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Advanced Anal Carcinoma

MedGen UID:
1755020
•Concept ID:
C5418596
•
Neoplastic Process

Definition

Anal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Anal Carcinoma

Professional guidelines

PubMed

Treatment algorithm and prognostic factors for patients with stage I-III carcinoma of the anal canal: a 20-year multicenter study.
Bruyere D, Monnien F, Colpart P, Roncarati P, Vuitton L, Hendrick E, Lepinoy A, Luquain A, Pilard C, Lerho T, Molimard C, Maingon P, Arnould L, Bone-Lepinoy MC, Dusserre L, Martin L, Reynders C, Ancion M, Peiffert D, Leroux A, Hubert P, Delhorme JB, Ghnassia JP, Woronoff AS, Delvenne P, Prétet JL, Bosset JF, Peulen O, Mougin C, Valmary-Degano S, Herfs M
Mod Pathol 2021 Jan;34(1):116-130. Epub 2020 Jul 29 doi: 10.1038/s41379-020-0637-6. PMID: 32728225
Volumetric intensity-modulated arc therapy vs. 3-dimensional conformal radiotherapy for primary chemoradiotherapy of anal carcinoma: Effects on treatment-related side effects and survival.
Weber HE, Dröge LH, Hennies S, Herrmann MK, Gaedcke J, Wolff HA
Strahlenther Onkol 2015 Nov;191(11):827-34. Epub 2015 Jun 8 doi: 10.1007/s00066-015-0859-6. PMID: 26050046
Chemoradiotherapy with capecitabine for locally advanced anal carcinoma: an alternative treatment option.
Meulendijks D, Dewit L, Tomasoa NB, van Tinteren H, Beijnen JH, Schellens JH, Cats A
Br J Cancer 2014 Oct 28;111(9):1726-33. Epub 2014 Aug 28 doi: 10.1038/bjc.2014.467. PMID: 25167226Free PMC Article

Recent clinical studies

Etiology

Treatment algorithm and prognostic factors for patients with stage I-III carcinoma of the anal canal: a 20-year multicenter study.
Bruyere D, Monnien F, Colpart P, Roncarati P, Vuitton L, Hendrick E, Lepinoy A, Luquain A, Pilard C, Lerho T, Molimard C, Maingon P, Arnould L, Bone-Lepinoy MC, Dusserre L, Martin L, Reynders C, Ancion M, Peiffert D, Leroux A, Hubert P, Delhorme JB, Ghnassia JP, Woronoff AS, Delvenne P, Prétet JL, Bosset JF, Peulen O, Mougin C, Valmary-Degano S, Herfs M
Mod Pathol 2021 Jan;34(1):116-130. Epub 2020 Jul 29 doi: 10.1038/s41379-020-0637-6. PMID: 32728225
Clinical Validity of HPV Circulating Tumor DNA in Advanced Anal Carcinoma: An Ancillary Study to the Epitopes-HPV02 Trial.
Bernard-Tessier A, Jeannot E, Guenat D, Debernardi A, Michel M, Proudhon C, Vincent-Salomon A, Bièche I, Pierga JY, Buecher B, Meurisse A, François É, Cohen R, Jary M, Vendrely V, Samalin E, El Hajbi F, Baba-Hamed N, Borg C, Bidard FC, Kim S
Clin Cancer Res 2019 Apr 1;25(7):2109-2115. Epub 2018 Nov 30 doi: 10.1158/1078-0432.CCR-18-2984. PMID: 30504426
Volumetric intensity-modulated arc therapy vs. 3-dimensional conformal radiotherapy for primary chemoradiotherapy of anal carcinoma: Effects on treatment-related side effects and survival.
Weber HE, Dröge LH, Hennies S, Herrmann MK, Gaedcke J, Wolff HA
Strahlenther Onkol 2015 Nov;191(11):827-34. Epub 2015 Jun 8 doi: 10.1007/s00066-015-0859-6. PMID: 26050046
Chemoradiotherapy with capecitabine for locally advanced anal carcinoma: an alternative treatment option.
Meulendijks D, Dewit L, Tomasoa NB, van Tinteren H, Beijnen JH, Schellens JH, Cats A
Br J Cancer 2014 Oct 28;111(9):1726-33. Epub 2014 Aug 28 doi: 10.1038/bjc.2014.467. PMID: 25167226Free PMC Article
Induction chemotherapy and radiotherapy in loco-regionally advanced epidermoid carcinoma of the anal canal.
Svensson C, Goldman S, Friberg B, Glimelius B
Int J Radiat Oncol Biol Phys 1998 Jul 1;41(4):863-7. doi: 10.1016/s0360-3016(98)00122-9. PMID: 9652850

Diagnosis

Treatment algorithm and prognostic factors for patients with stage I-III carcinoma of the anal canal: a 20-year multicenter study.
Bruyere D, Monnien F, Colpart P, Roncarati P, Vuitton L, Hendrick E, Lepinoy A, Luquain A, Pilard C, Lerho T, Molimard C, Maingon P, Arnould L, Bone-Lepinoy MC, Dusserre L, Martin L, Reynders C, Ancion M, Peiffert D, Leroux A, Hubert P, Delhorme JB, Ghnassia JP, Woronoff AS, Delvenne P, Prétet JL, Bosset JF, Peulen O, Mougin C, Valmary-Degano S, Herfs M
Mod Pathol 2021 Jan;34(1):116-130. Epub 2020 Jul 29 doi: 10.1038/s41379-020-0637-6. PMID: 32728225
Induction chemotherapy and radiotherapy in loco-regionally advanced epidermoid carcinoma of the anal canal.
Svensson C, Goldman S, Friberg B, Glimelius B
Int J Radiat Oncol Biol Phys 1998 Jul 1;41(4):863-7. doi: 10.1016/s0360-3016(98)00122-9. PMID: 9652850
Primary treatment of carcinoma of the anus by combined radiotherapy and chemotherapy.
Tveit KM, Karlsen KO, Fosså SD, Flokkmann A, Guldvog I, Haffner J
Scand J Gastroenterol 1989 Dec;24(10):1243-7. doi: 10.3109/00365528909090794. PMID: 2513640

Therapy

Safety and antitumor activity of the anti-PD-1 antibody pembrolizumab in patients with recurrent carcinoma of the anal canal.
Ott PA, Piha-Paul SA, Munster P, Pishvaian MJ, van Brummelen EMJ, Cohen RB, Gomez-Roca C, Ejadi S, Stein M, Chan E, Simonelli M, Morosky A, Saraf S, Emancipator K, Koshiji M, Bennouna J
Ann Oncol 2017 May 1;28(5):1036-1041. doi: 10.1093/annonc/mdx029. PMID: 28453692Free PMC Article
Chemoradiotherapy with capecitabine for locally advanced anal carcinoma: an alternative treatment option.
Meulendijks D, Dewit L, Tomasoa NB, van Tinteren H, Beijnen JH, Schellens JH, Cats A
Br J Cancer 2014 Oct 28;111(9):1726-33. Epub 2014 Aug 28 doi: 10.1038/bjc.2014.467. PMID: 25167226Free PMC Article
Simultaneous integrated boost-intensity modulated radiation therapy with concomitant capecitabine and mitomycin C for locally advanced anal carcinoma: a phase 1 study.
Deenen MJ, Dewit L, Boot H, Beijnen JH, Schellens JH, Cats A
Int J Radiat Oncol Biol Phys 2013 Apr 1;85(5):e201-7. doi: 10.1016/j.ijrobp.2012.12.008. PMID: 23517808
Combining cisplatin and mitomycin with radiotherapy in anal carcinoma.
Crehange G, Bosset M, Lorchel F, Dumas JL, Buffet-Miny J, Puyraveau M, Mercier M, Bosset JF
Dis Colon Rectum 2007 Jan;50(1):43-9. doi: 10.1007/s10350-006-0761-5. PMID: 17089083
Induction chemotherapy and radiotherapy in loco-regionally advanced epidermoid carcinoma of the anal canal.
Svensson C, Goldman S, Friberg B, Glimelius B
Int J Radiat Oncol Biol Phys 1998 Jul 1;41(4):863-7. doi: 10.1016/s0360-3016(98)00122-9. PMID: 9652850

Prognosis

Treatment algorithm and prognostic factors for patients with stage I-III carcinoma of the anal canal: a 20-year multicenter study.
Bruyere D, Monnien F, Colpart P, Roncarati P, Vuitton L, Hendrick E, Lepinoy A, Luquain A, Pilard C, Lerho T, Molimard C, Maingon P, Arnould L, Bone-Lepinoy MC, Dusserre L, Martin L, Reynders C, Ancion M, Peiffert D, Leroux A, Hubert P, Delhorme JB, Ghnassia JP, Woronoff AS, Delvenne P, Prétet JL, Bosset JF, Peulen O, Mougin C, Valmary-Degano S, Herfs M
Mod Pathol 2021 Jan;34(1):116-130. Epub 2020 Jul 29 doi: 10.1038/s41379-020-0637-6. PMID: 32728225
Clinical Validity of HPV Circulating Tumor DNA in Advanced Anal Carcinoma: An Ancillary Study to the Epitopes-HPV02 Trial.
Bernard-Tessier A, Jeannot E, Guenat D, Debernardi A, Michel M, Proudhon C, Vincent-Salomon A, Bièche I, Pierga JY, Buecher B, Meurisse A, François É, Cohen R, Jary M, Vendrely V, Samalin E, El Hajbi F, Baba-Hamed N, Borg C, Bidard FC, Kim S
Clin Cancer Res 2019 Apr 1;25(7):2109-2115. Epub 2018 Nov 30 doi: 10.1158/1078-0432.CCR-18-2984. PMID: 30504426
Volumetric intensity-modulated arc therapy vs. 3-dimensional conformal radiotherapy for primary chemoradiotherapy of anal carcinoma: Effects on treatment-related side effects and survival.
Weber HE, Dröge LH, Hennies S, Herrmann MK, Gaedcke J, Wolff HA
Strahlenther Onkol 2015 Nov;191(11):827-34. Epub 2015 Jun 8 doi: 10.1007/s00066-015-0859-6. PMID: 26050046
Chemoradiotherapy with capecitabine for locally advanced anal carcinoma: an alternative treatment option.
Meulendijks D, Dewit L, Tomasoa NB, van Tinteren H, Beijnen JH, Schellens JH, Cats A
Br J Cancer 2014 Oct 28;111(9):1726-33. Epub 2014 Aug 28 doi: 10.1038/bjc.2014.467. PMID: 25167226Free PMC Article
Induction chemotherapy and radiotherapy in loco-regionally advanced epidermoid carcinoma of the anal canal.
Svensson C, Goldman S, Friberg B, Glimelius B
Int J Radiat Oncol Biol Phys 1998 Jul 1;41(4):863-7. doi: 10.1016/s0360-3016(98)00122-9. PMID: 9652850

Clinical prediction guides

Treatment algorithm and prognostic factors for patients with stage I-III carcinoma of the anal canal: a 20-year multicenter study.
Bruyere D, Monnien F, Colpart P, Roncarati P, Vuitton L, Hendrick E, Lepinoy A, Luquain A, Pilard C, Lerho T, Molimard C, Maingon P, Arnould L, Bone-Lepinoy MC, Dusserre L, Martin L, Reynders C, Ancion M, Peiffert D, Leroux A, Hubert P, Delhorme JB, Ghnassia JP, Woronoff AS, Delvenne P, Prétet JL, Bosset JF, Peulen O, Mougin C, Valmary-Degano S, Herfs M
Mod Pathol 2021 Jan;34(1):116-130. Epub 2020 Jul 29 doi: 10.1038/s41379-020-0637-6. PMID: 32728225
Combining cisplatin and mitomycin with radiotherapy in anal carcinoma.
Crehange G, Bosset M, Lorchel F, Dumas JL, Buffet-Miny J, Puyraveau M, Mercier M, Bosset JF
Dis Colon Rectum 2007 Jan;50(1):43-9. doi: 10.1007/s10350-006-0761-5. PMID: 17089083
Primary treatment of carcinoma of the anus by combined radiotherapy and chemotherapy.
Tveit KM, Karlsen KO, Fosså SD, Flokkmann A, Guldvog I, Haffner J
Scand J Gastroenterol 1989 Dec;24(10):1243-7. doi: 10.3109/00365528909090794. PMID: 2513640

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