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Advanced Primary Malignant Central Nervous System Neoplasm

MedGen UID:
1747591
Concept ID:
C5418910
Neoplastic Process

Definition

A malignant neoplasm that arises from the central nervous system and has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Primary Malignant Central Nervous System Neoplasm

Professional guidelines

PubMed

Rudà R, Bruno F, Pellerino A, Soffietti R
Curr Oncol Rep 2022 Aug;24(8):985-993. Epub 2022 Apr 6 doi: 10.1007/s11912-022-01260-w. PMID: 35384591Free PMC Article
Maggio I, Franceschi E, Tosoni A, Nunno VD, Gatto L, Lodi R, Brandes AA
CNS Oncol 2021 Jun 1;10(2):CNS72. Epub 2021 May 21 doi: 10.2217/cns-2021-0003. PMID: 34015955Free PMC Article
Wen PY, Weller M, Lee EQ, Alexander BM, Barnholtz-Sloan JS, Barthel FP, Batchelor TT, Bindra RS, Chang SM, Chiocca EA, Cloughesy TF, DeGroot JF, Galanis E, Gilbert MR, Hegi ME, Horbinski C, Huang RY, Lassman AB, Le Rhun E, Lim M, Mehta MP, Mellinghoff IK, Minniti G, Nathanson D, Platten M, Preusser M, Roth P, Sanson M, Schiff D, Short SC, Taphoorn MJB, Tonn JC, Tsang J, Verhaak RGW, von Deimling A, Wick W, Zadeh G, Reardon DA, Aldape KD, van den Bent MJ
Neuro Oncol 2020 Aug 17;22(8):1073-1113. doi: 10.1093/neuonc/noaa106. PMID: 32328653Free PMC Article

Recent clinical studies

Etiology

Solomon BJ, Bauer TM, Mok TSK, Liu G, Mazieres J, de Marinis F, Goto Y, Kim DW, Wu YL, Jassem J, López FL, Soo RA, Shaw AT, Polli A, Messina R, Iadeluca L, Toffalorio F, Felip E
Lancet Respir Med 2023 Apr;11(4):354-366. Epub 2022 Dec 16 doi: 10.1016/S2213-2600(22)00437-4. PMID: 36535300
Rudà R, Bruno F, Pellerino A, Soffietti R
Curr Oncol Rep 2022 Aug;24(8):985-993. Epub 2022 Apr 6 doi: 10.1007/s11912-022-01260-w. PMID: 35384591Free PMC Article
Lapointe S, Perry A, Butowski NA
Lancet 2018 Aug 4;392(10145):432-446. Epub 2018 Jul 27 doi: 10.1016/S0140-6736(18)30990-5. PMID: 30060998
Peters S, Camidge DR, Shaw AT, Gadgeel S, Ahn JS, Kim DW, Ou SI, Pérol M, Dziadziuszko R, Rosell R, Zeaiter A, Mitry E, Golding S, Balas B, Noe J, Morcos PN, Mok T; ALEX Trial Investigators
N Engl J Med 2017 Aug 31;377(9):829-838. Epub 2017 Jun 6 doi: 10.1056/NEJMoa1704795. PMID: 28586279
Wiemels J, Wrensch M, Claus EB
J Neurooncol 2010 Sep;99(3):307-14. Epub 2010 Sep 7 doi: 10.1007/s11060-010-0386-3. PMID: 20821343Free PMC Article

Diagnosis

Wang LM, Englander ZK, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:1-30. doi: 10.1007/978-3-031-23705-8_1. PMID: 37452933
Schaff LR, Grommes C
Blood 2022 Sep 1;140(9):971-979. doi: 10.1182/blood.2020008377. PMID: 34699590Free PMC Article
Lah TT, Novak M, Breznik B
Semin Cancer Biol 2020 Feb;60:262-273. Epub 2019 Oct 22 doi: 10.1016/j.semcancer.2019.10.010. PMID: 31654711
Buerki RA, Horbinski CM, Kruser T, Horowitz PM, James CD, Lukas RV
Future Oncol 2018 Sep;14(21):2161-2177. Epub 2018 Aug 7 doi: 10.2217/fon-2018-0006. PMID: 30084265Free PMC Article
Lapointe S, Perry A, Butowski NA
Lancet 2018 Aug 4;392(10145):432-446. Epub 2018 Jul 27 doi: 10.1016/S0140-6736(18)30990-5. PMID: 30060998

Therapy

Solomon BJ, Bauer TM, Mok TSK, Liu G, Mazieres J, de Marinis F, Goto Y, Kim DW, Wu YL, Jassem J, López FL, Soo RA, Shaw AT, Polli A, Messina R, Iadeluca L, Toffalorio F, Felip E
Lancet Respir Med 2023 Apr;11(4):354-366. Epub 2022 Dec 16 doi: 10.1016/S2213-2600(22)00437-4. PMID: 36535300
Rodríguez-Camacho A, Flores-Vázquez JG, Moscardini-Martelli J, Torres-Ríos JA, Olmos-Guzmán A, Ortiz-Arce CS, Cid-Sánchez DR, Pérez SR, Macías-González MDS, Hernández-Sánchez LC, Heredia-Gutiérrez JC, Contreras-Palafox GA, Suárez-Campos JJE, Celis-López MÁ, Gutiérrez-Aceves GA, Moreno-Jiménez S
Int J Mol Sci 2022 Jun 29;23(13) doi: 10.3390/ijms23137207. PMID: 35806212Free PMC Article
Schaff LR, Grommes C
Blood 2022 Sep 1;140(9):971-979. doi: 10.1182/blood.2020008377. PMID: 34699590Free PMC Article
Wen PY, Weller M, Lee EQ, Alexander BM, Barnholtz-Sloan JS, Barthel FP, Batchelor TT, Bindra RS, Chang SM, Chiocca EA, Cloughesy TF, DeGroot JF, Galanis E, Gilbert MR, Hegi ME, Horbinski C, Huang RY, Lassman AB, Le Rhun E, Lim M, Mehta MP, Mellinghoff IK, Minniti G, Nathanson D, Platten M, Preusser M, Roth P, Sanson M, Schiff D, Short SC, Taphoorn MJB, Tonn JC, Tsang J, Verhaak RGW, von Deimling A, Wick W, Zadeh G, Reardon DA, Aldape KD, van den Bent MJ
Neuro Oncol 2020 Aug 17;22(8):1073-1113. doi: 10.1093/neuonc/noaa106. PMID: 32328653Free PMC Article
Peters S, Camidge DR, Shaw AT, Gadgeel S, Ahn JS, Kim DW, Ou SI, Pérol M, Dziadziuszko R, Rosell R, Zeaiter A, Mitry E, Golding S, Balas B, Noe J, Morcos PN, Mok T; ALEX Trial Investigators
N Engl J Med 2017 Aug 31;377(9):829-838. Epub 2017 Jun 6 doi: 10.1056/NEJMoa1704795. PMID: 28586279

Prognosis

Schaff LR, Grommes C
Blood 2022 Sep 1;140(9):971-979. doi: 10.1182/blood.2020008377. PMID: 34699590Free PMC Article
Ma R, Taphoorn MJB, Plaha P
J Neurol Neurosurg Psychiatry 2021 Oct;92(10):1103-1111. Epub 2021 Jun 23 doi: 10.1136/jnnp-2020-325334. PMID: 34162730
Buerki RA, Horbinski CM, Kruser T, Horowitz PM, James CD, Lukas RV
Future Oncol 2018 Sep;14(21):2161-2177. Epub 2018 Aug 7 doi: 10.2217/fon-2018-0006. PMID: 30084265Free PMC Article
Lapointe S, Perry A, Butowski NA
Lancet 2018 Aug 4;392(10145):432-446. Epub 2018 Jul 27 doi: 10.1016/S0140-6736(18)30990-5. PMID: 30060998
Peters S, Camidge DR, Shaw AT, Gadgeel S, Ahn JS, Kim DW, Ou SI, Pérol M, Dziadziuszko R, Rosell R, Zeaiter A, Mitry E, Golding S, Balas B, Noe J, Morcos PN, Mok T; ALEX Trial Investigators
N Engl J Med 2017 Aug 31;377(9):829-838. Epub 2017 Jun 6 doi: 10.1056/NEJMoa1704795. PMID: 28586279

Clinical prediction guides

Solomon BJ, Bauer TM, Mok TSK, Liu G, Mazieres J, de Marinis F, Goto Y, Kim DW, Wu YL, Jassem J, López FL, Soo RA, Shaw AT, Polli A, Messina R, Iadeluca L, Toffalorio F, Felip E
Lancet Respir Med 2023 Apr;11(4):354-366. Epub 2022 Dec 16 doi: 10.1016/S2213-2600(22)00437-4. PMID: 36535300
Driver J, Hoffman SE, Tavakol S, Woodward E, Maury EA, Bhave V, Greenwald NF, Nassiri F, Aldape K, Zadeh G, Choudhury A, Vasudevan HN, Magill ST, Raleigh DR, Abedalthagafi M, Aizer AA, Alexander BM, Ligon KL, Reardon DA, Wen PY, Al-Mefty O, Ligon AH, Dubuc AM, Beroukhim R, Claus EB, Dunn IF, Santagata S, Bi WL
Neuro Oncol 2022 May 4;24(5):796-808. doi: 10.1093/neuonc/noab213. PMID: 34508644Free PMC Article
Mok T, Camidge DR, Gadgeel SM, Rosell R, Dziadziuszko R, Kim DW, Pérol M, Ou SI, Ahn JS, Shaw AT, Bordogna W, Smoljanović V, Hilton M, Ruf T, Noé J, Peters S
Ann Oncol 2020 Aug;31(8):1056-1064. Epub 2020 May 11 doi: 10.1016/j.annonc.2020.04.478. PMID: 32418886
Soomro SH, Ting LR, Qing YY, Ren M
J Pak Med Assoc 2017 Sep;67(9):1410-1414. PMID: 28924284
Aldape K, Zadeh G, Mansouri S, Reifenberger G, von Deimling A
Acta Neuropathol 2015 Jun;129(6):829-48. Epub 2015 May 6 doi: 10.1007/s00401-015-1432-1. PMID: 25943888

Recent systematic reviews

Häuser W, Welsch P, Radbruch L, Fisher E, Bell RF, Moore RA
Cochrane Database Syst Rev 2023 Jun 5;6(6):CD014915. doi: 10.1002/14651858.CD014915.pub2. PMID: 37283486Free PMC Article
Cameron LB, Hitchen N, Chandran E, Morris T, Manser R, Solomon BJ, Jordan V
Cochrane Database Syst Rev 2022 Jan 7;1(1):CD013453. doi: 10.1002/14651858.CD013453.pub2. PMID: 34994987Free PMC Article
Nieblas-Bedolla E, Christophers B, Williams JR, Power-Hays A, Jimenez N, Rodriguez A
J Neurooncol 2021 May;152(3):451-466. Epub 2021 Mar 28 doi: 10.1007/s11060-021-03738-2. PMID: 33774801
Franca RA, Travaglino A, Varricchio S, Russo D, Picardi M, Pane F, Pace M, Del Basso De Caro M, Mascolo M
Pathol Res Pract 2020 Nov;216(11):153192. Epub 2020 Sep 6 doi: 10.1016/j.prp.2020.153192. PMID: 32956921
Yang Z, Zhang T, Gao H
Medicine (Baltimore) 2016 Nov;95(47):e5268. doi: 10.1097/MD.0000000000005268. PMID: 27893664Free PMC Article

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