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Incidental Gallbladder Carcinoma

MedGen UID:
1735569
•Concept ID:
C5417749
•
Neoplastic Process
Synonyms: Incidental Gallbladder Cancer; Occult Gallbladder Cancer; Occult Gallbladder Carcinoma

Definition

Gallbladder carcinoma that is discovered incidental to gallbladder surgery for another indication. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncidental Gallbladder Carcinoma

Professional guidelines

PubMed

Evaluation of surgical treatment for incidental gallbladder carcinoma diagnosed during or after laparoscopic cholecystectomy: single center results.
Utsumi M, Aoki H, Kunitomo T, Mushiake Y, Yasuhara I, Arata T, Katsuda K, Tanakaya K, Takeuchi H
BMC Res Notes 2017 Jan 21;10(1):56. doi: 10.1186/s13104-017-2387-1. PMID: 28109315Free PMC Article
Is port site resection necessary in the surgical management of gallbladder cancer?
Maker AV, Butte JM, Oxenberg J, Kuk D, Gonen M, Fong Y, Dematteo RP, D'Angelica MI, Allen PJ, Jarnagin WR
Ann Surg Oncol 2012 Feb;19(2):409-17. Epub 2011 Jun 23 doi: 10.1245/s10434-011-1850-9. PMID: 21698501

Recent clinical studies

Etiology

The role of ultrasonography in the diagnosis of gallbladder cancer.
Chu R, Bi W, Tian B, Liu L
Ann Ital Chir 2021;92:372-376. PMID: 34524118
BRAZILIAN CONSENSUS ON INCIDENTAL GALLBLADDER CARCINOMA.
Grupo Internacional de Estudos de Câncer Hepatopancreatobiliar - ISG-HPB-Cancer, Coimbra FJF, Torres OJM, Alikhanov R, Agarwal A, Pessaux P, Fernandes ESM, Quireze-Junior C, Araujo RLC, Godoy AL, Waechter FL, Resende AP, Boff MF, Coelho GR, Rezende MB, Linhares MM, Belotto M, Moraes-Junior JMA, Amaral PCG, Pinto RD, Genzini T, Lima AS, Ribeiro HSC, Ramos EJ, Anghinoni M, Pereira LL, Enne M, Sampaio A, Montagnini AL, Diniz A, Jesus VHF, Sirohi B, Shrikhande SV, Peixoto RDA, Kalil AN, Jarufe N, Smith M, Herman P
Arq Bras Cir Dig 2020 Jul 8;33(1):e1496. doi: 10.1590/0102-672020190001e1496. PMID: 32667526Free PMC Article
Laparoscopy Versus Open Reoperation for Incidental Gallbladder Carcinoma After Laparoscopic Cholecystectomy.
Wang Z, Xu Y, Hu D, Wu X, Chen Y, Ye Q, Wang J, Zhu J
J Laparoendosc Adv Surg Tech A 2020 Jul;30(7):764-768. Epub 2020 May 19 doi: 10.1089/lap.2019.0802. PMID: 32429744
Incidental Carcinoma Gallbladder: Incidence, Risk Factors, and Factors Affecting Survival-5-Year Experience from a Tertiary Care Institute.
Singh BP, Khan WF, Rathore YS, Pol MM
J Gastrointest Cancer 2020 Sep;51(3):980-987. doi: 10.1007/s12029-019-00347-1. PMID: 31808057
Incidental carcinoma of the gallbladder.
Varshney S, Butturini G, Gupta R
Eur J Surg Oncol 2002 Feb;28(1):4-10. doi: 10.1053/ejso.2001.1175. PMID: 11869005

Diagnosis

The role of ultrasonography in the diagnosis of gallbladder cancer.
Chu R, Bi W, Tian B, Liu L
Ann Ital Chir 2021;92:372-376. PMID: 34524118
Laparoscopy Versus Open Reoperation for Incidental Gallbladder Carcinoma After Laparoscopic Cholecystectomy.
Wang Z, Xu Y, Hu D, Wu X, Chen Y, Ye Q, Wang J, Zhu J
J Laparoendosc Adv Surg Tech A 2020 Jul;30(7):764-768. Epub 2020 May 19 doi: 10.1089/lap.2019.0802. PMID: 32429744
Predictive factors for incidental gallbladder dysplasia and carcinoma.
Solaini L, Sharma A, Watt J, Iosifidou S, Chin Aleong JA, Kocher HM
J Surg Res 2014 Jun 1;189(1):17-21. Epub 2014 Feb 5 doi: 10.1016/j.jss.2014.01.064. PMID: 24589178
Gallbladder carcinoma incidentally encountered during laparoscopic cholecystectomy: how to deal with it.
Jin K, Lan H, Zhu T, He K, Teng L
Clin Transl Oncol 2011 Jan;13(1):25-33. doi: 10.1007/s12094-011-0613-1. PMID: 21239352
Incidental carcinoma of the gallbladder.
Varshney S, Butturini G, Gupta R
Eur J Surg Oncol 2002 Feb;28(1):4-10. doi: 10.1053/ejso.2001.1175. PMID: 11869005

Therapy

Age, operation time and surgical approach can be used to detect incidental gallbladder carcinoma in cholecystectomy specimens from low-incidence settings.
Echelard P, Roy SF, Trinh VQ, Garant MP, Collin Y, Nguyen BN, Geha S
Histopathology 2021 Oct;79(4):667-673. Epub 2021 Aug 6 doi: 10.1111/his.14423. PMID: 34061406
The role of laparoscopic surgery in the surgical management of gallbladder carcinoma: A systematic review and meta-analysis.
Lv TR, Yang C, Regmi P, Ma WJ, Hu HJ, Liu F, Yin CH, Jin YW, Li FY
Asian J Surg 2021 Dec;44(12):1493-1502. Epub 2021 Apr 22 doi: 10.1016/j.asjsur.2021.03.015. PMID: 33895048
Identification of patients who may benefit the most from adjuvant chemotherapy following resection of incidental gallbladder carcinoma.
Xiang JX, Zhang XF, Weber SM, Poultsides G, Fields RC, Hatzaras I, Weiss M, Scoggins C, Idrees K, Shen P, Maithel SK, Pawlik TM
J Surg Oncol 2021 Mar;123(4):978-985. Epub 2021 Jan 26 doi: 10.1002/jso.26389. PMID: 33497466
Neoadjuvant chemotherapy with gemcitabine plus cisplatin followed by radical liver resection versus immediate radical liver resection alone with or without adjuvant chemotherapy in incidentally detected gallbladder carcinoma after simple cholecystectomy or in front of radical resection of BTC (ICC/ECC) - a phase III study of the German registry of incidental gallbladder carcinoma platform (GR)- the AIO/ CALGP/ ACO- GAIN-trial.
Goetze TO, Bechstein WO, Bankstahl US, Keck T, Königsrainer A, Lang SA, Pauligk C, Piso P, Vogel A, Al-Batran SE
BMC Cancer 2020 Feb 14;20(1):122. doi: 10.1186/s12885-020-6610-4. PMID: 32059704Free PMC Article
Incidental carcinoma of the gallbladder.
Varshney S, Butturini G, Gupta R
Eur J Surg Oncol 2002 Feb;28(1):4-10. doi: 10.1053/ejso.2001.1175. PMID: 11869005

Prognosis

BRAZILIAN CONSENSUS ON INCIDENTAL GALLBLADDER CARCINOMA.
Grupo Internacional de Estudos de Câncer Hepatopancreatobiliar - ISG-HPB-Cancer, Coimbra FJF, Torres OJM, Alikhanov R, Agarwal A, Pessaux P, Fernandes ESM, Quireze-Junior C, Araujo RLC, Godoy AL, Waechter FL, Resende AP, Boff MF, Coelho GR, Rezende MB, Linhares MM, Belotto M, Moraes-Junior JMA, Amaral PCG, Pinto RD, Genzini T, Lima AS, Ribeiro HSC, Ramos EJ, Anghinoni M, Pereira LL, Enne M, Sampaio A, Montagnini AL, Diniz A, Jesus VHF, Sirohi B, Shrikhande SV, Peixoto RDA, Kalil AN, Jarufe N, Smith M, Herman P
Arq Bras Cir Dig 2020 Jul 8;33(1):e1496. doi: 10.1590/0102-672020190001e1496. PMID: 32667526Free PMC Article
Laparoscopy Versus Open Reoperation for Incidental Gallbladder Carcinoma After Laparoscopic Cholecystectomy.
Wang Z, Xu Y, Hu D, Wu X, Chen Y, Ye Q, Wang J, Zhu J
J Laparoendosc Adv Surg Tech A 2020 Jul;30(7):764-768. Epub 2020 May 19 doi: 10.1089/lap.2019.0802. PMID: 32429744
Incidental Carcinoma Gallbladder: Incidence, Risk Factors, and Factors Affecting Survival-5-Year Experience from a Tertiary Care Institute.
Singh BP, Khan WF, Rathore YS, Pol MM
J Gastrointest Cancer 2020 Sep;51(3):980-987. doi: 10.1007/s12029-019-00347-1. PMID: 31808057
Predictive factors for incidental gallbladder dysplasia and carcinoma.
Solaini L, Sharma A, Watt J, Iosifidou S, Chin Aleong JA, Kocher HM
J Surg Res 2014 Jun 1;189(1):17-21. Epub 2014 Feb 5 doi: 10.1016/j.jss.2014.01.064. PMID: 24589178
Incidental carcinoma of the gallbladder.
Varshney S, Butturini G, Gupta R
Eur J Surg Oncol 2002 Feb;28(1):4-10. doi: 10.1053/ejso.2001.1175. PMID: 11869005

Clinical prediction guides

The role of laparoscopic surgery in the surgical management of gallbladder carcinoma: A systematic review and meta-analysis.
Lv TR, Yang C, Regmi P, Ma WJ, Hu HJ, Liu F, Yin CH, Jin YW, Li FY
Asian J Surg 2021 Dec;44(12):1493-1502. Epub 2021 Apr 22 doi: 10.1016/j.asjsur.2021.03.015. PMID: 33895048
Prognostic value and risk stratification of residual disease in patients with incidental gallbladder cancer.
Ramos E, Lluis N, Llado L, Torras J, Busquets J, Rafecas A, Serrano T, Mils K, Leiva D, Fabregat J
World J Surg Oncol 2020 Jan 24;18(1):18. doi: 10.1186/s12957-020-1794-2. PMID: 31980034Free PMC Article
Incidental Gallbladder Carcinoma Discovered after Laparoscopic Cholecystectomy: Identifying Patients Who will Benefit from Reoperation.
Addeo P, Centonze L, Locicero A, Faitot F, Jedidi H, Felli E, Fuchshuber P, Bachellier P
J Gastrointest Surg 2018 Apr;22(4):606-614. Epub 2017 Dec 22 doi: 10.1007/s11605-017-3655-z. PMID: 29274001
Minimally invasive surgical approach for radicalization of incidental post-cholecystectomy gallbladder carcinoma: safety, feasibility and outcomes.
Sinagra E, Garritano S, Iacopinelli SM, Messina M, Raimondo D, Rossi F, Spada M, Martorana G, Spampinato MG
Minim Invasive Ther Allied Technol 2018 Aug;27(4):217-220. Epub 2017 Dec 7 doi: 10.1080/13645706.2017.1410489. PMID: 29214888
Predictive factors for incidental gallbladder dysplasia and carcinoma.
Solaini L, Sharma A, Watt J, Iosifidou S, Chin Aleong JA, Kocher HM
J Surg Res 2014 Jun 1;189(1):17-21. Epub 2014 Feb 5 doi: 10.1016/j.jss.2014.01.064. PMID: 24589178

Recent systematic reviews

The role of laparoscopic surgery in the surgical management of gallbladder carcinoma: A systematic review and meta-analysis.
Lv TR, Yang C, Regmi P, Ma WJ, Hu HJ, Liu F, Yin CH, Jin YW, Li FY
Asian J Surg 2021 Dec;44(12):1493-1502. Epub 2021 Apr 22 doi: 10.1016/j.asjsur.2021.03.015. PMID: 33895048

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