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Head and Neck NUT Carcinoma

MedGen UID:
1756150
•Concept ID:
C5420031
•
Neoplastic Process

Definition

A highly aggressive, poorly differentiated carcinoma that arises from the head and neck. Most cases are in the nasal cavity and paranasal sinuses. It is characterized by mutations and rearrangement of the NUT gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHead and Neck NUT Carcinoma

Professional guidelines

PubMed

The contemporary management of cancers of the sinonasal tract in adults.
Thawani R, Kim MS, Arastu A, Feng Z, West MT, Taflin NF, Thein KZ, Li R, Geltzeiler M, Lee N, Fuller CD, Grandis JR, Floudas CS, Heinrich MC, Hanna E, Chandra RA
CA Cancer J Clin 2023 Jan;73(1):72-112. Epub 2022 Aug 2 doi: 10.3322/caac.21752. PMID: 35916666Free PMC Article
Clinical management of emerging sinonasal malignancies.
Contrera KJ, Woody NM, Rahman M, Sindwani R, Burkey BB
Head Neck 2020 Aug;42(8):2202-2212. Epub 2020 Mar 25 doi: 10.1002/hed.26150. PMID: 32212360
NUT Carcinoma: Clinicopathologic features, pathogenesis, and treatment.
French CA
Pathol Int 2018 Nov;68(11):583-595. Epub 2018 Oct 26 doi: 10.1111/pin.12727. PMID: 30362654

Recent clinical studies

Etiology

The prevalence of oral squamous cell carcinoma with oral submucous fibrosis.
Saalim M, Sansare K, Karjodkar FR, Johaley S, Ali IK, Sharma SR, Mehra A, Rahman B
J Cancer Res Ther 2021 Oct-Dec;17(6):1510-1514. doi: 10.4103/jcrt.JCRT_719_19. PMID: 34916386
Undifferentiated and dedifferentiated head and neck carcinomas.
Franchi A, Skalova A
Semin Diagn Pathol 2021 Nov;38(6):127-136. Epub 2021 Sep 26 doi: 10.1053/j.semdp.2021.09.001. PMID: 34583858
Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics.
Chamoli A, Gosavi AS, Shirwadkar UP, Wangdale KV, Behera SK, Kurrey NK, Kalia K, Mandoli A
Oral Oncol 2021 Oct;121:105451. Epub 2021 Jul 28 doi: 10.1016/j.oraloncology.2021.105451. PMID: 34329869
Squamous cell carcinoma of head and neck: what internists should know.
Jung K, Narwal M, Min SY, Keam B, Kang H
Korean J Intern Med 2020 Sep;35(5):1031-1044. Epub 2020 Jul 14 doi: 10.3904/kjim.2020.078. PMID: 32663913Free PMC Article
Prevalence of NUT carcinoma in head and neck: Analysis of 362 cases with literature review.
Lee T, Cho J, Baek CH, Son YI, Jeong HS, Chung MK, Hong SD, Ahn YC, Oh DR, Noh JM, Park K, Ahn MJ, Kim HJ, Kim YK, Ko YH
Head Neck 2020 May;42(5):924-938. Epub 2020 Jan 6 doi: 10.1002/hed.26067. PMID: 31903701

Diagnosis

The contemporary management of cancers of the sinonasal tract in adults.
Thawani R, Kim MS, Arastu A, Feng Z, West MT, Taflin NF, Thein KZ, Li R, Geltzeiler M, Lee N, Fuller CD, Grandis JR, Floudas CS, Heinrich MC, Hanna E, Chandra RA
CA Cancer J Clin 2023 Jan;73(1):72-112. Epub 2022 Aug 2 doi: 10.3322/caac.21752. PMID: 35916666Free PMC Article
The prevalence of oral squamous cell carcinoma with oral submucous fibrosis.
Saalim M, Sansare K, Karjodkar FR, Johaley S, Ali IK, Sharma SR, Mehra A, Rahman B
J Cancer Res Ther 2021 Oct-Dec;17(6):1510-1514. doi: 10.4103/jcrt.JCRT_719_19. PMID: 34916386
Undifferentiated and dedifferentiated head and neck carcinomas.
Franchi A, Skalova A
Semin Diagn Pathol 2021 Nov;38(6):127-136. Epub 2021 Sep 26 doi: 10.1053/j.semdp.2021.09.001. PMID: 34583858
Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics.
Chamoli A, Gosavi AS, Shirwadkar UP, Wangdale KV, Behera SK, Kurrey NK, Kalia K, Mandoli A
Oral Oncol 2021 Oct;121:105451. Epub 2021 Jul 28 doi: 10.1016/j.oraloncology.2021.105451. PMID: 34329869
Squamous cell carcinoma of head and neck: what internists should know.
Jung K, Narwal M, Min SY, Keam B, Kang H
Korean J Intern Med 2020 Sep;35(5):1031-1044. Epub 2020 Jul 14 doi: 10.3904/kjim.2020.078. PMID: 32663913Free PMC Article

Therapy

Systemic and Local Effects Among Patients With Betel Quid-Related Oral Cancer.
Chuang HC, Tsai MH, Lin YT, Chou MH, Yang KL, Chien CY
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221146870. doi: 10.1177/15330338221146870. PMID: 36575633Free PMC Article
Systemic therapy in non-conventional cancers of the larynx.
Tan E, Mody MD, Saba NF
Oral Oncol 2018 Jul;82:61-68. Epub 2018 May 26 doi: 10.1016/j.oraloncology.2018.05.005. PMID: 29909903
The importance of diagnosing NUT midline carcinoma.
French CA
Head Neck Pathol 2013 Mar;7(1):11-6. Epub 2013 Mar 5 doi: 10.1007/s12105-013-0428-1. PMID: 23463074Free PMC Article
Carcinoma of the head and neck in the HPV era.
Cardesa A, Nadal A
Acta Dermatovenerol Alp Pannonica Adriat 2011 Sep;20(3):161-73. PMID: 22131117
Habitual risk factors for head and neck cancer.
Goldenberg D, Lee J, Koch WM, Kim MM, Trink B, Sidransky D, Moon CS
Otolaryngol Head Neck Surg 2004 Dec;131(6):986-93. doi: 10.1016/j.otohns.2004.02.035. PMID: 15577802

Prognosis

Imaging spectrum of NUT carcinomas.
Virarkar M, Saleh M, Ramani NS, Morani AC, Bhosale P
Clin Imaging 2020 Nov;67:198-206. Epub 2020 Aug 2 doi: 10.1016/j.clinimag.2020.07.025. PMID: 32866821
The circEPSTI1/mir-942-5p/LTBP2 axis regulates the progression of OSCC in the background of OSF via EMT and the PI3K/Akt/mTOR pathway.
Wang J, Jiang C, Li N, Wang F, Xu Y, Shen Z, Yang L, Li Z, He C
Cell Death Dis 2020 Aug 12;11(8):682. doi: 10.1038/s41419-020-02851-w. PMID: 32826876Free PMC Article
Squamous cell carcinoma of head and neck: what internists should know.
Jung K, Narwal M, Min SY, Keam B, Kang H
Korean J Intern Med 2020 Sep;35(5):1031-1044. Epub 2020 Jul 14 doi: 10.3904/kjim.2020.078. PMID: 32663913Free PMC Article
Clinical management of emerging sinonasal malignancies.
Contrera KJ, Woody NM, Rahman M, Sindwani R, Burkey BB
Head Neck 2020 Aug;42(8):2202-2212. Epub 2020 Mar 25 doi: 10.1002/hed.26150. PMID: 32212360
Carcinoma of the head and neck in the HPV era.
Cardesa A, Nadal A
Acta Dermatovenerol Alp Pannonica Adriat 2011 Sep;20(3):161-73. PMID: 22131117

Clinical prediction guides

Clinicopathological and Preclinical Findings of NUT Carcinoma: A Multicenter Study.
Jung M, Kim S, Lee JK, Yoon SO, Park HS, Hong SW, Park WS, Kim JE, Kim J, Keam B, Kim HJ, Kang HJ, Kim DW, Jung KC, Kim YT, Heo DS, Kim TM, Jeon YK
Oncologist 2019 Aug;24(8):e740-e748. Epub 2019 Jan 29 doi: 10.1634/theoncologist.2018-0477. PMID: 30696721Free PMC Article
Targeting the DNA Damage Response in OSCC with TP53 Mutations.
Lindemann A, Takahashi H, Patel AA, Osman AA, Myers JN
J Dent Res 2018 Jun;97(6):635-644. Epub 2018 Feb 28 doi: 10.1177/0022034518759068. PMID: 29489434Free PMC Article
Prevalence and types of high-risk human papillomaviruses in head and neck cancers from Bangladesh.
Shaikh MH, Khan AI, Sadat A, Chowdhury AH, Jinnah SA, Gopalan V, Lam AK, Clarke DTW, McMillan NAJ, Johnson NW
BMC Cancer 2017 Nov 25;17(1):792. doi: 10.1186/s12885-017-3789-0. PMID: 29178862Free PMC Article
NUT carcinoma in children and adults: A multicenter retrospective study.
Lemelle L, Pierron G, Fréneaux P, Huybrechts S, Spiegel A, Plantaz D, Julieron M, Dumoucel S, Italiano A, Millot F, Le Tourneau C, Leverger G, Chastagner P, Carton M, Orbach D
Pediatr Blood Cancer 2017 Dec;64(12) Epub 2017 Jun 23 doi: 10.1002/pbc.26693. PMID: 28643357
Clinical, pathological and molecular determinants in squamous cell carcinoma of the oral cavity.
Al-Swiahb JN, Chen CH, Chuang HC, Fang FM, Tasi HT, Chien CY
Future Oncol 2010 May;6(5):837-50. doi: 10.2217/fon.10.35. PMID: 20465394

Recent systematic reviews

NUT carcinoma of the mandible in a child: case report and systematic review.
Jimenez C, Stanton E, Kondra K, Nickels EM, Jacob L, Shah R, Hammoudeh JA
Int J Oral Maxillofac Surg 2023 Mar;52(3):304-312. Epub 2022 Jul 19 doi: 10.1016/j.ijom.2022.07.002. PMID: 35868909
Salivary Gland NUT Carcinoma with Prolonged Survival in Children: Case Illustration and Systematic Review of Literature.
Wang H, Weiss VL, Hoffman RD, Abel T, Ho RH, Borinstein SC, Mannion K, Bridge JA, Black J, Liang J
Head Neck Pathol 2021 Mar;15(1):236-243. Epub 2020 Feb 19 doi: 10.1007/s12105-020-01141-3. PMID: 32077054Free PMC Article
Patterns of care and impact of prognostic factors in the outcome of NUT midline carcinoma: a systematic review and individual patient data analysis of 119 cases.
Giridhar P, Mallick S, Kashyap L, Rath GK
Eur Arch Otorhinolaryngol 2018 Mar;275(3):815-821. Epub 2018 Jan 22 doi: 10.1007/s00405-018-4882-y. PMID: 29356890

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