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Salivary Gland Non-Hodgkin Lymphoma

MedGen UID:
1740558
•Concept ID:
C2204343
•
Neoplastic Process
Synonym: Primary Salivary Gland Non-Hodgkin Lymphoma

Definition

A non-Hodgkin lymphoma that manifests initially in a salivary gland. It usually occurs in the parotid gland. Mucosa-associated lymphoid tissue lymphoma is the most common primary salivary gland non-Hodgkin lymphoma. [from NCI]

Professional guidelines

PubMed

Extranodal Head and Neck Mantle Cell Lymphoma: Characteristics, Treatment, and Survival.
Breen CT, Chao J, Mehra S, Kohli N
Ann Otol Rhinol Laryngol 2022 Apr;131(4):412-419. Epub 2021 Jun 17 doi: 10.1177/00034894211025171. PMID: 34137303
Overview on the management of non-gastric MALT lymphomas.
Defrancesco I, Arcaini L
Best Pract Res Clin Haematol 2018 Mar;31(1):57-64. Epub 2017 Nov 14 doi: 10.1016/j.beha.2017.11.001. PMID: 29452667
The diagnosis and management of NK/T-cell lymphomas.
Tse E, Kwong YL
J Hematol Oncol 2017 Apr 14;10(1):85. doi: 10.1186/s13045-017-0452-9. PMID: 28410601Free PMC Article

Recent clinical studies

Etiology

Sjögren Syndrome and Cancer.
Igoe A, Merjanah S, Scofield RH
Rheum Dis Clin North Am 2020 Aug;46(3):513-532. doi: 10.1016/j.rdc.2020.05.004. PMID: 32631601
Overview on the management of non-gastric MALT lymphomas.
Defrancesco I, Arcaini L
Best Pract Res Clin Haematol 2018 Mar;31(1):57-64. Epub 2017 Nov 14 doi: 10.1016/j.beha.2017.11.001. PMID: 29452667
The diagnosis and management of NK/T-cell lymphomas.
Tse E, Kwong YL
J Hematol Oncol 2017 Apr 14;10(1):85. doi: 10.1186/s13045-017-0452-9. PMID: 28410601Free PMC Article
Marginal zone lymphoma: Associated autoimmunity and auto-immune disorders.
Teixeira Mendes LS, Wotherspoon A
Best Pract Res Clin Haematol 2017 Mar-Jun;30(1-2):65-76. Epub 2016 Nov 5 doi: 10.1016/j.beha.2016.07.006. PMID: 28288719
Primary Sjögren's syndrome.
Rischmueller M, Tieu J, Lester S
Best Pract Res Clin Rheumatol 2016 Feb;30(1):189-220. Epub 2016 May 13 doi: 10.1016/j.berh.2016.04.003. PMID: 27421224

Diagnosis

Epithelial-immune cell interplay in primary Sjögren syndrome salivary gland pathogenesis.
Verstappen GM, Pringle S, Bootsma H, Kroese FGM
Nat Rev Rheumatol 2021 Jun;17(6):333-348. Epub 2021 Apr 28 doi: 10.1038/s41584-021-00605-2. PMID: 33911236Free PMC Article
Oral cancer: A multicenter study.
Dhanuthai K, Rojanawatsirivej S, Thosaporn W, Kintarak S, Subarnbhesaj A, Darling M, Kryshtalskyj E, Chiang CP, Shin HI, Choi SY, Lee SS, Aminishakib P
Med Oral Patol Oral Cir Bucal 2018 Jan 1;23(1):e23-e29. doi: 10.4317/medoral.21999. PMID: 29274153Free PMC Article
The diagnosis and management of NK/T-cell lymphomas.
Tse E, Kwong YL
J Hematol Oncol 2017 Apr 14;10(1):85. doi: 10.1186/s13045-017-0452-9. PMID: 28410601Free PMC Article
Primary Sjögren's syndrome.
Rischmueller M, Tieu J, Lester S
Best Pract Res Clin Rheumatol 2016 Feb;30(1):189-220. Epub 2016 May 13 doi: 10.1016/j.berh.2016.04.003. PMID: 27421224
IgG4-associated sialadenitis.
Geyer JT, Deshpande V
Curr Opin Rheumatol 2011 Jan;23(1):95-101. doi: 10.1097/BOR.0b013e3283413011. PMID: 21124091

Therapy

Epithelial-immune cell interplay in primary Sjögren syndrome salivary gland pathogenesis.
Verstappen GM, Pringle S, Bootsma H, Kroese FGM
Nat Rev Rheumatol 2021 Jun;17(6):333-348. Epub 2021 Apr 28 doi: 10.1038/s41584-021-00605-2. PMID: 33911236Free PMC Article
Overview on the management of non-gastric MALT lymphomas.
Defrancesco I, Arcaini L
Best Pract Res Clin Haematol 2018 Mar;31(1):57-64. Epub 2017 Nov 14 doi: 10.1016/j.beha.2017.11.001. PMID: 29452667
The diagnosis and management of NK/T-cell lymphomas.
Tse E, Kwong YL
J Hematol Oncol 2017 Apr 14;10(1):85. doi: 10.1186/s13045-017-0452-9. PMID: 28410601Free PMC Article
Extrahepatic Manifestations of Hepatitis C Virus.
Viganò M, Colombo M
Gastroenterol Clin North Am 2015 Dec;44(4):775-91. Epub 2015 Aug 12 doi: 10.1016/j.gtc.2015.07.006. PMID: 26600219
Lymphoma of the thyroid and head and neck.
Beasley MJ
Clin Oncol (R Coll Radiol) 2012 Jun;24(5):345-51. Epub 2012 Apr 2 doi: 10.1016/j.clon.2012.02.010. PMID: 22475637

Prognosis

Extranodal Head and Neck Mantle Cell Lymphoma: Characteristics, Treatment, and Survival.
Breen CT, Chao J, Mehra S, Kohli N
Ann Otol Rhinol Laryngol 2022 Apr;131(4):412-419. Epub 2021 Jun 17 doi: 10.1177/00034894211025171. PMID: 34137303
Oral cancer: A multicenter study.
Dhanuthai K, Rojanawatsirivej S, Thosaporn W, Kintarak S, Subarnbhesaj A, Darling M, Kryshtalskyj E, Chiang CP, Shin HI, Choi SY, Lee SS, Aminishakib P
Med Oral Patol Oral Cir Bucal 2018 Jan 1;23(1):e23-e29. doi: 10.4317/medoral.21999. PMID: 29274153Free PMC Article
The diagnosis and management of NK/T-cell lymphomas.
Tse E, Kwong YL
J Hematol Oncol 2017 Apr 14;10(1):85. doi: 10.1186/s13045-017-0452-9. PMID: 28410601Free PMC Article
Marginal zone lymphoma: Associated autoimmunity and auto-immune disorders.
Teixeira Mendes LS, Wotherspoon A
Best Pract Res Clin Haematol 2017 Mar-Jun;30(1-2):65-76. Epub 2016 Nov 5 doi: 10.1016/j.beha.2016.07.006. PMID: 28288719
HIV-related oral disease.
Greenspan D, Greenspan JS
Lancet 1996 Sep 14;348(9029):729-33. doi: 10.1016/S0140-6736(96)02308-2. PMID: 8806295

Clinical prediction guides

Mantle cell lymphoma, malt lymphoma, small lymphocytic lymphoma, and follicular lymphoma of the oral cavity: An update.
Wagner VP, Rodrigues-Fernandes CI, Carvalho MVR, Dos Santos JN, Barra MB, Hunter KD, Aguirre-Urizar JM, van Heerden WFP, Vargas PA, Fonseca FP, Martins MD
J Oral Pathol Med 2021 Jul;50(6):622-630. Epub 2021 Jul 1 doi: 10.1111/jop.13214. PMID: 34101256
Predicting lymphoma development in patients with Sjögren's syndrome.
De Vita S, Gandolfo S
Expert Rev Clin Immunol 2019 Sep;15(9):929-938. Epub 2019 Sep 12 doi: 10.1080/1744666X.2019.1649596. PMID: 31347413
Predictors for the development of non-Hodgkin lymphoma in primary Sjögren's syndrome.
Jonsson MV, Theander E, Jonsson R
Presse Med 2012 Sep;41(9 Pt 2):e511-6. Epub 2012 Aug 3 doi: 10.1016/j.lpm.2012.05.025. PMID: 22867948
Clinical, immunologic, and molecular factors predicting lymphoma development in Sjogren's syndrome patients.
Voulgarelis M, Skopouli FN
Clin Rev Allergy Immunol 2007 Jun;32(3):265-74. doi: 10.1007/s12016-007-8001-x. PMID: 17992593
Mucosa-associated lymphoid tissue lymphomas.
Thieblemont C, Berger F, Coiffier B
Curr Opin Oncol 1995 Sep;7(5):415-20. PMID: 8541385

Recent systematic reviews

Current evidence on diagnosis and treatment of parotid gland lymphomas: a systematic review.
Di Santo D, Bramati C, Festa BM, Pace GM, Comini LV, Luparello P, Cascardi E, Galizia D, Galli A, De Virgilio A, Giordano L, Bondi S
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5219-5227. Epub 2023 Aug 28 doi: 10.1007/s00405-023-08206-3. PMID: 37638999
Lymphomas of the salivary glands: a systematic review.
Al-Khafaf AE, Al-Shahrestani F, Baysal Y, Rahbek Gjerdrum LM, Heegaard S, Pedersen LM, Homøe P
Acta Otolaryngol 2023 Jul-Aug;143(7):610-616. Epub 2023 Aug 12 doi: 10.1080/00016489.2023.2226689. PMID: 37572309
Second primary malignancy risk in thyroid cancer survivors: a systematic review and meta-analysis.
Subramanian S, Goldstein DP, Parlea L, Thabane L, Ezzat S, Ibrahim-Zada I, Straus S, Brierley JD, Tsang RW, Gafni A, Rotstein L, Sawka AM
Thyroid 2007 Dec;17(12):1277-88. doi: 10.1089/thy.2007.0171. PMID: 18020916
A systematic overview of radiation therapy effects in non-Hodgkin's lymphoma.
Gustavsson A, Osterman B, Cavallin-Ståhl E
Acta Oncol 2003;42(5-6):605-19. doi: 10.1080/02841860310014435. PMID: 14596518

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