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Oxyntic Gland Adenoma

MedGen UID:
1738014
•Concept ID:
C5401356
•
Neoplastic Process

Definition

A benign epithelial neoplasm composed of columnar cells with differentiation to chief cells, parietal cells, or both, with a high rate of progression to adenocarcinoma (submucosal invasion). (WHO 2019) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOxyntic Gland Adenoma

Recent clinical studies

Etiology

Pathology and Clinical Relevance of Gastric Epithelial Dysplasia.
Ushiku T, Lauwers GY
Gastroenterol Clin North Am 2024 Mar;53(1):39-55. doi: 10.1016/j.gtc.2023.11.003. PMID: 38280750
Clinicopathological Features and the Prevalence of Oxyntic Gland Neoplasm: A Single-center Retrospective Study.
Asahara H, Takao T, Asahara Y, Asahara M, Motomura D, Sakaguchi H, Yoshizaki T, Ikezawa N, Takao M, Morita Y, Toyonaga T, Komatsu M, Kushima R, Kodama Y
Intern Med 2023 Oct 1;62(19):2763-2774. Epub 2023 Feb 15 doi: 10.2169/internalmedicine.0552-22. PMID: 36792200Free PMC Article
Endoscopic features of oxyntic gland adenoma and gastric adenocarcinoma of the fundic gland type differ between patients with and without Helicobacter pylori infection: a retrospective observational study.
Iwamuro M, Kusumoto C, Nakagawa M, Matsueda K, Kobayashi S, Yoshioka M, Inaba T, Toyokawa T, Sakaguchi C, Tanaka S, Tanaka T, Okada H
BMC Gastroenterol 2022 Jun 12;22(1):294. doi: 10.1186/s12876-022-02368-w. PMID: 35692036Free PMC Article
Pathological Diversity of Gastric Cancer from the Viewpoint of Background Condition.
Abe H, Ushiku T
Digestion 2022;103(1):45-53. Epub 2021 Oct 8 doi: 10.1159/000519337. PMID: 34628409
Oxyntic gland neoplasm of the stomach: expanding the spectrum and proposal of terminology.
Ushiku T, Kunita A, Kuroda R, Shinozaki-Ushiku A, Yamazawa S, Tsuji Y, Fujishiro M, Fukayama M
Mod Pathol 2020 Feb;33(2):206-216. Epub 2019 Aug 2 doi: 10.1038/s41379-019-0338-1. PMID: 31375767

Diagnosis

Pathology and Clinical Relevance of Gastric Epithelial Dysplasia.
Ushiku T, Lauwers GY
Gastroenterol Clin North Am 2024 Mar;53(1):39-55. doi: 10.1016/j.gtc.2023.11.003. PMID: 38280750
Clinicopathological Features and the Prevalence of Oxyntic Gland Neoplasm: A Single-center Retrospective Study.
Asahara H, Takao T, Asahara Y, Asahara M, Motomura D, Sakaguchi H, Yoshizaki T, Ikezawa N, Takao M, Morita Y, Toyonaga T, Komatsu M, Kushima R, Kodama Y
Intern Med 2023 Oct 1;62(19):2763-2774. Epub 2023 Feb 15 doi: 10.2169/internalmedicine.0552-22. PMID: 36792200Free PMC Article
Non-conventional types of dysplastic changes in gastrointestinal tract mucosa - review of morphological features of individual subtypes.
Kamaradová K
Cesk Patol 2022 Spring;58(1):38-51. PMID: 35387456
Diffuse MIST1 expression and decreased α1,4-linked N-acetylglucosamine (αGlcNAc) glycosylation on MUC6 are distinct hallmarks for gastric neoplasms showing oxyntic gland differentiation.
Yamada S, Yamanoi K, Sato Y, Nakayama J
Histopathology 2020 Sep;77(3):413-422. Epub 2020 Aug 5 doi: 10.1111/his.14165. PMID: 32502322
Oxyntic gland adenoma endoscopically mimicking a gastric neuroendocrine tumor: A case report.
Lee TI, Jang JY, Kim S, Kim JW, Chang YW, Kim YW
World J Gastroenterol 2015 Apr 28;21(16):5099-104. doi: 10.3748/wjg.v21.i16.5099. PMID: 25945027Free PMC Article

Prognosis

Pathology and Clinical Relevance of Gastric Epithelial Dysplasia.
Ushiku T, Lauwers GY
Gastroenterol Clin North Am 2024 Mar;53(1):39-55. doi: 10.1016/j.gtc.2023.11.003. PMID: 38280750
Oxyntic gland adenoma endoscopically mimicking a gastric neuroendocrine tumor: A case report.
Lee TI, Jang JY, Kim S, Kim JW, Chang YW, Kim YW
World J Gastroenterol 2015 Apr 28;21(16):5099-104. doi: 10.3748/wjg.v21.i16.5099. PMID: 25945027Free PMC Article

Clinical prediction guides

Pathology and Clinical Relevance of Gastric Epithelial Dysplasia.
Ushiku T, Lauwers GY
Gastroenterol Clin North Am 2024 Mar;53(1):39-55. doi: 10.1016/j.gtc.2023.11.003. PMID: 38280750
Clinicopathological Features and the Prevalence of Oxyntic Gland Neoplasm: A Single-center Retrospective Study.
Asahara H, Takao T, Asahara Y, Asahara M, Motomura D, Sakaguchi H, Yoshizaki T, Ikezawa N, Takao M, Morita Y, Toyonaga T, Komatsu M, Kushima R, Kodama Y
Intern Med 2023 Oct 1;62(19):2763-2774. Epub 2023 Feb 15 doi: 10.2169/internalmedicine.0552-22. PMID: 36792200Free PMC Article
On the origin of gastric tumours: analysis of a case with intramucosal gastric carcinoma and oxyntic gland adenoma.
Kumagai K, Shimizu T, Nikaido M, Hirano T, Kakiuchi N, Takeuchi Y, Minamiguchi S, Sakurai T, Teramura M, Utsumi T, Hiramatsu Y, Nakanishi Y, Takai A, Miyamoto S, Ogawa S, Seno H
J Pathol 2023 Apr;259(4):362-368. Epub 2023 Jan 26 doi: 10.1002/path.6050. PMID: 36625379
Endoscopic features of oxyntic gland adenoma and gastric adenocarcinoma of the fundic gland type differ between patients with and without Helicobacter pylori infection: a retrospective observational study.
Iwamuro M, Kusumoto C, Nakagawa M, Matsueda K, Kobayashi S, Yoshioka M, Inaba T, Toyokawa T, Sakaguchi C, Tanaka S, Tanaka T, Okada H
BMC Gastroenterol 2022 Jun 12;22(1):294. doi: 10.1186/s12876-022-02368-w. PMID: 35692036Free PMC Article
Diffuse MIST1 expression and decreased α1,4-linked N-acetylglucosamine (αGlcNAc) glycosylation on MUC6 are distinct hallmarks for gastric neoplasms showing oxyntic gland differentiation.
Yamada S, Yamanoi K, Sato Y, Nakayama J
Histopathology 2020 Sep;77(3):413-422. Epub 2020 Aug 5 doi: 10.1111/his.14165. PMID: 32502322

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