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Chromosome 17p Abnormality

MedGen UID:
1746045
Concept ID:
C5418979
Cell or Molecular Dysfunction
Synonyms: 17p Aberration; 17p Abnormality

Definition

An irregularity in the structure of the short arm of chromosome 17. [from NCI]

Professional guidelines

PubMed

Hanamura I
Int J Hematol 2022 Jun;115(6):762-777. Epub 2022 May 9 doi: 10.1007/s12185-022-03353-5. PMID: 35534749Free PMC Article
Allan JN, Furman RR
Best Pract Res Clin Haematol 2018 Mar;31(1):73-82. Epub 2017 Nov 20 doi: 10.1016/j.beha.2017.10.012. PMID: 29452669
Sonneveld P, Avet-Loiseau H, Lonial S, Usmani S, Siegel D, Anderson KC, Chng WJ, Moreau P, Attal M, Kyle RA, Caers J, Hillengass J, San Miguel J, van de Donk NW, Einsele H, Bladé J, Durie BG, Goldschmidt H, Mateos MV, Palumbo A, Orlowski R
Blood 2016 Jun 16;127(24):2955-62. Epub 2016 Mar 21 doi: 10.1182/blood-2016-01-631200. PMID: 27002115Free PMC Article

Recent clinical studies

Etiology

Hanamura I
Int J Hematol 2022 Jun;115(6):762-777. Epub 2022 May 9 doi: 10.1007/s12185-022-03353-5. PMID: 35534749Free PMC Article
Baliakas P, Jeromin S, Iskas M, Puiggros A, Plevova K, Nguyen-Khac F, Davis Z, Rigolin GM, Visentin A, Xochelli A, Delgado J, Baran-Marszak F, Stalika E, Abrisqueta P, Durechova K, Papaioannou G, Eclache V, Dimou M, Iliakis T, Collado R, Doubek M, Calasanz MJ, Ruiz-Xiville N, Moreno C, Jarosova M, Leeksma AC, Panayiotidis P, Podgornik H, Cymbalista F, Anagnostopoulos A, Trentin L, Stavroyianni N, Davi F, Ghia P, Kater AP, Cuneo A, Pospisilova S, Espinet B, Athanasiadou A, Oscier D, Haferlach C, Stamatopoulos K; ERIC, the European Research Initiative on CLL
Blood 2019 Mar 14;133(11):1205-1216. Epub 2019 Jan 2 doi: 10.1182/blood-2018-09-873083. PMID: 30602617Free PMC Article
Sonneveld P, Avet-Loiseau H, Lonial S, Usmani S, Siegel D, Anderson KC, Chng WJ, Moreau P, Attal M, Kyle RA, Caers J, Hillengass J, San Miguel J, van de Donk NW, Einsele H, Bladé J, Durie BG, Goldschmidt H, Mateos MV, Palumbo A, Orlowski R
Blood 2016 Jun 16;127(24):2955-62. Epub 2016 Mar 21 doi: 10.1182/blood-2016-01-631200. PMID: 27002115Free PMC Article
Palumbo A, Avet-Loiseau H, Oliva S, Lokhorst HM, Goldschmidt H, Rosinol L, Richardson P, Caltagirone S, Lahuerta JJ, Facon T, Bringhen S, Gay F, Attal M, Passera R, Spencer A, Offidani M, Kumar S, Musto P, Lonial S, Petrucci MT, Orlowski RZ, Zamagni E, Morgan G, Dimopoulos MA, Durie BG, Anderson KC, Sonneveld P, San Miguel J, Cavo M, Rajkumar SV, Moreau P
J Clin Oncol 2015 Sep 10;33(26):2863-9. Epub 2015 Aug 3 doi: 10.1200/JCO.2015.61.2267. PMID: 26240224Free PMC Article
Döhner H, Stilgenbauer S, Benner A, Leupolt E, Kröber A, Bullinger L, Döhner K, Bentz M, Lichter P
N Engl J Med 2000 Dec 28;343(26):1910-6. doi: 10.1056/NEJM200012283432602. PMID: 11136261

Diagnosis

Clarke SE, Fuller KA, Erber WN
Blood Rev 2024 Mar;64:101168. Epub 2024 Jan 4 doi: 10.1016/j.blre.2024.101168. PMID: 38212176
Hanamura I
Int J Hematol 2022 Jun;115(6):762-777. Epub 2022 May 9 doi: 10.1007/s12185-022-03353-5. PMID: 35534749Free PMC Article
Palumbo A, Avet-Loiseau H, Oliva S, Lokhorst HM, Goldschmidt H, Rosinol L, Richardson P, Caltagirone S, Lahuerta JJ, Facon T, Bringhen S, Gay F, Attal M, Passera R, Spencer A, Offidani M, Kumar S, Musto P, Lonial S, Petrucci MT, Orlowski RZ, Zamagni E, Morgan G, Dimopoulos MA, Durie BG, Anderson KC, Sonneveld P, San Miguel J, Cavo M, Rajkumar SV, Moreau P
J Clin Oncol 2015 Sep 10;33(26):2863-9. Epub 2015 Aug 3 doi: 10.1200/JCO.2015.61.2267. PMID: 26240224Free PMC Article
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Collins VP
Cancer Surv 1998;32:37-51. PMID: 10489622

Therapy

Hanamura I
Int J Hematol 2022 Jun;115(6):762-777. Epub 2022 May 9 doi: 10.1007/s12185-022-03353-5. PMID: 35534749Free PMC Article
Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum K, Sharman JP, Wierda W, Zhao W, Heerema NA, Luan Y, Liu EA, Dean JP, O'Brien S
Clin Cancer Res 2020 Aug 1;26(15):3918-3927. Epub 2020 Mar 24 doi: 10.1158/1078-0432.CCR-19-2856. PMID: 32209572Free PMC Article
Sonneveld P, Avet-Loiseau H, Lonial S, Usmani S, Siegel D, Anderson KC, Chng WJ, Moreau P, Attal M, Kyle RA, Caers J, Hillengass J, San Miguel J, van de Donk NW, Einsele H, Bladé J, Durie BG, Goldschmidt H, Mateos MV, Palumbo A, Orlowski R
Blood 2016 Jun 16;127(24):2955-62. Epub 2016 Mar 21 doi: 10.1182/blood-2016-01-631200. PMID: 27002115Free PMC Article
Chen C, Puvvada S
Curr Hematol Malig Rep 2016 Feb;11(1):37-42. doi: 10.1007/s11899-015-0294-x. PMID: 26748932
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793

Prognosis

Hanamura I
Int J Hematol 2022 Jun;115(6):762-777. Epub 2022 May 9 doi: 10.1007/s12185-022-03353-5. PMID: 35534749Free PMC Article
Baliakas P, Jeromin S, Iskas M, Puiggros A, Plevova K, Nguyen-Khac F, Davis Z, Rigolin GM, Visentin A, Xochelli A, Delgado J, Baran-Marszak F, Stalika E, Abrisqueta P, Durechova K, Papaioannou G, Eclache V, Dimou M, Iliakis T, Collado R, Doubek M, Calasanz MJ, Ruiz-Xiville N, Moreno C, Jarosova M, Leeksma AC, Panayiotidis P, Podgornik H, Cymbalista F, Anagnostopoulos A, Trentin L, Stavroyianni N, Davi F, Ghia P, Kater AP, Cuneo A, Pospisilova S, Espinet B, Athanasiadou A, Oscier D, Haferlach C, Stamatopoulos K; ERIC, the European Research Initiative on CLL
Blood 2019 Mar 14;133(11):1205-1216. Epub 2019 Jan 2 doi: 10.1182/blood-2018-09-873083. PMID: 30602617Free PMC Article
Sonneveld P, Avet-Loiseau H, Lonial S, Usmani S, Siegel D, Anderson KC, Chng WJ, Moreau P, Attal M, Kyle RA, Caers J, Hillengass J, San Miguel J, van de Donk NW, Einsele H, Bladé J, Durie BG, Goldschmidt H, Mateos MV, Palumbo A, Orlowski R
Blood 2016 Jun 16;127(24):2955-62. Epub 2016 Mar 21 doi: 10.1182/blood-2016-01-631200. PMID: 27002115Free PMC Article
Palumbo A, Avet-Loiseau H, Oliva S, Lokhorst HM, Goldschmidt H, Rosinol L, Richardson P, Caltagirone S, Lahuerta JJ, Facon T, Bringhen S, Gay F, Attal M, Passera R, Spencer A, Offidani M, Kumar S, Musto P, Lonial S, Petrucci MT, Orlowski RZ, Zamagni E, Morgan G, Dimopoulos MA, Durie BG, Anderson KC, Sonneveld P, San Miguel J, Cavo M, Rajkumar SV, Moreau P
J Clin Oncol 2015 Sep 10;33(26):2863-9. Epub 2015 Aug 3 doi: 10.1200/JCO.2015.61.2267. PMID: 26240224Free PMC Article
Döhner H, Stilgenbauer S, Benner A, Leupolt E, Kröber A, Bullinger L, Döhner K, Bentz M, Lichter P
N Engl J Med 2000 Dec 28;343(26):1910-6. doi: 10.1056/NEJM200012283432602. PMID: 11136261

Clinical prediction guides

Hanamura I
Int J Hematol 2022 Jun;115(6):762-777. Epub 2022 May 9 doi: 10.1007/s12185-022-03353-5. PMID: 35534749Free PMC Article
Byrd JC, Furman RR, Coutre SE, Flinn IW, Burger JA, Blum K, Sharman JP, Wierda W, Zhao W, Heerema NA, Luan Y, Liu EA, Dean JP, O'Brien S
Clin Cancer Res 2020 Aug 1;26(15):3918-3927. Epub 2020 Mar 24 doi: 10.1158/1078-0432.CCR-19-2856. PMID: 32209572Free PMC Article
Vriend J, Marzban H
Cell Mol Life Sci 2017 Feb;74(3):449-467. Epub 2016 Sep 3 doi: 10.1007/s00018-016-2354-3. PMID: 27592301Free PMC Article
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Döhner H, Stilgenbauer S, Benner A, Leupolt E, Kröber A, Bullinger L, Döhner K, Bentz M, Lichter P
N Engl J Med 2000 Dec 28;343(26):1910-6. doi: 10.1056/NEJM200012283432602. PMID: 11136261

Recent systematic reviews

Mao X, Lillington DM, Czepulkowski B, Russell-Jones R, Young BD, Whittaker S
Genes Chromosomes Cancer 2003 Mar;36(3):250-60. doi: 10.1002/gcc.10152. PMID: 12557225

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