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Unresectable Prostate Carcinoma

MedGen UID:
1757847
•Concept ID:
C5419210
•
Neoplastic Process

Definition

Prostate carcinoma that is not amenable to surgical resection. [from NCI]

Professional guidelines

PubMed

Beyond chemoradiotherapy: improving treatment outcomes for patients with stage III unresectable non-small-cell lung cancer through immuno-oncology and durvalumab (Imfinzi®▼, AstraZeneca UK Limited).
Patel P, Alrifai D, McDonald F, Forster M; AstraZeneca UK Limited
Br J Cancer 2020 Dec;123(Suppl 1):18-27. doi: 10.1038/s41416-020-01071-5. PMID: 33293672Free PMC Article
Gemcitabine chemotherapy for the treatment of metastatic bladder carcinoma.
Shelley MD, Cleves A, Wilt TJ, Mason MD
BJU Int 2011 Jul;108(2):168-79. doi: 10.1111/j.1464-410X.2011.10341.x. PMID: 21718430
Management of patients with low-stage nonseminomatous germ cell testicular cancer.
Stephenson AJ, Sheinfeld J
Curr Treat Options Oncol 2005 Sep;6(5):367-77. doi: 10.1007/s11864-005-0040-z. PMID: 16107240

Recent clinical studies

Etiology

Metformin in Combination With Chemoradiotherapy in Locally Advanced Non-Small Cell Lung Cancer: The OCOG-ALMERA Randomized Clinical Trial.
Tsakiridis T, Pond GR, Wright J, Ellis PM, Ahmed N, Abdulkarim B, Roa W, Robinson A, Swaminath A, Okawara G, Wierzbicki M, Valdes M, Levine M
JAMA Oncol 2021 Sep 1;7(9):1333-1341. doi: 10.1001/jamaoncol.2021.2328. PMID: 34323924Free PMC Article
Tecemotide: an antigen-specific cancer immunotherapy.
Wurz GT, Kao CJ, Wolf M, DeGregorio MW
Hum Vaccin Immunother 2014;10(11):3383-93. doi: 10.4161/hv.29836. PMID: 25483673Free PMC Article
Gemcitabine chemotherapy for the treatment of metastatic bladder carcinoma.
Shelley MD, Cleves A, Wilt TJ, Mason MD
BJU Int 2011 Jul;108(2):168-79. doi: 10.1111/j.1464-410X.2011.10341.x. PMID: 21718430
Gemcitabine for unresectable, locally advanced or metastatic bladder cancer.
Shelley M, Cleves A, Wilt TJ, Mason M
Cochrane Database Syst Rev 2011 Apr 13;(4):CD008976. doi: 10.1002/14651858.CD008976.pub2. PMID: 21491413
Management of patients with low-stage nonseminomatous germ cell testicular cancer.
Stephenson AJ, Sheinfeld J
Curr Treat Options Oncol 2005 Sep;6(5):367-77. doi: 10.1007/s11864-005-0040-z. PMID: 16107240

Diagnosis

Comparison of 68Ga-PSMA-HBED-CC and 18F-FDG PET/CT in the Evaluation of Adenoid Cystic Carcinoma-A Prospective Study.
Shamim SA, Kumar N, Arora G, Kumar D, Pathak A, Thakkar A, Sikka K, Singh CA, Kakkar A, Bhalla AS
Clin Nucl Med 2023 Nov 1;48(11):e509-e515. doi: 10.1097/RLU.0000000000004868. PMID: 37812520
Iodine-125 seed implantation for synchronous pancreatic metastases from hepatocellular carcinoma: A case report and literature review.
Xiong J, Kwong Chian S, Li J, Liu X
Medicine (Baltimore) 2017 Nov;96(46):e8726. doi: 10.1097/MD.0000000000008726. PMID: 29145315Free PMC Article
The spectrum of neuroendocrine tumors: histologic classification, unique features and areas of overlap.
Klimstra DS, Beltran H, Lilenbaum R, Bergsland E
Am Soc Clin Oncol Educ Book 2015:92-103. doi: 10.14694/EdBook_AM.2015.35.92. PMID: 25993147
Management of patients with low-stage nonseminomatous germ cell testicular cancer.
Stephenson AJ, Sheinfeld J
Curr Treat Options Oncol 2005 Sep;6(5):367-77. doi: 10.1007/s11864-005-0040-z. PMID: 16107240
Prostatic carcinosarcoma: case report and review of literature.
Nazeer T, Barada JH, Fisher HA, Ross JS
J Urol 1991 Nov;146(5):1370-3. doi: 10.1016/s0022-5347(17)38099-0. PMID: 1942296

Therapy

Immune Checkpoint Inhibitor Therapy for Bone Metastases: Specific Microenvironment and Current Situation.
Liu C, Wang M, Xu C, Li B, Chen J, Chen J, Wang Z
J Immunol Res 2021;2021:8970173. Epub 2021 Nov 28 doi: 10.1155/2021/8970173. PMID: 34877360Free PMC Article
Tecemotide: an antigen-specific cancer immunotherapy.
Wurz GT, Kao CJ, Wolf M, DeGregorio MW
Hum Vaccin Immunother 2014;10(11):3383-93. doi: 10.4161/hv.29836. PMID: 25483673Free PMC Article
Stromal expression of SPARC in pancreatic adenocarcinoma.
Neuzillet C, Tijeras-Raballand A, Cros J, Faivre S, Hammel P, Raymond E
Cancer Metastasis Rev 2013 Dec;32(3-4):585-602. doi: 10.1007/s10555-013-9439-3. PMID: 23690170
Gemcitabine chemotherapy for the treatment of metastatic bladder carcinoma.
Shelley MD, Cleves A, Wilt TJ, Mason MD
BJU Int 2011 Jul;108(2):168-79. doi: 10.1111/j.1464-410X.2011.10341.x. PMID: 21718430
Gemcitabine for unresectable, locally advanced or metastatic bladder cancer.
Shelley M, Cleves A, Wilt TJ, Mason M
Cochrane Database Syst Rev 2011 Apr 13;(4):CD008976. doi: 10.1002/14651858.CD008976.pub2. PMID: 21491413

Prognosis

The spectrum of neuroendocrine tumors: histologic classification, unique features and areas of overlap.
Klimstra DS, Beltran H, Lilenbaum R, Bergsland E
Am Soc Clin Oncol Educ Book 2015:92-103. doi: 10.14694/EdBook_AM.2015.35.92. PMID: 25993147
Clinicopathological significance of androgen receptor, HER2, Ki-67 and EGFR expressions in salivary duct carcinoma.
Masubuchi T, Tada Y, Maruya S, Osamura Y, Kamata SE, Miura K, Fushimi C, Takahashi H, Kawakita D, Kishimoto S, Nagao T
Int J Clin Oncol 2015 Feb;20(1):35-44. Epub 2014 Feb 20 doi: 10.1007/s10147-014-0674-6. PMID: 24553861
Stromal expression of SPARC in pancreatic adenocarcinoma.
Neuzillet C, Tijeras-Raballand A, Cros J, Faivre S, Hammel P, Raymond E
Cancer Metastasis Rev 2013 Dec;32(3-4):585-602. doi: 10.1007/s10555-013-9439-3. PMID: 23690170
Gemcitabine chemotherapy for the treatment of metastatic bladder carcinoma.
Shelley MD, Cleves A, Wilt TJ, Mason MD
BJU Int 2011 Jul;108(2):168-79. doi: 10.1111/j.1464-410X.2011.10341.x. PMID: 21718430
Gemcitabine for unresectable, locally advanced or metastatic bladder cancer.
Shelley M, Cleves A, Wilt TJ, Mason M
Cochrane Database Syst Rev 2011 Apr 13;(4):CD008976. doi: 10.1002/14651858.CD008976.pub2. PMID: 21491413

Clinical prediction guides

Clinicopathological significance of androgen receptor, HER2, Ki-67 and EGFR expressions in salivary duct carcinoma.
Masubuchi T, Tada Y, Maruya S, Osamura Y, Kamata SE, Miura K, Fushimi C, Takahashi H, Kawakita D, Kishimoto S, Nagao T
Int J Clin Oncol 2015 Feb;20(1):35-44. Epub 2014 Feb 20 doi: 10.1007/s10147-014-0674-6. PMID: 24553861
Gemcitabine chemotherapy for the treatment of metastatic bladder carcinoma.
Shelley MD, Cleves A, Wilt TJ, Mason MD
BJU Int 2011 Jul;108(2):168-79. doi: 10.1111/j.1464-410X.2011.10341.x. PMID: 21718430
The role of radical cystectomy in patients with clinical T4b bladder cancer.
Black PC, Dinney CP, Brown GA, Kassouf W, Siefker-Radtke AO, Munsell MF, Grossman HB, Kamat AM
Urol Oncol 2011 Mar-Apr;29(2):157-61. Epub 2010 Apr 24 doi: 10.1016/j.urolonc.2009.12.015. PMID: 20456984Free PMC Article
Clinical trials of neutron radiotherapy in the United States.
Lindsley KL, Cho P, Stelzer KJ, Koh WJ, Austin-Seymour M, Russell KJ, Laramore GE, Griffin TW
Bull Cancer Radiother 1996;83 Suppl:78s-86s. doi: 10.1016/0924-4212(96)84889-4. PMID: 8949756
Radical prostatectomy and adjuvant radioactive gold seed placement: results of treatment at 5 and 10 years for clinical stages A2, B1 and B2 cancer of the prostate.
Kwon ED, Loening SA, Hawtrey CE
J Urol 1991 Mar;145(3):524-31. doi: 10.1016/s0022-5347(17)38387-8. PMID: 1997703

Recent systematic reviews

Gemcitabine for unresectable, locally advanced or metastatic bladder cancer.
Shelley M, Cleves A, Wilt TJ, Mason M
Cochrane Database Syst Rev 2011 Apr 13;(4):CD008976. doi: 10.1002/14651858.CD008976.pub2. PMID: 21491413

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