U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

COVID-19-Associated Thromboembolism

MedGen UID:
1742891
•Concept ID:
C5419175
•
Disease or Syndrome
Synonym: SARS-CoV-2-Associated Thromboembolism

Definition

Thromboembolism caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCOVID-19-Associated Thromboembolism

Professional guidelines

PubMed

Clinical Features and Management of COVID-19-Associated Hypercoagulability.
Massaro G, Lecis D, Martuscelli E, Chiricolo G, Sangiorgi GM
Card Electrophysiol Clin 2022 Mar;14(1):41-52. Epub 2021 Oct 30 doi: 10.1016/j.ccep.2021.10.005. PMID: 35221084Free PMC Article
Prophylaxis and treatment of COVID-19 related venous thromboembolism.
Kaptein FHJ, Stals MAM, Huisman MV, Klok FA
Postgrad Med 2021 Aug;133(sup1):27-35. Epub 2021 Mar 4 doi: 10.1080/00325481.2021.1891788. PMID: 33657964Free PMC Article
Proposal for the management of COVID-19-associated coagulopathy in children.
Ávila-Castro D, Ortiz-Torres G, Sánchez-Jara B, Valle-Cárdenas T, Aquino-Fernández E, González-Ávila AI, Majluf-Cruz A
Gac Med Mex 2020;156(4):344-353. doi: 10.24875/GMM.20000418. PMID: 32831339

Recent clinical studies

Etiology

COVID-19-Associated Pulmonary Embolism: Review of the Pathophysiology, Epidemiology, Prevention, Diagnosis, and Treatment.
Ortega-Paz L, Talasaz AH, Sadeghipour P, Potpara TS, Aronow HD, Jara-Palomares L, Sholzberg M, Angiolillo DJ, Lip GYH, Bikdeli B
Semin Thromb Hemost 2023 Nov;49(8):816-832. Epub 2022 Oct 12 doi: 10.1055/s-0042-1757634. PMID: 36223804
Clinical Features and Management of COVID-19-Associated Hypercoagulability.
Massaro G, Lecis D, Martuscelli E, Chiricolo G, Sangiorgi GM
Card Electrophysiol Clin 2022 Mar;14(1):41-52. Epub 2021 Oct 30 doi: 10.1016/j.ccep.2021.10.005. PMID: 35221084Free PMC Article
COVID-19 and coagulopathy.
Sarkar M, Madabhavi IV, Quy PN, Govindagoudar MB
Clin Respir J 2021 Dec;15(12):1259-1274. Epub 2021 Aug 30 doi: 10.1111/crj.13438. PMID: 34399021Free PMC Article
Stroke in COVID-19: A systematic review and meta-analysis.
Nannoni S, de Groot R, Bell S, Markus HS
Int J Stroke 2021 Feb;16(2):137-149. Epub 2020 Nov 11 doi: 10.1177/1747493020972922. PMID: 33103610Free PMC Article
COVID-19-associated coagulopathy.
Franchini M, Marano G, Cruciani M, Mengoli C, Pati I, Masiello F, Veropalumbo E, Pupella S, Vaglio S, Liumbruno GM
Diagnosis (Berl) 2020 Nov 18;7(4):357-363. doi: 10.1515/dx-2020-0078. PMID: 32683333

Diagnosis

Pulmonary Aspects of COVID-19.
Doerschug KC, Schmidt GA
Annu Rev Med 2022 Jan 27;73:81-93. doi: 10.1146/annurev-med-042220-014817. PMID: 35084996
COVID-19-associated coagulopathy and antithrombotic agents-lessons after 1 year.
Leentjens J, van Haaps TF, Wessels PF, Schutgens REG, Middeldorp S
Lancet Haematol 2021 Jul;8(7):e524-e533. Epub 2021 Apr 27 doi: 10.1016/S2352-3026(21)00105-8. PMID: 33930350Free PMC Article
Prophylaxis and treatment of COVID-19 related venous thromboembolism.
Kaptein FHJ, Stals MAM, Huisman MV, Klok FA
Postgrad Med 2021 Aug;133(sup1):27-35. Epub 2021 Mar 4 doi: 10.1080/00325481.2021.1891788. PMID: 33657964Free PMC Article
COVID-19-associated coagulopathy.
Franchini M, Marano G, Cruciani M, Mengoli C, Pati I, Masiello F, Veropalumbo E, Pupella S, Vaglio S, Liumbruno GM
Diagnosis (Berl) 2020 Nov 18;7(4):357-363. doi: 10.1515/dx-2020-0078. PMID: 32683333
COVID-19-associated coagulopathy: An exploration of mechanisms.
Colling ME, Kanthi Y
Vasc Med 2020 Oct;25(5):471-478. Epub 2020 Jun 19 doi: 10.1177/1358863X20932640. PMID: 32558620Free PMC Article

Therapy

Interrelationship between COVID-19 and Coagulopathy: Pathophysiological and Clinical Evidence.
Ragnoli B, Da Re B, Galantino A, Kette S, Salotti A, Malerba M
Int J Mol Sci 2023 May 18;24(10) doi: 10.3390/ijms24108945. PMID: 37240292Free PMC Article
Clinical Features and Management of COVID-19-Associated Hypercoagulability.
Massaro G, Lecis D, Martuscelli E, Chiricolo G, Sangiorgi GM
Card Electrophysiol Clin 2022 Mar;14(1):41-52. Epub 2021 Oct 30 doi: 10.1016/j.ccep.2021.10.005. PMID: 35221084Free PMC Article
COVID-19: Thrombosis, thromboinflammation, and anticoagulation considerations.
Levy JH, Iba T, Olson LB, Corey KM, Ghadimi K, Connors JM
Int J Lab Hematol 2021 Jul;43 Suppl 1(Suppl 1):29-35. doi: 10.1111/ijlh.13500. PMID: 34288441Free PMC Article
Stroke in COVID-19: A systematic review and meta-analysis.
Nannoni S, de Groot R, Bell S, Markus HS
Int J Stroke 2021 Feb;16(2):137-149. Epub 2020 Nov 11 doi: 10.1177/1747493020972922. PMID: 33103610Free PMC Article
COVID-19-associated coagulopathy.
Franchini M, Marano G, Cruciani M, Mengoli C, Pati I, Masiello F, Veropalumbo E, Pupella S, Vaglio S, Liumbruno GM
Diagnosis (Berl) 2020 Nov 18;7(4):357-363. doi: 10.1515/dx-2020-0078. PMID: 32683333

Prognosis

COVID-19 and immunothrombosis: Pathophysiology and therapeutic implications.
Lim MS, Mcrae S
Crit Rev Oncol Hematol 2021 Dec;168:103529. Epub 2021 Nov 17 doi: 10.1016/j.critrevonc.2021.103529. PMID: 34800652Free PMC Article
COVID-19-associated coagulopathy and antithrombotic agents-lessons after 1 year.
Leentjens J, van Haaps TF, Wessels PF, Schutgens REG, Middeldorp S
Lancet Haematol 2021 Jul;8(7):e524-e533. Epub 2021 Apr 27 doi: 10.1016/S2352-3026(21)00105-8. PMID: 33930350Free PMC Article
Prophylaxis and treatment of COVID-19 related venous thromboembolism.
Kaptein FHJ, Stals MAM, Huisman MV, Klok FA
Postgrad Med 2021 Aug;133(sup1):27-35. Epub 2021 Mar 4 doi: 10.1080/00325481.2021.1891788. PMID: 33657964Free PMC Article
COVID-19, immunothrombosis and venous thromboembolism: biological mechanisms.
Loo J, Spittle DA, Newnham M
Thorax 2021 Apr;76(4):412-420. Epub 2021 Jan 6 doi: 10.1136/thoraxjnl-2020-216243. PMID: 33408195
COVID-19-associated coagulopathy: An exploration of mechanisms.
Colling ME, Kanthi Y
Vasc Med 2020 Oct;25(5):471-478. Epub 2020 Jun 19 doi: 10.1177/1358863X20932640. PMID: 32558620Free PMC Article

Clinical prediction guides

Platelet-neutrophil interaction in COVID-19 and vaccine-induced thrombotic thrombocytopenia.
Hirsch J, Uzun G, Zlamal J, Singh A, Bakchoul T
Front Immunol 2023;14:1186000. Epub 2023 May 19 doi: 10.3389/fimmu.2023.1186000. PMID: 37275917Free PMC Article
Interrelationship between COVID-19 and Coagulopathy: Pathophysiological and Clinical Evidence.
Ragnoli B, Da Re B, Galantino A, Kette S, Salotti A, Malerba M
Int J Mol Sci 2023 May 18;24(10) doi: 10.3390/ijms24108945. PMID: 37240292Free PMC Article
COVID-19 related thrombosis: A mini-review.
Cheng NM, Chan YC, Cheng SW
Phlebology 2022 Jun;37(5):326-337. Epub 2022 Apr 10 doi: 10.1177/02683555211052170. PMID: 35403487Free PMC Article
COVID-19 and immunothrombosis: Pathophysiology and therapeutic implications.
Lim MS, Mcrae S
Crit Rev Oncol Hematol 2021 Dec;168:103529. Epub 2021 Nov 17 doi: 10.1016/j.critrevonc.2021.103529. PMID: 34800652Free PMC Article
COVID-19-associated coagulopathy: An exploration of mechanisms.
Colling ME, Kanthi Y
Vasc Med 2020 Oct;25(5):471-478. Epub 2020 Jun 19 doi: 10.1177/1358863X20932640. PMID: 32558620Free PMC Article

Recent systematic reviews

The Impact of COVID-19 on Vascular Surgery Practice: A Systematic Review.
Ulloa JH, Figueroa V, Cifuentes JS, Pinto P, Lurie F
Vasc Endovascular Surg 2021 Aug;55(6):601-611. Epub 2021 Mar 4 doi: 10.1177/1538574421998212. PMID: 33657926
Cerebral venous thrombosis and severe acute respiratory syndrome coronavirus-2 infection: A systematic review and meta-analysis.
Baldini T, Asioli GM, Romoli M, Carvalho Dias M, Schulte EC, Hauer L, Aguiar De Sousa D, Sellner J, Zini A
Eur J Neurol 2021 Oct;28(10):3478-3490. Epub 2021 Feb 2 doi: 10.1111/ene.14727. PMID: 33426733Free PMC Article
A Review of Pathophysiology, Clinical Features, and Management Options of COVID-19 Associated Coagulopathy.
Goswami J, MacArthur TA, Sridharan M, Pruthi RK, McBane RD 2nd, Witzig TE, Park MS
Shock 2021 Jun 1;55(6):700-716. doi: 10.1097/SHK.0000000000001680. PMID: 33378321Free PMC Article
Stroke in COVID-19: A systematic review and meta-analysis.
Nannoni S, de Groot R, Bell S, Markus HS
Int J Stroke 2021 Feb;16(2):137-149. Epub 2020 Nov 11 doi: 10.1177/1747493020972922. PMID: 33103610Free PMC Article
Clinical Characteristics of Stroke with COVID-19: A Systematic Review and Meta-Analysis.
Yamakawa M, Kuno T, Mikami T, Takagi H, Gronseth G
J Stroke Cerebrovasc Dis 2020 Dec;29(12):105288. Epub 2020 Aug 29 doi: 10.1016/j.jstrokecerebrovasdis.2020.105288. PMID: 32992199Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...