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Small Progressed Hepatocellular Carcinoma

MedGen UID:
1749508
Concept ID:
C5419809
Neoplastic Process
Synonym: Small pHCC

Definition

A well to moderately differentiated small hepatocellular carcinoma. It is characterized by the presence of obvious stromal invasion and increase atypia compared with early hepatocellular carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall Progressed Hepatocellular Carcinoma

Professional guidelines

PubMed

Harris PE, Zhernosekov K
Front Endocrinol (Lausanne) 2022;13:941832. Epub 2022 Oct 31 doi: 10.3389/fendo.2022.941832. PMID: 36387893Free PMC Article
De Mattia E, Cecchin E, Guardascione M, Foltran L, Di Raimo T, Angelini F, D'Andrea M, Toffoli G
World J Gastroenterol 2019 Aug 7;25(29):3870-3896. doi: 10.3748/wjg.v25.i29.3870. PMID: 31413525Free PMC Article
Singh S, Osna NA, Kharbanda KK
World J Gastroenterol 2017 Sep 28;23(36):6549-6570. doi: 10.3748/wjg.v23.i36.6549. PMID: 29085205Free PMC Article

Recent clinical studies

Etiology

Gudan A, Kozłowska-Petriczko K, Wunsch E, Bodnarczuk T, Stachowska E
Nutrients 2023 Mar 8;15(6) doi: 10.3390/nu15061323. PMID: 36986052Free PMC Article
Sunami Y
Int J Mol Sci 2020 Sep 16;21(18) doi: 10.3390/ijms21186799. PMID: 32947972Free PMC Article
Erkekoglu P, Oral D, Chao MW, Kocer-Gumusel B
J Environ Pathol Toxicol Oncol 2017;36(2):171-190. doi: 10.1615/JEnvironPatholToxicolOncol.2017020927. PMID: 29199597
Schlageter M, Terracciano LM, D'Angelo S, Sorrentino P
World J Gastroenterol 2014 Nov 21;20(43):15955-64. doi: 10.3748/wjg.v20.i43.15955. PMID: 25473149Free PMC Article
Forner A, Llovet JM, Bruix J
Lancet 2012 Mar 31;379(9822):1245-55. Epub 2012 Feb 20 doi: 10.1016/S0140-6736(11)61347-0. PMID: 22353262

Diagnosis

Xing R, Gao J, Cui Q, Wang Q
Front Immunol 2021;12:783236. Epub 2021 Nov 26 doi: 10.3389/fimmu.2021.783236. PMID: 34899747Free PMC Article
Kröner PT, Engels MM, Glicksberg BS, Johnson KW, Mzaik O, van Hooft JE, Wallace MB, El-Serag HB, Krittanawong C
World J Gastroenterol 2021 Oct 28;27(40):6794-6824. doi: 10.3748/wjg.v27.i40.6794. PMID: 34790008Free PMC Article
Takahashi Y, Dungubat E, Kusano H, Ganbat D, Tomita Y, Odgerel S, Fukusato T
Int J Mol Sci 2021 May 28;22(11) doi: 10.3390/ijms22115780. PMID: 34071338Free PMC Article
Ye Q, Ling S, Zheng S, Xu X
Mol Cancer 2019 Jul 3;18(1):114. doi: 10.1186/s12943-019-1043-x. PMID: 31269959Free PMC Article
Liang TJ
Hepatology 2009 May;49(5 Suppl):S13-21. doi: 10.1002/hep.22881. PMID: 19399811Free PMC Article

Therapy

Harris PE, Zhernosekov K
Front Endocrinol (Lausanne) 2022;13:941832. Epub 2022 Oct 31 doi: 10.3389/fendo.2022.941832. PMID: 36387893Free PMC Article
Xing R, Gao J, Cui Q, Wang Q
Front Immunol 2021;12:783236. Epub 2021 Nov 26 doi: 10.3389/fimmu.2021.783236. PMID: 34899747Free PMC Article
Pfister D, Núñez NG, Pinyol R, Govaere O, Pinter M, Szydlowska M, Gupta R, Qiu M, Deczkowska A, Weiner A, Müller F, Sinha A, Friebel E, Engleitner T, Lenggenhager D, Moncsek A, Heide D, Stirm K, Kosla J, Kotsiliti E, Leone V, Dudek M, Yousuf S, Inverso D, Singh I, Teijeiro A, Castet F, Montironi C, Haber PK, Tiniakos D, Bedossa P, Cockell S, Younes R, Vacca M, Marra F, Schattenberg JM, Allison M, Bugianesi E, Ratziu V, Pressiani T, D'Alessio A, Personeni N, Rimassa L, Daly AK, Scheiner B, Pomej K, Kirstein MM, Vogel A, Peck-Radosavljevic M, Hucke F, Finkelmeier F, Waidmann O, Trojan J, Schulze K, Wege H, Koch S, Weinmann A, Bueter M, Rössler F, Siebenhüner A, De Dosso S, Mallm JP, Umansky V, Jugold M, Luedde T, Schietinger A, Schirmacher P, Emu B, Augustin HG, Billeter A, Müller-Stich B, Kikuchi H, Duda DG, Kütting F, Waldschmidt DT, Ebert MP, Rahbari N, Mei HE, Schulz AR, Ringelhan M, Malek N, Spahn S, Bitzer M, Ruiz de Galarreta M, Lujambio A, Dufour JF, Marron TU, Kaseb A, Kudo M, Huang YH, Djouder N, Wolter K, Zender L, Marche PN, Decaens T, Pinato DJ, Rad R, Mertens JC, Weber A, Unger K, Meissner F, Roth S, Jilkova ZM, Claassen M, Anstee QM, Amit I, Knolle P, Becher B, Llovet JM, Heikenwalder M
Nature 2021 Apr;592(7854):450-456. Epub 2021 Mar 24 doi: 10.1038/s41586-021-03362-0. PMID: 33762733Free PMC Article
Al-Salama ZT, Syed YY, Scott LJ
Drugs 2019 Apr;79(6):665-674. doi: 10.1007/s40265-019-01116-x. PMID: 30993651
Cullis PR, Hope MJ
Mol Ther 2017 Jul 5;25(7):1467-1475. Epub 2017 Apr 13 doi: 10.1016/j.ymthe.2017.03.013. PMID: 28412170Free PMC Article

Prognosis

Liu L, Zhang R, Deng J, Dai X, Zhu X, Fu Q, Zhang H, Tong Z, Zhao P, Fang W, Zheng Y, Bao X
Cancer Immunol Immunother 2022 Jan;71(1):121-136. Epub 2021 May 24 doi: 10.1007/s00262-021-02967-8. PMID: 34028567
Xing R, Gao J, Cui Q, Wang Q
Front Immunol 2021;12:783236. Epub 2021 Nov 26 doi: 10.3389/fimmu.2021.783236. PMID: 34899747Free PMC Article
Ye Q, Ling S, Zheng S, Xu X
Mol Cancer 2019 Jul 3;18(1):114. doi: 10.1186/s12943-019-1043-x. PMID: 31269959Free PMC Article
Zhou Y, Ren H, Dai B, Li J, Shang L, Huang J, Shi X
J Exp Clin Cancer Res 2018 Dec 27;37(1):324. doi: 10.1186/s13046-018-0965-2. PMID: 30591064Free PMC Article
Forner A, Llovet JM, Bruix J
Lancet 2012 Mar 31;379(9822):1245-55. Epub 2012 Feb 20 doi: 10.1016/S0140-6736(11)61347-0. PMID: 22353262

Clinical prediction guides

Liang J, Li G, Liao J, Huang Z, Wen J, Wang Y, Chen Z, Cai G, Xu W, Ding Z, Liang H, Datta PK, Chu L, Chen X, Zhang B
Cell Death Differ 2022 May;29(5):988-1003. Epub 2022 Jan 15 doi: 10.1038/s41418-022-00929-w. PMID: 35034103Free PMC Article
Liu L, Zhang R, Deng J, Dai X, Zhu X, Fu Q, Zhang H, Tong Z, Zhao P, Fang W, Zheng Y, Bao X
Cancer Immunol Immunother 2022 Jan;71(1):121-136. Epub 2021 May 24 doi: 10.1007/s00262-021-02967-8. PMID: 34028567
Kim TH, Koh YH, Kim BH, Kim MJ, Lee JH, Park B, Park JW
J Hepatol 2021 Mar;74(3):603-612. Epub 2020 Oct 5 doi: 10.1016/j.jhep.2020.09.026. PMID: 33031846
Steins M, Thomas M, Geissler M
Recent Results Cancer Res 2014;201:109-23. doi: 10.1007/978-3-642-54490-3_6. PMID: 24756788
Liang TJ
Hepatology 2009 May;49(5 Suppl):S13-21. doi: 10.1002/hep.22881. PMID: 19399811Free PMC Article

Recent systematic reviews

Wade R, South E, Anwer S, Sharif-Hurst S, Harden M, Fulbright H, Hodgson R, Dias S, Simmonds M, Rowe I, Thornton P, Eastwood A
Health Technol Assess 2023 Dec;27(29):1-172. doi: 10.3310/GK5221. PMID: 38149643Free PMC Article
Li LQ, Su TS, Wu QY, Lin ZT, Liang SX
Clin Oncol (R Coll Radiol) 2023 Oct;35(10):652-664. Epub 2023 Jul 13 doi: 10.1016/j.clon.2023.07.002. PMID: 37541936
González-Moles MÁ, de Porras-Carrique T, Ramos-García P
Med Oral Patol Oral Cir Bucal 2023 May 1;28(3):e229-e237. doi: 10.4317/medoral.25661. PMID: 36806023Free PMC Article
Nathani P, Gopal P, Rich N, Yopp A, Yokoo T, John B, Marrero J, Parikh N, Singal AG
Gut 2021 Feb;70(2):401-407. Epub 2020 May 12 doi: 10.1136/gutjnl-2020-321040. PMID: 32398224Free PMC Article
Li L, Zhao W, Wang M, Hu J, Wang E, Zhao Y, Liu L
BMC Gastroenterol 2018 Sep 4;18(1):138. doi: 10.1186/s12876-018-0849-0. PMID: 30180810Free PMC Article

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