U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Head and Neck NUT Carcinoma

MedGen UID:
1756150
•Concept ID:
C5420031
•
Neoplastic Process

Definition

A highly aggressive, poorly differentiated carcinoma that arises from the head and neck. Most cases are in the nasal cavity and paranasal sinuses. It is characterized by mutations and rearrangement of the NUT gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHead and Neck NUT Carcinoma

Professional guidelines

PubMed

The contemporary management of cancers of the sinonasal tract in adults.
Thawani R, Kim MS, Arastu A, Feng Z, West MT, Taflin NF, Thein KZ, Li R, Geltzeiler M, Lee N, Fuller CD, Grandis JR, Floudas CS, Heinrich MC, Hanna E, Chandra RA
CA Cancer J Clin 2023 Jan;73(1):72-112. Epub 2022 Aug 2 doi: 10.3322/caac.21752. PMID: 35916666Free PMC Article
Clinical management of emerging sinonasal malignancies.
Contrera KJ, Woody NM, Rahman M, Sindwani R, Burkey BB
Head Neck 2020 Aug;42(8):2202-2212. Epub 2020 Mar 25 doi: 10.1002/hed.26150. PMID: 32212360
NUT Carcinoma: Clinicopathologic features, pathogenesis, and treatment.
French CA
Pathol Int 2018 Nov;68(11):583-595. Epub 2018 Oct 26 doi: 10.1111/pin.12727. PMID: 30362654

Recent clinical studies

Etiology

Epidemiology, Risk Factors, and Prevention of Head and Neck Squamous Cell Carcinoma.
Barsouk A, Aluru JS, Rawla P, Saginala K, Barsouk A
Med Sci (Basel) 2023 Jun 13;11(2) doi: 10.3390/medsci11020042. PMID: 37367741Free PMC Article
Undifferentiated and dedifferentiated head and neck carcinomas.
Franchi A, Skalova A
Semin Diagn Pathol 2021 Nov;38(6):127-136. Epub 2021 Sep 26 doi: 10.1053/j.semdp.2021.09.001. PMID: 34583858
Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics.
Chamoli A, Gosavi AS, Shirwadkar UP, Wangdale KV, Behera SK, Kurrey NK, Kalia K, Mandoli A
Oral Oncol 2021 Oct;121:105451. Epub 2021 Jul 28 doi: 10.1016/j.oraloncology.2021.105451. PMID: 34329869
Squamous cell carcinoma of head and neck: what internists should know.
Jung K, Narwal M, Min SY, Keam B, Kang H
Korean J Intern Med 2020 Sep;35(5):1031-1044. Epub 2020 Jul 14 doi: 10.3904/kjim.2020.078. PMID: 32663913Free PMC Article
Prevalence of NUT carcinoma in head and neck: Analysis of 362 cases with literature review.
Lee T, Cho J, Baek CH, Son YI, Jeong HS, Chung MK, Hong SD, Ahn YC, Oh DR, Noh JM, Park K, Ahn MJ, Kim HJ, Kim YK, Ko YH
Head Neck 2020 May;42(5):924-938. Epub 2020 Jan 6 doi: 10.1002/hed.26067. PMID: 31903701

Diagnosis

Epidemiology, Risk Factors, and Prevention of Head and Neck Squamous Cell Carcinoma.
Barsouk A, Aluru JS, Rawla P, Saginala K, Barsouk A
Med Sci (Basel) 2023 Jun 13;11(2) doi: 10.3390/medsci11020042. PMID: 37367741Free PMC Article
The contemporary management of cancers of the sinonasal tract in adults.
Thawani R, Kim MS, Arastu A, Feng Z, West MT, Taflin NF, Thein KZ, Li R, Geltzeiler M, Lee N, Fuller CD, Grandis JR, Floudas CS, Heinrich MC, Hanna E, Chandra RA
CA Cancer J Clin 2023 Jan;73(1):72-112. Epub 2022 Aug 2 doi: 10.3322/caac.21752. PMID: 35916666Free PMC Article
Undifferentiated and dedifferentiated head and neck carcinomas.
Franchi A, Skalova A
Semin Diagn Pathol 2021 Nov;38(6):127-136. Epub 2021 Sep 26 doi: 10.1053/j.semdp.2021.09.001. PMID: 34583858
Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics.
Chamoli A, Gosavi AS, Shirwadkar UP, Wangdale KV, Behera SK, Kurrey NK, Kalia K, Mandoli A
Oral Oncol 2021 Oct;121:105451. Epub 2021 Jul 28 doi: 10.1016/j.oraloncology.2021.105451. PMID: 34329869
Squamous cell carcinoma of head and neck: what internists should know.
Jung K, Narwal M, Min SY, Keam B, Kang H
Korean J Intern Med 2020 Sep;35(5):1031-1044. Epub 2020 Jul 14 doi: 10.3904/kjim.2020.078. PMID: 32663913Free PMC Article

Therapy

Initial Chemotherapy for Locally Advanced and Metastatic NUT Carcinoma.
Luo J, Sanchez M, Lee E, Hertzler H, Luong N, Mazzola E, Finstein B, Tamen R, Brisbane G, Nguyen T, Paik PK, Chaft JE, Cheng ML, Khalil H, Piha-Paul SA, Sholl LM, Nishino M, Jänne PA, DuBois SG, Hanna GJ, Shapiro GI, French CA
J Thorac Oncol 2024 May;19(5):829-838. Epub 2023 Dec 27 doi: 10.1016/j.jtho.2023.12.022. PMID: 38154515Free PMC Article
NUT Carcinoma in Children and Adolescents: The Expert European Standard Clinical Practice Harmonized Recommendations.
Lemelle L, Flaadt T, Fresneau B, Moya-Plana A, Timmermann B, Roganovic J, Ferrari A, Fichera G, Lauer UM, Ben-Ami T, Schneider DT, Vokuhl C, Bolle S, Fox E, DuBois SG, Rodriguez-Galindo C, Bisogno G, Surun A, Brecht IB, Orbach D
J Pediatr Hematol Oncol 2023 May 1;45(4):165-173. Epub 2022 Oct 10 doi: 10.1097/MPH.0000000000002568. PMID: 36219702
Systemic therapy in non-conventional cancers of the larynx.
Tan E, Mody MD, Saba NF
Oral Oncol 2018 Jul;82:61-68. Epub 2018 May 26 doi: 10.1016/j.oraloncology.2018.05.005. PMID: 29909903
Carcinoma of the head and neck in the HPV era.
Cardesa A, Nadal A
Acta Dermatovenerol Alp Pannonica Adriat 2011 Sep;20(3):161-73. PMID: 22131117
Habitual risk factors for head and neck cancer.
Goldenberg D, Lee J, Koch WM, Kim MM, Trink B, Sidransky D, Moon CS
Otolaryngol Head Neck Surg 2004 Dec;131(6):986-93. doi: 10.1016/j.otohns.2004.02.035. PMID: 15577802

Prognosis

Imaging spectrum of NUT carcinomas.
Virarkar M, Saleh M, Ramani NS, Morani AC, Bhosale P
Clin Imaging 2020 Nov;67:198-206. Epub 2020 Aug 2 doi: 10.1016/j.clinimag.2020.07.025. PMID: 32866821
Squamous cell carcinoma of head and neck: what internists should know.
Jung K, Narwal M, Min SY, Keam B, Kang H
Korean J Intern Med 2020 Sep;35(5):1031-1044. Epub 2020 Jul 14 doi: 10.3904/kjim.2020.078. PMID: 32663913Free PMC Article
Clinical management of emerging sinonasal malignancies.
Contrera KJ, Woody NM, Rahman M, Sindwani R, Burkey BB
Head Neck 2020 Aug;42(8):2202-2212. Epub 2020 Mar 25 doi: 10.1002/hed.26150. PMID: 32212360
Recently described neoplasms of the sinonasal tract.
Bishop JA
Semin Diagn Pathol 2016 Mar;33(2):62-70. Epub 2015 Dec 23 doi: 10.1053/j.semdp.2015.12.001. PMID: 26776744
Review: Head and neck squamous cell carcinoma in sub-Saharan Africa.
Faggons CE, Mabedi C, Shores CG, Gopal S
Malawi Med J 2015 Sep;27(3):79-87. doi: 10.4314/mmj.v27i3.2. PMID: 26715951Free PMC Article

Clinical prediction guides

The histological spectrum and immunoprofile of head and neck NUT carcinoma: A multicentre series of 30 cases.
Viswanathan K, Hahn E, Dogan S, Weinreb I, Dickson BC, MacMillan C, Katabi N, Magliocca K, Ghossein R, Xu B
Histopathology 2024 Aug;85(2):317-326. Epub 2024 May 6 doi: 10.1111/his.15204. PMID: 38708903Free PMC Article
Prediction of Prognosis of Tongue Squamous Cell Carcinoma Based on Clinical MR Imaging Data Modeling.
Liu J, Song L, Zhou J, Yu M, Hu Y, Zhang J, Song P, Ye Y, Wang J, Feng G, Guo H, An P
Technol Cancer Res Treat 2023 Jan-Dec;22:15330338231207006. doi: 10.1177/15330338231207006. PMID: 37872687Free PMC Article
Targeting the DNA Damage Response in OSCC with TP53 Mutations.
Lindemann A, Takahashi H, Patel AA, Osman AA, Myers JN
J Dent Res 2018 Jun;97(6):635-644. Epub 2018 Feb 28 doi: 10.1177/0022034518759068. PMID: 29489434Free PMC Article
NUT carcinoma in children and adults: A multicenter retrospective study.
Lemelle L, Pierron G, Fréneaux P, Huybrechts S, Spiegel A, Plantaz D, Julieron M, Dumoucel S, Italiano A, Millot F, Le Tourneau C, Leverger G, Chastagner P, Carton M, Orbach D
Pediatr Blood Cancer 2017 Dec;64(12) Epub 2017 Jun 23 doi: 10.1002/pbc.26693. PMID: 28643357
Clinical, pathological and molecular determinants in squamous cell carcinoma of the oral cavity.
Al-Swiahb JN, Chen CH, Chuang HC, Fang FM, Tasi HT, Chien CY
Future Oncol 2010 May;6(5):837-50. doi: 10.2217/fon.10.35. PMID: 20465394

Recent systematic reviews

Therapeutic approaches to sinonasal NUT carcinoma: a systematic review.
Urbanelli A, Nitro L, Pipolo C, Maccari A, Albera A, Fadda GL, Felisati G, Albera R, Pecorari G, Fuccillo E, Saibene AM
Eur Arch Otorhinolaryngol 2024 Jul;281(7):3361-3369. Epub 2024 Feb 8 doi: 10.1007/s00405-024-08489-0. PMID: 38329527Free PMC Article
Sinonasal NUT carcinoma: A consecutive case series and systematic review.
Ramesh U, Contrera KJ, Shakibai N, Su SY, Brahimaj B, Roberts D, Williams MD, Ferrarotto R, Phan J, Gunn GB, Raza S, DeMonte F, Hanna EY
Head Neck 2024 Jan;46(1):29-36. Epub 2023 Oct 18 doi: 10.1002/hed.27553. PMID: 37853958
NUT carcinoma of the mandible in a child: case report and systematic review.
Jimenez C, Stanton E, Kondra K, Nickels EM, Jacob L, Shah R, Hammoudeh JA
Int J Oral Maxillofac Surg 2023 Mar;52(3):304-312. Epub 2022 Jul 19 doi: 10.1016/j.ijom.2022.07.002. PMID: 35868909
Salivary Gland NUT Carcinoma with Prolonged Survival in Children: Case Illustration and Systematic Review of Literature.
Wang H, Weiss VL, Hoffman RD, Abel T, Ho RH, Borinstein SC, Mannion K, Bridge JA, Black J, Liang J
Head Neck Pathol 2021 Mar;15(1):236-243. Epub 2020 Feb 19 doi: 10.1007/s12105-020-01141-3. PMID: 32077054Free PMC Article
Patterns of care and impact of prognostic factors in the outcome of NUT midline carcinoma: a systematic review and individual patient data analysis of 119 cases.
Giridhar P, Mallick S, Kashyap L, Rath GK
Eur Arch Otorhinolaryngol 2018 Mar;275(3):815-821. Epub 2018 Jan 22 doi: 10.1007/s00405-018-4882-y. PMID: 29356890

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...