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Pancreatic Intraductal Papillary-Mucinous Neoplasm, Low Grade

MedGen UID:
1749655
Concept ID:
C5399947
Neoplastic Process
Synonyms: Intraductal papillary mucinous neoplasm with low grade dysplasia of pancreas; Pancreatic Intraductal Papillary Mucinous Neoplasm with Low Grade Dysplasia; Pancreatic Intraductal Papillary-Mucinous Neoplasm with Low Grade Dysplasia; Pancreatic Intraductal Papillary-Mucinous Neoplasm, Low-Grade
SNOMED CT: Intraductal papillary mucinous neoplasm with low grade dysplasia of pancreas (473418001)

Definition

A non-invasive pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells that form a single layer and are well polarized. The neoplastic cells exhibit small and uniform nuclei, mild pleomorphism, and rare mitotic figures. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic Intraductal Papillary-Mucinous Neoplasm, Low Grade

Professional guidelines

PubMed

Agostini A, Guerriero I, Piro G, Quero G, Roberto L, Esposito A, Caggiano A, Priori L, Scaglione G, De Sanctis F, Sistigu A, Musella M, Larghi A, Rizzatti G, Lucchetti D, Alfieri S, Sgambato A, Bria E, Bizzozero L, Arena S, Ugel S, Corbo V, Tortora G, Carbone C
J Transl Med 2023 Nov 23;21(1):843. doi: 10.1186/s12967-023-04733-z. PMID: 37996891Free PMC Article
Lim J, Allen PJ
Updates Surg 2019 Jun;71(2):209-216. Epub 2019 Jun 7 doi: 10.1007/s13304-019-00661-0. PMID: 31175628
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Recent clinical studies

Etiology

Pitman MB, Centeno BA, Reid MD, Siddiqui MT, Layfield LJ, Perez-Machado M, Weynand B, Stelow EB, Lozano MD, Fukushima N, Cree IA, Mehrotra R, Schmitt FC, Field AS
Acta Cytol 2023;67(3):304-320. Epub 2022 Dec 14 doi: 10.1159/000527912. PMID: 36516741
Nista EC, Schepis T, Candelli M, Giuli L, Pignataro G, Franceschi F, Gasbarrini A, Ojetti V
Int J Mol Sci 2021 Nov 27;22(23) doi: 10.3390/ijms222312839. PMID: 34884643Free PMC Article
Aslanian HR, Lee JH, Canto MI
Gastroenterology 2020 Jul;159(1):358-362. Epub 2020 May 19 doi: 10.1053/j.gastro.2020.03.088. PMID: 32416142
Hirono S, Yamaue H
Surg Today 2020 Jan;50(1):50-55. Epub 2019 Dec 5 doi: 10.1007/s00595-019-01931-5. PMID: 31807871Free PMC Article
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Diagnosis

Pitman MB, Centeno BA, Reid MD, Siddiqui MT, Layfield LJ, Perez-Machado M, Weynand B, Stelow EB, Lozano MD, Fukushima N, Cree IA, Mehrotra R, Schmitt FC, Field AS
Acta Cytol 2023;67(3):304-320. Epub 2022 Dec 14 doi: 10.1159/000527912. PMID: 36516741
Nista EC, Schepis T, Candelli M, Giuli L, Pignataro G, Franceschi F, Gasbarrini A, Ojetti V
Int J Mol Sci 2021 Nov 27;22(23) doi: 10.3390/ijms222312839. PMID: 34884643Free PMC Article
Aslanian HR, Lee JH, Canto MI
Gastroenterology 2020 Jul;159(1):358-362. Epub 2020 May 19 doi: 10.1053/j.gastro.2020.03.088. PMID: 32416142
Hirono S, Yamaue H
Surg Today 2020 Jan;50(1):50-55. Epub 2019 Dec 5 doi: 10.1007/s00595-019-01931-5. PMID: 31807871Free PMC Article
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Therapy

Dong W, Zhen D, Xiaoyan W, Bin C, Ruifeng W, Shanyu Q, Zhuoran L, Kai S, Wenming W, Aiming Y, Xi W
Surg Endosc 2023 Jun;37(6):4681-4688. Epub 2023 Mar 7 doi: 10.1007/s00464-022-09752-3. PMID: 36881188Free PMC Article
Aussilhou B, Ftériche FS, Bouquot M, Lesurtel M, Sauvanet A, Dokmak S
Surg Endosc 2023 Jan;37(1):544-555. Epub 2022 Aug 24 doi: 10.1007/s00464-022-09527-w. PMID: 36002687
Chhoda A, Singh S, Sheth AH, Grimshaw AA, Gunderson CG, Sharma P, Kunstman JW, Sharma A, Ahuja N, Gonda TA, Farrell JJ
Clin Gastroenterol Hepatol 2023 Jun;21(6):1430-1446. Epub 2022 May 11 doi: 10.1016/j.cgh.2022.04.025. PMID: 35568304
Aleotti F, Crippa S, Belfiori G, Tamburrino D, Partelli S, Longo E, Palumbo D, Pecorelli N, Lena MS, Capurso G, Arcidiacono PG, Falconi M
Surgery 2022 Oct;172(4):1202-1209. Epub 2022 Jun 3 doi: 10.1016/j.surg.2022.04.036. PMID: 35667898
Hipp J, Mohamed S, Pott J, Sick O, Makowiec F, Hopt UT, Fichtner-Feigl S, Wittel UA
BJS Open 2019 Aug;3(4):490-499. Epub 2019 Mar 21 doi: 10.1002/bjs5.50156. PMID: 31388641Free PMC Article

Prognosis

Pitman MB, Centeno BA, Reid MD, Siddiqui MT, Layfield LJ, Perez-Machado M, Weynand B, Stelow EB, Lozano MD, Fukushima N, Cree IA, Mehrotra R, Schmitt FC, Field AS
Acta Cytol 2023;67(3):304-320. Epub 2022 Dec 14 doi: 10.1159/000527912. PMID: 36516741
Nista EC, Schepis T, Candelli M, Giuli L, Pignataro G, Franceschi F, Gasbarrini A, Ojetti V
Int J Mol Sci 2021 Nov 27;22(23) doi: 10.3390/ijms222312839. PMID: 34884643Free PMC Article
Hirono S, Yamaue H
Surg Today 2020 Jan;50(1):50-55. Epub 2019 Dec 5 doi: 10.1007/s00595-019-01931-5. PMID: 31807871Free PMC Article
Attiyeh MA, Fernández-Del Castillo C, Al Efishat M, Eaton AA, Gönen M, Batts R, Pergolini I, Rezaee N, Lillemoe KD, Ferrone CR, Mino-Kenudson M, Weiss MJ, Cameron JL, Hruban RH, D'Angelica MI, DeMatteo RP, Kingham TP, Jarnagin WR, Wolfgang CL, Allen PJ
Ann Surg 2018 Jan;267(1):157-163. doi: 10.1097/SLA.0000000000002015. PMID: 28079542Free PMC Article
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Clinical prediction guides

Nista EC, Schepis T, Candelli M, Giuli L, Pignataro G, Franceschi F, Gasbarrini A, Ojetti V
Int J Mol Sci 2021 Nov 27;22(23) doi: 10.3390/ijms222312839. PMID: 34884643Free PMC Article
Hirono S, Yamaue H
Surg Today 2020 Jan;50(1):50-55. Epub 2019 Dec 5 doi: 10.1007/s00595-019-01931-5. PMID: 31807871Free PMC Article
Attiyeh MA, Fernández-Del Castillo C, Al Efishat M, Eaton AA, Gönen M, Batts R, Pergolini I, Rezaee N, Lillemoe KD, Ferrone CR, Mino-Kenudson M, Weiss MJ, Cameron JL, Hruban RH, D'Angelica MI, DeMatteo RP, Kingham TP, Jarnagin WR, Wolfgang CL, Allen PJ
Ann Surg 2018 Jan;267(1):157-163. doi: 10.1097/SLA.0000000000002015. PMID: 28079542Free PMC Article
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Shi C, Hruban RH
Hum Pathol 2012 Jan;43(1):1-16. Epub 2011 Jul 20 doi: 10.1016/j.humpath.2011.04.003. PMID: 21777948

Recent systematic reviews

Bi S, Liu Y, Dai W, Pang L, Yang S, Zheng Y, Zhang X, Wu S, Kong J
Int J Surg 2023 Jul 1;109(7):2025-2036. doi: 10.1097/JS9.0000000000000326. PMID: 37300889Free PMC Article
Chhoda A, Singh S, Sheth AH, Grimshaw AA, Gunderson CG, Sharma P, Kunstman JW, Sharma A, Ahuja N, Gonda TA, Farrell JJ
Clin Gastroenterol Hepatol 2023 Jun;21(6):1430-1446. Epub 2022 May 11 doi: 10.1016/j.cgh.2022.04.025. PMID: 35568304
Zhao W, Liu S, Cong L, Zhao Y
Ann Surg Oncol 2022 Feb;29(2):1297-1312. Epub 2021 Sep 23 doi: 10.1245/s10434-021-10662-2. PMID: 34554343
Caravati A, Andrianello S, Pollini T, Biancotto M, Balduzzi A, Malleo G, Salvia R, Marchegiani G
Scand J Surg 2020 Mar;109(1):34-41. Epub 2020 Feb 2 doi: 10.1177/1457496919900414. PMID: 32009571
Ratnayake CB, Biela C, Windsor JA, Pandanaboyana S
HPB (Oxford) 2019 Dec;21(12):1593-1602. Epub 2019 May 29 doi: 10.1016/j.hpb.2019.04.015. PMID: 31153837

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