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Increased circulating cathepsin D level

MedGen UID:
1737278
•Concept ID:
C5421667
•
Finding
HPO: HP:0033182

Definition

An increase in concentration of cathepsin D in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating cathepsin D level

Recent clinical studies

Etiology

Circulating cathepsin B and D in pregnancy.
Kim HY, Baek HS
J Obstet Gynaecol 2019 Jan;39(1):17-21. Epub 2018 Jun 8 doi: 10.1080/01443615.2018.1454412. PMID: 29884105
Increased Cathepsin D Correlates with Clinical Parameters in Newly Diagnosed Type 2 Diabetes.
Liu L, Chen B, Zhang X, Tan L, Wang DW
Dis Markers 2017;2017:5286408. Epub 2017 Dec 10 doi: 10.1155/2017/5286408. PMID: 29375176Free PMC Article
Elevated serum cathepsin B concentration in pregnant women is associated with preeclampsia.
Kim HY, Kim BW, Kim YJ
Arch Gynecol Obstet 2016 Nov;294(6):1145-1150. Epub 2016 Jun 6 doi: 10.1007/s00404-016-4129-3. PMID: 27264724
Quest for novel cardiovascular biomarkers by proteomic analysis.
Vivanco F, Martín-Ventura JL, Duran MC, Barderas MG, Blanco-Colio L, Dardé VM, Mas S, Meilhac O, Michel JB, Tuñón J, Egido J
J Proteome Res 2005 Jul-Aug;4(4):1181-91. doi: 10.1021/pr0500197. PMID: 16083268
Cathepsin D, B and L circulating levels as prognostic markers of malignant progression.
Tumminello FM, Leto G, Pizzolanti G, Candiloro V, Crescimanno M, Crosta L, Flandina C, Montalto G, Soresi M, Carroccio A, Bascone F, Ruggeri I, Ippolito S, Gebbia N
Anticancer Res 1996 Jul-Aug;16(4B):2315-9. PMID: 8694562

Diagnosis

Increased Cathepsin D Correlates with Clinical Parameters in Newly Diagnosed Type 2 Diabetes.
Liu L, Chen B, Zhang X, Tan L, Wang DW
Dis Markers 2017;2017:5286408. Epub 2017 Dec 10 doi: 10.1155/2017/5286408. PMID: 29375176Free PMC Article
Quest for novel cardiovascular biomarkers by proteomic analysis.
Vivanco F, Martín-Ventura JL, Duran MC, Barderas MG, Blanco-Colio L, Dardé VM, Mas S, Meilhac O, Michel JB, Tuñón J, Egido J
J Proteome Res 2005 Jul-Aug;4(4):1181-91. doi: 10.1021/pr0500197. PMID: 16083268
Insulin clearance in obesity.
Valera Mora ME, Scarfone A, Calvani M, Greco AV, Mingrone G
J Am Coll Nutr 2003 Dec;22(6):487-93. doi: 10.1080/07315724.2003.10719326. PMID: 14684753
Low levels of basic fibroblast growth factor (bFGF) are associated with a poor prognosis in human breast carcinoma.
Colomer R, Aparicio J, Montero S, Guzmán C, Larrodera L, Cortés-Funes H
Br J Cancer 1997;76(9):1215-20. doi: 10.1038/bjc.1997.536. PMID: 9365172Free PMC Article
Cathepsin D, B and L circulating levels as prognostic markers of malignant progression.
Tumminello FM, Leto G, Pizzolanti G, Candiloro V, Crescimanno M, Crosta L, Flandina C, Montalto G, Soresi M, Carroccio A, Bascone F, Ruggeri I, Ippolito S, Gebbia N
Anticancer Res 1996 Jul-Aug;16(4B):2315-9. PMID: 8694562

Therapy

The role of cathepsin D in the pathophysiology of heart failure and its potentially beneficial properties: a translational approach.
Hoes MF, Tromp J, Ouwerkerk W, Bomer N, Oberdorf-Maass SU, Samani NJ, Ng LL, Lang CC, van der Harst P, Hillege H, Anker SD, Metra M, van Veldhuisen DJ, Voors AA, van der Meer P
Eur J Heart Fail 2020 Nov;22(11):2102-2111. Epub 2019 Dec 3 doi: 10.1002/ejhf.1674. PMID: 31797504Free PMC Article
Increased cathepsin D level in the serum of patients with metastatic breast carcinoma detected with a specific pro-cathepsin D immunoassay.
Brouillet JP, Dufour F, Lemamy G, Garcia M, Schlup N, Grenier J, Mani JC, Rochefort H
Cancer 1997 Jun 1;79(11):2132-6. PMID: 9179059
Influence of increased circulating levels of splanchnic lysosomal enzymes on the response to myocardial ischemia.
Spath JA, Reed EA, Lefer AM
Ann Surg 1975 Jun;181(6):813-8. doi: 10.1097/00000658-197506000-00009. PMID: 1138631Free PMC Article

Prognosis

The role of cathepsin D in the pathophysiology of heart failure and its potentially beneficial properties: a translational approach.
Hoes MF, Tromp J, Ouwerkerk W, Bomer N, Oberdorf-Maass SU, Samani NJ, Ng LL, Lang CC, van der Harst P, Hillege H, Anker SD, Metra M, van Veldhuisen DJ, Voors AA, van der Meer P
Eur J Heart Fail 2020 Nov;22(11):2102-2111. Epub 2019 Dec 3 doi: 10.1002/ejhf.1674. PMID: 31797504Free PMC Article
Insulin clearance in obesity.
Valera Mora ME, Scarfone A, Calvani M, Greco AV, Mingrone G
J Am Coll Nutr 2003 Dec;22(6):487-93. doi: 10.1080/07315724.2003.10719326. PMID: 14684753
Low levels of basic fibroblast growth factor (bFGF) are associated with a poor prognosis in human breast carcinoma.
Colomer R, Aparicio J, Montero S, Guzmán C, Larrodera L, Cortés-Funes H
Br J Cancer 1997;76(9):1215-20. doi: 10.1038/bjc.1997.536. PMID: 9365172Free PMC Article
Increased cathepsin D level in the serum of patients with metastatic breast carcinoma detected with a specific pro-cathepsin D immunoassay.
Brouillet JP, Dufour F, Lemamy G, Garcia M, Schlup N, Grenier J, Mani JC, Rochefort H
Cancer 1997 Jun 1;79(11):2132-6. PMID: 9179059
Cathepsin D, B and L circulating levels as prognostic markers of malignant progression.
Tumminello FM, Leto G, Pizzolanti G, Candiloro V, Crescimanno M, Crosta L, Flandina C, Montalto G, Soresi M, Carroccio A, Bascone F, Ruggeri I, Ippolito S, Gebbia N
Anticancer Res 1996 Jul-Aug;16(4B):2315-9. PMID: 8694562

Clinical prediction guides

Biologic role of activated leukocyte cell adhesion molecule overexpression in breast cancer cell lines and clinical tumor tissue.
Hein S, Müller V, Köhler N, Wikman H, Krenkel S, Streichert T, Schweizer M, Riethdorf S, Assmann V, Ihnen M, Beck K, Issa R, Jänicke F, Pantel K, Milde-Langosch K
Breast Cancer Res Treat 2011 Sep;129(2):347-60. Epub 2010 Oct 23 doi: 10.1007/s10549-010-1219-y. PMID: 20972617
Significant lower VVH7-like immunoreactivity serum level in diabetic patients: evidence for independence from metabolic control and three key enzymes in hemorphin metabolism, cathepsin D, ACE and DPP-IV.
Feron D, Begu-Le Corroller A, Piot JM, Frelicot C, Vialettes B, Fruitier-Arnaudin I
Peptides 2009 Feb;30(2):256-61. Epub 2008 Nov 17 doi: 10.1016/j.peptides.2008.11.004. PMID: 19061927
Increased cathepsin D level in the serum of patients with metastatic breast carcinoma detected with a specific pro-cathepsin D immunoassay.
Brouillet JP, Dufour F, Lemamy G, Garcia M, Schlup N, Grenier J, Mani JC, Rochefort H
Cancer 1997 Jun 1;79(11):2132-6. PMID: 9179059
Cathepsin D, B and L circulating levels as prognostic markers of malignant progression.
Tumminello FM, Leto G, Pizzolanti G, Candiloro V, Crescimanno M, Crosta L, Flandina C, Montalto G, Soresi M, Carroccio A, Bascone F, Ruggeri I, Ippolito S, Gebbia N
Anticancer Res 1996 Jul-Aug;16(4B):2315-9. PMID: 8694562
Increased mRNA levels for components of the lysosomal, Ca2+-activated, and ATP-ubiquitin-dependent proteolytic pathways in skeletal muscle from head trauma patients.
Mansoor O, Beaufrere B, Boirie Y, Ralliere C, Taillandier D, Aurousseau E, Schoeffler P, Arnal M, Attaix D
Proc Natl Acad Sci U S A 1996 Apr 2;93(7):2714-8. doi: 10.1073/pnas.93.7.2714. PMID: 8610106Free PMC Article

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