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Small Hepatocellular Carcinoma

MedGen UID:
1754837
•Concept ID:
C5419807
•
Neoplastic Process
Synonym: Small HCC

Definition

Hepatocellular carcinoma measuring equal to or less than 2 cm in diameter. It includes early hepatocellular carcinoma and small progressed hepatocellular carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall Hepatocellular Carcinoma

Professional guidelines

PubMed

Practice guidelines for the pathological diagnosis of primary liver cancer: 2015 update.
Cong WM, Bu H, Chen J, Dong H, Zhu YY, Feng LH, Chen J; Guideline Committee
World J Gastroenterol 2016 Nov 14;22(42):9279-9287. doi: 10.3748/wjg.v22.i42.9279. PMID: 27895416Free PMC Article
Management of small hepatocellular carcinoma in cirrhosis: focus on portal hypertension.
Hernandez-Gea V, Turon F, Berzigotti A, Villanueva A
World J Gastroenterol 2013 Feb 28;19(8):1193-9. doi: 10.3748/wjg.v19.i8.1193. PMID: 23482437Free PMC Article
Management of small hepatocellular carcinoma: a review of transplantation, resection, and ablation.
Jarnagin WR
Ann Surg Oncol 2010 May;17(5):1226-33. Epub 2010 Apr 20 doi: 10.1245/s10434-010-0978-3. PMID: 20405327Free PMC Article

Recent clinical studies

Etiology

New predictors of microvascular invasion for small hepatocellular carcinoma ≤ 3 cm.
Fukushima R, Harimoto N, Okuyama T, Seki T, Hoshino K, Hagiwara K, Kawai S, Ishii N, Tsukagoshi M, Igarashi T, Araki K, Tomonaga H, Higuchi T, Shimokawa M, Shirabe K
Int J Clin Oncol 2024 Aug;29(8):1182-1190. Epub 2024 May 20 doi: 10.1007/s10147-024-02553-9. PMID: 38769190
Laparoscopic liver resection versus radiofrequency ablation for small hepatocellular carcinoma: randomized clinical trial.
Song J, Cao L, Ma K, Li J, Wang X, Chen J, Zheng S
Br J Surg 2024 Apr 3;111(4) doi: 10.1093/bjs/znae099. PMID: 38650579
Ablative and non-surgical therapies for early and very early hepatocellular carcinoma: a systematic review and network meta-analysis.
Wade R, South E, Anwer S, Sharif-Hurst S, Harden M, Fulbright H, Hodgson R, Dias S, Simmonds M, Rowe I, Thornton P, Eastwood A
Health Technol Assess 2023 Dec;27(29):1-172. doi: 10.3310/GK5221. PMID: 38149643Free PMC Article
Clinical Significance of Liver MR Imaging.
Ichikawa S, Goshima S
Magn Reson Med Sci 2023 Apr 1;22(2):157-175. Epub 2023 Feb 1 doi: 10.2463/mrms.rev.2022-0100. PMID: 36725068Free PMC Article
Hepatocellular carcinoma.
Marrero JA
Curr Opin Gastroenterol 2006 May;22(3):248-53. doi: 10.1097/01.mog.0000218961.86182.8c. PMID: 16550039

Diagnosis

New predictors of microvascular invasion for small hepatocellular carcinoma ≤ 3 cm.
Fukushima R, Harimoto N, Okuyama T, Seki T, Hoshino K, Hagiwara K, Kawai S, Ishii N, Tsukagoshi M, Igarashi T, Araki K, Tomonaga H, Higuchi T, Shimokawa M, Shirabe K
Int J Clin Oncol 2024 Aug;29(8):1182-1190. Epub 2024 May 20 doi: 10.1007/s10147-024-02553-9. PMID: 38769190
Recommended 10-Year Follow-Up Strategy for Small Hepatocellular Carcinoma After Radiofrequency Ablation: A Cost-Effectiveness Evaluation.
Chen QF, Chen S, Yi JZ, Wang JL, Zhong SX, Jiang XY, Hu Y, Tan GJ, Xu J, Lyu N, Zhao M
Am J Gastroenterol 2024 Oct 1;119(10):2052-2060. Epub 2024 Mar 25 doi: 10.14309/ajg.0000000000002774. PMID: 38526213
Ablative and non-surgical therapies for early and very early hepatocellular carcinoma: a systematic review and network meta-analysis.
Wade R, South E, Anwer S, Sharif-Hurst S, Harden M, Fulbright H, Hodgson R, Dias S, Simmonds M, Rowe I, Thornton P, Eastwood A
Health Technol Assess 2023 Dec;27(29):1-172. doi: 10.3310/GK5221. PMID: 38149643Free PMC Article
Clinical Significance of Liver MR Imaging.
Ichikawa S, Goshima S
Magn Reson Med Sci 2023 Apr 1;22(2):157-175. Epub 2023 Feb 1 doi: 10.2463/mrms.rev.2022-0100. PMID: 36725068Free PMC Article
Hepatocellular carcinoma.
Marrero JA
Curr Opin Gastroenterol 2006 May;22(3):248-53. doi: 10.1097/01.mog.0000218961.86182.8c. PMID: 16550039

Therapy

Laparoscopic liver resection versus radiofrequency ablation for small hepatocellular carcinoma: randomized clinical trial.
Song J, Cao L, Ma K, Li J, Wang X, Chen J, Zheng S
Br J Surg 2024 Apr 3;111(4) doi: 10.1093/bjs/znae099. PMID: 38650579
Laparoscopic liver resection is superior to radiofrequency ablation for small hepatocellular carcinoma: a systematic review and meta-analysis of propensity score-matched studies.
Chen W, Lin X, Wu Z, Pan W, Ke Q, Chen Y
Hepatol Int 2024 Jun;18(3):998-1010. Epub 2024 Mar 14 doi: 10.1007/s12072-024-10645-x. PMID: 38480604
Ablative and non-surgical therapies for early and very early hepatocellular carcinoma: a systematic review and network meta-analysis.
Wade R, South E, Anwer S, Sharif-Hurst S, Harden M, Fulbright H, Hodgson R, Dias S, Simmonds M, Rowe I, Thornton P, Eastwood A
Health Technol Assess 2023 Dec;27(29):1-172. doi: 10.3310/GK5221. PMID: 38149643Free PMC Article
Proton beam radiotherapy vs. radiofrequency ablation for recurrent hepatocellular carcinoma: A randomized phase III trial.
Kim TH, Koh YH, Kim BH, Kim MJ, Lee JH, Park B, Park JW
J Hepatol 2021 Mar;74(3):603-612. Epub 2020 Oct 5 doi: 10.1016/j.jhep.2020.09.026. PMID: 33031846
Hepatocellular carcinoma.
Marrero JA
Curr Opin Gastroenterol 2006 May;22(3):248-53. doi: 10.1097/01.mog.0000218961.86182.8c. PMID: 16550039

Prognosis

New predictors of microvascular invasion for small hepatocellular carcinoma ≤ 3 cm.
Fukushima R, Harimoto N, Okuyama T, Seki T, Hoshino K, Hagiwara K, Kawai S, Ishii N, Tsukagoshi M, Igarashi T, Araki K, Tomonaga H, Higuchi T, Shimokawa M, Shirabe K
Int J Clin Oncol 2024 Aug;29(8):1182-1190. Epub 2024 May 20 doi: 10.1007/s10147-024-02553-9. PMID: 38769190
Laparoscopic liver resection versus radiofrequency ablation for small hepatocellular carcinoma: randomized clinical trial.
Song J, Cao L, Ma K, Li J, Wang X, Chen J, Zheng S
Br J Surg 2024 Apr 3;111(4) doi: 10.1093/bjs/znae099. PMID: 38650579
Recommended 10-Year Follow-Up Strategy for Small Hepatocellular Carcinoma After Radiofrequency Ablation: A Cost-Effectiveness Evaluation.
Chen QF, Chen S, Yi JZ, Wang JL, Zhong SX, Jiang XY, Hu Y, Tan GJ, Xu J, Lyu N, Zhao M
Am J Gastroenterol 2024 Oct 1;119(10):2052-2060. Epub 2024 Mar 25 doi: 10.14309/ajg.0000000000002774. PMID: 38526213
Association of alpha-fetoprotein and metastasis for small hepatocellular carcinoma: A propensity-matched analysis.
Wang YQ, Wang AJ, Zhang TT, Chen SH
Sci Rep 2022 Sep 20;12(1):15676. doi: 10.1038/s41598-022-19531-8. PMID: 36127436Free PMC Article
Hepatocellular carcinoma.
Marrero JA
Curr Opin Gastroenterol 2006 May;22(3):248-53. doi: 10.1097/01.mog.0000218961.86182.8c. PMID: 16550039

Clinical prediction guides

New predictors of microvascular invasion for small hepatocellular carcinoma ≤ 3 cm.
Fukushima R, Harimoto N, Okuyama T, Seki T, Hoshino K, Hagiwara K, Kawai S, Ishii N, Tsukagoshi M, Igarashi T, Araki K, Tomonaga H, Higuchi T, Shimokawa M, Shirabe K
Int J Clin Oncol 2024 Aug;29(8):1182-1190. Epub 2024 May 20 doi: 10.1007/s10147-024-02553-9. PMID: 38769190
Recommended 10-Year Follow-Up Strategy for Small Hepatocellular Carcinoma After Radiofrequency Ablation: A Cost-Effectiveness Evaluation.
Chen QF, Chen S, Yi JZ, Wang JL, Zhong SX, Jiang XY, Hu Y, Tan GJ, Xu J, Lyu N, Zhao M
Am J Gastroenterol 2024 Oct 1;119(10):2052-2060. Epub 2024 Mar 25 doi: 10.14309/ajg.0000000000002774. PMID: 38526213
Laparoscopic liver resection is superior to radiofrequency ablation for small hepatocellular carcinoma: a systematic review and meta-analysis of propensity score-matched studies.
Chen W, Lin X, Wu Z, Pan W, Ke Q, Chen Y
Hepatol Int 2024 Jun;18(3):998-1010. Epub 2024 Mar 14 doi: 10.1007/s12072-024-10645-x. PMID: 38480604
Association of alpha-fetoprotein and metastasis for small hepatocellular carcinoma: A propensity-matched analysis.
Wang YQ, Wang AJ, Zhang TT, Chen SH
Sci Rep 2022 Sep 20;12(1):15676. doi: 10.1038/s41598-022-19531-8. PMID: 36127436Free PMC Article
Proton beam radiotherapy vs. radiofrequency ablation for recurrent hepatocellular carcinoma: A randomized phase III trial.
Kim TH, Koh YH, Kim BH, Kim MJ, Lee JH, Park B, Park JW
J Hepatol 2021 Mar;74(3):603-612. Epub 2020 Oct 5 doi: 10.1016/j.jhep.2020.09.026. PMID: 33031846

Recent systematic reviews

Laparoscopic liver resection is superior to radiofrequency ablation for small hepatocellular carcinoma: a systematic review and meta-analysis of propensity score-matched studies.
Chen W, Lin X, Wu Z, Pan W, Ke Q, Chen Y
Hepatol Int 2024 Jun;18(3):998-1010. Epub 2024 Mar 14 doi: 10.1007/s12072-024-10645-x. PMID: 38480604
Efficacy and safety of laparoscopic liver resection versus radiofrequency ablation in patients with early and small hepatocellular carcinoma: an updated meta-analysis and meta-regression of observational studies.
Shaaban Abdelgalil M, Amer BE, Yasen N, El-Samahy M, Awad AK, Elfakharany B, Saeed O, Abd-ElGawad M
World J Surg Oncol 2024 Feb 7;22(1):47. doi: 10.1186/s12957-023-03292-3. PMID: 38326841Free PMC Article
Ablative and non-surgical therapies for early and very early hepatocellular carcinoma: a systematic review and network meta-analysis.
Wade R, South E, Anwer S, Sharif-Hurst S, Harden M, Fulbright H, Hodgson R, Dias S, Simmonds M, Rowe I, Thornton P, Eastwood A
Health Technol Assess 2023 Dec;27(29):1-172. doi: 10.3310/GK5221. PMID: 38149643Free PMC Article
Therapeutic Outcome of Stereotactic Body Radiotherapy for Small Hepatocellular Carcinoma Lesions - A Systematic Review and Network Meta-analysis.
Li LQ, Su TS, Wu QY, Lin ZT, Liang SX
Clin Oncol (R Coll Radiol) 2023 Oct;35(10):652-664. Epub 2023 Jul 13 doi: 10.1016/j.clon.2023.07.002. PMID: 37541936
Oncological outcomes of anatomic versus non-anatomic resections for small hepatocellular carcinoma: systematic review and meta-analysis of propensity-score matched studies.
Dai XM, Xiang ZQ, Wang Q, Li HJ, Zhu Z
World J Surg Oncol 2022 Sep 19;20(1):299. doi: 10.1186/s12957-022-02770-4. PMID: 36117165Free PMC Article

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