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Metastatic Malignant Mixed Mesodermal (Mullerian) Tumor

MedGen UID:: 1747700
•Concept ID:: C5418883
•: Neoplastic Process

Definition

A malignant mixed mesodermal (Mullerian) tumor that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMetastatic Malignant Mixed Mesodermal (Mullerian) Tumor

Disease
- Neoplasm
  - Malignant neoplastic disease
    - Malignant mixed neoplasm
      - Carcinosarcoma
        Malignant Mixed Mesodermal (Mullerian) Tumor
        Metastatic Malignant Mixed Mesodermal (Mullerian) Tumor
        Advanced Malignant Mixed Mesodermal (Mullerian) Tumor
        Advanced Ovarian Carcinosarcoma
        Advanced Uterine Corpus Carcinosarcoma
        Metastatic Ovarian Carcinosarcoma
        Metastatic Uterine Corpus Carcinosarcoma

Recent clinical studies

Etiology

Ovarian sex cord-stromal tumours and their mimics.

Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723

Carcinosarcoma (malignant mixed mesodermal tumor) of the uterus: clinicoimmunohistochemical and histogenetic characteristics.

Kedzia W, Pruski D, Iwaniec K, Przybylski M, Friebe Z, Rajpert-Kedzia H
Folia Histochem Cytobiol 2012;50(4):513-8. doi: 10.5603/19688. PMID: 23264213

Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications.

Kurman RJ, Shih IeM
Int J Gynecol Pathol 2008 Apr;27(2):151-60. doi: 10.1097/PGP.0b013e318161e4f5. PMID: 18317228 Free PMC Article

Malignant mixed mullerian tumor of the uterus in a patient taking raloxifene.

Goldman NA, de Los Angeles MM, Jones JG, Goldberg GL
Obstet Gynecol 2005 May;105(5 Pt 2):1278-80. doi: 10.1097/01.AOG.0000160480.55365.a8. PMID: 15863610

Laparoscopic lymphadenectomy for gynecologic malignancies.

Dottino PR, Tobias DH, Beddoe A, Golden AL, Cohen CJ
Gynecol Oncol 1999 Jun;73(3):383-8. doi: 10.1006/gyno.1999.5376. PMID: 10366464

See all (15)

Diagnosis

Ovarian sex cord-stromal tumours and their mimics.

Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723

Carcinosarcoma (malignant mixed mesodermal tumor) of the uterus: clinicoimmunohistochemical and histogenetic characteristics.

Kedzia W, Pruski D, Iwaniec K, Przybylski M, Friebe Z, Rajpert-Kedzia H
Folia Histochem Cytobiol 2012;50(4):513-8. doi: 10.5603/19688. PMID: 23264213

Malignant mixed mullerian tumor of the cervix including components of a rhabdomyosarcoma: case report and literature review.

Lee SH, Kim J, Kim JH, Lee KH, Park JS, Hur SY
Eur J Gynaecol Oncol 2010;31(4):462-6. PMID: 20882897

Malignant mixed mullerian tumor of the uterus in a patient taking raloxifene.

Goldman NA, de Los Angeles MM, Jones JG, Goldberg GL
Obstet Gynecol 2005 May;105(5 Pt 2):1278-80. doi: 10.1097/01.AOG.0000160480.55365.a8. PMID: 15863610

Coexistent choriocarcinoma and malignant mixed mesodermal tumor of the uterus.

Nguyen CP, Levi AW, Montz FJ, Bristow RE
Gynecol Oncol 2000 Dec;79(3):499-503. doi: 10.1006/gyno.2000.5976. PMID: 11104628

See all (27)

Therapy

Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications.

Kurman RJ, Shih IeM
Int J Gynecol Pathol 2008 Apr;27(2):151-60. doi: 10.1097/PGP.0b013e318161e4f5. PMID: 18317228 Free PMC Article

Malignant mixed mullerian tumor of the uterus in a patient taking raloxifene.

Goldman NA, de Los Angeles MM, Jones JG, Goldberg GL
Obstet Gynecol 2005 May;105(5 Pt 2):1278-80. doi: 10.1097/01.AOG.0000160480.55365.a8. PMID: 15863610

Systemic therapy for advanced uterine sarcoma: a systematic review of the literature.

Kanjeekal S, Chambers A, Fung MF, Verma S
Gynecol Oncol 2005 May;97(2):624-37. doi: 10.1016/j.ygyno.2005.01.041. PMID: 15863170

Dedifferentiated extrauterine adenosarcoma responsive to chemotherapy.

Roman LD, Mitchell MF, Tornos C, Glover A, Kavanagh JJ
Gynecol Oncol 1993 Jun;49(3):389-94. doi: 10.1006/gyno.1993.1146. PMID: 8390963

Cisplatin therapy for disseminated mixed mesodermal sarcoma of the uterus.

Gershenson DM, Kavanagh JJ, Copeland LJ, Edwards CL, Stringer CA, Wharton JT
J Clin Oncol 1987 Apr;5(4):618-21. doi: 10.1200/JCO.1987.5.4.618. PMID: 3559652

See all (13)

Prognosis

Carcinosarcoma (malignant mixed mesodermal tumor) of the uterus: clinicoimmunohistochemical and histogenetic characteristics.

Kedzia W, Pruski D, Iwaniec K, Przybylski M, Friebe Z, Rajpert-Kedzia H
Folia Histochem Cytobiol 2012;50(4):513-8. doi: 10.5603/19688. PMID: 23264213

Malignant mixed mullerian tumor of the cervix including components of a rhabdomyosarcoma: case report and literature review.

Lee SH, Kim J, Kim JH, Lee KH, Park JS, Hur SY
Eur J Gynaecol Oncol 2010;31(4):462-6. PMID: 20882897

Primary peritoneal malignant mixed mesodermal (Müllerian) tumor.

Hussein MR, Hussein SR, Abd-Elwahed AR
Tumori 2009 Jul-Aug;95(4):525-31. doi: 10.1177/030089160909500421. PMID: 19856669

Malignant mixed mullerian tumor of the uterus in a patient taking raloxifene.

Goldman NA, de Los Angeles MM, Jones JG, Goldberg GL
Obstet Gynecol 2005 May;105(5 Pt 2):1278-80. doi: 10.1097/01.AOG.0000160480.55365.a8. PMID: 15863610

Coexistent choriocarcinoma and malignant mixed mesodermal tumor of the uterus.

Nguyen CP, Levi AW, Montz FJ, Bristow RE
Gynecol Oncol 2000 Dec;79(3):499-503. doi: 10.1006/gyno.2000.5976. PMID: 11104628

See all (30)

Clinical prediction guides

Carcinosarcoma (malignant mixed mesodermal tumor) of the uterus: clinicoimmunohistochemical and histogenetic characteristics.

Kedzia W, Pruski D, Iwaniec K, Przybylski M, Friebe Z, Rajpert-Kedzia H
Folia Histochem Cytobiol 2012;50(4):513-8. doi: 10.5603/19688. PMID: 23264213

Are all pelvic (nonuterine) serous carcinomas of tubal origin?

Przybycin CG, Kurman RJ, Ronnett BM, Shih IeM, Vang R
Am J Surg Pathol 2010 Oct;34(10):1407-16. doi: 10.1097/PAS.0b013e3181ef7b16. PMID: 20861711

Endometrial mesodermal mixed tumor occurring after tamoxifen treatment: report on a new case and review of the literature.

Dumortier J, Freyer G, Sasco AJ, Frappart L, Zénone T, Romestaing P, Trillet-Lenoir V
Ann Oncol 2000 Mar;11(3):355-8. doi: 10.1023/a:1008338231169. PMID: 10811505

Primary malignant mixed Müllerian tumor (metaplastic carcinoma) of the female peritoneum. A clinical, pathologic, and immunohistochemical study of three cases and a review of the literature.

Garamvoelgyi E, Guillou L, Gebhard S, Salmeron M, Seematter RJ, Hadji MH
Cancer 1994 Aug 1;74(3):854-63. doi: 10.1002/1097-0142(19940801)74:3<854::aid-cncr2820740311>3.0.co;2-r. PMID: 7518735

Treatment of patients with sarcoma of the uterus.

Bokhman JV, Yakovleva IA, Urmanchejeva AF
Eur J Gynaecol Oncol 1990;11(3):225-31. PMID: 2209643

See all (8)