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Oral Multifocal Epithelial Hyperplasia

MedGen UID:
1756776
•Concept ID:
C5420221
•
Disease or Syndrome

Definition

Benign multifocal squamous epithelial proliferation affecting the oral mucosa. It is associated with human papilloma virus infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOral Multifocal Epithelial Hyperplasia

Professional guidelines

PubMed

Effect of CD4+ lymphocyte count, viral load, and duration of taking anti-retroviral treatment on presence of oral lesions in a sample of South African children with HIV+/AIDS.
Duggal MS, Abudiak H, Dunn C, Tong HJ, Munyombwe T
Eur Arch Paediatr Dent 2010 Oct;11(5):242-6. doi: 10.1007/BF03262755. PMID: 20932399

Recent clinical studies

Etiology

Focal Epithelial Hyperplasia.
Bendtsen SK, Jakobsen KK, Carlander AF, Grønhøj C, von Buchwald C
Viruses 2021 Aug 2;13(8) doi: 10.3390/v13081529. PMID: 34452393Free PMC Article
HPV-Related Papillary Lesions of the Oral Mucosa: A Review.
Betz SJ
Head Neck Pathol 2019 Mar;13(1):80-90. Epub 2019 Jan 29 doi: 10.1007/s12105-019-01003-7. PMID: 30693456Free PMC Article
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77. doi: 10.1111/jcpe.12940. PMID: 29926499
Human papillomavirus and oral disease - emerging evidence: a review.
Prabhu SR, Wilson DF
Aust Dent J 2013 Mar;58(1):2-10; quiz 125. Epub 2013 Jan 31 doi: 10.1111/adj.12020. PMID: 23441786

Diagnosis

Focal Epithelial Hyperplasia.
Bendtsen SK, Jakobsen KK, Carlander AF, Grønhøj C, von Buchwald C
Viruses 2021 Aug 2;13(8) doi: 10.3390/v13081529. PMID: 34452393Free PMC Article
Oral human papilloma virus infection: an overview of clinical-laboratory diagnosis and treatment.
Orrù G, Mameli A, Demontis C, Rossi P, Ratto D, Occhinegro A, Piras V, Kuqi L, Berretta M, Taibi R, Scano A, Coni P
Eur Rev Med Pharmacol Sci 2019 Sep;23(18):8148-8157. doi: 10.26355/eurrev_201909_19035. PMID: 31599444
HPV-Related Papillary Lesions of the Oral Mucosa: A Review.
Betz SJ
Head Neck Pathol 2019 Mar;13(1):80-90. Epub 2019 Jan 29 doi: 10.1007/s12105-019-01003-7. PMID: 30693456Free PMC Article
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77. doi: 10.1111/jcpe.12940. PMID: 29926499

Therapy

Focal epithelial hyperplasia (Heck disease) related to highly active antiretroviral therapy in an HIV-seropositive child. A report of a case, and a review of the literature.
Feller L, Khammissa RA, Wood NH, Malema V, Meyerov R, Lemmer J
SADJ 2010 May;65(4):172-5. PMID: 20632701
Actinic cheilitis: clinical and histological features.
Cavalcante AS, Anbinder AL, Carvalho YR
J Oral Maxillofac Surg 2008 Mar;66(3):498-503. doi: 10.1016/j.joms.2006.09.016. PMID: 18280383
Multifocal epithelial hyperplasia. Report of nine cases.
Ledesma-Montes C, Vega-Memije E, Garcés-Ortíz M, Cardiel-Nieves M, Juárez-Luna C
Med Oral Patol Oral Cir Bucal 2005 Nov-Dec;10(5):394-401. PMID: 16264387
Intraoral melanoma: long-term follow-up and implication for dental clinicians. A case report and literature review.
Gu GM, Epstein JB, Morton TH Jr
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003 Oct;96(4):404-13. doi: 10.1016/s1079-2104(03)00320-2. PMID: 14561964
Multifocal papillomavirus epithelial hyperplasia: successful treatment with CO2 laser therapy combined with interferon alpha-2b.
Akyol A, Anadolu R, Anadolu Y, Ekmekci P, Gürgey E, Akay N
Int J Dermatol 2003 Sep;42(9):733-5. doi: 10.1046/j.1365-4362.2003.01777.x. PMID: 12956692

Prognosis

CD133 Role in Oral Carcinogenesis.
Luna ECM, Bezerra TMM, Barros Silva PG, Cavalcante RB, Costa FWG, Alves APNN, Chaves FN, Pereira KMA
Asian Pac J Cancer Prev 2020 Sep 1;21(9):2501-2506. doi: 10.31557/APJCP.2020.21.9.2501. PMID: 32986345Free PMC Article
Human genetic dissection of papillomavirus-driven diseases: new insight into their pathogenesis.
Béziat V
Hum Genet 2020 Jun;139(6-7):919-939. Epub 2020 May 20 doi: 10.1007/s00439-020-02183-x. PMID: 32435828Free PMC Article
Oral human papilloma virus infection: an overview of clinical-laboratory diagnosis and treatment.
Orrù G, Mameli A, Demontis C, Rossi P, Ratto D, Occhinegro A, Piras V, Kuqi L, Berretta M, Taibi R, Scano A, Coni P
Eur Rev Med Pharmacol Sci 2019 Sep;23(18):8148-8157. doi: 10.26355/eurrev_201909_19035. PMID: 31599444
Unusually high incidence of multifocal epithelial hyperplasia in children of the Nahuatl population of Mexico.
Ledesma-Montes C, Mendez-Mendoza A
Indian J Dermatol Venereol Leprol 2017 Nov-Dec;83(6):663-666. doi: 10.4103/ijdvl.IJDVL_442_16. PMID: 28799531
Human papillomavirus and Epstein-Barr virus associated conditions of the oral mucosa.
Stojanov IJ, Woo SB
Semin Diagn Pathol 2015 Jan;32(1):3-11. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.003. PMID: 25749203

Clinical prediction guides

Localized juvenile spongiotic gingival hyperplasia: Microscopic variations and proposed change to nomenclature.
Theofilou VI, Pettas E, Georgaki M, Daskalopoulos A, Nikitakis NG
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Mar;131(3):329-338. Epub 2020 Nov 5 doi: 10.1016/j.oooo.2020.10.024. PMID: 33309266
CD133 Role in Oral Carcinogenesis.
Luna ECM, Bezerra TMM, Barros Silva PG, Cavalcante RB, Costa FWG, Alves APNN, Chaves FN, Pereira KMA
Asian Pac J Cancer Prev 2020 Sep 1;21(9):2501-2506. doi: 10.31557/APJCP.2020.21.9.2501. PMID: 32986345Free PMC Article
Human papillomavirus and Epstein-Barr virus associated conditions of the oral mucosa.
Stojanov IJ, Woo SB
Semin Diagn Pathol 2015 Jan;32(1):3-11. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.003. PMID: 25749203
Focal epithelial hyperplasia - an update.
Said AK, Leao JC, Fedele S, Porter SR
J Oral Pathol Med 2013 Jul;42(6):435-42. Epub 2012 Oct 14 doi: 10.1111/jop.12009. PMID: 23061874
Clinicopathological and immunocytochemical study of multifocal epithelial hyperplasia.
Ledesma-Montes C, Garcés-Ortíz M, Hernández-Guerrero JC
J Oral Maxillofac Surg 2007 Nov;65(11):2211-7. doi: 10.1016/j.joms.2006.11.035. PMID: 17954316

Recent systematic reviews

An update on Heck's disease-a systematic review.
Sethi S, Ali A, Ju X, Antonsson A, Logan R, Jamieson L
J Public Health (Oxf) 2022 Jun 27;44(2):269-285. doi: 10.1093/pubmed/fdaa256. PMID: 33501985

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