J Surg Oncol 2022 Sep;48(9):1911-1921. Epub 2022 Jun 2 doi: 10.1016/j.ejso.2022.05.030. PMID: 35688711
Clinical impact of primary tumor sidedness and sex on unresectable post-recurrence survival in resected pathological stage II-III colorectal cancers: a nationwide multicenter retrospective study.
Abe S, Kawai K, Nozawa H, Sasaki K, Murono K, Emoto S, Ozawa T, Yokoyama Y, Nagai Y, Anzai H, Sonoda H, Yamauchi S, Sugihara K, Ishihara S
BMC Cancer 2022 May 2;22(1):486. doi: 10.1186/s12885-022-09615-z. PMID: 35501727Free PMC Article
Efficacy of modified FOLFOX6 chemotherapy for patients with unresectable pseudomyxoma peritonei.
Hiraide S, Komine K, Sato Y, Ouchi K, Imai H, Saijo K, Takahashi M, Takahashi S, Shirota H, Takahashi M, Ishioka C
Int J Clin Oncol 2020 Apr;25(4):774-781. Epub 2019 Dec 10 doi: 10.1007/s10147-019-01592-x. PMID: 31823151Free PMC Article
Systematic review of prognostic factors related to overall survival in patients with stage IV colorectal cancer and unresectable metastases.
Stillwell AP, Ho YH, Veitch C
World J Surg 2011 Mar;35(3):684-92. doi: 10.1007/s00268-010-0891-8. PMID: 21181473
Pancreatic adenocarcinoma.
Howard TJ
Curr Probl Cancer 1996 Sep-Oct;20(5):281-328. doi: 10.1016/s0147-0272(96)80001-8. PMID: 8902402

Recent systematic reviews

Intraperitoneal chemotherapy in the management of pancreatic adenocarcinoma: A systematic review and meta-analysis.
Frassini S, Calabretto F, Granieri S, Fugazzola P, Viganò J, Fazzini N, Ansaloni L, Cobianchi L
Eur J Surg Oncol 2022 Sep;48(9):1911-1921. Epub 2022 Jun 2 doi: 10.1016/j.ejso.2022.05.030. PMID: 35688711
Diagnostic accuracy of staging laparoscopy for detecting metastasized or locally advanced perihilar cholangiocarcinoma: a systematic review and meta-analysis.
Coelen RJ, Ruys AT, Besselink MG, Busch OR, van Gulik TM
Surg Endosc 2016 Oct;30(10):4163-73. Epub 2016 Feb 19 doi: 10.1007/s00464-016-4788-y. PMID: 26895909Free PMC Article
Systematic review of prognostic factors related to overall survival in patients with stage IV colorectal cancer and unresectable metastases.
Stillwell AP, Ho YH, Veitch C
World J Surg 2011 Mar;35(3):684-92. doi: 10.1007/s00268-010-0891-8. PMID: 21181473

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