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Atypical Vascular Lesion of Breast

MedGen UID:
1744840
•Concept ID:
C5419511
•
Disease or Syndrome
Synonym: Atypical Vascular Proliferation of Breast

Definition

Benign vascular proliferations following external radiation for breast carcinoma. The lesions arise from the radiated skin and are papules, small vesicles, or erythematous ecchymotic plaques with prominent telangiectasias. There is an increased risk for subsequent development of angiosarcoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAtypical Vascular Lesion of Breast

Professional guidelines

PubMed

Low to Intermediate (Borderline) Grade Breast Spindle Cell Lesions on Needle Biopsy: Diagnostic Approach and Clinical Management.
Russell DH, Montgomery EA, Susnik B
Adv Anat Pathol 2022 Sep 1;29(5):309-323. Epub 2022 Jul 12 doi: 10.1097/PAP.0000000000000353. PMID: 35838633
Follow-up outcomes of benign vascular lesions of breast diagnosed on core needle biopsy: A study of 117 cases.
Zhang H, Han M, Varma K, Dabbs DJ
Breast J 2019 May;25(3):401-407. Epub 2019 Apr 18 doi: 10.1111/tbj.13233. PMID: 31001867
Diagnosis and management of benign, atypical, and indeterminate breast lesions detected on core needle biopsy.
Neal L, Sandhu NP, Hieken TJ, Glazebrook KN, Mac Bride MB, Dilaveri CA, Wahner-Roedler DL, Ghosh K, Visscher DW
Mayo Clin Proc 2014 Apr;89(4):536-47. doi: 10.1016/j.mayocp.2014.02.004. PMID: 24684875

Recent clinical studies

Etiology

Radiation Induced Atypical Vascular Lesion in the Breast.
Gotland N, Loya A, Lanng C, Rønning H, Tvedskov TF
Clin Breast Cancer 2022 Dec;22(8):e874-e876. Epub 2022 Aug 27 doi: 10.1016/j.clbc.2022.08.010. PMID: 36137938
Spectrum of imaging findings of papillary breast disease: A radiopathological review in a tertiary center.
Fadzli F, Rahmat K, Ramli MT, Rozalli FI, Hooi TK, Fadzli AN, Hoong SM, Ramli NM, Taib NAM
Medicine (Baltimore) 2021 Apr 23;100(16):e25297. doi: 10.1097/MD.0000000000025297. PMID: 33879660Free PMC Article
Effectiveness of Superb Microvascular Imaging for the differentiation of intraductal breast lesions.
Bakdik S, Arslan S, Oncu F, Durmaz MS, Altunkeser A, Eryilmaz MA, Unlu Y
Med Ultrason 2018 Aug 30;20(3):306-312. doi: 10.11152/mu-1433. PMID: 30167583
Vascular lesions of the breast.
Baker GM, Schnitt SJ
Semin Diagn Pathol 2017 Sep;34(5):410-419. Epub 2017 May 30 doi: 10.1053/j.semdp.2017.05.013. PMID: 28676174
Diagnosis and management of benign, atypical, and indeterminate breast lesions detected on core needle biopsy.
Neal L, Sandhu NP, Hieken TJ, Glazebrook KN, Mac Bride MB, Dilaveri CA, Wahner-Roedler DL, Ghosh K, Visscher DW
Mayo Clin Proc 2014 Apr;89(4):536-47. doi: 10.1016/j.mayocp.2014.02.004. PMID: 24684875

Diagnosis

Contemporary diagnostic approach to atypical vascular lesion and angiosarcoma.
Rutland CD, Bean GR, Charville GW
Semin Diagn Pathol 2023 Jul;40(4):284-294. Epub 2023 Apr 25 doi: 10.1053/j.semdp.2023.04.017. PMID: 37121782
Radiation Induced Atypical Vascular Lesion in the Breast.
Gotland N, Loya A, Lanng C, Rønning H, Tvedskov TF
Clin Breast Cancer 2022 Dec;22(8):e874-e876. Epub 2022 Aug 27 doi: 10.1016/j.clbc.2022.08.010. PMID: 36137938
Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.
Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889
Post-radiation vascular lesions of the breast.
Ronen S, Ivan D, Torres-Cabala CA, Curry JL, Tetzlaff MT, Aung PP, Nagarajan P, Suster S, Prieto VG
J Cutan Pathol 2019 Jan;46(1):52-58. Epub 2018 Nov 4 doi: 10.1111/cup.13363. PMID: 30251277
Vascular lesions of the breast.
Baker GM, Schnitt SJ
Semin Diagn Pathol 2017 Sep;34(5):410-419. Epub 2017 May 30 doi: 10.1053/j.semdp.2017.05.013. PMID: 28676174

Therapy

Post-radiation vascular lesions of the breast.
Ronen S, Ivan D, Torres-Cabala CA, Curry JL, Tetzlaff MT, Aung PP, Nagarajan P, Suster S, Prieto VG
J Cutan Pathol 2019 Jan;46(1):52-58. Epub 2018 Nov 4 doi: 10.1111/cup.13363. PMID: 30251277
Angiosarcoma and atypical vascular lesions of the breast: diagnostic and prognostic role of MYC gene amplification and protein expression.
Fraga-Guedes C, André S, Mastropasqua MG, Botteri E, Toesca A, Rocha RM, Peradze N, Rotmensz N, Viale G, Veronesi P, Gobbi H
Breast Cancer Res Treat 2015 May;151(1):131-40. Epub 2015 Apr 19 doi: 10.1007/s10549-015-3379-2. PMID: 25893585
Clinicopathological and immunohistochemical study of 30 cases of post-radiation atypical vascular lesion of the breast.
Fraga-Guedes C, Gobbi H, Mastropasqua MG, Rocha RM, Botteri E, Toesca A, Viale G
Breast Cancer Res Treat 2014 Jul;146(2):347-54. Epub 2014 Jun 19 doi: 10.1007/s10549-014-3020-9. PMID: 24943869
Post radiation skin tumors: basal cell carcinomas, squamous cell carcinomas and angiosarcomas. A review of this late effect of radiotherapy.
Cuperus E, Leguit R, Albregts M, Toonstra J
Eur J Dermatol 2013 Nov-Dec;23(6):749-57. doi: 10.1684/ejd.2013.2106. PMID: 24153098
Radiotherapy-associated atypical vascular lesions of the breast.
Uchin JM, Billings SD
J Cutan Pathol 2009 Jan;36(1):87-8. doi: 10.1111/j.1600-0560.2008.01211.x. PMID: 19125741

Prognosis

Benign Vascular Lesions of the Breast: A Clinical, Radiographic, and Pathologic Review.
Braun A, Solari M, Gattuso P, Agarwal I
Int J Surg Pathol 2023 Dec;31(8):1437-1448. Epub 2023 Apr 9 doi: 10.1177/10668969231160254. PMID: 37032453
Radiation Induced Atypical Vascular Lesion in the Breast.
Gotland N, Loya A, Lanng C, Rønning H, Tvedskov TF
Clin Breast Cancer 2022 Dec;22(8):e874-e876. Epub 2022 Aug 27 doi: 10.1016/j.clbc.2022.08.010. PMID: 36137938
Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.
Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889
Post-radiation vascular lesions of the breast.
Ronen S, Ivan D, Torres-Cabala CA, Curry JL, Tetzlaff MT, Aung PP, Nagarajan P, Suster S, Prieto VG
J Cutan Pathol 2019 Jan;46(1):52-58. Epub 2018 Nov 4 doi: 10.1111/cup.13363. PMID: 30251277
Vascular lesions of the breast.
Baker GM, Schnitt SJ
Semin Diagn Pathol 2017 Sep;34(5):410-419. Epub 2017 May 30 doi: 10.1053/j.semdp.2017.05.013. PMID: 28676174

Clinical prediction guides

Clinicopathologic and immunohistochemical study of breast angiosarcoma.
Yan M, Gilmore H, Bomeisl P, Harbhajanka A
Ann Diagn Pathol 2021 Oct;54:151795. Epub 2021 Jul 19 doi: 10.1016/j.anndiagpath.2021.151795. PMID: 34392127
Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.
Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889
Effectiveness of Superb Microvascular Imaging for the differentiation of intraductal breast lesions.
Bakdik S, Arslan S, Oncu F, Durmaz MS, Altunkeser A, Eryilmaz MA, Unlu Y
Med Ultrason 2018 Aug 30;20(3):306-312. doi: 10.11152/mu-1433. PMID: 30167583
Vascular lesions of the breast.
Baker GM, Schnitt SJ
Semin Diagn Pathol 2017 Sep;34(5):410-419. Epub 2017 May 30 doi: 10.1053/j.semdp.2017.05.013. PMID: 28676174
Myoepithelial and epithelial-myoepithelial, mesenchymal and fibroepithelial breast lesions: updates from the WHO Classification of Tumours of the Breast 2012.
Tan PH, Ellis IO
J Clin Pathol 2013 Jun;66(6):465-70. Epub 2013 Mar 26 doi: 10.1136/jclinpath-2012-201078. PMID: 23533258

Recent systematic reviews

MYC gene amplification by fluorescence in situ hybridization and MYC protein expression by immunohistochemistry in the diagnosis of cutaneous angiosarcoma: Systematic review and appropriate use criteria.
Motaparthi K, Lauer SR, Patel RM, Vidal CI, Linos K
J Cutan Pathol 2021 Apr;48(4):578-586. Epub 2020 Nov 16 doi: 10.1111/cup.13912. PMID: 33128474
Granular cell tumor a study of 42 cases and systemic review of the literature.
Mobarki M, Dumollard JM, Dal Col P, Camy F, Peoc'h M, Karpathiou G
Pathol Res Pract 2020 Apr;216(4):152865. Epub 2020 Feb 12 doi: 10.1016/j.prp.2020.152865. PMID: 32089415

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