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Small Hepatocellular Carcinoma

MedGen UID:
1754837
•Concept ID:
C5419807
•
Neoplastic Process
Synonym: Small HCC

Definition

Hepatocellular carcinoma measuring equal to or less than 2 cm in diameter. It includes early hepatocellular carcinoma and small progressed hepatocellular carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall Hepatocellular Carcinoma

Professional guidelines

PubMed

Practice guidelines for the pathological diagnosis of primary liver cancer: 2015 update.
Cong WM, Bu H, Chen J, Dong H, Zhu YY, Feng LH, Chen J; Guideline Committee
World J Gastroenterol 2016 Nov 14;22(42):9279-9287. doi: 10.3748/wjg.v22.i42.9279. PMID: 27895416Free PMC Article
Management of small hepatocellular carcinoma in cirrhosis: focus on portal hypertension.
Hernandez-Gea V, Turon F, Berzigotti A, Villanueva A
World J Gastroenterol 2013 Feb 28;19(8):1193-9. doi: 10.3748/wjg.v19.i8.1193. PMID: 23482437Free PMC Article
Management of small hepatocellular carcinoma.
Leoni S, Piscaglia F, Righini R, Bolondi L
Acta Gastroenterol Belg 2006 Apr-Jun;69(2):230-5. PMID: 16929622

Recent clinical studies

Etiology

Clinical Significance of Liver MR Imaging.
Ichikawa S, Goshima S
Magn Reson Med Sci 2023 Apr 1;22(2):157-175. Epub 2023 Feb 1 doi: 10.2463/mrms.rev.2022-0100. PMID: 36725068Free PMC Article
Association of alpha-fetoprotein and metastasis for small hepatocellular carcinoma: A propensity-matched analysis.
Wang YQ, Wang AJ, Zhang TT, Chen SH
Sci Rep 2022 Sep 20;12(1):15676. doi: 10.1038/s41598-022-19531-8. PMID: 36127436Free PMC Article
Update on Hepatocellular Carcinoma: a Brief Review from Pathologist Standpoint.
Karadag Soylu N
J Gastrointest Cancer 2020 Dec;51(4):1176-1186. doi: 10.1007/s12029-020-00499-5. PMID: 32844348
Ablation of hepatocellular carcinoma.
Kim YS, Lim HK, Rhim H, Lee MW
Best Pract Res Clin Gastroenterol 2014 Oct;28(5):897-908. Epub 2014 Aug 23 doi: 10.1016/j.bpg.2014.08.011. PMID: 25260316
Hepatocellular carcinoma.
Marrero JA
Curr Opin Gastroenterol 2006 May;22(3):248-53. doi: 10.1097/01.mog.0000218961.86182.8c. PMID: 16550039

Diagnosis

Clinical Significance of Liver MR Imaging.
Ichikawa S, Goshima S
Magn Reson Med Sci 2023 Apr 1;22(2):157-175. Epub 2023 Feb 1 doi: 10.2463/mrms.rev.2022-0100. PMID: 36725068Free PMC Article
Targeted-detection and sequential-treatment of small hepatocellular carcinoma in the complex liver environment by GPC-3-targeted nanoparticles.
Deng H, Shang W, Wang K, Guo K, Liu Y, Tian J, Fang C
J Nanobiotechnology 2022 Mar 24;20(1):156. doi: 10.1186/s12951-022-01378-w. PMID: 35331259Free PMC Article
Update on Hepatocellular Carcinoma: a Brief Review from Pathologist Standpoint.
Karadag Soylu N
J Gastrointest Cancer 2020 Dec;51(4):1176-1186. doi: 10.1007/s12029-020-00499-5. PMID: 32844348
Small hepatocellular carcinoma: using MRI to predict histological grade and Ki-67 expression.
Li Y, Chen J, Weng S, Sun H, Yan C, Xu X, Ye R, Hong J
Clin Radiol 2019 Aug;74(8):653.e1-653.e9. Epub 2019 Jun 11 doi: 10.1016/j.crad.2019.05.009. PMID: 31200932
Hepatocellular carcinoma.
Marrero JA
Curr Opin Gastroenterol 2006 May;22(3):248-53. doi: 10.1097/01.mog.0000218961.86182.8c. PMID: 16550039

Therapy

Therapeutic Outcome of Stereotactic Body Radiotherapy for Small Hepatocellular Carcinoma Lesions - A Systematic Review and Network Meta-analysis.
Li LQ, Su TS, Wu QY, Lin ZT, Liang SX
Clin Oncol (R Coll Radiol) 2023 Oct;35(10):652-664. Epub 2023 Jul 13 doi: 10.1016/j.clon.2023.07.002. PMID: 37541936
Proton beam radiotherapy vs. radiofrequency ablation for recurrent hepatocellular carcinoma: A randomized phase III trial.
Kim TH, Koh YH, Kim BH, Kim MJ, Lee JH, Park B, Park JW
J Hepatol 2021 Mar;74(3):603-612. Epub 2020 Oct 5 doi: 10.1016/j.jhep.2020.09.026. PMID: 33031846
Clinical outcome of small hepatocellular carcinoma after different treatments: a meta-analysis.
Dong W, Zhang T, Wang ZG, Liu H
World J Gastroenterol 2014 Aug 7;20(29):10174-82. doi: 10.3748/wjg.v20.i29.10174. PMID: 25110446Free PMC Article
Management of small hepatocellular carcinoma: a review of transplantation, resection, and ablation.
Jarnagin WR
Ann Surg Oncol 2010 May;17(5):1226-33. Epub 2010 Apr 20 doi: 10.1245/s10434-010-0978-3. PMID: 20405327Free PMC Article
Hepatocellular carcinoma.
Marrero JA
Curr Opin Gastroenterol 2006 May;22(3):248-53. doi: 10.1097/01.mog.0000218961.86182.8c. PMID: 16550039

Prognosis

Association of alpha-fetoprotein and metastasis for small hepatocellular carcinoma: A propensity-matched analysis.
Wang YQ, Wang AJ, Zhang TT, Chen SH
Sci Rep 2022 Sep 20;12(1):15676. doi: 10.1038/s41598-022-19531-8. PMID: 36127436Free PMC Article
Update on Hepatocellular Carcinoma: a Brief Review from Pathologist Standpoint.
Karadag Soylu N
J Gastrointest Cancer 2020 Dec;51(4):1176-1186. doi: 10.1007/s12029-020-00499-5. PMID: 32844348
Small hepatocellular carcinoma: using MRI to predict histological grade and Ki-67 expression.
Li Y, Chen J, Weng S, Sun H, Yan C, Xu X, Ye R, Hong J
Clin Radiol 2019 Aug;74(8):653.e1-653.e9. Epub 2019 Jun 11 doi: 10.1016/j.crad.2019.05.009. PMID: 31200932
Laparoscopic radiofrequency ablation of solitary small hepatocellular carcinoma in the caudate lobe.
Jiang K, Zhang W, Su M, Liu Y, Zhao X, Wang J, Yao M, Ogbonna J, Dong J, Huang Z
Eur J Surg Oncol 2013 Nov;39(11):1236-42. Epub 2013 Aug 29 doi: 10.1016/j.ejso.2013.08.002. PMID: 23993049
Hepatocellular carcinoma.
Marrero JA
Curr Opin Gastroenterol 2006 May;22(3):248-53. doi: 10.1097/01.mog.0000218961.86182.8c. PMID: 16550039

Clinical prediction guides

Surgery or external beam radiation for solitary small hepatocellular carcinoma.
Wu X, Wei M, Chen Y, Peng Z
J Cancer Res Ther 2023 Apr;19(Supplement):S166-S171. doi: 10.4103/jcrt.JCRT_1604_20. PMID: 37147994
Association of alpha-fetoprotein and metastasis for small hepatocellular carcinoma: A propensity-matched analysis.
Wang YQ, Wang AJ, Zhang TT, Chen SH
Sci Rep 2022 Sep 20;12(1):15676. doi: 10.1038/s41598-022-19531-8. PMID: 36127436Free PMC Article
Oncological outcomes of anatomic versus non-anatomic resections for small hepatocellular carcinoma: systematic review and meta-analysis of propensity-score matched studies.
Dai XM, Xiang ZQ, Wang Q, Li HJ, Zhu Z
World J Surg Oncol 2022 Sep 19;20(1):299. doi: 10.1186/s12957-022-02770-4. PMID: 36117165Free PMC Article
Proton beam radiotherapy vs. radiofrequency ablation for recurrent hepatocellular carcinoma: A randomized phase III trial.
Kim TH, Koh YH, Kim BH, Kim MJ, Lee JH, Park B, Park JW
J Hepatol 2021 Mar;74(3):603-612. Epub 2020 Oct 5 doi: 10.1016/j.jhep.2020.09.026. PMID: 33031846
Small hepatocellular carcinoma: using MRI to predict histological grade and Ki-67 expression.
Li Y, Chen J, Weng S, Sun H, Yan C, Xu X, Ye R, Hong J
Clin Radiol 2019 Aug;74(8):653.e1-653.e9. Epub 2019 Jun 11 doi: 10.1016/j.crad.2019.05.009. PMID: 31200932

Recent systematic reviews

Ablative and non-surgical therapies for early and very early hepatocellular carcinoma: a systematic review and network meta-analysis.
Wade R, South E, Anwer S, Sharif-Hurst S, Harden M, Fulbright H, Hodgson R, Dias S, Simmonds M, Rowe I, Thornton P, Eastwood A
Health Technol Assess 2023 Dec;27(29):1-172. doi: 10.3310/GK5221. PMID: 38149643Free PMC Article
Therapeutic Outcome of Stereotactic Body Radiotherapy for Small Hepatocellular Carcinoma Lesions - A Systematic Review and Network Meta-analysis.
Li LQ, Su TS, Wu QY, Lin ZT, Liang SX
Clin Oncol (R Coll Radiol) 2023 Oct;35(10):652-664. Epub 2023 Jul 13 doi: 10.1016/j.clon.2023.07.002. PMID: 37541936
Efficacy and safety of no-touch radiofrequency ablation for small hepatocellular carcinoma-a systematic review and single-arm meta-analysis.
Du F, Zhang L, Zhang Y, Fan H, Ren L
Clin Res Hepatol Gastroenterol 2023 Jan;47(1):102069. Epub 2022 Dec 10 doi: 10.1016/j.clinre.2022.102069. PMID: 36513251
Oncological outcomes of anatomic versus non-anatomic resections for small hepatocellular carcinoma: systematic review and meta-analysis of propensity-score matched studies.
Dai XM, Xiang ZQ, Wang Q, Li HJ, Zhu Z
World J Surg Oncol 2022 Sep 19;20(1):299. doi: 10.1186/s12957-022-02770-4. PMID: 36117165Free PMC Article
Laparoscopic radiofrequency ablation of solitary small hepatocellular carcinoma in the caudate lobe.
Jiang K, Zhang W, Su M, Liu Y, Zhao X, Wang J, Yao M, Ogbonna J, Dong J, Huang Z
Eur J Surg Oncol 2013 Nov;39(11):1236-42. Epub 2013 Aug 29 doi: 10.1016/j.ejso.2013.08.002. PMID: 23993049

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