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Small Progressed Hepatocellular Carcinoma

MedGen UID:
1749508
•Concept ID:
C5419809
•
Neoplastic Process
Synonym: Small pHCC

Definition

A well to moderately differentiated small hepatocellular carcinoma. It is characterized by the presence of obvious stromal invasion and increase atypia compared with early hepatocellular carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall Progressed Hepatocellular Carcinoma

Professional guidelines

PubMed

The evolution of PRRT for the treatment of neuroendocrine tumors; What comes next?
Harris PE, Zhernosekov K
Front Endocrinol (Lausanne) 2022;13:941832. Epub 2022 Oct 31 doi: 10.3389/fendo.2022.941832. PMID: 36387893Free PMC Article
Treatment options for alcoholic and non-alcoholic fatty liver disease: A review.
Singh S, Osna NA, Kharbanda KK
World J Gastroenterol 2017 Sep 28;23(36):6549-6570. doi: 10.3748/wjg.v23.i36.6549. PMID: 29085205Free PMC Article
Alpha-1 antitrypsin deficiency: pathogenesis, clinical presentation, diagnosis, and treatment.
Köhnlein T, Welte T
Am J Med 2008 Jan;121(1):3-9. doi: 10.1016/j.amjmed.2007.07.025. PMID: 18187064

Recent clinical studies

Etiology

Hepatitis D Virus and Hepatocellular Carcinoma.
Farci P, Niro GA, Zamboni F, Diaz G
Viruses 2021 May 4;13(5) doi: 10.3390/v13050830. PMID: 34064419Free PMC Article
Tumor-derived adenosine promotes macrophage proliferation in human hepatocellular carcinoma.
Wang J, Wang Y, Chu Y, Li Z, Yu X, Huang Z, Xu J, Zheng L
J Hepatol 2021 Mar;74(3):627-637. Epub 2020 Oct 31 doi: 10.1016/j.jhep.2020.10.021. PMID: 33137360
NASH, Fibrosis and Hepatocellular Carcinoma: Lipid Synthesis and Glutamine/Acetate Signaling.
Sunami Y
Int J Mol Sci 2020 Sep 16;21(18) doi: 10.3390/ijms21186799. PMID: 32947972Free PMC Article
Molecular Mechanisms: Connections between Nonalcoholic Fatty Liver Disease, Steatohepatitis and Hepatocellular Carcinoma.
Kanda T, Goto T, Hirotsu Y, Masuzaki R, Moriyama M, Omata M
Int J Mol Sci 2020 Feb 23;21(4) doi: 10.3390/ijms21041525. PMID: 32102237Free PMC Article
Hepatocellular carcinoma.
Forner A, Llovet JM, Bruix J
Lancet 2012 Mar 31;379(9822):1245-55. Epub 2012 Feb 20 doi: 10.1016/S0140-6736(11)61347-0. PMID: 22353262

Diagnosis

Artificial intelligence in gastroenterology: A state-of-the-art review.
Kröner PT, Engels MM, Glicksberg BS, Johnson KW, Mzaik O, van Hooft JE, Wallace MB, El-Serag HB, Krittanawong C
World J Gastroenterol 2021 Oct 28;27(40):6794-6824. doi: 10.3748/wjg.v27.i40.6794. PMID: 34790008Free PMC Article
Application of Immunohistochemistry in the Pathological Diagnosis of Liver Tumors.
Takahashi Y, Dungubat E, Kusano H, Ganbat D, Tomita Y, Odgerel S, Fukusato T
Int J Mol Sci 2021 May 28;22(11) doi: 10.3390/ijms22115780. PMID: 34071338Free PMC Article
Liquid biopsy in hepatocellular carcinoma: circulating tumor cells and circulating tumor DNA.
Ye Q, Ling S, Zheng S, Xu X
Mol Cancer 2019 Jul 3;18(1):114. doi: 10.1186/s12943-019-1043-x. PMID: 31269959Free PMC Article
Hepatocellular carcinoma.
Forner A, Llovet JM, Bruix J
Lancet 2012 Mar 31;379(9822):1245-55. Epub 2012 Feb 20 doi: 10.1016/S0140-6736(11)61347-0. PMID: 22353262
Hepatitis B: the virus and disease.
Liang TJ
Hepatology 2009 May;49(5 Suppl):S13-21. doi: 10.1002/hep.22881. PMID: 19399811Free PMC Article

Therapy

The evolution of PRRT for the treatment of neuroendocrine tumors; What comes next?
Harris PE, Zhernosekov K
Front Endocrinol (Lausanne) 2022;13:941832. Epub 2022 Oct 31 doi: 10.3389/fendo.2022.941832. PMID: 36387893Free PMC Article
NASH limits anti-tumour surveillance in immunotherapy-treated HCC.
Pfister D, Núñez NG, Pinyol R, Govaere O, Pinter M, Szydlowska M, Gupta R, Qiu M, Deczkowska A, Weiner A, Müller F, Sinha A, Friebel E, Engleitner T, Lenggenhager D, Moncsek A, Heide D, Stirm K, Kosla J, Kotsiliti E, Leone V, Dudek M, Yousuf S, Inverso D, Singh I, Teijeiro A, Castet F, Montironi C, Haber PK, Tiniakos D, Bedossa P, Cockell S, Younes R, Vacca M, Marra F, Schattenberg JM, Allison M, Bugianesi E, Ratziu V, Pressiani T, D'Alessio A, Personeni N, Rimassa L, Daly AK, Scheiner B, Pomej K, Kirstein MM, Vogel A, Peck-Radosavljevic M, Hucke F, Finkelmeier F, Waidmann O, Trojan J, Schulze K, Wege H, Koch S, Weinmann A, Bueter M, Rössler F, Siebenhüner A, De Dosso S, Mallm JP, Umansky V, Jugold M, Luedde T, Schietinger A, Schirmacher P, Emu B, Augustin HG, Billeter A, Müller-Stich B, Kikuchi H, Duda DG, Kütting F, Waldschmidt DT, Ebert MP, Rahbari N, Mei HE, Schulz AR, Ringelhan M, Malek N, Spahn S, Bitzer M, Ruiz de Galarreta M, Lujambio A, Dufour JF, Marron TU, Kaseb A, Kudo M, Huang YH, Djouder N, Wolter K, Zender L, Marche PN, Decaens T, Pinato DJ, Rad R, Mertens JC, Weber A, Unger K, Meissner F, Roth S, Jilkova ZM, Claassen M, Anstee QM, Amit I, Knolle P, Becher B, Llovet JM, Heikenwalder M
Nature 2021 Apr;592(7854):450-456. Epub 2021 Mar 24 doi: 10.1038/s41586-021-03362-0. PMID: 33762733Free PMC Article
Lenvatinib: A Review in Hepatocellular Carcinoma.
Al-Salama ZT, Syed YY, Scott LJ
Drugs 2019 Apr;79(6):665-674. doi: 10.1007/s40265-019-01116-x. PMID: 30993651
Lipid Nanoparticle Systems for Enabling Gene Therapies.
Cullis PR, Hope MJ
Mol Ther 2017 Jul 5;25(7):1467-1475. Epub 2017 Apr 13 doi: 10.1016/j.ymthe.2017.03.013. PMID: 28412170Free PMC Article
Hepatocellular carcinoma.
Forner A, Llovet JM, Bruix J
Lancet 2012 Mar 31;379(9822):1245-55. Epub 2012 Feb 20 doi: 10.1016/S0140-6736(11)61347-0. PMID: 22353262

Prognosis

Involvement of microRNAs and their potential diagnostic, therapeutic, and prognostic role in hepatocellular carcinoma.
Zhou Y, Liu F, Ma C, Cheng Q
J Clin Lab Anal 2022 Oct;36(10):e24673. Epub 2022 Aug 29 doi: 10.1002/jcla.24673. PMID: 36036748Free PMC Article
Tumor-derived adenosine promotes macrophage proliferation in human hepatocellular carcinoma.
Wang J, Wang Y, Chu Y, Li Z, Yu X, Huang Z, Xu J, Zheng L
J Hepatol 2021 Mar;74(3):627-637. Epub 2020 Oct 31 doi: 10.1016/j.jhep.2020.10.021. PMID: 33137360
Molecular Mechanisms: Connections between Nonalcoholic Fatty Liver Disease, Steatohepatitis and Hepatocellular Carcinoma.
Kanda T, Goto T, Hirotsu Y, Masuzaki R, Moriyama M, Omata M
Int J Mol Sci 2020 Feb 23;21(4) doi: 10.3390/ijms21041525. PMID: 32102237Free PMC Article
Liquid biopsy in hepatocellular carcinoma: circulating tumor cells and circulating tumor DNA.
Ye Q, Ling S, Zheng S, Xu X
Mol Cancer 2019 Jul 3;18(1):114. doi: 10.1186/s12943-019-1043-x. PMID: 31269959Free PMC Article
Hepatocellular carcinoma.
Forner A, Llovet JM, Bruix J
Lancet 2012 Mar 31;379(9822):1245-55. Epub 2012 Feb 20 doi: 10.1016/S0140-6736(11)61347-0. PMID: 22353262

Clinical prediction guides

Non-coding small nucleolar RNA SNORD17 promotes the progression of hepatocellular carcinoma through a positive feedback loop upon p53 inactivation.
Liang J, Li G, Liao J, Huang Z, Wen J, Wang Y, Chen Z, Cai G, Xu W, Ding Z, Liang H, Datta PK, Chu L, Chen X, Zhang B
Cell Death Differ 2022 May;29(5):988-1003. Epub 2022 Jan 15 doi: 10.1038/s41418-022-00929-w. PMID: 35034103Free PMC Article
Construction of TME and Identification of crosstalk between malignant cells and macrophages by SPP1 in hepatocellular carcinoma.
Liu L, Zhang R, Deng J, Dai X, Zhu X, Fu Q, Zhang H, Tong Z, Zhao P, Fang W, Zheng Y, Bao X
Cancer Immunol Immunother 2022 Jan;71(1):121-136. Epub 2021 May 24 doi: 10.1007/s00262-021-02967-8. PMID: 34028567
Proton beam radiotherapy vs. radiofrequency ablation for recurrent hepatocellular carcinoma: A randomized phase III trial.
Kim TH, Koh YH, Kim BH, Kim MJ, Lee JH, Park B, Park JW
J Hepatol 2021 Mar;74(3):603-612. Epub 2020 Oct 5 doi: 10.1016/j.jhep.2020.09.026. PMID: 33031846
Erlotinib.
Steins M, Thomas M, Geissler M
Recent Results Cancer Res 2014;201:109-23. doi: 10.1007/978-3-642-54490-3_6. PMID: 24756788
Hepatitis B: the virus and disease.
Liang TJ
Hepatology 2009 May;49(5 Suppl):S13-21. doi: 10.1002/hep.22881. PMID: 19399811Free PMC Article

Recent systematic reviews

Efficacy and safety of no-touch radiofrequency ablation for small hepatocellular carcinoma-a systematic review and single-arm meta-analysis.
Du F, Zhang L, Zhang Y, Fan H, Ren L
Clin Res Hepatol Gastroenterol 2023 Jan;47(1):102069. Epub 2022 Dec 10 doi: 10.1016/j.clinre.2022.102069. PMID: 36513251
Hepatocellular carcinoma tumour volume doubling time: a systematic review and meta-analysis.
Nathani P, Gopal P, Rich N, Yopp A, Yokoo T, John B, Marrero J, Parikh N, Singal AG
Gut 2021 Feb;70(2):401-407. Epub 2020 May 12 doi: 10.1136/gutjnl-2020-321040. PMID: 32398224Free PMC Article
Selective internal radiation therapies for unresectable early-, intermediate- or advanced-stage hepatocellular carcinoma: systematic review, network meta-analysis and economic evaluation.
Walton M, Wade R, Claxton L, Sharif-Hurst S, Harden M, Patel J, Rowe I, Hodgson R, Eastwood A
Health Technol Assess 2020 Sep;24(48):1-264. doi: 10.3310/hta24480. PMID: 33001024Free PMC Article
Transarterial chemoembolization plus sorafenib for the management of unresectable hepatocellular carcinoma: a systematic review and meta-analysis.
Li L, Zhao W, Wang M, Hu J, Wang E, Zhao Y, Liu L
BMC Gastroenterol 2018 Sep 4;18(1):138. doi: 10.1186/s12876-018-0849-0. PMID: 30180810Free PMC Article
Effect of dendritic cell-based immunotherapy on hepatocellular carcinoma: A systematic review and meta-analysis.
Chen C, Ma YH, Zhang YT, Zhang F, Zhou N, Wang X, Liu T, Li YM
Cytotherapy 2018 Aug;20(8):975-989. Epub 2018 Jul 30 doi: 10.1016/j.jcyt.2018.06.002. PMID: 30072299

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