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Increased sulfur amino acid level in urine

MedGen UID:
1746960
•Concept ID:
C5421606
•
Finding
Synonyms: Increased sulfur-containing amino acid level in urine; Increased sulphur amino acid level in urine
 
HPO: HP:0033095

Definition

An elevated level of a sulfur-containing amino acid in the urine. [from HPO]

Professional guidelines

PubMed

Clinical characteristics and genotype analysis of five infants with cblX type of methylmalonic acidemia.
Wang F, Liang L, Ling S, Yu Y, Chen T, Xu F, Gong Z, Han L
Zhejiang Da Xue Xue Bao Yi Xue Ban 2022 Jun 25;51(3):298-305. doi: 10.3724/zdxbyxb-2022-0194. PMID: 36207831Free PMC Article
The Interaction of thiol drugs and urine pH in the treatment of cystinuria.
Asplin DM, Asplin JR
J Urol 2013 Jun;189(6):2147-51. Epub 2012 Dec 20 doi: 10.1016/j.juro.2012.12.031. PMID: 23261477
Metal element excretion in 24-h urine in patients with Wilson disease under treatment of D-penicillamine.
Huang L, Yu X, Zhang J, Liu X, Zhang Y, Jiao X, Yu X
Biol Trace Elem Res 2012 May;146(2):154-9. Epub 2011 Nov 11 doi: 10.1007/s12011-011-9250-3. PMID: 22076732

Recent clinical studies

Etiology

Systematic Review of Roles of Arecoline and Arecoline N-Oxide in Oral Cancer and Strategies to Block Carcinogenesis.
Ko AM, Tu HP, Ko YC
Cells 2023 Apr 21;12(8) doi: 10.3390/cells12081208. PMID: 37190117Free PMC Article
Increased Levels of the Acrolein Metabolite 3-Hydroxypropyl Mercapturic Acid in the Urine of e-Cigarette Users.
Chen M, Carmella SG, Lindgren BR, Luo X, Ikuemonisan J, Niesen B, Thomson NM, Murphy SE, Hatsukami DK, Hecht SS
Chem Res Toxicol 2023 Apr 17;36(4):583-588. Epub 2022 Jul 20 doi: 10.1021/acs.chemrestox.2c00145. PMID: 35858275Free PMC Article
Safety of Dietary Guanidinoacetic Acid: A Villain of a Good Guy?
Ostojic SM
Nutrients 2021 Dec 24;14(1) doi: 10.3390/nu14010075. PMID: 35010949Free PMC Article
Cystinuria: genetic aspects, mouse models, and a new approach to therapy.
Sahota A, Tischfield JA, Goldfarb DS, Ward MD, Hu L
Urolithiasis 2019 Feb;47(1):57-66. Epub 2018 Dec 4 doi: 10.1007/s00240-018-1101-7. PMID: 30515543Free PMC Article
Metabolism of sulfur compounds in homocystinurias.
Kožich V, Ditrói T, Sokolová J, Křížková M, Krijt J, Ješina P, Nagy P
Br J Pharmacol 2019 Feb;176(4):594-606. Epub 2018 Nov 25 doi: 10.1111/bph.14523. PMID: 30341787Free PMC Article

Diagnosis

Systematic Review of Roles of Arecoline and Arecoline N-Oxide in Oral Cancer and Strategies to Block Carcinogenesis.
Ko AM, Tu HP, Ko YC
Cells 2023 Apr 21;12(8) doi: 10.3390/cells12081208. PMID: 37190117Free PMC Article
Acrolein Exposure Impaired Glucose Homeostasis and Increased Risk of Type 2 Diabetes: An Urban Adult Population-Based Cohort Study with Repeated Measures.
Wang B, Liu W, Yu L, Ye Z, Cheng M, Qiu W, Zhou M, Ma J, Wang X, Yang M, Song J, Chen W
Environ Sci Technol 2023 May 9;57(18):7162-7173. Epub 2023 Apr 25 doi: 10.1021/acs.est.2c09299. PMID: 37098180
Clinical Significance and Value of Serum Homocysteine and Urine 11 Dehydrothromboxane B2 Combined with Transferrin-Specific Peptide in the Diagnosis of Cerebral Apoplexy.
Liu J, He J, Zhang C
Comput Math Methods Med 2022;2022:6130413. Epub 2022 May 17 doi: 10.1155/2022/6130413. PMID: 35620205Free PMC Article
Significance of 5-S-Cysteinyldopa as a Marker for Melanoma.
Wakamatsu K, Fukushima S, Minagawa A, Omodaka T, Hida T, Hatta N, Takata M, Uhara H, Okuyama R, Ihn H
Int J Mol Sci 2020 Jan 9;21(2) doi: 10.3390/ijms21020432. PMID: 31936623Free PMC Article
Increased glutamate and homocysteine and decreased glutamine levels in autism: a review and strategies for future studies of amino acids in autism.
Ghanizadeh A
Dis Markers 2013;35(5):281-6. Epub 2013 Sep 12 doi: 10.1155/2013/536521. PMID: 24167375Free PMC Article

Therapy

Accurate 24-h urine cystine quantification for patients on cystine-binding thiol drugs.
Mikel CC, Goldfarb DS, Ponte A, Steigelman K, Latyshev S
Urolithiasis 2022 Dec;50(6):721-727. Epub 2022 Oct 6 doi: 10.1007/s00240-022-01364-9. PMID: 36201021Free PMC Article
Safety of Dietary Guanidinoacetic Acid: A Villain of a Good Guy?
Ostojic SM
Nutrients 2021 Dec 24;14(1) doi: 10.3390/nu14010075. PMID: 35010949Free PMC Article
Cystinuria: genetic aspects, mouse models, and a new approach to therapy.
Sahota A, Tischfield JA, Goldfarb DS, Ward MD, Hu L
Urolithiasis 2019 Feb;47(1):57-66. Epub 2018 Dec 4 doi: 10.1007/s00240-018-1101-7. PMID: 30515543Free PMC Article
Fenofibrate, homocysteine and renal function.
Foucher C, Brugère L, Ansquer JC
Curr Vasc Pharmacol 2010 Sep;8(5):589-603. doi: 10.2174/157016110792006987. PMID: 20507276
Pediatric arsenic ingestion.
Cullen NM, Wolf LR, St Clair D
Am J Emerg Med 1995 Jul;13(4):432-5. doi: 10.1016/0735-6757(95)90133-7. PMID: 7605532

Prognosis

Systematic Review of Roles of Arecoline and Arecoline N-Oxide in Oral Cancer and Strategies to Block Carcinogenesis.
Ko AM, Tu HP, Ko YC
Cells 2023 Apr 21;12(8) doi: 10.3390/cells12081208. PMID: 37190117Free PMC Article
Significance of 5-S-Cysteinyldopa as a Marker for Melanoma.
Wakamatsu K, Fukushima S, Minagawa A, Omodaka T, Hida T, Hatta N, Takata M, Uhara H, Okuyama R, Ihn H
Int J Mol Sci 2020 Jan 9;21(2) doi: 10.3390/ijms21020432. PMID: 31936623Free PMC Article
Homocysteine Levels in Autism Spectrum Disorder: A Clinical Update.
Fuentes-Albero M, Cauli O
Endocr Metab Immune Disord Drug Targets 2018;18(4):289-296. doi: 10.2174/1871530318666180213110815. PMID: 29437021
Urine cysteinyl leukotriene levels in children with sleep disordered breathing before and after adenotonsillectomy.
Satdhabudha A, Sritipsukho P, Manochantr S, Chanvimalueng W, Chaumrattanakul U, Chaumphol P
Int J Pediatr Otorhinolaryngol 2017 Mar;94:112-116. Epub 2017 Jan 20 doi: 10.1016/j.ijporl.2017.01.021. PMID: 28167000
Dietary animal and plant protein and human bone health: a whole foods approach.
Massey LK
J Nutr 2003 Mar;133(3):862S-865S. doi: 10.1093/jn/133.3.862S. PMID: 12612170

Clinical prediction guides

Significance of 5-S-Cysteinyldopa as a Marker for Melanoma.
Wakamatsu K, Fukushima S, Minagawa A, Omodaka T, Hida T, Hatta N, Takata M, Uhara H, Okuyama R, Ihn H
Int J Mol Sci 2020 Jan 9;21(2) doi: 10.3390/ijms21020432. PMID: 31936623Free PMC Article
Urine cysteinyl leukotriene levels in children with sleep disordered breathing before and after adenotonsillectomy.
Satdhabudha A, Sritipsukho P, Manochantr S, Chanvimalueng W, Chaumrattanakul U, Chaumphol P
Int J Pediatr Otorhinolaryngol 2017 Mar;94:112-116. Epub 2017 Jan 20 doi: 10.1016/j.ijporl.2017.01.021. PMID: 28167000
Long-term patterns of urinary pyroglutamic acid in healthy humans.
Lord RS
Physiol Rep 2016 Feb;4(4) doi: 10.14814/phy2.12706. PMID: 26908712Free PMC Article
Fenofibrate, homocysteine and renal function.
Foucher C, Brugère L, Ansquer JC
Curr Vasc Pharmacol 2010 Sep;8(5):589-603. doi: 10.2174/157016110792006987. PMID: 20507276
Dietary animal and plant protein and human bone health: a whole foods approach.
Massey LK
J Nutr 2003 Mar;133(3):862S-865S. doi: 10.1093/jn/133.3.862S. PMID: 12612170

Recent systematic reviews

Systematic Review of Roles of Arecoline and Arecoline N-Oxide in Oral Cancer and Strategies to Block Carcinogenesis.
Ko AM, Tu HP, Ko YC
Cells 2023 Apr 21;12(8) doi: 10.3390/cells12081208. PMID: 37190117Free PMC Article
Is a low blood level of vitamin B12 a cardiovascular and diabetes risk factor? A systematic review of cohort studies.
Rafnsson SB, Saravanan P, Bhopal RS, Yajnik CS
Eur J Nutr 2011 Mar;50(2):97-106. Epub 2010 Jun 29 doi: 10.1007/s00394-010-0119-6. PMID: 20585951

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