U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Metastatic Malignant Skin Neoplasm

MedGen UID:
1756077
Concept ID:
C5401226
Neoplastic Process

Definition

A malignant neoplasm of the skin that has spread to other anatomic sites. [from NCI]

Professional guidelines

PubMed

Garbe C, Amaral T, Peris K, Hauschild A, Arenberger P, Basset-Seguin N, Bastholt L, Bataille V, Del Marmol V, Dréno B, Fargnoli MC, Forsea AM, Grob JJ, Höller C, Kaufmann R, Kelleners-Smeets N, Lallas A, Lebbé C, Lytvynenko B, Malvehy J, Moreno-Ramirez D, Nathan P, Pellacani G, Saiag P, Stratigos AJ, Van Akkooi ACJ, Vieira R, Zalaudek I, Lorigan P; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2022 Jul;170:236-255. Epub 2022 May 12 doi: 10.1016/j.ejca.2022.03.008. PMID: 35570085
Davis LE, Shalin SC, Tackett AJ
Cancer Biol Ther 2019;20(11):1366-1379. Epub 2019 Aug 1 doi: 10.1080/15384047.2019.1640032. PMID: 31366280Free PMC Article
Peris K, Fargnoli MC, Garbe C, Kaufmann R, Bastholt L, Seguin NB, Bataille V, Marmol VD, Dummer R, Harwood CA, Hauschild A, Höller C, Haedersdal M, Malvehy J, Middleton MR, Morton CA, Nagore E, Stratigos AJ, Szeimies RM, Tagliaferri L, Trakatelli M, Zalaudek I, Eggermont A, Grob JJ; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2019 Sep;118:10-34. Epub 2019 Jul 6 doi: 10.1016/j.ejca.2019.06.003. PMID: 31288208

Recent clinical studies

Etiology

Kibbi N, Owen JL, Worley B, Wang JX, Harikumar V, Downing MB, Aasi SZ, Aung PP, Barker CA, Bolotin D, Bordeaux JS, Cartee TV, Chandra S, Cho NL, Choi JN, Chung KY, Cliby WA, Dorigo O, Eisen DB, Fujisawa Y, Golda N, Halfdanarson TR, Iavazzo C, Jiang SIB, Kanitakis J, Khan A, Kim JYS, Kuzel TM, Lawrence N, Leitao MM Jr, MacLean AB, Maher IA, Mittal BB, Nehal KS, Ozog DM, Pettaway CA, Ross JS, Rossi AM, Servaes S, Solomon MJ, Thomas VD, Tolia M, Voelzke BB, Waldman A, Wong MK, Zhou Y, Arai N, Brackett A, Ibrahim SA, Kang BY, Poon E, Alam M
JAMA Oncol 2022 Apr 1;8(4):618-628. doi: 10.1001/jamaoncol.2021.7148. PMID: 35050310
Turner N, Ware O, Bosenberg M
Clin Exp Metastasis 2018 Aug;35(5-6):379-391. Epub 2018 May 2 doi: 10.1007/s10585-018-9893-y. PMID: 29722002
Que SKT, Zwald FO, Schmults CD
J Am Acad Dermatol 2018 Feb;78(2):237-247. doi: 10.1016/j.jaad.2017.08.059. PMID: 29332704
Wood BA
Pathology 2016 Feb;48(2):155-65. Epub 2016 Jan 16 doi: 10.1016/j.pathol.2015.12.001. PMID: 27020388
Elder DE
Pathology 2016 Feb;48(2):147-54. Epub 2016 Jan 16 doi: 10.1016/j.pathol.2015.12.002. PMID: 27020387

Diagnosis

Sleiwah A, Wright TC, Chapman T, Dangoor A, Maggiani F, Clancy R
Curr Treat Options Oncol 2022 Jun;23(6):843-854. Epub 2022 Apr 8 doi: 10.1007/s11864-022-00979-9. PMID: 35394606
Kibbi N, Owen JL, Worley B, Wang JX, Harikumar V, Downing MB, Aasi SZ, Aung PP, Barker CA, Bolotin D, Bordeaux JS, Cartee TV, Chandra S, Cho NL, Choi JN, Chung KY, Cliby WA, Dorigo O, Eisen DB, Fujisawa Y, Golda N, Halfdanarson TR, Iavazzo C, Jiang SIB, Kanitakis J, Khan A, Kim JYS, Kuzel TM, Lawrence N, Leitao MM Jr, MacLean AB, Maher IA, Mittal BB, Nehal KS, Ozog DM, Pettaway CA, Ross JS, Rossi AM, Servaes S, Solomon MJ, Thomas VD, Tolia M, Voelzke BB, Waldman A, Wong MK, Zhou Y, Arai N, Brackett A, Ibrahim SA, Kang BY, Poon E, Alam M
JAMA Oncol 2022 Apr 1;8(4):618-628. doi: 10.1001/jamaoncol.2021.7148. PMID: 35050310
Lezcano C, Jungbluth AA, Busam KJ
Surg Pathol Clin 2021 Jun;14(2):165-175. Epub 2021 Apr 28 doi: 10.1016/j.path.2021.01.001. PMID: 34023098Free PMC Article
Alter M, Mengoni M, Gaffal E
J Dtsch Dermatol Ges 2020 May;18(5):456-469. Epub 2020 Apr 20 doi: 10.1111/ddg.14093. PMID: 32311823
Que SKT, Zwald FO, Schmults CD
J Am Acad Dermatol 2018 Feb;78(2):237-247. doi: 10.1016/j.jaad.2017.08.059. PMID: 29332704

Therapy

Gorry C, McCullagh L, O'Donnell H, Barrett S, Schmitz S, Barry M, Curtin K, Beausang E, Barry R, Coyne I
Cochrane Database Syst Rev 2023 Jan 17;1(1):CD012974. doi: 10.1002/14651858.CD012974.pub2. PMID: 36648215Free PMC Article
Kibbi N, Owen JL, Worley B, Wang JX, Harikumar V, Downing MB, Aasi SZ, Aung PP, Barker CA, Bolotin D, Bordeaux JS, Cartee TV, Chandra S, Cho NL, Choi JN, Chung KY, Cliby WA, Dorigo O, Eisen DB, Fujisawa Y, Golda N, Halfdanarson TR, Iavazzo C, Jiang SIB, Kanitakis J, Khan A, Kim JYS, Kuzel TM, Lawrence N, Leitao MM Jr, MacLean AB, Maher IA, Mittal BB, Nehal KS, Ozog DM, Pettaway CA, Ross JS, Rossi AM, Servaes S, Solomon MJ, Thomas VD, Tolia M, Voelzke BB, Waldman A, Wong MK, Zhou Y, Arai N, Brackett A, Ibrahim SA, Kang BY, Poon E, Alam M
JAMA Oncol 2022 Apr 1;8(4):618-628. doi: 10.1001/jamaoncol.2021.7148. PMID: 35050310
Angeles CV, Sabel MS
J Surg Oncol 2021 Mar;123(3):775-781. doi: 10.1002/jso.26319. PMID: 33595894
Long GV, Hauschild A, Santinami M, Atkinson V, Mandalà M, Chiarion-Sileni V, Larkin J, Nyakas M, Dutriaux C, Haydon A, Robert C, Mortier L, Schachter J, Schadendorf D, Lesimple T, Plummer R, Ji R, Zhang P, Mookerjee B, Legos J, Kefford R, Dummer R, Kirkwood JM
N Engl J Med 2017 Nov 9;377(19):1813-1823. Epub 2017 Sep 10 doi: 10.1056/NEJMoa1708539. PMID: 28891408
Berciano-Guerrero MA, Montesa-Pino A, Castaneda-Penalvo G, Munoz-Fernandez L, Rodriguez-Flores J
Curr Med Chem 2014;21(32):3701-16. doi: 10.2174/0929867321666140716092512. PMID: 25039783

Prognosis

Turner N, Ware O, Bosenberg M
Clin Exp Metastasis 2018 Aug;35(5-6):379-391. Epub 2018 May 2 doi: 10.1007/s10585-018-9893-y. PMID: 29722002
Que SKT, Zwald FO, Schmults CD
J Am Acad Dermatol 2018 Feb;78(2):237-247. doi: 10.1016/j.jaad.2017.08.059. PMID: 29332704
Elder DE
Arch Pathol Lab Med 2011 Mar;135(3):342-6. doi: 10.5858/2009-0479-RA.1. PMID: 21366458
Cummins DL, Cummins JM, Pantle H, Silverman MA, Leonard AL, Chanmugam A
Mayo Clin Proc 2006 Apr;81(4):500-7. doi: 10.4065/81.4.500. PMID: 16610570
Stadler FJ, Scott GA, Brown MD
Semin Cutan Med Surg 1998 Jun;17(2):141-52. doi: 10.1016/s1085-5629(98)80007-2. PMID: 9669607

Clinical prediction guides

Mohammadpour A, Derakhshan M, Darabi H, Hedayat P, Momeni M
J Cell Physiol 2019 Apr;234(4):3307-3320. Epub 2018 Oct 26 doi: 10.1002/jcp.27286. PMID: 30362507
Gaiser MR, von Bubnoff N, Gebhardt C, Utikal JS
J Dtsch Dermatol Ges 2018 Apr;16(4):405-414. Epub 2018 Mar 7 doi: 10.1111/ddg.13461. PMID: 29512873
Lazova R, Seeley EH
Dermatol Clin 2017 Oct;35(4):513-519. Epub 2017 Jul 11 doi: 10.1016/j.det.2017.06.012. PMID: 28886807
Pulitzer MP, Amin BD, Busam KJ
Adv Anat Pathol 2009 May;16(3):135-44. doi: 10.1097/PAP.0b013e3181a12f5a. PMID: 19395876
Ahmed I
Mayo Clin Proc 1997 Apr;72(4):356-61. doi: 10.4065/72.4.356. PMID: 9121184

Recent systematic reviews

Seth R, Agarwala SS, Messersmith H, Alluri KC, Ascierto PA, Atkins MB, Bollin K, Chacon M, Davis N, Faries MB, Funchain P, Gold JS, Guild S, Gyorki DE, Kaur V, Khushalani NI, Kirkwood JM, McQuade JL, Meyers MO, Provenzano A, Robert C, Santinami M, Sehdev A, Sondak VK, Spurrier G, Swami U, Truong TG, Tsai KK, van Akkooi A, Weber J
J Clin Oncol 2023 Oct 20;41(30):4794-4820. Epub 2023 Aug 14 doi: 10.1200/JCO.23.01136. PMID: 37579248
Jones OT, Matin RN, van der Schaar M, Prathivadi Bhayankaram K, Ranmuthu CKI, Islam MS, Behiyat D, Boscott R, Calanzani N, Emery J, Williams HC, Walter FM
Lancet Digit Health 2022 Jun;4(6):e466-e476. doi: 10.1016/S2589-7500(22)00023-1. PMID: 35623799
Alonso-Belmonte C, Montero-Vilchez T, Arias-Santiago S, Buendía-Eisman A
Actas Dermosifiliogr 2022 Sep;113(8):781-791. Epub 2022 May 5 doi: 10.1016/j.ad.2022.04.015. PMID: 35526566
Kibbi N, Owen JL, Worley B, Wang JX, Harikumar V, Downing MB, Aasi SZ, Aung PP, Barker CA, Bolotin D, Bordeaux JS, Cartee TV, Chandra S, Cho NL, Choi JN, Chung KY, Cliby WA, Dorigo O, Eisen DB, Fujisawa Y, Golda N, Halfdanarson TR, Iavazzo C, Jiang SIB, Kanitakis J, Khan A, Kim JYS, Kuzel TM, Lawrence N, Leitao MM Jr, MacLean AB, Maher IA, Mittal BB, Nehal KS, Ozog DM, Pettaway CA, Ross JS, Rossi AM, Servaes S, Solomon MJ, Thomas VD, Tolia M, Voelzke BB, Waldman A, Wong MK, Zhou Y, Arai N, Brackett A, Ibrahim SA, Kang BY, Poon E, Alam M
JAMA Oncol 2022 Apr 1;8(4):618-628. doi: 10.1001/jamaoncol.2021.7148. PMID: 35050310
Ezzo J, Manheimer E, McNeely ML, Howell DM, Weiss R, Johansson KI, Bao T, Bily L, Tuppo CM, Williams AF, Karadibak D
Cochrane Database Syst Rev 2015 May 21;2015(5):CD003475. doi: 10.1002/14651858.CD003475.pub2. PMID: 25994425Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...