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Locally Advanced Esophageal Adenocarcinoma

MedGen UID:
1750366
Concept ID:
C5419520
Neoplastic Process

Definition

Esophageal adenocarcinoma that has spread to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Esophageal Adenocarcinoma

Professional guidelines

PubMed

Bouckaert A, Moons J, Lerut T, Coosemans W, Depypere L, Van Veer H, Nafteux P
Ann Thorac Surg 2023 Sep;116(3):571-578. Epub 2023 Mar 30 doi: 10.1016/j.athoracsur.2023.02.060. PMID: 37003580
Groth SS, Burt BM, Farjah F, Smaglo BG, Sada YH, Sugarbaker DJ, Massarweh NN
J Thorac Cardiovasc Surg 2019 Apr;157(4):1682-1693.e1. Epub 2018 Dec 15 doi: 10.1016/j.jtcvs.2018.11.131. PMID: 30711279
Matsui D, Zaidi AH, Martin SA, Omstead AN, Kosovec JE, Huleihel L, Saldin LT, DiCarlo C, Silverman JF, Hoppo T, Finley GG, Badylak SF, Kelly RJ, Jobe BA
Oncotarget 2016 Dec 6;7(49):81281-81291. doi: 10.18632/oncotarget.12832. PMID: 27793030Free PMC Article

Recent clinical studies

Etiology

Shitara K, Lordick F, Bang YJ, Enzinger P, Ilson D, Shah MA, Van Cutsem E, Xu RH, Aprile G, Xu J, Chao J, Pazo-Cid R, Kang YK, Yang J, Moran D, Bhattacharya P, Arozullah A, Park JW, Oh M, Ajani JA
Lancet 2023 May 20;401(10389):1655-1668. Epub 2023 Apr 15 doi: 10.1016/S0140-6736(23)00620-7. PMID: 37068504
Donlon NE, Moran B, Kamilli A, Davern M, Sheppard A, King S, Donohoe CL, Lowery M, Cunningham M, Ravi N, Mueller C, Cools-Lartigue J, Ferri L, Reynolds JV
Ann Surg 2022 Nov 1;276(5):792-798. Epub 2022 Jul 25 doi: 10.1097/SLA.0000000000005617. PMID: 35876385
Zhang X, Liang H, Li Z, Xue Y, Wang Y, Zhou Z, Yu J, Bu Z, Chen L, Du Y, Wang X, Wu A, Li G, Su X, Xiao G, Cui M, Wu D, Chen L, Wu X, Zhou Y, Zhang L, Dang C, He Y, Zhang Z, Sun Y, Li Y, Chen H, Bai Y, Qi C, Yu P, Zhu G, Suo J, Jia B, Li L, Huang C, Li F, Ye Y, Xu H, Wang X, Yuan Y, E JY, Ying X, Yao C, Shen L, Ji J; RESOLVE study group
Lancet Oncol 2021 Aug;22(8):1081-1092. Epub 2021 Jul 9 doi: 10.1016/S1470-2045(21)00297-7. PMID: 34252374
Lagergren J, Smyth E, Cunningham D, Lagergren P
Lancet 2017 Nov 25;390(10110):2383-2396. Epub 2017 Jun 22 doi: 10.1016/S0140-6736(17)31462-9. PMID: 28648400
Cunningham D, Allum WH, Stenning SP, Thompson JN, Van de Velde CJ, Nicolson M, Scarffe JH, Lofts FJ, Falk SJ, Iveson TJ, Smith DB, Langley RE, Verma M, Weeden S, Chua YJ, MAGIC Trial Participants
N Engl J Med 2006 Jul 6;355(1):11-20. doi: 10.1056/NEJMoa055531. PMID: 16822992

Diagnosis

Ajani JA, D'Amico TA, Bentrem DJ, Cooke D, Corvera C, Das P, Enzinger PC, Enzler T, Farjah F, Gerdes H, Gibson M, Grierson P, Hofstetter WL, Ilson DH, Jalal S, Keswani RN, Kim S, Kleinberg LR, Klempner S, Lacy J, Licciardi F, Ly QP, Matkowskyj KA, McNamara M, Miller A, Mukherjee S, Mulcahy MF, Outlaw D, Perry KA, Pimiento J, Poultsides GA, Reznik S, Roses RE, Strong VE, Su S, Wang HL, Wiesner G, Willett CG, Yakoub D, Yoon H, McMillian NR, Pluchino LA
J Natl Compr Canc Netw 2023 Apr;21(4):393-422. doi: 10.6004/jnccn.2023.0019. PMID: 37015332
Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807Free PMC Article
Harada K, Rogers JE, Iwatsuki M, Yamashita K, Baba H, Ajani JA
F1000Res 2020;9 Epub 2020 Oct 1 doi: 10.12688/f1000research.22926.1. PMID: 33042518Free PMC Article
Kelly RJ
J Natl Compr Canc Netw 2019 Aug 1;17(8):1009-1014. doi: 10.6004/jnccn.2019.7337. PMID: 31390584
Van Cutsem E, Sagaert X, Topal B, Haustermans K, Prenen H
Lancet 2016 Nov 26;388(10060):2654-2664. Epub 2016 May 5 doi: 10.1016/S0140-6736(16)30354-3. PMID: 27156933

Therapy

Shitara K, Lordick F, Bang YJ, Enzinger P, Ilson D, Shah MA, Van Cutsem E, Xu RH, Aprile G, Xu J, Chao J, Pazo-Cid R, Kang YK, Yang J, Moran D, Bhattacharya P, Arozullah A, Park JW, Oh M, Ajani JA
Lancet 2023 May 20;401(10389):1655-1668. Epub 2023 Apr 15 doi: 10.1016/S0140-6736(23)00620-7. PMID: 37068504
Moehler M, Högner A, Wagner AD, Obermannova R, Alsina M, Thuss-Patience P, van Laarhoven H, Smyth E
Eur J Cancer 2022 Nov;176:13-29. Epub 2022 Sep 29 doi: 10.1016/j.ejca.2022.08.023. PMID: 36183651
Zhang X, Liang H, Li Z, Xue Y, Wang Y, Zhou Z, Yu J, Bu Z, Chen L, Du Y, Wang X, Wu A, Li G, Su X, Xiao G, Cui M, Wu D, Chen L, Wu X, Zhou Y, Zhang L, Dang C, He Y, Zhang Z, Sun Y, Li Y, Chen H, Bai Y, Qi C, Yu P, Zhu G, Suo J, Jia B, Li L, Huang C, Li F, Ye Y, Xu H, Wang X, Yuan Y, E JY, Ying X, Yao C, Shen L, Ji J; RESOLVE study group
Lancet Oncol 2021 Aug;22(8):1081-1092. Epub 2021 Jul 9 doi: 10.1016/S1470-2045(21)00297-7. PMID: 34252374
Al-Batran SE, Homann N, Pauligk C, Goetze TO, Meiler J, Kasper S, Kopp HG, Mayer F, Haag GM, Luley K, Lindig U, Schmiegel W, Pohl M, Stoehlmacher J, Folprecht G, Probst S, Prasnikar N, Fischbach W, Mahlberg R, Trojan J, Koenigsmann M, Martens UM, Thuss-Patience P, Egger M, Block A, Heinemann V, Illerhaus G, Moehler M, Schenk M, Kullmann F, Behringer DM, Heike M, Pink D, Teschendorf C, Löhr C, Bernhard H, Schuch G, Rethwisch V, von Weikersthal LF, Hartmann JT, Kneba M, Daum S, Schulmann K, Weniger J, Belle S, Gaiser T, Oduncu FS, Güntner M, Hozaeel W, Reichart A, Jäger E, Kraus T, Mönig S, Bechstein WO, Schuler M, Schmalenberg H, Hofheinz RD; FLOT4-AIO Investigators
Lancet 2019 May 11;393(10184):1948-1957. Epub 2019 Apr 11 doi: 10.1016/S0140-6736(18)32557-1. PMID: 30982686
Van Cutsem E, Sagaert X, Topal B, Haustermans K, Prenen H
Lancet 2016 Nov 26;388(10060):2654-2664. Epub 2016 May 5 doi: 10.1016/S0140-6736(16)30354-3. PMID: 27156933

Prognosis

Ajani JA, D'Amico TA, Bentrem DJ, Cooke D, Corvera C, Das P, Enzinger PC, Enzler T, Farjah F, Gerdes H, Gibson M, Grierson P, Hofstetter WL, Ilson DH, Jalal S, Keswani RN, Kim S, Kleinberg LR, Klempner S, Lacy J, Licciardi F, Ly QP, Matkowskyj KA, McNamara M, Miller A, Mukherjee S, Mulcahy MF, Outlaw D, Perry KA, Pimiento J, Poultsides GA, Reznik S, Roses RE, Strong VE, Su S, Wang HL, Wiesner G, Willett CG, Yakoub D, Yoon H, McMillian NR, Pluchino LA
J Natl Compr Canc Netw 2023 Apr;21(4):393-422. doi: 10.6004/jnccn.2023.0019. PMID: 37015332
Harada K, Rogers JE, Iwatsuki M, Yamashita K, Baba H, Ajani JA
F1000Res 2020;9 Epub 2020 Oct 1 doi: 10.12688/f1000research.22926.1. PMID: 33042518Free PMC Article
Maron SB, Chase LM, Lomnicki S, Kochanny S, Moore KL, Joshi SS, Landron S, Johnson J, Kiedrowski LA, Nagy RJ, Lanman RB, Kim ST, Lee J, Catenacci DVT
Clin Cancer Res 2019 Dec 1;25(23):7098-7112. Epub 2019 Aug 19 doi: 10.1158/1078-0432.CCR-19-1704. PMID: 31427281Free PMC Article
Lagergren J, Smyth E, Cunningham D, Lagergren P
Lancet 2017 Nov 25;390(10110):2383-2396. Epub 2017 Jun 22 doi: 10.1016/S0140-6736(17)31462-9. PMID: 28648400
Cunningham D, Allum WH, Stenning SP, Thompson JN, Van de Velde CJ, Nicolson M, Scarffe JH, Lofts FJ, Falk SJ, Iveson TJ, Smith DB, Langley RE, Verma M, Weeden S, Chua YJ, MAGIC Trial Participants
N Engl J Med 2006 Jul 6;355(1):11-20. doi: 10.1056/NEJMoa055531. PMID: 16822992

Clinical prediction guides

Shitara K, Lordick F, Bang YJ, Enzinger P, Ilson D, Shah MA, Van Cutsem E, Xu RH, Aprile G, Xu J, Chao J, Pazo-Cid R, Kang YK, Yang J, Moran D, Bhattacharya P, Arozullah A, Park JW, Oh M, Ajani JA
Lancet 2023 May 20;401(10389):1655-1668. Epub 2023 Apr 15 doi: 10.1016/S0140-6736(23)00620-7. PMID: 37068504
Ge F, Huo Z, Cai X, Hu Q, Chen W, Lin G, Zhong R, You Z, Wang R, Lu Y, Wang R, Huang Q, Zhang H, Song A, Li C, Wen Y, Jiang Y, Liang H, He J, Liang W, Liu J
JAMA Netw Open 2022 Nov 1;5(11):e2239778. doi: 10.1001/jamanetworkopen.2022.39778. PMID: 36322089Free PMC Article
Moehler M, Högner A, Wagner AD, Obermannova R, Alsina M, Thuss-Patience P, van Laarhoven H, Smyth E
Eur J Cancer 2022 Nov;176:13-29. Epub 2022 Sep 29 doi: 10.1016/j.ejca.2022.08.023. PMID: 36183651
Zhang X, Liang H, Li Z, Xue Y, Wang Y, Zhou Z, Yu J, Bu Z, Chen L, Du Y, Wang X, Wu A, Li G, Su X, Xiao G, Cui M, Wu D, Chen L, Wu X, Zhou Y, Zhang L, Dang C, He Y, Zhang Z, Sun Y, Li Y, Chen H, Bai Y, Qi C, Yu P, Zhu G, Suo J, Jia B, Li L, Huang C, Li F, Ye Y, Xu H, Wang X, Yuan Y, E JY, Ying X, Yao C, Shen L, Ji J; RESOLVE study group
Lancet Oncol 2021 Aug;22(8):1081-1092. Epub 2021 Jul 9 doi: 10.1016/S1470-2045(21)00297-7. PMID: 34252374
Shah MA, Kojima T, Hochhauser D, Enzinger P, Raimbourg J, Hollebecque A, Lordick F, Kim SB, Tajika M, Kim HT, Lockhart AC, Arkenau HT, El-Hajbi F, Gupta M, Pfeiffer P, Liu Q, Lunceford J, Kang SP, Bhagia P, Kato K
JAMA Oncol 2019 Apr 1;5(4):546-550. doi: 10.1001/jamaoncol.2018.5441. PMID: 30570649Free PMC Article

Recent systematic reviews

Ge F, Huo Z, Cai X, Hu Q, Chen W, Lin G, Zhong R, You Z, Wang R, Lu Y, Wang R, Huang Q, Zhang H, Song A, Li C, Wen Y, Jiang Y, Liang H, He J, Liang W, Liu J
JAMA Netw Open 2022 Nov 1;5(11):e2239778. doi: 10.1001/jamanetworkopen.2022.39778. PMID: 36322089Free PMC Article
Tomita Y, Moldovan M, Chang Lee R, Hsieh AH, Townsend A, Price T
Cochrane Database Syst Rev 2020 Nov 19;11(11):CD012078. doi: 10.1002/14651858.CD012078.pub2. PMID: 33210731Free PMC Article
Shah MA, Kennedy EB, Catenacci DV, Deighton DC, Goodman KA, Malhotra NK, Willett C, Stiles B, Sharma P, Tang L, Wijnhoven BPL, Hofstetter WL
J Clin Oncol 2020 Aug 10;38(23):2677-2694. Epub 2020 Jun 22 doi: 10.1200/JCO.20.00866. PMID: 32568633
Vellayappan BA, Soon YY, Ku GY, Leong CN, Lu JJ, Tey JC
Cochrane Database Syst Rev 2017 Aug 22;8(8):CD010511. doi: 10.1002/14651858.CD010511.pub2. PMID: 28829911Free PMC Article
Courrech Staal EF, Aleman BM, Boot H, van Velthuysen ML, van Tinteren H, van Sandick JW
Br J Surg 2010 Oct;97(10):1482-96. doi: 10.1002/bjs.7175. PMID: 20645400

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