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Transplant-Associated Thrombotic Microangiopathy

MedGen UID:
1758357
Concept ID:
C5417748
Disease or Syndrome

Definition

Thrombotic microangiopathy that presents in some patients undergoing hematopoietic stem cell transplantation (HSCT). Though similar in presentation to thrombotic thrombocytopenic purpura (TTP) and atypical hemolytic uremic syndrome (aHUS), transplant-associated thrombotic microangiopathy (TA-TMA) is a distinct disorder. Several risk factors may be associated with TA-TMA, including high-dose chemotherapy, radiation therapy, HLA mismatch, use of calcineurin inhibitors, acute graft-versus-host disease (GVHD), and infections. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTransplant-Associated Thrombotic Microangiopathy

Professional guidelines

PubMed

McEwan A, Greenwood M, Ward C, Ritchie D, Szer J, Gardiner E, Colic A, Sipavicius J, Panek-Hudson Y, Kerridge I
Intern Med J 2023 Dec;53(12):2162-2174. Epub 2023 Aug 1 doi: 10.1111/imj.16188. PMID: 37528613
Elemary M, Sabry W, Seghatchian J, Goubran H
Transfus Apher Sci 2019 Jun;58(3):347-350. Epub 2019 May 1 doi: 10.1016/j.transci.2019.04.022. PMID: 31097308
Jodele S
Semin Hematol 2018 Jul;55(3):159-166. Epub 2018 Apr 11 doi: 10.1053/j.seminhematol.2018.04.003. PMID: 30032753

Recent clinical studies

Etiology

Jodele S, Dandoy CE, Aguayo-Hiraldo P, Lane A, Teusink-Cross A, Sabulski A, Mizuno K, Laskin BL, Freedman J, Davies SM
Blood 2024 Mar 21;143(12):1112-1123. doi: 10.1182/blood.2023022526. PMID: 37946262Free PMC Article
Lazana I
Int J Mol Sci 2023 Jan 6;24(2) doi: 10.3390/ijms24021159. PMID: 36674666Free PMC Article
Emberesh M, Rubinstein JD, Young J, Benoit SW, Dandoy CE, Weiss BD
Pediatr Blood Cancer 2021 Mar;68(3):e28852. Epub 2020 Dec 31 doi: 10.1002/pbc.28852. PMID: 33381917
Jodele S, Dandoy CE, Lane A, Laskin BL, Teusink-Cross A, Myers KC, Wallace G, Nelson A, Bleesing J, Chima RS, Hirsch R, Ryan TD, Benoit S, Mizuno K, Warren M, Davies SM
Blood 2020 Mar 26;135(13):1049-1057. doi: 10.1182/blood.2019004218. PMID: 31932840Free PMC Article
Fujiwara H, Maeda Y, Sando Y, Nakamura M, Tani K, Ishikawa T, Nishimori H, Matsuoka K, Fujii N, Kondo E, Tanimoto M
Transfusion 2016 Apr;56(4):886-92. Epub 2015 Dec 29 doi: 10.1111/trf.13437. PMID: 26711692

Diagnosis

Hartjes K, Koo D, Al-Ibraheemi A, Sweeny KF, Wehrman A, Elisofon S, Lee CK, Cuenca AG, Kim HB, Lee EJ
Pediatr Transplant 2024 Aug;28(5):e14818. doi: 10.1111/petr.14818. PMID: 38940480
Jodele S, Dandoy CE, Aguayo-Hiraldo P, Lane A, Teusink-Cross A, Sabulski A, Mizuno K, Laskin BL, Freedman J, Davies SM
Blood 2024 Mar 21;143(12):1112-1123. doi: 10.1182/blood.2023022526. PMID: 37946262Free PMC Article
Lazana I
Int J Mol Sci 2023 Jan 6;24(2) doi: 10.3390/ijms24021159. PMID: 36674666Free PMC Article
Young JA, Pallas CR, Knovich MA
Bone Marrow Transplant 2021 Aug;56(8):1805-1817. Epub 2021 Apr 19 doi: 10.1038/s41409-021-01283-0. PMID: 33875812Free PMC Article
Jodele S, Dandoy CE, Lane A, Laskin BL, Teusink-Cross A, Myers KC, Wallace G, Nelson A, Bleesing J, Chima RS, Hirsch R, Ryan TD, Benoit S, Mizuno K, Warren M, Davies SM
Blood 2020 Mar 26;135(13):1049-1057. doi: 10.1182/blood.2019004218. PMID: 31932840Free PMC Article

Therapy

Hartjes K, Koo D, Al-Ibraheemi A, Sweeny KF, Wehrman A, Elisofon S, Lee CK, Cuenca AG, Kim HB, Lee EJ
Pediatr Transplant 2024 Aug;28(5):e14818. doi: 10.1111/petr.14818. PMID: 38940480
Jodele S, Dandoy CE, Aguayo-Hiraldo P, Lane A, Teusink-Cross A, Sabulski A, Mizuno K, Laskin BL, Freedman J, Davies SM
Blood 2024 Mar 21;143(12):1112-1123. doi: 10.1182/blood.2023022526. PMID: 37946262Free PMC Article
Lazana I
Int J Mol Sci 2023 Jan 6;24(2) doi: 10.3390/ijms24021159. PMID: 36674666Free PMC Article
Young JA, Pallas CR, Knovich MA
Bone Marrow Transplant 2021 Aug;56(8):1805-1817. Epub 2021 Apr 19 doi: 10.1038/s41409-021-01283-0. PMID: 33875812Free PMC Article
Jodele S, Dandoy CE, Lane A, Laskin BL, Teusink-Cross A, Myers KC, Wallace G, Nelson A, Bleesing J, Chima RS, Hirsch R, Ryan TD, Benoit S, Mizuno K, Warren M, Davies SM
Blood 2020 Mar 26;135(13):1049-1057. doi: 10.1182/blood.2019004218. PMID: 31932840Free PMC Article

Prognosis

Hartjes K, Koo D, Al-Ibraheemi A, Sweeny KF, Wehrman A, Elisofon S, Lee CK, Cuenca AG, Kim HB, Lee EJ
Pediatr Transplant 2024 Aug;28(5):e14818. doi: 10.1111/petr.14818. PMID: 38940480
Lazana I
Int J Mol Sci 2023 Jan 6;24(2) doi: 10.3390/ijms24021159. PMID: 36674666Free PMC Article
Emberesh M, Rubinstein JD, Young J, Benoit SW, Dandoy CE, Weiss BD
Pediatr Blood Cancer 2021 Mar;68(3):e28852. Epub 2020 Dec 31 doi: 10.1002/pbc.28852. PMID: 33381917
Jodele S, Dandoy CE, Lane A, Laskin BL, Teusink-Cross A, Myers KC, Wallace G, Nelson A, Bleesing J, Chima RS, Hirsch R, Ryan TD, Benoit S, Mizuno K, Warren M, Davies SM
Blood 2020 Mar 26;135(13):1049-1057. doi: 10.1182/blood.2019004218. PMID: 31932840Free PMC Article
Gavriilaki E, Sakellari I, Anagnostopoulos A, Brodsky RA
Bone Marrow Transplant 2017 Oct;52(10):1355-1360. Epub 2017 Mar 13 doi: 10.1038/bmt.2017.39. PMID: 28287636

Clinical prediction guides

Schoettler ML, Lehmann L, Kao PC, Chen N, Jodele S, Chonat S, Williams KM, London WB, Duncan C, Dandoy C
Blood Adv 2024 Mar 12;8(5):1220-1233. doi: 10.1182/bloodadvances.2023011078. PMID: 38154068Free PMC Article
Zhang Z, Hong W, Wu Q, Tsavachidis S, Li JR, Amos CI, Cheng C, Sartain SE, Afshar-Kharghan V, Dong JF, Bhatraju P, Martin PJ, Makar RS, Bendapudi PK, Li A
Thromb Res 2023 May;225:39-46. Epub 2023 Mar 15 doi: 10.1016/j.thromres.2023.03.001. PMID: 36948020Free PMC Article
Lazana I
Int J Mol Sci 2023 Jan 6;24(2) doi: 10.3390/ijms24021159. PMID: 36674666Free PMC Article
Sabulski A, Arcuri G, Szabo S, Care MM, Dandoy CE, Davies SM, Jodele S
Blood Adv 2022 Jul 26;6(14):4310-4319. doi: 10.1182/bloodadvances.2022007453. PMID: 35877136Free PMC Article
Jodele S, Medvedovic M, Luebbering N, Chen J, Dandoy CE, Laskin BL, Davies SM
Blood Adv 2020 Mar 24;4(6):1166-1177. doi: 10.1182/bloodadvances.2020001515. PMID: 32208488Free PMC Article

Recent systematic reviews

Guo M, Qi J, Hou Q, Li X, Han Y
Expert Rev Hematol 2023 Mar;16(3):191-203. Epub 2023 Jan 2 doi: 10.1080/17474086.2023.2162501. PMID: 36588482
Kashyap R, Anwer F, Iqbal MA, Khalid F, Khan A, Ali MA, Anwar MY, Chaudhary A, Jaan A
Hematol Oncol Stem Cell Ther 2023 Jan 17;16(2):93-101. doi: 10.1016/j.hemonc.2021.09.002. PMID: 34655527
Schoettler ML, Bhatt H, Vasu S
Front Immunol 2022;13:1064203. Epub 2023 Feb 2 doi: 10.3389/fimmu.2022.1064203. PMID: 36818475Free PMC Article
Zhang R, Zhou M, Qi J, Miao W, Zhang Z, Wu D, Han Y
Front Immunol 2020;11:564647. Epub 2021 Jan 20 doi: 10.3389/fimmu.2020.564647. PMID: 33552043Free PMC Article
Warren M, Jodele S, Dandoy C, Myers KC, Wallace G, Nelson A, El-Bietar J
Arch Pathol Lab Med 2017 Nov;141(11):1558-1566. Epub 2017 Aug 10 doi: 10.5858/arpa.2016-0599-RA. PMID: 28795840

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