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Unresectable Anal Squamous Cell Carcinoma

MedGen UID:
1758331
•Concept ID:
C5420068
•
Neoplastic Process

Definition

Anal squamous cell carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Anal Squamous Cell Carcinoma

Professional guidelines

PubMed

Radiotherapy in the management of rare gastrointestinal cancers: A systematic review.
Bellefkih FZ, Benchakroun N, Lalya I, Amaoui B, El Kacemi H, Acharki A, El Hfid M, El Mazghi A, Chekrine T, Bouchbika Z, Jouhadi H, Sahraoui S, Tawfiq N, Michalet M
Cancer Radiother 2023 Sep;27(6-7):622-637. Epub 2023 Jul 25 doi: 10.1016/j.canrad.2023.06.010. PMID: 37500390
The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies.
Jácome AA, Morris VK, Eng C
Curr Treat Options Oncol 2022 Aug;23(8):1073-1085. Epub 2022 Jun 6 doi: 10.1007/s11864-022-00939-3. PMID: 35666353
FOLFCIS Treatment and Genomic Correlates of Response in Advanced Anal Squamous Cell Cancer.
Mondaca S, Chatila WK, Bates D, Hechtman JF, Cercek A, Segal NH, Stadler ZK, Varghese AM, Kundra R, Capanu M, Shia J, Schultz N, Saltz L, Yaeger R
Clin Colorectal Cancer 2019 Mar;18(1):e39-e52. Epub 2018 Sep 21 doi: 10.1016/j.clcc.2018.09.005. PMID: 30316684Free PMC Article

Recent clinical studies

Therapy

Atezolizumab plus modified docetaxel, cisplatin, and fluorouracil as first-line treatment for advanced anal cancer (SCARCE C17-02 PRODIGE 60): a randomised, non-comparative, phase 2 study.
Kim S, Ghiringhelli F, de la Fouchardière C, Evesque L, Smith D, Badet N, Samalin E, Lopez-Trabada Ataz D, Parzy A, Desramé J, Baba Hamed N, Buecher B, Tougeron D, Bouché O, Dahan L, Chibaudel B, El Hajbi F, Mineur L, Dubreuil O, Ben Abdelghani M, Pecout S, Bibeau F, Herfs M, Garcia ML, Meurisse A, Vernerey D, Taïeb J, Borg C
Lancet Oncol 2024 Apr;25(4):518-528. doi: 10.1016/S1470-2045(24)00081-0. PMID: 38547895
The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies.
Jácome AA, Morris VK, Eng C
Curr Treat Options Oncol 2022 Aug;23(8):1073-1085. Epub 2022 Jun 6 doi: 10.1007/s11864-022-00939-3. PMID: 35666353
FOLFCIS Treatment and Genomic Correlates of Response in Advanced Anal Squamous Cell Cancer.
Mondaca S, Chatila WK, Bates D, Hechtman JF, Cercek A, Segal NH, Stadler ZK, Varghese AM, Kundra R, Capanu M, Shia J, Schultz N, Saltz L, Yaeger R
Clin Colorectal Cancer 2019 Mar;18(1):e39-e52. Epub 2018 Sep 21 doi: 10.1016/j.clcc.2018.09.005. PMID: 30316684Free PMC Article
Image-guided Interstitial Brachytherapy in the Management of Metastasized Anal Squamous Cell Carcinoma.
Heinze C, Omari J, Othmer M, Hass P, Seidensticker M, Damm R, Ricke J, Pech M, Powerski MJ
Anticancer Res 2018 Sep;38(9):5401-5407. doi: 10.21873/anticanres.12870. PMID: 30194195
Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multicentre, single-arm, phase 2 study.
Morris VK, Salem ME, Nimeiri H, Iqbal S, Singh P, Ciombor K, Polite B, Deming D, Chan E, Wade JL, Xiao L, Bekaii-Saab T, Vence L, Blando J, Mahvash A, Foo WC, Ohaji C, Pasia M, Bland G, Ohinata A, Rogers J, Mehdizadeh A, Banks K, Lanman R, Wolff RA, Streicher H, Allison J, Sharma P, Eng C
Lancet Oncol 2017 Apr;18(4):446-453. Epub 2017 Feb 18 doi: 10.1016/S1470-2045(17)30104-3. PMID: 28223062Free PMC Article

Prognosis

Atezolizumab plus modified docetaxel, cisplatin, and fluorouracil as first-line treatment for advanced anal cancer (SCARCE C17-02 PRODIGE 60): a randomised, non-comparative, phase 2 study.
Kim S, Ghiringhelli F, de la Fouchardière C, Evesque L, Smith D, Badet N, Samalin E, Lopez-Trabada Ataz D, Parzy A, Desramé J, Baba Hamed N, Buecher B, Tougeron D, Bouché O, Dahan L, Chibaudel B, El Hajbi F, Mineur L, Dubreuil O, Ben Abdelghani M, Pecout S, Bibeau F, Herfs M, Garcia ML, Meurisse A, Vernerey D, Taïeb J, Borg C
Lancet Oncol 2024 Apr;25(4):518-528. doi: 10.1016/S1470-2045(24)00081-0. PMID: 38547895
Prognostic and Predictive Markers for Patients With Anal Cancer.
Holliday EB, Peddireddy A, Morris VK
J Natl Compr Canc Netw 2023 Jun;21(6):678-684. doi: 10.6004/jnccn.2023.7031. PMID: 37308122
The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies.
Jácome AA, Morris VK, Eng C
Curr Treat Options Oncol 2022 Aug;23(8):1073-1085. Epub 2022 Jun 6 doi: 10.1007/s11864-022-00939-3. PMID: 35666353
FOLFCIS Treatment and Genomic Correlates of Response in Advanced Anal Squamous Cell Cancer.
Mondaca S, Chatila WK, Bates D, Hechtman JF, Cercek A, Segal NH, Stadler ZK, Varghese AM, Kundra R, Capanu M, Shia J, Schultz N, Saltz L, Yaeger R
Clin Colorectal Cancer 2019 Mar;18(1):e39-e52. Epub 2018 Sep 21 doi: 10.1016/j.clcc.2018.09.005. PMID: 30316684Free PMC Article
Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multicentre, single-arm, phase 2 study.
Morris VK, Salem ME, Nimeiri H, Iqbal S, Singh P, Ciombor K, Polite B, Deming D, Chan E, Wade JL, Xiao L, Bekaii-Saab T, Vence L, Blando J, Mahvash A, Foo WC, Ohaji C, Pasia M, Bland G, Ohinata A, Rogers J, Mehdizadeh A, Banks K, Lanman R, Wolff RA, Streicher H, Allison J, Sharma P, Eng C
Lancet Oncol 2017 Apr;18(4):446-453. Epub 2017 Feb 18 doi: 10.1016/S1470-2045(17)30104-3. PMID: 28223062Free PMC Article

Clinical prediction guides

Atezolizumab plus modified docetaxel, cisplatin, and fluorouracil as first-line treatment for advanced anal cancer (SCARCE C17-02 PRODIGE 60): a randomised, non-comparative, phase 2 study.
Kim S, Ghiringhelli F, de la Fouchardière C, Evesque L, Smith D, Badet N, Samalin E, Lopez-Trabada Ataz D, Parzy A, Desramé J, Baba Hamed N, Buecher B, Tougeron D, Bouché O, Dahan L, Chibaudel B, El Hajbi F, Mineur L, Dubreuil O, Ben Abdelghani M, Pecout S, Bibeau F, Herfs M, Garcia ML, Meurisse A, Vernerey D, Taïeb J, Borg C
Lancet Oncol 2024 Apr;25(4):518-528. doi: 10.1016/S1470-2045(24)00081-0. PMID: 38547895
Prognostic and Predictive Markers for Patients With Anal Cancer.
Holliday EB, Peddireddy A, Morris VK
J Natl Compr Canc Netw 2023 Jun;21(6):678-684. doi: 10.6004/jnccn.2023.7031. PMID: 37308122
The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies.
Jácome AA, Morris VK, Eng C
Curr Treat Options Oncol 2022 Aug;23(8):1073-1085. Epub 2022 Jun 6 doi: 10.1007/s11864-022-00939-3. PMID: 35666353
Docetaxel, cisplatin, and fluorouracil chemotherapy for metastatic or unresectable locally recurrent anal squamous cell carcinoma (Epitopes-HPV02): a multicentre, single-arm, phase 2 study.
Kim S, François E, André T, Samalin E, Jary M, El Hajbi F, Baba-Hamed N, Pernot S, Kaminsky MC, Bouché O, Desrame J, Zoubir M, Ghiringhelli F, Parzy A, De La Fouchardiere C, Smith D, Deberne M, Spehner L, Badet N, Adotevi O, Anota A, Meurisse A, Vernerey D, Taieb J, Vendrely V, Buecher B, Borg C
Lancet Oncol 2018 Aug;19(8):1094-1106. Epub 2018 Jul 2 doi: 10.1016/S1470-2045(18)30321-8. PMID: 30042063
Docetaxel, Cisplatin, and 5-fluorouracil (DCF) chemotherapy in the treatment of metastatic or unresectable locally recurrent anal squamous cell carcinoma: a phase II study of French interdisciplinary GERCOR and FFCD groups (Epitopes-HPV02 study).
Kim S, Jary M, André T, Vendrely V, Buecher B, François E, Bidard FC, Dumont S, Samalin E, Peiffert D, Pernot S, Baba-Hamed N, El Hajbi F, Bouché O, Desrame J, Parzy A, Zoubir M, Louvet C, Bachet JB, Nguyen T, Abdelghani MB, Smith D, De La Fouchardière C, Aparicio T, Bennouna J, Gornet JM, Jacquin M, Bonnetain F, Borg C
BMC Cancer 2017 Aug 25;17(1):574. doi: 10.1186/s12885-017-3566-0. PMID: 28841909Free PMC Article

Recent systematic reviews

Radiotherapy in the management of rare gastrointestinal cancers: A systematic review.
Bellefkih FZ, Benchakroun N, Lalya I, Amaoui B, El Kacemi H, Acharki A, El Hfid M, El Mazghi A, Chekrine T, Bouchbika Z, Jouhadi H, Sahraoui S, Tawfiq N, Michalet M
Cancer Radiother 2023 Sep;27(6-7):622-637. Epub 2023 Jul 25 doi: 10.1016/j.canrad.2023.06.010. PMID: 37500390

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