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Zoonotic Spillover

MedGen UID:
1740540
•Concept ID:
C5400989
•
Disease or Syndrome
Synonyms: Spillovers, Zoonotic; Zoonotic Spillovers

Definition

Transmission of an infectious disease from a reservoir vertebrate population with a high pathogen prevalence coming into contact with a naive human population. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVZoonotic Spillover

Professional guidelines

PubMed

Brucellosis: epidemiology, pathogenesis, diagnosis and treatment-a comprehensive review.
Qureshi KA, Parvez A, Fahmy NA, Abdel Hady BH, Kumar S, Ganguly A, Atiya A, Elhassan GO, Alfadly SO, Parkkila S, Aspatwar A
Ann Med 2023;55(2):2295398. Epub 2024 Jan 2 doi: 10.1080/07853890.2023.2295398. PMID: 38165919Free PMC Article
Chikungunya: Epidemiology, Pathogenesis, Clinical Features, Management, and Prevention.
Vairo F, Haider N, Kock R, Ntoumi F, Ippolito G, Zumla A
Infect Dis Clin North Am 2019 Dec;33(4):1003-1025. doi: 10.1016/j.idc.2019.08.006. PMID: 31668189
Human rabies: neuropathogenesis, diagnosis, and management.
Hemachudha T, Ugolini G, Wacharapluesadee S, Sungkarat W, Shuangshoti S, Laothamatas J
Lancet Neurol 2013 May;12(5):498-513. doi: 10.1016/S1474-4422(13)70038-3. PMID: 23602163

Recent clinical studies

Etiology

Farmed fur animals harbour viruses with zoonotic spillover potential.
Zhao J, Wan W, Yu K, Lemey P, Pettersson JH, Bi Y, Lu M, Li X, Chen Z, Zheng M, Yan G, Dai J, Li Y, Haerheng A, He N, Tu C, Suchard MA, Holmes EC, He WT, Su S
Nature 2024 Oct;634(8032):228-233. Epub 2024 Sep 4 doi: 10.1038/s41586-024-07901-3. PMID: 39232170
Host-Pathogen Interactions Influencing Zoonotic Spillover Potential and Transmission in Humans.
Escudero-Pérez B, Lalande A, Mathieu C, Lawrence P
Viruses 2023 Feb 22;15(3) doi: 10.3390/v15030599. PMID: 36992308Free PMC Article
Pandemic origins and a One Health approach to preparedness and prevention: Solutions based on SARS-CoV-2 and other RNA viruses.
Keusch GT, Amuasi JH, Anderson DE, Daszak P, Eckerle I, Field H, Koopmans M, Lam SK, Das Neves CG, Peiris M, Perlman S, Wacharapluesadee S, Yadana S, Saif L
Proc Natl Acad Sci U S A 2022 Oct 18;119(42):e2202871119. Epub 2022 Oct 10 doi: 10.1073/pnas.2202871119. PMID: 36215506Free PMC Article
Wildmeat consumption and zoonotic spillover: contextualising disease emergence and policy responses.
Milbank C, Vira B
Lancet Planet Health 2022 May;6(5):e439-e448. doi: 10.1016/S2542-5196(22)00064-X. PMID: 35550083Free PMC Article
Climate change increases cross-species viral transmission risk.
Carlson CJ, Albery GF, Merow C, Trisos CH, Zipfel CM, Eskew EA, Olival KJ, Ross N, Bansal S
Nature 2022 Jul;607(7919):555-562. Epub 2022 Apr 28 doi: 10.1038/s41586-022-04788-w. PMID: 35483403

Diagnosis

Zoonotic spillover and viral mutations from low and middle-income countries: improving prevention strategies and bridging policy gaps.
Haq Z, Nazir J, Manzoor T, Saleem A, Hamadani H, Khan AA, Saleem Bhat S, Jha P, Ahmad SM
PeerJ 2024;12:e17394. Epub 2024 May 30 doi: 10.7717/peerj.17394. PMID: 38827296Free PMC Article
4'-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses.
Lieber CM, Aggarwal M, Yoon JJ, Cox RM, Kang HJ, Sourimant J, Toots M, Johnson SK, Jones CA, Sticher ZM, Kolykhalov AA, Saindane MT, Tompkins SM, Planz O, Painter GR, Natchus MG, Sakamoto K, Plemper RK
PLoS Pathog 2023 Apr;19(4):e1011342. Epub 2023 Apr 17 doi: 10.1371/journal.ppat.1011342. PMID: 37068076Free PMC Article
Detecting zoonotic Influenza A using QIAstat-Dx Respiratory SARS-CoV-2 panel for pandemic preparedness.
Peñarrubia L, Rao SN, Porco R, Varo M, Muñoz-Torrero P, Ortiz-Martinez F, Pareja J, López-Fontanals M, Manissero D
Sci Rep 2023 Feb 17;13(1):2833. doi: 10.1038/s41598-023-29838-9. PMID: 36807577Free PMC Article
Monkeypox emerges on a global scale: A historical review and dermatologic primer.
Bryer J, Freeman EE, Rosenbach M
J Am Acad Dermatol 2022 Nov;87(5):1069-1074. Epub 2022 Jul 8 doi: 10.1016/j.jaad.2022.07.007. PMID: 35817333Free PMC Article
Behavioral-biological surveillance of emerging infectious diseases among a dynamic cohort in Thailand.
Yadana S, Cheun-Arom T, Li H, Hagan E, Mendelsohn E, Latinne A, Martinez S, Putcharoen O, Homvijitkul J, Sathaporntheera O, Rattanapreeda N, Chartpituck P, Yamsakul S, Sutham K, Komolsiri S, Pornphatthananikhom S, Petcharat S, Ampoot W, Francisco L, Hemachudha T, Daszak P, Olival KJ, Wacharapluesadee S
BMC Infect Dis 2022 May 16;22(1):472. doi: 10.1186/s12879-022-07439-7. PMID: 35578171Free PMC Article

Therapy

Seasonality of agricultural exposure as an important predictor of seasonal yellow fever spillover in Brazil.
Hamlet A, Ramos DG, Gaythorpe KAM, Romano APM, Garske T, Ferguson NM
Nat Commun 2021 Jun 15;12(1):3647. doi: 10.1038/s41467-021-23926-y. PMID: 34131128Free PMC Article
Targeting viral genome synthesis as broad-spectrum approach against RNA virus infections.
Huchting J
Antivir Chem Chemother 2020 Jan-Dec;28:2040206620976786. doi: 10.1177/2040206620976786. PMID: 33297724Free PMC Article
Integrating data mining and transmission theory in the ecology of infectious diseases.
Han BA, O'Regan SM, Paul Schmidt J, Drake JM
Ecol Lett 2020 Aug;23(8):1178-1188. Epub 2020 May 22 doi: 10.1111/ele.13520. PMID: 32441459Free PMC Article
Exploring the human-animal interface of Ebola virus disease outbreaks.
Ponce L, Kinoshita R, Nishiura H
Math Biosci Eng 2019 Apr 11;16(4):3130-3143. doi: 10.3934/mbe.2019155. PMID: 31137254
Conservation as vaccination: Integrated approaches to public health and environmental protection could prevent future disease outbreaks.
Hayman DT
EMBO Rep 2016 Mar;17(3):286-91. Epub 2016 Jan 29 doi: 10.15252/embr.201541675. PMID: 26825428Free PMC Article

Prognosis

Human behaviors driving disease emergence.
Friant S
Evol Anthropol 2024 Apr;33(2):e22015. Epub 2023 Dec 21 doi: 10.1002/evan.22015. PMID: 38130075
Host-Pathogen Interactions Influencing Zoonotic Spillover Potential and Transmission in Humans.
Escudero-Pérez B, Lalande A, Mathieu C, Lawrence P
Viruses 2023 Feb 22;15(3) doi: 10.3390/v15030599. PMID: 36992308Free PMC Article
Climate change increases cross-species viral transmission risk.
Carlson CJ, Albery GF, Merow C, Trisos CH, Zipfel CM, Eskew EA, Olival KJ, Ross N, Bansal S
Nature 2022 Jul;607(7919):555-562. Epub 2022 Apr 28 doi: 10.1038/s41586-022-04788-w. PMID: 35483403
Ecology, evolution and spillover of coronaviruses from bats.
Ruiz-Aravena M, McKee C, Gamble A, Lunn T, Morris A, Snedden CE, Yinda CK, Port JR, Buchholz DW, Yeo YY, Faust C, Jax E, Dee L, Jones DN, Kessler MK, Falvo C, Crowley D, Bharti N, Brook CE, Aguilar HC, Peel AJ, Restif O, Schountz T, Parrish CR, Gurley ES, Lloyd-Smith JO, Hudson PJ, Munster VJ, Plowright RK
Nat Rev Microbiol 2022 May;20(5):299-314. Epub 2021 Nov 19 doi: 10.1038/s41579-021-00652-2. PMID: 34799704Free PMC Article
Pathways to zoonotic spillover.
Plowright RK, Parrish CR, McCallum H, Hudson PJ, Ko AI, Graham AL, Lloyd-Smith JO
Nat Rev Microbiol 2017 Aug;15(8):502-510. Epub 2017 May 30 doi: 10.1038/nrmicro.2017.45. PMID: 28555073Free PMC Article

Clinical prediction guides

Human behaviors driving disease emergence.
Friant S
Evol Anthropol 2024 Apr;33(2):e22015. Epub 2023 Dec 21 doi: 10.1002/evan.22015. PMID: 38130075
Host-Pathogen Interactions Influencing Zoonotic Spillover Potential and Transmission in Humans.
Escudero-Pérez B, Lalande A, Mathieu C, Lawrence P
Viruses 2023 Feb 22;15(3) doi: 10.3390/v15030599. PMID: 36992308Free PMC Article
Climate change increases cross-species viral transmission risk.
Carlson CJ, Albery GF, Merow C, Trisos CH, Zipfel CM, Eskew EA, Olival KJ, Ross N, Bansal S
Nature 2022 Jul;607(7919):555-562. Epub 2022 Apr 28 doi: 10.1038/s41586-022-04788-w. PMID: 35483403
Ecology, evolution and spillover of coronaviruses from bats.
Ruiz-Aravena M, McKee C, Gamble A, Lunn T, Morris A, Snedden CE, Yinda CK, Port JR, Buchholz DW, Yeo YY, Faust C, Jax E, Dee L, Jones DN, Kessler MK, Falvo C, Crowley D, Bharti N, Brook CE, Aguilar HC, Peel AJ, Restif O, Schountz T, Parrish CR, Gurley ES, Lloyd-Smith JO, Hudson PJ, Munster VJ, Plowright RK
Nat Rev Microbiol 2022 May;20(5):299-314. Epub 2021 Nov 19 doi: 10.1038/s41579-021-00652-2. PMID: 34799704Free PMC Article
Pathways to zoonotic spillover.
Plowright RK, Parrish CR, McCallum H, Hudson PJ, Ko AI, Graham AL, Lloyd-Smith JO
Nat Rev Microbiol 2017 Aug;15(8):502-510. Epub 2017 May 30 doi: 10.1038/nrmicro.2017.45. PMID: 28555073Free PMC Article

Recent systematic reviews

Zoonotic spillover and extreme weather events drive the global outbreaks of airborne viral emerging infectious diseases.
Wang Z, Pei S, Cui H, Zhang J, Jia Z
J Med Virol 2024 Jun;96(6):e29737. doi: 10.1002/jmv.29737. PMID: 38874191
Policies to prevent zoonotic spillover: a systematic scoping review of evaluative evidence.
Clifford Astbury C, Lee KM, Mcleod R, Aguiar R, Atique A, Balolong M, Clarke J, Demeshko A, Labonté R, Ruckert A, Sibal P, Togño KC, Viens AM, Wiktorowicz M, Yambayamba MK, Yau A, Penney TL
Global Health 2023 Nov 8;19(1):82. doi: 10.1186/s12992-023-00986-x. PMID: 37940941Free PMC Article
Spillover of zoonotic pathogens: A review of reviews.
Sánchez CA, Venkatachalam-Vaz J, Drake JM
Zoonoses Public Health 2021 Sep;68(6):563-577. Epub 2021 May 20 doi: 10.1111/zph.12846. PMID: 34018336

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