U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Salivary Gland Non-Hodgkin Lymphoma

MedGen UID:
1740558
•Concept ID:
C2204343
•
Neoplastic Process
Synonym: Primary Salivary Gland Non-Hodgkin Lymphoma

Definition

A non-Hodgkin lymphoma that manifests initially in a salivary gland. It usually occurs in the parotid gland. Mucosa-associated lymphoid tissue lymphoma is the most common primary salivary gland non-Hodgkin lymphoma. [from NCI]

Professional guidelines

PubMed

Current evidence on diagnosis and treatment of parotid gland lymphomas: a systematic review.
Di Santo D, Bramati C, Festa BM, Pace GM, Comini LV, Luparello P, Cascardi E, Galizia D, Galli A, De Virgilio A, Giordano L, Bondi S
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5219-5227. Epub 2023 Aug 28 doi: 10.1007/s00405-023-08206-3. PMID: 37638999
Overview on the management of non-gastric MALT lymphomas.
Defrancesco I, Arcaini L
Best Pract Res Clin Haematol 2018 Mar;31(1):57-64. Epub 2017 Nov 14 doi: 10.1016/j.beha.2017.11.001. PMID: 29452667
The diagnosis and management of NK/T-cell lymphomas.
Tse E, Kwong YL
J Hematol Oncol 2017 Apr 14;10(1):85. doi: 10.1186/s13045-017-0452-9. PMID: 28410601Free PMC Article

Recent clinical studies

Etiology

Lymphomas of the salivary glands: a systematic review.
Al-Khafaf AE, Al-Shahrestani F, Baysal Y, Rahbek Gjerdrum LM, Heegaard S, Pedersen LM, Homøe P
Acta Otolaryngol 2023 Jul-Aug;143(7):610-616. Epub 2023 Aug 12 doi: 10.1080/00016489.2023.2226689. PMID: 37572309
Sjögren Syndrome and Cancer.
Igoe A, Merjanah S, Scofield RH
Rheum Dis Clin North Am 2020 Aug;46(3):513-532. doi: 10.1016/j.rdc.2020.05.004. PMID: 32631601
The diagnosis and management of NK/T-cell lymphomas.
Tse E, Kwong YL
J Hematol Oncol 2017 Apr 14;10(1):85. doi: 10.1186/s13045-017-0452-9. PMID: 28410601Free PMC Article
Marginal zone lymphoma: Associated autoimmunity and auto-immune disorders.
Teixeira Mendes LS, Wotherspoon A
Best Pract Res Clin Haematol 2017 Mar-Jun;30(1-2):65-76. Epub 2016 Nov 5 doi: 10.1016/j.beha.2016.07.006. PMID: 28288719
Primary Sjögren's syndrome.
Rischmueller M, Tieu J, Lester S
Best Pract Res Clin Rheumatol 2016 Feb;30(1):189-220. Epub 2016 May 13 doi: 10.1016/j.berh.2016.04.003. PMID: 27421224

Diagnosis

Current evidence on diagnosis and treatment of parotid gland lymphomas: a systematic review.
Di Santo D, Bramati C, Festa BM, Pace GM, Comini LV, Luparello P, Cascardi E, Galizia D, Galli A, De Virgilio A, Giordano L, Bondi S
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5219-5227. Epub 2023 Aug 28 doi: 10.1007/s00405-023-08206-3. PMID: 37638999
Epithelial-immune cell interplay in primary Sjögren syndrome salivary gland pathogenesis.
Verstappen GM, Pringle S, Bootsma H, Kroese FGM
Nat Rev Rheumatol 2021 Jun;17(6):333-348. Epub 2021 Apr 28 doi: 10.1038/s41584-021-00605-2. PMID: 33911236Free PMC Article
Oral cancer: A multicenter study.
Dhanuthai K, Rojanawatsirivej S, Thosaporn W, Kintarak S, Subarnbhesaj A, Darling M, Kryshtalskyj E, Chiang CP, Shin HI, Choi SY, Lee SS, Aminishakib P
Med Oral Patol Oral Cir Bucal 2018 Jan 1;23(1):e23-e29. doi: 10.4317/medoral.21999. PMID: 29274153Free PMC Article
Primary Sjögren's syndrome.
Rischmueller M, Tieu J, Lester S
Best Pract Res Clin Rheumatol 2016 Feb;30(1):189-220. Epub 2016 May 13 doi: 10.1016/j.berh.2016.04.003. PMID: 27421224
IgG4-associated sialadenitis.
Geyer JT, Deshpande V
Curr Opin Rheumatol 2011 Jan;23(1):95-101. doi: 10.1097/BOR.0b013e3283413011. PMID: 21124091

Therapy

Epithelial-immune cell interplay in primary Sjögren syndrome salivary gland pathogenesis.
Verstappen GM, Pringle S, Bootsma H, Kroese FGM
Nat Rev Rheumatol 2021 Jun;17(6):333-348. Epub 2021 Apr 28 doi: 10.1038/s41584-021-00605-2. PMID: 33911236Free PMC Article
Overview on the management of non-gastric MALT lymphomas.
Defrancesco I, Arcaini L
Best Pract Res Clin Haematol 2018 Mar;31(1):57-64. Epub 2017 Nov 14 doi: 10.1016/j.beha.2017.11.001. PMID: 29452667
The diagnosis and management of NK/T-cell lymphomas.
Tse E, Kwong YL
J Hematol Oncol 2017 Apr 14;10(1):85. doi: 10.1186/s13045-017-0452-9. PMID: 28410601Free PMC Article
Lymphoma of the thyroid and head and neck.
Beasley MJ
Clin Oncol (R Coll Radiol) 2012 Jun;24(5):345-51. Epub 2012 Apr 2 doi: 10.1016/j.clon.2012.02.010. PMID: 22475637
Sjögren's syndrome.
Chambers MS
ORL Head Neck Nurs 2004 Fall;22(4):22-30; quiz 32-3. PMID: 15617317

Prognosis

Lymphomas of the salivary glands: a systematic review.
Al-Khafaf AE, Al-Shahrestani F, Baysal Y, Rahbek Gjerdrum LM, Heegaard S, Pedersen LM, Homøe P
Acta Otolaryngol 2023 Jul-Aug;143(7):610-616. Epub 2023 Aug 12 doi: 10.1080/00016489.2023.2226689. PMID: 37572309
Oral cancer: A multicenter study.
Dhanuthai K, Rojanawatsirivej S, Thosaporn W, Kintarak S, Subarnbhesaj A, Darling M, Kryshtalskyj E, Chiang CP, Shin HI, Choi SY, Lee SS, Aminishakib P
Med Oral Patol Oral Cir Bucal 2018 Jan 1;23(1):e23-e29. doi: 10.4317/medoral.21999. PMID: 29274153Free PMC Article
The diagnosis and management of NK/T-cell lymphomas.
Tse E, Kwong YL
J Hematol Oncol 2017 Apr 14;10(1):85. doi: 10.1186/s13045-017-0452-9. PMID: 28410601Free PMC Article
Marginal zone lymphoma: Associated autoimmunity and auto-immune disorders.
Teixeira Mendes LS, Wotherspoon A
Best Pract Res Clin Haematol 2017 Mar-Jun;30(1-2):65-76. Epub 2016 Nov 5 doi: 10.1016/j.beha.2016.07.006. PMID: 28288719
HIV-related oral disease.
Greenspan D, Greenspan JS
Lancet 1996 Sep 14;348(9029):729-33. doi: 10.1016/S0140-6736(96)02308-2. PMID: 8806295

Clinical prediction guides

FDG-PET/CT discriminates between patients with and without lymphomas in primary Sjögren's syndrome.
van Ginkel MS, Arends S, van der Vegt B, Nijland M, Spijkervet FKL, Vissink A, Kroese FGM, Glaudemans AWJM, Bootsma H
Rheumatology (Oxford) 2023 Oct 3;62(10):3323-3331. doi: 10.1093/rheumatology/kead071. PMID: 36759907Free PMC Article
EBV Association with Lymphomas and Carcinomas in the Oral Compartment.
Ward BJH, Schaal DL, Nkadi EH, Scott RS
Viruses 2022 Dec 1;14(12) doi: 10.3390/v14122700. PMID: 36560704Free PMC Article
Mantle cell lymphoma, malt lymphoma, small lymphocytic lymphoma, and follicular lymphoma of the oral cavity: An update.
Wagner VP, Rodrigues-Fernandes CI, Carvalho MVR, Dos Santos JN, Barra MB, Hunter KD, Aguirre-Urizar JM, van Heerden WFP, Vargas PA, Fonseca FP, Martins MD
J Oral Pathol Med 2021 Jul;50(6):622-630. Epub 2021 Jul 1 doi: 10.1111/jop.13214. PMID: 34101256
Predicting lymphoma development in patients with Sjögren's syndrome.
De Vita S, Gandolfo S
Expert Rev Clin Immunol 2019 Sep;15(9):929-938. Epub 2019 Sep 12 doi: 10.1080/1744666X.2019.1649596. PMID: 31347413
Predictors for the development of non-Hodgkin lymphoma in primary Sjögren's syndrome.
Jonsson MV, Theander E, Jonsson R
Presse Med 2012 Sep;41(9 Pt 2):e511-6. Epub 2012 Aug 3 doi: 10.1016/j.lpm.2012.05.025. PMID: 22867948

Recent systematic reviews

Current evidence on diagnosis and treatment of parotid gland lymphomas: a systematic review.
Di Santo D, Bramati C, Festa BM, Pace GM, Comini LV, Luparello P, Cascardi E, Galizia D, Galli A, De Virgilio A, Giordano L, Bondi S
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5219-5227. Epub 2023 Aug 28 doi: 10.1007/s00405-023-08206-3. PMID: 37638999
Lymphomas of the salivary glands: a systematic review.
Al-Khafaf AE, Al-Shahrestani F, Baysal Y, Rahbek Gjerdrum LM, Heegaard S, Pedersen LM, Homøe P
Acta Otolaryngol 2023 Jul-Aug;143(7):610-616. Epub 2023 Aug 12 doi: 10.1080/00016489.2023.2226689. PMID: 37572309
Second primary malignancy risk in thyroid cancer survivors: a systematic review and meta-analysis.
Subramanian S, Goldstein DP, Parlea L, Thabane L, Ezzat S, Ibrahim-Zada I, Straus S, Brierley JD, Tsang RW, Gafni A, Rotstein L, Sawka AM
Thyroid 2007 Dec;17(12):1277-88. doi: 10.1089/thy.2007.0171. PMID: 18020916
A systematic overview of radiation therapy effects in non-Hodgkin's lymphoma.
Gustavsson A, Osterman B, Cavallin-Ståhl E
Acta Oncol 2003;42(5-6):605-19. doi: 10.1080/02841860310014435. PMID: 14596518

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...